? Automated monitoring vs. single point testing ? Around the clock on-line monitoring ? Real-time...
-
Upload
matthew-mcdonald -
Category
Documents
-
view
217 -
download
1
Transcript of ? Automated monitoring vs. single point testing ? Around the clock on-line monitoring ? Real-time...
![Page 1: ? Automated monitoring vs. single point testing ? Around the clock on-line monitoring ? Real-time blood analysis ? Superior sampling process ? Self-Calibration.](https://reader035.fdokument.com/reader035/viewer/2022062511/55161a3f550346cf6f8b6637/html5/thumbnails/1.jpg)
Ins titut für Chem o - und B iosensorik
Automated monitoring vs. single point testing
Around the clock on-line monitoring
Real-time blood analysis
Superior sampling process
Self-Calibration
Improved safety and patient care
BlutmonitorMulti-Sensor-Cartridge-SystemClick&Test
Idee und Vorentwicklung im Rahmen eines Projektes des Ministerium für Wirtschaft und Mittelstand, Energie und Verkehr des Landes Nordrhein-Westfalen
Produktentwicklung in Industriekooperation
![Page 2: ? Automated monitoring vs. single point testing ? Around the clock on-line monitoring ? Real-time blood analysis ? Superior sampling process ? Self-Calibration.](https://reader035.fdokument.com/reader035/viewer/2022062511/55161a3f550346cf6f8b6637/html5/thumbnails/2.jpg)
Ins titut für Chem o - und B iosensorik
Click&Test: T - Connector with adapter
Click&Test: Single use disposable Multi-Sensor-Cartridge
Click&Test: Reusable Console
Click&Test: Monitor Display and Store Data Management
BlutmonitorMulti-Sensor-Cartridge-SystemClick&Test
The Click&Test System consists:
• Fast, safe, simple
• Superior patient management
• Cost effectiveness
![Page 3: ? Automated monitoring vs. single point testing ? Around the clock on-line monitoring ? Real-time blood analysis ? Superior sampling process ? Self-Calibration.](https://reader035.fdokument.com/reader035/viewer/2022062511/55161a3f550346cf6f8b6637/html5/thumbnails/3.jpg)
Ins titut für Chem o - und B iosensorikBlutmonitorMulti-Sensor-Cartridge-SystemClick&Test
Extracorporal Blood Circle
Standard Solution 1 Standard Solution 2W aste
M1 M2 M3
Monitor and Control Device
Reference ChannelW aste Channel
Reference
Containment Chip
MultianalytContainment Chip
Schematic view of Click&Test
![Page 4: ? Automated monitoring vs. single point testing ? Around the clock on-line monitoring ? Real-time blood analysis ? Superior sampling process ? Self-Calibration.](https://reader035.fdokument.com/reader035/viewer/2022062511/55161a3f550346cf6f8b6637/html5/thumbnails/4.jpg)
Ins titut für Chem o - und B iosensorikBlutmonitorMulti-Sensor-Cartridge-SystemClick&Test
Operations with cardiopulmonary bypass
Dialysis
Hemofiltration
High volume transfusions
Organ transplantations
postoperative care
Quality control of culture medium
Tissue engineering
Clinical Applications
![Page 5: ? Automated monitoring vs. single point testing ? Around the clock on-line monitoring ? Real-time blood analysis ? Superior sampling process ? Self-Calibration.](https://reader035.fdokument.com/reader035/viewer/2022062511/55161a3f550346cf6f8b6637/html5/thumbnails/5.jpg)
Ins titut für Chem o - und B iosensorikBlutmonitorMulti-Sensor-Cartridge-SystemClick&Test
Heart surgery centers
Transplantation centers
Intensiv care units (ICU)
Emergency departments
Center of treatment of burnings
Modern tissue culture laboratories
Potential Customers
![Page 6: ? Automated monitoring vs. single point testing ? Around the clock on-line monitoring ? Real-time blood analysis ? Superior sampling process ? Self-Calibration.](https://reader035.fdokument.com/reader035/viewer/2022062511/55161a3f550346cf6f8b6637/html5/thumbnails/6.jpg)
Ins titut für Chem o - und B iosensorikBlutmonitorMulti-Sensor-Cartridge-SystemClick&Test
Operationen mit der Herz-Lungen-Maschine (HLM) in den deutschen Herzzentren 2000
326 238 253 147
15590
72894
4737 4649
Herzklappenfehler koronare Herzerkrankungen angeborene Herzfehler sonstige Indikation0
10000
60000
70000
80000
Za
hl d
er
Op
era
tion
en
Art der Operation
Operationen mit HLM 2000 Veränderung gegenüber 1999
![Page 7: ? Automated monitoring vs. single point testing ? Around the clock on-line monitoring ? Real-time blood analysis ? Superior sampling process ? Self-Calibration.](https://reader035.fdokument.com/reader035/viewer/2022062511/55161a3f550346cf6f8b6637/html5/thumbnails/7.jpg)
Ins titut für Chem o - und B iosensorikBlutmonitorMulti-Sensor-Cartridge-SystemClick&Test
341.179 Operationen mit der Herz-Lungen-Maschine (HLM) in Europa 1999
Deutschland 96.906
Frankreich 43.000
Großbritanien 38.152
Italien 34.000
Spanien 17.000
Niederland 14.150
Belgien 12.492
Polen 14.061
![Page 8: ? Automated monitoring vs. single point testing ? Around the clock on-line monitoring ? Real-time blood analysis ? Superior sampling process ? Self-Calibration.](https://reader035.fdokument.com/reader035/viewer/2022062511/55161a3f550346cf6f8b6637/html5/thumbnails/8.jpg)
Ins titut für Chem o - und B iosensorikBlutmonitorMulti-Sensor-Cartridge-SystemClick&Test
Containment Technology
Silicon technology
Membrane technology
Microsystem technology
![Page 9: ? Automated monitoring vs. single point testing ? Around the clock on-line monitoring ? Real-time blood analysis ? Superior sampling process ? Self-Calibration.](https://reader035.fdokument.com/reader035/viewer/2022062511/55161a3f550346cf6f8b6637/html5/thumbnails/9.jpg)
Ins titut für Chem o - und B iosensorikBlutmonitorMulti-Sensor-Cartridge-SystemClick&Test
Containment TechnologyFeatures
Suitable for mass production
Suitable for miniaturisation
Substance-detecting sensor components securely anchored
Simple housing and connection methods using through-contacted sensors
Potential for development as multianalyte sensor and as sensor array
![Page 10: ? Automated monitoring vs. single point testing ? Around the clock on-line monitoring ? Real-time blood analysis ? Superior sampling process ? Self-Calibration.](https://reader035.fdokument.com/reader035/viewer/2022062511/55161a3f550346cf6f8b6637/html5/thumbnails/10.jpg)
Ins titut für Chem o - und B iosensorikBlutmonitorMulti-Sensor-Cartridge-SystemClick&Test
Containment Technology
Cross-sectional view of a containment sensor
Cross-sectional view of a flow through chip
flow channel
containment
glass
silicon chip
Encapsulation
silicon chip active membrane
active surface of the sensor
gold electrode
•Potentiometric ion sensors
•Amperometric enzyme sensors
•Amperometric microbial sensors
![Page 11: ? Automated monitoring vs. single point testing ? Around the clock on-line monitoring ? Real-time blood analysis ? Superior sampling process ? Self-Calibration.](https://reader035.fdokument.com/reader035/viewer/2022062511/55161a3f550346cf6f8b6637/html5/thumbnails/11.jpg)
Ins titut für Chem o - und B iosensorikBlutmonitorMulti-Sensor-Cartridge-SystemClick&Test
Potentiometric ion - selective sensors
![Page 12: ? Automated monitoring vs. single point testing ? Around the clock on-line monitoring ? Real-time blood analysis ? Superior sampling process ? Self-Calibration.](https://reader035.fdokument.com/reader035/viewer/2022062511/55161a3f550346cf6f8b6637/html5/thumbnails/12.jpg)
Ins titut für Chem o - und B iosensorikBlutmonitorMulti-Sensor-Cartridge-SystemClick&Test
AgSiO2
SiO2
Potentiometric ion - selective sensor
•(a) SEM micrograph showing a containment element with patterned silver electrode for use in potentiometric sensors
•(b) SEM micrograph showing the membrane surface of the potassium sensor
![Page 13: ? Automated monitoring vs. single point testing ? Around the clock on-line monitoring ? Real-time blood analysis ? Superior sampling process ? Self-Calibration.](https://reader035.fdokument.com/reader035/viewer/2022062511/55161a3f550346cf6f8b6637/html5/thumbnails/13.jpg)
Ins titut für Chem o - und B iosensorikBlutmonitorMulti-Sensor-Cartridge-SystemClick&Test
Containment sensors for medical diagnosticsAnalysis of blood electrolytes
Potassium K+
Calcium iCa2+
pH
Sodium Na+
Hematocrit
SaO2
Hemoglobin
![Page 14: ? Automated monitoring vs. single point testing ? Around the clock on-line monitoring ? Real-time blood analysis ? Superior sampling process ? Self-Calibration.](https://reader035.fdokument.com/reader035/viewer/2022062511/55161a3f550346cf6f8b6637/html5/thumbnails/14.jpg)
Ins titut für Chem o - und B iosensorikBlutmonitorMulti-Sensor-Cartridge-SystemClick&Test
Containment sensors for medical diagnostics
![Page 15: ? Automated monitoring vs. single point testing ? Around the clock on-line monitoring ? Real-time blood analysis ? Superior sampling process ? Self-Calibration.](https://reader035.fdokument.com/reader035/viewer/2022062511/55161a3f550346cf6f8b6637/html5/thumbnails/15.jpg)
Ins titut für Chem o - und B iosensorikBlutmonitorMulti-Sensor-Cartridge-SystemClick&Test
Containment sensors for medical diagnostics
![Page 16: ? Automated monitoring vs. single point testing ? Around the clock on-line monitoring ? Real-time blood analysis ? Superior sampling process ? Self-Calibration.](https://reader035.fdokument.com/reader035/viewer/2022062511/55161a3f550346cf6f8b6637/html5/thumbnails/16.jpg)
Ins titut für Chem o - und B iosensorikBlutmonitorMulti-Sensor-Cartridge-SystemClick&Test
Containment sensors for medical diagnostics
![Page 17: ? Automated monitoring vs. single point testing ? Around the clock on-line monitoring ? Real-time blood analysis ? Superior sampling process ? Self-Calibration.](https://reader035.fdokument.com/reader035/viewer/2022062511/55161a3f550346cf6f8b6637/html5/thumbnails/17.jpg)
Ins titut für Chem o - und B iosensorikBlutmonitorMulti-Sensor-Cartridge-SystemClick&Test
Containment sensors for medical diagnostics
![Page 18: ? Automated monitoring vs. single point testing ? Around the clock on-line monitoring ? Real-time blood analysis ? Superior sampling process ? Self-Calibration.](https://reader035.fdokument.com/reader035/viewer/2022062511/55161a3f550346cf6f8b6637/html5/thumbnails/18.jpg)
Ins titut für Chem o - und B iosensorikBlutmonitorMulti-Sensor-Cartridge-SystemClick&Test
Containment sensors for medical diagnostics
![Page 19: ? Automated monitoring vs. single point testing ? Around the clock on-line monitoring ? Real-time blood analysis ? Superior sampling process ? Self-Calibration.](https://reader035.fdokument.com/reader035/viewer/2022062511/55161a3f550346cf6f8b6637/html5/thumbnails/19.jpg)
Ins titut für Chem o - und B iosensorikBlutmonitorMulti-Sensor-Cartridge-SystemClick&Test
Containment sensors for medical diagnostics
![Page 20: ? Automated monitoring vs. single point testing ? Around the clock on-line monitoring ? Real-time blood analysis ? Superior sampling process ? Self-Calibration.](https://reader035.fdokument.com/reader035/viewer/2022062511/55161a3f550346cf6f8b6637/html5/thumbnails/20.jpg)
Ins titut für Chem o - und B iosensorikBlutmonitorMulti-Sensor-Cartridge-SystemClick&Test
Containment sensors for medical diagnostics
![Page 21: ? Automated monitoring vs. single point testing ? Around the clock on-line monitoring ? Real-time blood analysis ? Superior sampling process ? Self-Calibration.](https://reader035.fdokument.com/reader035/viewer/2022062511/55161a3f550346cf6f8b6637/html5/thumbnails/21.jpg)
Ins titut für Chem o - und B iosensorikBlutmonitorMulti-Sensor-Cartridge-SystemClick&Test
• Segment of the potential-time plot of a three point calibration of a long-term experiment for potassium, sodium, calcium, and pH taken simultaneously in two flow-through cells coupled in series
Measurements and results
![Page 22: ? Automated monitoring vs. single point testing ? Around the clock on-line monitoring ? Real-time blood analysis ? Superior sampling process ? Self-Calibration.](https://reader035.fdokument.com/reader035/viewer/2022062511/55161a3f550346cf6f8b6637/html5/thumbnails/22.jpg)
Ins titut für Chem o - und B iosensorikBlutmonitorMulti-Sensor-Cartridge-SystemClick&Test
Measurements and results
•Reproducibility and stability of the potential difference between two standard calibration solutions ( U = U [cal.3] - U[cal.1]) during 125h
![Page 23: ? Automated monitoring vs. single point testing ? Around the clock on-line monitoring ? Real-time blood analysis ? Superior sampling process ? Self-Calibration.](https://reader035.fdokument.com/reader035/viewer/2022062511/55161a3f550346cf6f8b6637/html5/thumbnails/23.jpg)
Ins titut für Chem o - und B iosensorikBlutmonitorMulti-Sensor-Cartridge-SystemClick&Test
Preclinical measurements and results
•Potential-time plot of potassium concentration as measured during an extracorporal animal blood circulation run
![Page 24: ? Automated monitoring vs. single point testing ? Around the clock on-line monitoring ? Real-time blood analysis ? Superior sampling process ? Self-Calibration.](https://reader035.fdokument.com/reader035/viewer/2022062511/55161a3f550346cf6f8b6637/html5/thumbnails/24.jpg)
Ins titut für Chem o - und B iosensorikBlutmonitorMulti-Sensor-Cartridge-SystemClick&Test
0 10 20 30 40 50 60
80
120
160
200
240
280
pH - Sensor
Sodium sensor
Potassium sensor
Whole BloodStandard 2
Time in minutes
Standard 1
Sen
sor
sign
al in
mV
Preclinical measurements and results
•Potential-time plot of simultaneous on-line monitoring by a sensor chip integrated with three different sensor elements used in whole blood measurement
![Page 25: ? Automated monitoring vs. single point testing ? Around the clock on-line monitoring ? Real-time blood analysis ? Superior sampling process ? Self-Calibration.](https://reader035.fdokument.com/reader035/viewer/2022062511/55161a3f550346cf6f8b6637/html5/thumbnails/25.jpg)
Ins titut für Chem o - und B iosensorikBlutmonitorMulti-Sensor-Cartridge-SystemClick&Test
Preclinical measurements and results
•Correlation of K+ measurements of 18 human whole blood samples as obtained by our on-line monitoring system and by the clinical laboratory blood gas/electrolyte analyzer RADIOMETER ABL 625