Jaarverslag2008Statistiek - Universiteit Hasselt · transmission: an illustration for variacella...

= N

Onderzoeksgroep: STATISTIEK 2008

A Identiteit van de deelnemende onderzoekers Aerts Marc, Alonso Ariel, Beunckens Caroline, Bijnens Luc, Birhanu Teshome Ayele,

Bollaerts Kaatje, Braekers Roel, Bruckers Liesbeth, Burzykowski Tomasz, Buyse Marc, Callaert Herman, Castro Sanchez Yovanna Amparo, Cortiñas Abrahantas José, Creemers An, Del Fava Emanuele, Duchateau Luc, Faes Christel, Gaddah Auguste, Geys Helena, Girma Minalu, Gitome Arthur, Goeyvaerts Nele, Lin Dan, Haldermans Philippe, Hens Niel, Jacobs Tom, Jansen Ivy, Janssen Paul, Kadankova Tetyana, Kasim Adetayo, Laenen Annouschka, Lesaffre Emmanuel, Litière Saskia, Maringwa John, Massonnet Goele, Molenberghs Geert, Namata Harriet, Pramana Setia, Pryseley Assam Nkouibert, Qi Zhu, Renard Didier, Rizopoulos Dimitris, Serroyen Jan, Skhedy Ziv, Sotto Cristina, Thijs Herbert, Tilahun Eshete Abel, Valkenborg Dirk, Van Effelterre Thierry, Van Keilegom Ingrid, Van Rompaye Bart, Van Sanden Suzy, Veraverbeke Noël, Verbeke Geert, Weyler Joost, Winters Bart, Wouters Kristien, Wouters Luc.

B Titel(s) van het (de) onderzoeksproject(en)

a. Mathematische statistiek

ÄK Biostatistiek

C Beschrijving van de ontwikkelde onderzoeksactiviteit(en) per project

- Research on statistical education (HC)

- Resampling, goodness of fit (NV, PJ, Jan Swanepoel)

- Extension of Koziol-Green model (RB, NV)

- Copula process with covariates (NV)

- Empirical likelihood for non smooth criterion function (NV, Ingrid Van Keilegom, Elisa

Molanes)

- Weak convergence for copula estimator (NV, Irène Gijbels, Marek Omelka)

- Risk theory (NV, Stéphane Loisel, Claudio Macci)

- Difference of compound Poisson and compound renewal process (TK)

- Two-boundary characteristics (TK)

- Queueing systems with limited waiting room and applications (TK)

- Extension of the Koziol-Green model by introducing a copula on lifetime and censoring time.

Non- and semiparametric estimation of the copula. Goodness-of-fit for the copula family

(RB, AG)

- Copula model for association between error and covariate in homoscedastic regression (RB,

Ingrid Van Keilegom)

- A zero-inflated Cox regression model for left-censored data. (RB, Paul Markel)

- Semi-competing risk model with fixed covariate. Copula-graphic estimation for the

conditional distribution of the smallest lifetime (RB, NV)

- Two-stage estimation in copula models: methodology and udder infection example (GMa, PJ,

Luc Duchateau)

- The choice of the copula using pseudo-likelihood ratio tests (GMa, PJ, Luc Duchateau)

= O

- General goodness-of-fit test for four-dimensional copula models (GMa, PJ)

- Spatial and temporal frailty models (PJ, Luc Duchateau, Yehenew Getachew (Jimma

University))

- Frailty models and general linear models with time-varying coefficients (PJ, Ingrid Van

Keilegom, Catherine Legrand)

- Study of bias in frailty models (PJ, Dimitris Karlis)

- Fitting frailty models via transformation: the continuous case (PJ, Ricardo Cao, Ignacio Lopez

de Ullibarri)

- Missing data and sensitivity analysis (GM, MA, HT, IJ, CB, CS, AC, Geert Verbeke, Dimitris

Rizopoulos, Sypridoula Tsonaka, Kristel Van Steen, Els Goetghebeur, Michael G. Kenward,

Stijn Vansteelandt)

- Missing data in clinical trials (GM, Michael G. Kenward, Raymond J. Caroll, Craig Millinckrodt,

CB, IJ, CS)

- Pattern-mixture models (GM, HT, Michael G. Kenward, CB, IJ)

- Surrogate markers (GM, TB, HG, Fabián Tibaldi, JC, AA, ZS, Tony Vangeneugden, Didier

Renard, AT, PA)

- Neuron synchronization (Carmen Cadarso, HG, GM, AA, CF)

- Logistic mixed models in item response theory (GM, Geert Verbeke, Paul De Boeck, Dirk

Smits, Edward Ip, Yuri Goegebeur)

- Models for discrete repeated measures (GM, Geert Verbeke)

- Small-sample degrees of freedom (GM, CF, MA, Geert Verbeke, Michael G. Kenward)

- Methods for clustered data (MA, HG, CF, GM)

- Models for infectious diseases (MA, ZS, GM, NH)

- Methods for optimization in statistics (GM, Geert Verbeke, Iven Van Mechelen, Francis

Tuerlinckx)

- Psychometric methods in clinical studies (GM, AL, AA, Tony Vangeneugden)

- Combined longitudinal-overdispersed models (GM, Geert Verbeke, Clarice Demétrio, Tony

Vangeneugden, Afranio Vieira)

- Psueo-likelihood for incomplete data (GM, Geert Verbeke, BT, Michael G. Kenward)

- Topics in modeling infectious diseases (MA, NH, ZS, CF, JC, NG, KB, YC, HN, Pierre Van

Damme, Philippe Beutels, Heidi Theeten, Ogenjimi Benson, Koen Van Herck, Elke Leuridan,

Gaelle Boulet, John-Paul Bogers, Olivier Lejeune (UA), Koen Mintiens, Stefan Roels, Yves

Vanderstede, Estelle Méroc (Centrum voor Onderzoek in de Diergeneeskunde en Argonomie),

Dirk Berkvens, Nico Speybroeck (Instituut voor Tropische Geneeskunde), Patrick Cras (UA),

Claude Saegerman (ULiège), Peter Theunis, Jacco Wallinga (RIVM, Bilthoven, NL))

- Topics in microbial risk assessment, Zoonotic diseases (e.g. Salmonella), Vectorborne

diseases (e.g. Bluetongue) and food safety (MA, CF, ZS, SL, JC, KB, HN, Koen Mintiens, Ides

Boone, Yves Van der Stede en Stefan Roels (Centrum voor Onderzoek in de

Diergeneeskunden en Agrochemie), Stefaan Ribbens en Jeroen Dewulf (Ugent), Koen

Grijspeerdt (Instituut voor landbouw- en Visserijonderzoek), Peter Teunis (RIVM, Bilthoven,

NL)

- Topics in model selection (MA, NH, Jeffrey Simonoff (New York University)

- Topics in correlated frailty models (MA, NH, GM, Andreas Wienke (University Halle-

Wittenberg))

- Topics in missing data (MA, GM, HT, NH, IJ, AC, Geert Verbeke, Mike Kenward)

- Topics in safety assessment of lactobacilli (MA, NH, GiM, GM, Vanessa Vankerckhoven,

Hermans Goossens (UA))

- Topics in diagnosis of M. pneumoniae infections (MA, NH, GM, Katherine Loens, Greet Ieven,

Herman Goossens (UA))

P

- Dealing with various issues when modelling infectious diseases (NH, MA, KB, AC, CF, NG,

GiM, HN, ZS, Philippe Beutels, Joke Bilcke, Olivier Lejeune, Benson Ongunjimi, Pierre Van

Damme (UA))

- Modelling the force of infection from seroprevalence data: to monotonize or not to

monotonize ? (NH, MA, Andrea Kvitkovicova, David Hlubinka (Prague), Pierre Van Damme,

Philippe Beutels (UA))

- Elucidation on country-specific differences of the sero-epidemiology of B19 and VZV in five

different European countries (NH, MA, ZS, Nigel Gay, John Edmunds, Alessia Melagaro

(Heatlh Protection Agency))

- Caregiver concerns about the number of vaccine injections and willingness to pay to reduce

them (NH, MA, Heidi Theeten, Pierre Van Damme, Philippe Beutels (UA), Corinne

Vandermeulen, Mathieu Roelants, Karel Hoppenbrouwers (KULeuven))

- Modelling cell and matrix adhesion for bacterial infectious (Vanessa Van Kerkhoven,

Katherine Loens, Greet Ieven and Herman Goossens (UA), NH, MA, GiM)

- Modelling pandemic influenza: the impact on Flanders (NH, MA, CF, Samuel Xavier de Souza,

Elke Moons, Davy Jansen, Philippe Beutels (UA), Marc Van Ranst, Pieter Maes (KULeuven),

Ignace Glorieux (VUB))

- Penalized splines methodology (CF)

- Pseuo-likelihood estimation method (CF)

- Infectious disease modeling (CF)

- Spatio-temporal spread of infectious diseases (CF)

- Spatial distribution of Bluetongue in Belgium, Germany and the Netherlands (CF)

- Correcting the apparten herd-prevalence based on the diagnostic test characteristics for

tests applied to individuals (CF)

- Using empirical social contact data to model person to person infectious disease

transmission: an illustration for variacella (NG, NH, MA, Pierre Van Damme, Philippe Beutels)

- Mining social mixing patterns for infectious disease models based on a two-day population

survey in Belgium (NG, NH, MA, ZS, Pierre Van Damme, Philippe Beutels)

- Estimating infectious disease parameters for data on social contact and serological status

(NG, NH, Benson Ogunjimi, MA, ZS, Pierre Van Damme, Philippe Beutels)

- Parvovirus B19 in five European countries; disentangling the sociological and microbiological

mechanisms underlying infectious disease transmission (NG, John Edmunds, MA, Philippe

Beutels)

- Modeling infectious diseases: HiV, Amsterdam Cohort Studies (ACS, MA, NH, ZS)

- Diagnostic tools for misspecification in mixed models (SL, AA)

- Dose-response study of microarray experiments: investigating the dose-response

relationship, dose-response curve shapes using isotonic regression, parametric modeling,

and information theory for model selection, Bayesian method, multiple contrast tests (DL,

SP, AK, ZS, An de Bondt, Willem Talloen, Hinrich Goelhmann, Luc Bijnens)

- Selection and evaluation of genomic biomarkers: identifying two types of biomarkers,

prognostic and therapeutic using the joint model and hierarchical Bayesian modeling

approach, and constructing a joint biomarker profile for the selected biomarkers (DL, AT, ZS,

An de Bondt, Willem Talloen, Hinrich Goehlmann, Luc Bijnens)

- Analysis of microarray data: biomarkers and analysis based on Laplace distribution (SV, DL,

AT, AK, AG, SP)

- I/NI calls: a latent variable approach (AK, DL, SV, ZS)

- Order restricted clustering for dose-response microarray experiment (AK, DL, ZS)

- Modeling dose-reponse trends in microarray experiments: hierarchical Bayesian approach

(AK, DL, ZS)

= Q

- Gene signatures with bivariate expression (AK, DL, SV, JC and ZS)

- Fractional polynomial mixed models, Linear discriminant analysis, Flexible discriminant

analysis, Mixture discriminant analysis, Model average, Mutual information, Pseuo-Likelihood

Modeling, Functional Discriminant Analysis (KW, JC, GM)

- Estimating kinase activity in early drug development proteomics experiments using mixed

models (AG, AK, DL, SV, ZS, Matthias Versele, Willem Talloen, Tim Perera, Luc Bijnens

(Janssen Pharmaceutica))

- Molecular phylogenetic analysis on viral sequences and estimation of skyline plots (AG, DL,

SP, ZS)

- Normalization of microarrays. Using microarray, peptide data for the prediction of dose-

response data (PH, ZS, SV, DL, SP)

- Methods of the analysis of microarray (TB, SV, ZS)

- Methods of the analysis mass-spectrometry data (TB, DV, QZ, IJ, AK)

- Validation of surrogate endpoints in multiple randomized clinical trials (TB, Marc Buyse)

- Modelling prevalence and force of infection on case notification and serological data (KB, MA,

ZS, NH, HN, CF, Frank Boelaert (EFSA))

- Ontwikkeling van een methodlogie voor de kwantitatieve beoordeling van zonotische risico’s

toegepast op het model Salmonella bij varkens (KB, MA, ZS, UL: George Daube, UGent:

Lieven De Zutter; ILVO: Koen Grijspeerdt; CODA: Koen Mintiens)

- P-splines regression with shape contraints (KB, MA; University Rotterdam: Paul Eilers)

- Nonlinear mixed effects modelling: IVIVC modelling; pharmacology (TJ, GM, A. Dunne

(University College, Dublin), R. Straetemans (Janssen Pharmaceutica, Beerse))

- Incomplete longitudinal data: generalized mixed models, (weighted) generalized estimating

equations, multiple imputation, sensitivity analysis, local influence, pattern-mixture models,

shared-parameters models, latent-class models (CB, CS)

- Surrogate marker validation and selection and evaluation of genomic biomarkers (AT, GM,

ZS, TB, Marc Buyse, AA, JC, DL)

- Genetic distance, likelihood-based estimation repreduction number, transmission network

(SP, AG, DL, ZS)

- Nonlinear models, isotonic regression, tests for monotone trend, ratio tests, Graphical Use

Inference (SP, PH, DL, ZS, An de Bondt, Willem Taloen, Hinrich Goehlmann, Luc Bijnens

(Janssen Pharmaceutica))

- Supervised learning techniques, classification of psychotropic drugs and gait patterns (JC,

KW)

- Aternative methods to evaluate surrogacy, using supervised learning methodology (JC, GM,

ZS)

- Solution for separation problems in logistic regression with clustered data (JC)

- Survival analysis, clustered interval censored data (JC)

- Identification of risk groups using mixed modelling techniques (JC)

- Use of mixture models to estimate seroprevalence and, possibly, the force of infection in

some infectious diseases, directly from antibody levels, in absence of a standard cut-off

point. Study of the co-infection between HiV and HCV in injected-drugs users, using both

cross-sectional and longitudinal data (ED, Infectious Disease Modelling Group UH, P.

Manfredi (Pisa), G. Scalia Tomba (Roma), Mirjam Kretzschmar (Utrecht), Peter Theunis

(RIVM, Bilthoven))

- Bayseian modelling; Proteomics; Mass-spectrometry data; Detection of overlapping peptides

(IJ, QZ, TB, DV, AK)

- Protein-protein interaction networks; Modelling of sampling distributions (IJ, Frank Neven,

Peter Boyen, Dirk Valkenborg)

R

- Psychiatric epidemiology: uncovering groups of similar patients in complex data sets with

repeated measurements (LB, GM, AL)

- Information-theory based surrogate marker evaluation for time-to-event clinical and

surrogate endpoints (PA, AT, AA, TB, GM)

- Information-theory based surrogate marker evaluation for time-to-event clinical endpoint

and longitudinal surrogate endpoints (PA, AT, AA, TB, GM)

- Applying concepts of generalizability theory on data from experimental pain studies to

investigate reliability (PA, Edouard Ledent, Lars Arendt-Nielsen)

- Investigating the performance of hierarchical formulations of marginal models for non-

Gaussian data for estimating negative intraclass correlations. (PA, GM)

- Biomarker discovery from COFRADIC MALDITOF-MS data: deconvolution and feature

extraction for mass spectral serum profiles (DV, TB, Janne Lahtiö (Karolinska Institute),

Koen Kas, (Pronota))

- A model based method for predicting the isotropic distribition of peptides (DV, TB, IJ)

- Missing observations in mass spectrometry data (DV, TB, IJ)

- A discrete-time Markov-model for estimating the relative abundance in enzymatic 18O stable-

isotope labeled MALDI-TOF mass spectra. (DV, TB, Koen Kas (Pronota), Etienne Waelkens

(KULeuven))

- Methods to detect overlapping peptide peaks in m/z-dimension. (DV, TB, IJ, AK)

- MCMC-based estimation for continuous longitudinal data with missingness (CS, CB, GM, Mike

Kenward)

- Sensitivity analysis (CS, CB, GM, Geert Verbeke)

- Marginalizing pattern-mixture models for categorical data with missingness (CS, CB, GM, IJ,

Geert verbeke)

- Extensions of latent class mixed models (CS, CB, GM)

- Meaningful parametrizations for missing data models (CS, GM, Geert Verbeke)

- Reliability estimation in clinical trial data with repeated measurements (AL, AA, GM, Tony

Vangeneugden)

- Minimal Psychiatric Data: development of a new registration instrument (AL, GM)

- Missing data: a new method to handle missing covariates (AC, MA, NH)

- Shared parameter models and MAR (AC, NH, MA, Geert Verbeke, Michael Kenward)

- Sensitivity analysis for the shared parameter model (AC, GM, NH, MA, Geert Verbeke,

Michael Kenward)

- Medical costs in infectious diseases (pneumococcal disease) (AC, MA, NH, ZS, Philippe

Beutels)

- Psychometrics (AA, GM, AL)

- Reliability of rating scales (AA, GM, AL)

- Miss-specified random effects distribution (AA, GM, SL)

- Generalized linear mixed models (GLMM) (AA, GM, SL)

- Diagnostic tools for GLMM (AA, GM, SL)

- Biomarkers (AA, GM, Didier Renard, Christelle Darstein)

- Surrogate marker validation (AA, GM, AP, AT)

- Survival data and measures of association (AA, GM, AP, AT)

- Investigating associations between behavior and corticosterone levels in rats using surrogate

marker validation technique (JM)

- Analysis of cross-over cardiovascular safety experiments (JM)

= S

D Mededelingen van resultaten van het onderzoekswerk

1 Doctoraats- en aggregaatsthesissen

11 In de onderzoeksgroep behaalde doctoraten

Dan Lin

Classification, dose-response modelling, and the evaluation of biomarker in a microarray

setting. 28 maart 2008. Supervisor: Tomazs Burzykowski

Tony Vangeneugden

Psychometric validation methodology to longitudinal clinical trial data. 19 mei 2008.

Supervisor: Geert Molenberghs

Goele Massonnet

Contributions to frailty and copula modelling with applications to clinical trials and dairy

cows data. 8 september 2008. Supervisor: Paul Janssen

Kristien Wouters

Classification methods for multi-class multivariate longitudinal data. 9 september 2008.

Supervisor: Geert Molenberghs

Suzy Van Sanden

Statistical methods for microarray-based analysis of gene-expression, classification, and

biomarker validation. 11 september 2008. Supervisor: Tomasz Burzykowski

Dirk Valkenborg

Statistical methods for the analysis of high-resolution mass spectrometry data. 12

september 2008. Supervisor: Tomasz Burzykowski

Harriet Namata

Flexible statistical models for microbial risk assessment and infectious diseases. 15

september 2008. Supervisor: Marc Aerts

John Maringwa

Flexible modelling techniques and use of historical controls in animal studies. 26

september 2008. Supervisor: Helena Geys

Annouschka Laenen

Psychometric validation of continuous rating scales from complex data. 12 december

2008. Supervisor: Geert Molenberghs

12 (Co)promoties van doctoraten, niet behaald aan de UHasselt

13 Lidmaatschappen van jury's van buitenlandse doctoraten

Noël Veraverbeke

2 april 2008. Charles University, Prague, Czech Republic. Jurylid voor doctoraat van

David Kraus. “Neyman’s smooth test in suurvival analysis” (promotor: Peter Volf)

Tomasz Burzykowski

5 september 2008. Karolinkska Institute, Stockholm, Sweden. Jurylid voor doctoraat van

ChuenSeng Tan “Statistical methods for biomarker discovery in proteomics” (promotor:

Yudi Pawitan)

T

14 Lidmaatschappen van jury's van binnenlandse doctoraten

Noël Veraverbeke

19 mei 2008. Vrije Universiteit Brussel. Jurylid voor doctoraat van Julia Dony

“Nonparametric regression estimation: an empirical process approach to uniform

bandwidth consistency of kernel estimators and conditional U-statistics”. (Promotor: Uwe

Einmahl)

Geert Molenberghs

5 mei 2008. Universiteit Antwerpen. Co-supervisor van doctoraat van Willem Aelvoet

“Ambtelijke registraties voor een evaluatief gezondheidsbeleid. Aspecten van

beleidsonderbouwing op landelijk, intermediair en lokaal niveau” (promotor: Marc Van

Sprundel)

5 augustus 2008. KULeuven. Jurylid voor doctoraat van Dimitris Rizopoulos (promotor:

Geert Verbeke)

5 augustus 2008. KULeuven. Jurylid voor doctoraat van Spyridoula Tsonaka (promotor:

Geert Verbeke)

Marc Aerts

5 augustus 2008. KULeuven. Jurylid voor doctoraat van Dimitris Rizopoulos (promotor:

Geert Verbeke)

5 augustus 2008. KULeuven. Jurylid voor Spyridoula Tsonaka (promotor: Geert Verbeke)

Paul Janssen

19 december 2008. UCL, Louvain-la-Neuve. Jurylid voor doctoraat van Bianca Teodorescu

“General conditional linear models with time-dependent coefficients under censoring and

truncation (promotor: Ingrid Van Keilegom)

2 Wetenschappelijke publicaties

Internationale wetenschappelijke publicaties

20 Gepubliceerde artikels in internationale tijdschriften (opgenomen in de JCR1 of

in een door de Onderzoeksraad erkende alternatieve tijdschriftenlijst)

Wang, L. and Veraverbeke, N. (2008). MSE superiority of Bayes and empirical Bayes

estimators in two generalized seemingly unrelated regressions. Statistics and Probability

Letters, 78, 109-117.

Braekers, R. and Veraverbeke, N. (2008). A conditional Koziol-Green model under dependent

censoring. Statistics and Probability Letters 78, 927-937.

==============================================1 JCR : Journal Citation Reports (als afzonderlijke publicatie van de Science Citation Index en van de Social Sciences Citation Index, opgemaakt door het Institute for Scientific Information).

= U

Omelka, M., Gijbels, I. and Veraverbeke, N. (2008). Improved kernel estimation of copulas:

weak convergence and goodness-of-fit testing. Annals of Statistics (to appear).

Molanes, E.M., Van Keilegom, I. and Veraverbeke, N. (2008). Empirical likelihood for non-

smooth criterion functions. Scandinavian Journal of Statistics (to appear).

Verbeke, G., Molenberghs, G. and Beunckens, C. (2008). Formal and informal model selection

with incomplete data. Statistical Science, 23, 201-218.

Vloeberghs, E., Van Dam, D., Frank, F., Serroyen, J., Molenberghs, G., Staufenbiel, M., and De

Deyn, P.P. (2008). Altered ingestive behavior, weight changes and intact olfactory sense

in an APP overexpression model. Behavioral Neuroscience, 122, 491-497.

Alonso, A. and Molenberghs, G. (2008). Evaluating time to cancer recurrence as a surrogate

marker for survival from an information theory perspective. Statistical Methods in Medical

Research, 17, 497-504.

Litière, S., Alonso, A., Molenberghs, G. and Geys, H. (2008). The impact of a misspecified

random-effects distribution on the estimation and performance of inferential procedures

in generalized linear mixed models. Statistics in Medicine, 27, 3125-3144.

Vangeneugden, T., Molenberghs, G., Laenen, A., Alonso, A. and Geys, H. (2008).

Generalizability in non-Gaussian longitudinal clinical trial data based on generalized linear

mixed models. Journal of Biopharmaceutical Statistics, 18, 1-22.

Faes, C., Molenberghs, G., Geys, H., Aerts, M., Cadarso-Suarez, C., Acuña, C., and Cano, M.

(2008). A flexible method to measure synchrony in neuronal firing. Journal of American

Statistical Association, Case Studies, 103, 140-161.

Jansen, I. and Molenberghs, G. (2008). A flexible marginal modeling strategy for non-

monotone missing data. Journal of the Royal Statistical Society, Series A, 171, 347-373.

Tilahun, A., Assam, P., Alonso, A. and Molenberghs, G. (2008). Information theory-based

surrogate marker evaluation from several randomized clinical trials with binary endpoints,

using SAS. Journal of Biopharmaceutical Statistics, 18, 326-341.

Molenberghs, G., Beunckens, C., Sotto, C. and Kenward, M.G. (2008). Every missing not at

random model has got a missing at random counterpart with equal fit. Journal of the

Royal Statistical Society, Series B, 70, 371-388.

Molenberghs, G., Burzykowski, T., Alonso, A., Assam, P., Tilahun, A. and Buyse, M. (2008).

The meta-analytic framework for the evaluation of surrogate endpoints in clinical trials.

Journal of Statistical Planning and Inference, 138, 432-449.

Wouters, K., Cortiñas, J., Molenberghs, G., Ahnaou, A., Bijnens, L. and Drinkenburg, H.I.M.

(2008). A comparison of doubly hierarchical supervised learning procedures for multiple

class longitudinal data from EEG experiments. Journal of Biopharmaceutical Statistics, 18,

1120-1135.

Speybroeck, N., Marcotty, T., Aerts, M., Dolan, T., Williams, B., Lauer, J., Molenberghs, G.,

Burzykowski, T., Mulumba, M. and Berkvens, D. (2008). Titrating Theileria parva: single

stocks against combination of stocks. International Journal for Parasitology, 118, 522-

530.

Hughes, S., Keene, O., Roes, K., Ashby, D., Beltangadu, M., Bird, S.M., Burton, C., Buyse, M.,

Day, S., van Ewijk, P., Fletcher, C., Grieve, A.P., Guinot, C., Hemmings, R., Hold, D.,

Hothorn, L., Jagers, P., Keiding, N., Korhonen, P., Lesaffre, E., Lewis, J.A., Molenberghs,

G., Neumann, N., Olsen, K.J., van Osta, G., Pocock, S., Rockhold, F., Rossi, A., Senn, S.,

Stijnen, T., Vaeth, M., Wiklund, S.J. and Wolfram, J. (2008). Open Letter to the Heads of

the European Regulatory Agencies. British Medical Journal, 336, 250-250.

Rizopoulos, D., Verbeke, G. and Molenberghs, G. (2008). Shared parameter models under

random-effects misspecification. Biometrika, 95, 63-74.

V

Gyselaers, W., Verswijvel, G., Molenberghs, G. and Ombelet, W. (2008). Interlobar venous

flow is different between left and right kidney in uncomplicated third trimester pregnancy.

Gynecologic and Obstetric Investigation, 65, 6-11.

Van Effelterre, T., Shkedy, Z., Aerts, M., Molenberghs, G., Van Damme, P. and Beutels, P.

(2009). Contact patterns and their implied basic reproductive numbers: an illustration for

varicella-zoster virus. Epidemiology and Infection, 127, 48-57.

Alonso, A., Litière, S. and Molenberghs, G. (2008). A family of tests to detect misspecifications

in the random effects distribution of generalized linear mixed models. Computational

Statistics and Data Analysis, 52, 4474-4486.

Cortiñas, J., Shkedy, Z. and Molenberghs, G. (2008). Alternative methods to evaluate trial

level surrogacy. Clinical Trials, 5, 194-208.

Jacobs, T., Rossenu, S., Dunne, A., Molenberghs, G., Straetemans, R. and Bijnens, L. (2008).

Combined models for data from in vivo-in vitro correlation experiments. Journal of

Biopharmaceutical Statistics, 18, 1197-1211.

Laenen, A., Alonso, A., Molenberghs, G. and Vangeneugden, T. (2008). A family of measures

to evaluate scale reliability in a longitudinal setting. Journal of the Royal Statistical

Society, Series A, 171, 000-000.

Faes, C., Aerts, M., Molenberghs, G., Geys, H., Teuns, G. and Bijnens, L. (2008). A high-

dimensional joint model for longitudinal endpoints of different nature. Statistics in

Medicine, 27, 4408-4427.

Sotto, C., Beunckens, C., Molenberghs, G., Jansen, I. and Verbeke, G. (2008). Marginalizing

pattern-mixture models for categorical data subject to monotone missingness. Metrika,

00, 000-000.

Alonso, A. and Molenberghs, G. (2008). Surrogate markers: Hopes and Perils.

Pharmacoeconomics and Outcomes Research, 8, 255-259.

Gyselaers, W., Molenberghs, G., Van Mieghem, W. and Ombelet, W. (2008). Doppler

measurement of renal interlobar vein impedance index in uncomplicated and pre-

eclamptic pregnancies: a pilot study. Hypertension in Pregnancy, 00, 000-000.

Maringwa, J., Geys, H., Shkedy, Z., Faes, C., Molenberghs, G., Aerts, M., Van Ammel, K.,

Teisman, A. and Bijnens, L. (2008). Tutorial in Biostatistics: Analysis of cross-over

designs with serial correlation within periods using semiparametric mixed models.

Statistics in Medicine, 27, 6009-6033.

Alonso, A., Molenberghs, G., Renard, D. and Darstein, C. (2008). Evaluation of biomarkers for

pharmacological activity. Journal of Biopharmaceutical Statistics, 00, 000-000.

Hill, R.C. Choate, C.J., Scott, K.C. and Molenberghs, G. (2008). Comparison of the guaranteed

analysis with the measured nutrient composition of commercial pet foods. Journal of the

American Veterinary Medical Association, 00, 000-000.

Laenen, A., Alonso, A., Molenberghs, G. and Vangeneugden, T. (2008). Reliability of a

longitudinal sequence of scale ratings. Psychometrika, 00, 000-000. (doi:10:1007/S1136-

008-9079-7)

Jacobs, T., De Ridder, F., Rusch, S., Van Peer, A., Molenberghs, G. and Bijnens, L. (2008).

Including information on the therapeutic window in bioequivalence specifications.

Pharmaceutical Research, 25, 2628-2638.

Decramer, M. and Molenberghs, G. (2008). Letter to the Editor: Does pharmacotherapy

reduce rate of decline of lung function in COPD? American Journal of Respiratory and

Critical Care Medicine, 00, 000-000.

Maringwa, J.T., Faes, C., Geys, H., Molenberghs, G., Cadarso-Suárez, C., Pardo-Vàzquez, J.L.,

Leborán, V. and Acuña, C. (2008). Application of penalized smoothing splines in analyzing

neuronal data. Biometrical Journal, 00, 000--000.

= NM

Molenberghs, G. (2008). Incomplete data in clinical studies: analysis, sensitivity, and

sensitivity analysis (with discussion and rejoinder). Drug Information Journal, 00, 000-

000.

Beunckens, C., Sotto, C., Molenberghs, G. and Verbeke, G. (2008). A multi-faceted sensitivity

analysis of the Slovenian Public Opinion Survey data. Applied Statistics, 00, 000-000.

Laenen, A., Alonso, A., Molenberghs, G., Vangeneugden, T. and Mallinckrodt, C. (2008). Using

longitudinal data from a clinical trial in depression to assess the reliability of its outcome

scale. Journal of Psychiatric Research, 00, 000-000. (doi:10.1016/j.jpsychires.

2008.09.010).

Mwambi, H., Ramroop, S., Shkedy, Z. and Molenberghs, G. (2008). An approach to estimating

the force of infection and the rate of recovery fom Respiratory Syncytial Virus (RSV) data.

Statistical Methods in Medical Research, 00, 000-000.

Goegebeur, Y., De Boeck, P. and Molenberghs, G. (2008). Person fit for test speededness:

Normal curvature, likelihood ratio tests, and empirical Bayes estimates. Methodology, 00,

000-000.

Molenberghs, G., Burzykowski, T., Alonso, A., Assam, P., Tilahun, A. and Buyse, M. (2008). A

unified framework for the evaluation of surrogate endpoints in clinical trials. Statistical

Methods in Medical Research, 00, 000-000.

Serroyen, J., Bruckers, L., Rogiers, G. and Molenberghs, G. (2008). Characterizing persistent

disturbing behavior using longitudinal and multivariate techniques. Journal of Applied

Statistics, 00, 000-000.

Tilahun, A., Maringwa, J.T., Geys, H., Alonso, A., Raeymaekers, L., Molenberghs, G., Van Den

Kieboom, G., Drinkenburg, P. and Bijnens, L. (2009). Investigating association between

behavior, corticosterone, heart rate, and blood pressure in rats using surrogate marker

evaluation methodology. Journal of Biopharmaceutical Statistics, 19, 1-17.

Verbeke, G. and Molenberghs, G. (2009). Arbitrariness of models for augmented and coarse

data, with emphasis on incomplete-data and random-effects models. Statistical Modelling,

00, 000-000.

Beunckens, C., Molenberghs, G., Verbeke, G. and Millinckrodt, C. (2008). A latent-class

mixture model for incomplete longitudinal Gaussian data. Biometrics, 64, 96-105.

Beunckens, C., Sotto, C. and Molenberghs, G. (2008). A simulation study comparing weighted

estimating equations with multiple imputation based estimating equations for longitudinal

binary data. Computational Statistics and Data Analysis. 52, 1533-1548.

Mwambi, K., Ramroop, S., Shkedy, Z. and Molenberghs, G. (2008). A frequentist appraoch to

estimating the force of infection and the recovery rate for respiratory disease among

infants in coastal Kenya. Statistical Methods in Medical Research 000-000.

Gaddah, A. and Braekers, R. (2008). Weak convergence for the conditional distribution

function in a Koziol-Green model under dependent censoring. Journal of Statistical

Planning and Inference (Doi: 10.1016/j.jspi.2008.06.001).

Braekers, R. and Van Keilegom, I. (2008). Flexible modeling base on copulas in

nonparametric median regression. Journal of Multivariate Analysis (Doi:

10.1016/j.jmva.2008.11.2009).

Burzykowski, T., Buyse, M. Yothers, G., Skamoto, J. and Sargent, D. (2008). Exploring and

validating surrogate endpoints in colorectal cancer. Lifetime Data Analysis, 14, 54-64.

Valkenborg, D., Van Sanden, S., Lin, D. , Kasim, A; Zhu, Qi, Haldermans, P., Jansen I.,

Shkedy, Z. and Burzykowski, T. (2008). A cross-validation study to select a classification

procedure for clinical diagnosis base on proteomic mass spectrometry. Statistical

Applications in Genetics and Molecular Biology 7(2), article 12 (available at:

http://www.bepress.com/sagmb/vol7/iss2/art12).

NN

Van Sanden, S., Lin, D. and Burzykowski, T. (2008). Performance of gene selection and

classification methods in a microarray setting: A simulation study. Communications in

Statistics – Simulation and Computation, 37, 409-424.

Burzykowski, T., Buyse, M., Piccart-Gebhart, MJ., Sledge, G., Carmichael, J., Luck, H-J.,

Mackey J.R., Nabholtz, J-M, Paridaens, R., Biganzoli, L., Jasem, J., Bontenbal, M.,

Bonneterre, J., Chan, S., Atalay Basaran, G. and Therasse, P. (2008). Evaluation of

tumor response, disease control, progression-free survival, and time to progression as

potential surrogate endpoints in metastatic breast cancer. Journal of Clinical Oncology,

26, 1987-1992.

Piccart-Gebhart, M.J., Burzyokowski, T., Buyse, M., Sledge, G., Carmichael, J., Luck, H-J.,

Mackey, J.R., Mabholtz, J-M., Paridaens, R., Biganzoli, L., Jassem, J., Bontenbal, M.

Bonneterre, J., Chan, S., Atalay Basaran G. and Therasse, P. (2008). Effects of taxanes

ablone or in combination with antracyclines as first-line therapy of patients with

metastatic breast cancer. Journal of Clinical Oncology, 26, 1980-1986.

Valkenborg, D., Janssen, I. and Burzykowski, T. (2008). A model-based method for the

prediction of the isotopic distribution of peptides. Journal of the American Society of

Mass Spectrometry, 19, 703-712.

Massonnet, G., Janssen, P. and Burzykowski, T. (2008). Fitting conditional survival models to

meta-analytic data by using a transformation towards mixed-effects models. Biometrics,

64, 8634-842.

Burzykowski, T. (2008). Surrogate endpoints: wishful thinking or reality? Statistical Methods in

Medical Research, 17, 463-466.

Buyse, M., Burzykowski, T., Michiels, S. and Carroll, K. (2008). Individual- and trial-level

surrogacy in colorector cancer. Statistical Methods in Medical Research, 17, 467-475.

Lin, D., Shkedy, Z., Burzykowski, T., Ion, R., Göhlmann, H.W., Bondt, A.D., Perer, T., Geerts,

T., Van den Wyngaert, I. and Bijnens, L. (2008). An investigation on performance of

Significance Analysis of Microarray (SAM) for the comparisions of several treatments with

one control in the presence of small-variance genes. Biometrical Journal, 50, 801-823.

Massonnet, G., Janssen, P. and Burzykowski, T. (2008). Fitting conditional survival models to

meta-analytic data by using a transformation toward mixed-effects models. Biometrics,

64, 834-842.

Hens, N., Aerts, M., Shkedy, Z., Thetten, H., Van Damme, P. and Beutels, P. (2008).

Modelling multi-sera data: the estimation of new joint and conditional epidemiological

parameters. Statistics in Medicine, 27, 2651-2664.

Namata, H., Méroc, E., Aerts, M. , Faes, C., Cortiñas, A.J., Imberechts, H. and Mintiens K.

(2008). Salmonella in Belgian laying hens: An identification of risk factors. Preventive

Veterinary Medicine, 83, 323-336.

Hens, N., Aerts, M., Shkedy, Z., Kimani, P.K., Kojouharova, M., Van Damme, P. and Beutels,

P. (2008). Estimating the impact of vaccination using age-time dependent incidence rates

of Hepatitis B. Epidemiology and Infection, 136, 341-351.

Méroc, E., Faes, C., Herr, C., Verheyden, B., Vanbinst, T., Vandenbussche, F., Hooyberghs, J.

Aerts, M. De Clercq, K., Mintiens, K. and Staubach, C. (2008). Establishing the spread of

bluetongue virus at the end of the 2006 epidemic in Belgium. Veterinary Microbiology,

131, 133-144.

Namata, H., Aerts, M., Faes, C. and Theunis, P. (2008). Model averaging in microbioal risk

assessment using fractional polynomials and generalized linear mixed models. Risk

Analysis, 28, 891-905.

= NO

Theeten, H., Hens, N., Aerts, M., Vandermeulen, C., Roelants, M., Hoppenbrouwers, K., Van

Damme, P. and Beutels, P. (2008). Caregivers’ willingness to pay to reduce the number

of vaccine injections in infants. The Pediatric Infectious Disease Journal, 0, 000-000.

Mintients, K., Méroc, E., Faes, C., Cortiñas Abrahantes, J., Hendrickx, G., Staubach, C.,

Gerbier, G., Elbers, A.R.W., Aerts, M., De Claercq, K. and Deluyker, H. (2008). Impact of

human interventions on the spread of Bluetongue virus serotype 8 during the 2006

epidemic in north-western Europe. Preventive Veterinary Medicine, 87, 145-161.

Cortiñas Abrahantes, J., Bollaerts, K. Aerts, M. Van der Stede, Y., Ogunsanya, V. and Mintiens,

K. (2008). Salmonella serosurveillance: Different statistical methods to categorize pig

herds based in serological data. Preventive Veterinary Medicine 00, 000-000.

Mossong, J., Hens, N., Jit, M., Beutels, P., Auranen, K., Mikolajczyk, R. Massari, M., Scalia

Tomba, G., Wallinga, J., Sadkowska-Todys, Rosinska, M. and Edmunds, J.W. (2008).

Social contacts and mixing patterns relevant to the spread of infectious diseases. PloS

Med 5(3) (e74. doi:10.1371/journal.pmed.0050074).

Hens, N., Aerts, M., Shkedy, Z., Kimani, P.K., Kojouhariva, M., Van Damme, P. and Beutels, P.

(2008). Modeling age-time dependent incidence rates of hepatitis B and estimating the

prevalence and force of infaction using generalized additive models. Epidemiology and

Infection, 136, 341-351.

Mossong, J., Hens, N., Friederichs, V., Davidkin, I., Broman, M., Litwinska, A., Siennicka, J.,

Trzcinska, A., Van Damme, P., Beutels, P., Vyse, A., Shkedy, Z., Aerts, M., Massari, M.

and Gabutti, G. (2008). Epidemiology of parvovirus B19 infection in Europe: results from

a seroprevalence studies in Belgium, England and Wales, Finland, Italy and Poland.

Epidemilogy and Infection, 136, 1059-1068.

Hens, N.,Kvitkovicova, A., Aerts, M., Hlubinka, D. and Beutels, P. (2008). Modelling disortions

in seroprevalence data using change-point fractional polynomials. Statistical Modelling.

(to appear)

Hens, N., Goeyvaerts, N., Aerts, M., Shkedy, Z., Van Damme, P. and Beutels, P. (2008).

Mining social mixing patterns for infectious disease models based on a two-day population

survey in Belgium. (to appear).

Ogunjimi, B., Hens, N., Goeyvaerts, N., Aerts, M. and Beutels, P. (2008). Using empirical

social contact data to model person to person infectious disease transmission: an

illustration for varicella. Mathematical Biosciences. (to appear).

Claeskens, G., Nguti, R. and Janssen, P. (2008) Likelihood ratio and scoretest for a shared

frailty model: a non-standard problem. Test, 17, 69-82.

Goethals, K., Janssen, P. and Duchateau, L. (2008). Frailty models and copulas: Similarities

and differences; Journal of Applied Statistics 35, 1071-1079.

Bollaerts, K., Aerts, M., Ribbens, S., Van der Stede, Y., Boone, I. and Mintiens K. (2008).

Idenficiation of Salmonella high risk pig herds in Belgiumusing semi-parametric quantiles

regression. Journal of the Royal Statistical Society. Series A., 171, 1-16.

Bollaerts, K., Aerts, M., Faes, C., Grijspeerdt, K., Dewulf, J. and Mintiens, K. (2008). Human

Salmonellosis: estimation of dose-illness from outbreak data. Risk Analysis, 28, 427-440.

Delhalle, L., De Sadeleer, L., Bollaerts, K., Farnir, F., Saegerman, C., Korsak, N., Dewulf, J.,

De Zutter, L. and Daube, G. (2008). Risk factors for Salmonella and hygiene indicators in

the 10 largest Belgian pig slaughterhouses. Journal of Food Protection, 71, 1320-1329.

Bollaerts, K., Messens, W., Delhalle, L., Aerts, M., Van der Stede, Y., Dewulf, J., Quoillin, S.,

Maes, D., Mintiens, K. and Grijspreedt, K. (2008) METZOON: Development of a

quantitative microbial risk assessment for human salmonellosis through household

consumption of fresh minced pork meat in Belgium. Risk Analysis (to appear).

NP

Boone, I., Van der Stede, Y., Bollaerts, K., Vose, D., Daube, G., Aerts, M. and Mintiens, K.

(2008). NUSAP method for evaluating the data quality in a quantitative microbial risk

assessment model for Salmonella in the pork production chain. Risk analysis (to appear).

Goethals, K., Ampe, B., Berkvens, D., Laevens, H., Janssen, P. and Duchateau, L. (2008).

Modelling interval-censored, clustered cow udder quarter infection times through the

shared gamma frailty model. Journal of Agricultural, Biological and Ecological Statistics

(to appear).

Legrand, C., Duchateau, L. Janssen, P., Ducrocq, V. and Sylvester, R. (2008/2009). Validation

of prognostic indices using the frailty model. Lifetime Data Analysis (to appear).

Maringwa, J.T., Geys, H., Shkedy, Z., Faes, C., Molenberghs, G., Aerts, M., Van Ammel, K.,

Teisman, A., and Bijnens, L. (2008). Application of semiparametric mixed midels in

simultaneous confidence bands in a cardiovascular safety experiment with longitudinal

data. Journal of Biopharmacuetical Statistics, 18, 1043-1062.

Vyt, P., Maes, D., Quinten, C., Rysselaere, T., Deley, W., Aerts, M., de Kruif A. and Van Soom,

A. (2008). Detailed motility evaluation of boar semen and it predictive value for

reproductive performance in sows. Flemish Veterinary Journal, 77, 291-299.

Faes, C., Geys, H., Aerts, M. and Molenberghs, G. (2008). A flexible method to measure

synchrony in neuronal firing. Journal of the American Statistical Association, 00, 000-

000.

Faes, C., Aerts, M., Geys, H. and De Schaepdrijver, L. (2008). Modeling spatial learning in

rats based on morris water maze experiment. Pharmaceutical Statistics (to appear).

Bilau, M., Matthys, C., Baeyens, W., Bruckers, L., De Backer, G., Den Hond, E., Keune, H.,

Koppen, G., Nelen, V., Schoeters, G., Van Larebeke, N., Willems, J.L. and De Henauw, S.

(2008). Dietary exposure to dioxin-like compounds in three age groups: results from the

Flemish environment and health study. Chemosphere, 70, 584-592.

Schroijen, C., Baeyens, W., Schoeters, G., Den Hond, E., Koppen, G., Bruckers, L., Nelen, V.,

De Mieroop, E., Bilau, M., Covaci, A., Keune, H., Loots, I., Kleinjans, J., Dhooge, W. and

Van Larebeke, N. (2008). Internal exposure to pollutants measured in blood and urine of

Flemish adolescents in function of aera of residence. Chemosphere, 71, 1317-1325.

Abatih, E., Van Oyen, H., Bossuyt, N. and Bruckers, L. (2008). Variance estimation methods

for health expectancy by relative socio-economic status. European Journal of

Epidemiology, 23, 243-249.

Robaeys, G., Nevens, F., Van Eyken, P., Starkel, P., Colle, I., Bruckers, L., Van Ranst, M. and

Buntinx, F. (2008). Intavenous substance use and the outcome if liver transplantation for

chroinc hepatitis C. Journal of Hepatology, 48(Supp.2), 230-…

De Coster, S., Koppen, G., Bracke, M., Schroijen, C., Den Hond, E., Nelen, V., de Mierrrop,

E.V., Bruckers, L., Bilau, M., B aeyens, W., Schoeters, G. and van Larebeke, N. (2008).

Pollutant effects of genotoxic parameters and tumor-associated protein levels in adults: a

cross sectional study. Environmental Health, 7.

Keune, H., Loots, . I., Bruckers, L., Bilau, M. Koppen, G., van Larebeke, N., Schoeters, G. and

Nelen, V. (2008). Monitoring environment, health and perception; an experimental survey

on health and environment in Flanders, Belgium. International Journal of global

environmental issues, 8, 90-111.

Bilau, M., De Henauw, S., Schroijen, C., Bruckers, L., Den Hond, E., Koppen, G., Matthys, C.,

Van de Mieroop, E., Keune, H., Baeyens, W., Nelen; V., Van Larebeke, N., Willems, J.L.

and Schoeters, G. (2009) The relation between the estimated dietary intake of PCDD/Fs)

and levels in blood in a Flemish population (50-65 years). Environment International, 35,

9-13.

= NQ

Stracjzek, A., Wannijn, J., Van Hees, M., Thijs, H. and Thiry Y., (2008). Tolerance of hairy

roots of carrots to U-chronic exposure in standardized in vitro device. Environmental and

Experimental Botany (to appear).

Komárek, A. and Lesaffre, E. (2008). Generalized linear mixed model with a penalized

Gaussian mixture as a random-effects distribution. Computation Statistics and Data

Analysis 52, 3441-3458.

Mwalili, S., Lesaffre, E. and Declerck, S. (2008). The zero-inflated negative binomial

regression model dith correction for misclassification: an example in caries research.

Statistical methods in Medical Research, 17, 123-139.

Rizopoulos, D. Verbeke, G., Lesaffre, E. and Vanrenterghem, Y. (2008). A two-part joint

model for the analysis of survival and longitudinal binary data with excess zeros.

Biometrics, 64, 611-619.

Rizopoulos, D., Verbeke, G. and Lesaffre, E. (2008). Fully exponential Laplace approximations

for the joint modelling of survival and longitudinal data. Journal of the Royal Statistical

Association, Series B, in press.

Fieuws, S., Verbeke, G., Maes, B. and Vanrenterghem Y. (2008). Predicting renal graft failure

using multivariate longitudinal profiles. Biostatistics, 9, 419-431.

Ghidey, W., Lesaffre, E. and Verbeke, G. (2008). A comparison of methods for estimating the

random effects distribution of a linear mixed model. Statistical Methods in Medical

Research (in press).

Einmahl, J. and Van Keilegom, I. (2008). Specification tests in nonparametric regression.

Journal of Econometrics, 143, 88-102.

Linton, O., Sperlich, S. and Van Keilegom, I. (2008). Estimation of a semiparametric

transformation model. Annals of Statistics, 36, 686-718.

El Ghouch, A. and Van Keilegom, I. (2008). Nonparametric regression with dependent

censored data. Scandinavian Journal of Statistics, 35, 228-247.

Tas, O., De Rooster, H., Baert, E., Doom, M.H. and Duchateau, L. (2008). The accuracy of the

lactate pro hand-held analyser to determine blood lactate in healthy dogs. Journal of

Small Animals Practice, 49, 504-508.

Catry, D., Duchateau, L. Van De Ven, J. Laevens, H., Opsomer, G., Hasebrouck, F. and De

Kruit, A. (2008). Efficacy of metaphylactic florfenicol therapy during natural outbreaks of

bovine respiratory disease. Journal of Veterinary Pharmacological Therapy, 31, 479-487.

Beijerink, N.J., Bhatti, S.F.M., Okkens, A.C., Dieleman, S.J., Duchateau, L. and Kooistra, H.S.

(2008). Pulsatile plasma profiles of FSH and LH before and during medroxyprogesterone

acetate treatment in the bitch. Theriogenology 70, 179-185.

Buyse, M. and Piedbois, E. (2008) Endpoints and surrogate endpoints in colorectal cancer, a

review of recent developments. Current Opinion Oncol., 20, 466-471.

Baigent, C., Harrell, F., Buyse, M., Emberson, J. and Altman, D. (2008). Ensuring trial validity

by data quality assurance and diversification of monitoring methods. Clinical Trials 5, 49-

55.

Desmedt, C., Haibe-Kains, B., Wirapati, P., Buyse, M., Bontempi, G., Delorenzi, M. Piccart M.

and Sotiriou, C. (2008). Biological processes associated with breast cancer clinical

outcome depend on the molecular subtypes. Clinical Cancer Research, 14, 5158-5165.

Sardari Nia, P., Colpaert, C., Vermeulen, P., Weyler, J., Pezzella, F., Van Schil, P. and Van

Marck, E. (2008). Different growth patterns of non-small cell lung cancer represent

distinct biologic subtypes. Annals of Thorac Surgery, 85(2), 395-405.

Trinh, X.B., Tjalma, W.A., Makar, A.P., Buytaert, G., Weyler, J. and Van Damme, P.A. (2008).

Use of the levonorgestral-releasing intrauterine system in breast cancer patients. Fertil

Steril, 90, 17-22.

NR

Van Dessel, E., Hubens, G., Ruppert, M., Balliu, L., Weyler, J. and Vaneerdeweg W. (2008).

Roux-en-Y gastric bypass as a re-do procedure for failed restrictive gastric surgery. Surg

Endosc. 22, 1014-1018.

Crop, F., Van Rompaye, B., Paelinck, L., Vakaet, L., Thierens, H. and De Wagter, C. (2008).

On the calibration process of film dosimetry: OLS inverse regression versus WLS inverse

prediction. Physics in Medicine and Biology, 53, 3971-3984.

Overige wetenschappelijke publicaties

25 Overige artikels

Veraverbeke, N. (2008). Conditional residual life under random censorship. In: Advances in

Statistics. Felicitation volume in honour of B.K.Kale. B.C. Armold, U. Gather, S.M. Bendre

(eds). MacMillan India, New Dehli, pp. 174-185.

Molenberghs, G. and Orman, C. (2008). Surrogate endpoints: application in pediatric clinical

trials. In: Concepts and Applications of Pediatric Drug Development Mulberg, A. (ed.)

Ip, E. and Molenberghs, G. (2008). Empirical Bayes. In: International Encyclopedia in

Education.

Sterna, J., Burzykowski, T. (2008). Assessment of the usefulness of the fenestration method

in case of disc extrusion in the cervical and thoraco-lumbar spine in chondrodystrophic

dogs. Polish Journal of Veterinary Sciences, 11, 55-62.

26 Artikels in proceedings

Callaert, H., (2008). Understanding confidence intervals. Proceedings of the Fifth Conference

of the European Society for Research in Mathematics Education. CD-ROM edited by D.

Pantazi and G. Philippou. ISBN 978-9963-671-25-0.

Burzykowski, T., Valkenborg, D. (2008). Processing of high-resolution MALDI-TOF mass

spectrometry data by using an average isotopic distribution. Proceedings of the

Fourteenth National Conference on Application of Mathematics in Biology and Medine.

Warsaw, Poland. Bodnar, M., Forys, U., (eds), 33-38. ISBN 83-903893-4-7.

Bollaerts, K., Messens, W., Delhalle, L., Aerts, M., Dewulf, J., Debusser, E., Boone, I.

Grijspeerdt, K. (2008). Development of a modular quantitative microbial risk assessment

to evaluate zoonotic risks in Belgium: Salmonellosis through consumption of pork as an

example. In Proceedings of 10th European Symposium on Statistical Methods for the Food

Industry, Louvain-la-Neuve, Belgium.

Messens, W., Bollaerts, K., Delhalle, L., Aerts, M., Van der Stede, Y., Quoilin, S., De Busser,

E., Dewulf, J., Maes, D., Boone, I., Mintiens, K.,Grijspeerdt, K. (2008). Development of a

quantitaive microbial risk assessment to evaluate zoonotic risks in belgium: human

salmonellosis through household consumption of minced pork meat. In First Belgian

Symposium on Salmonella Research and Control in Pigs, Ghent Belgium, Book of

proceedings, 43-47. F. Boyens, F. Pasmans (eds) (ISBN 9789058641434).

Bollaerts, K., Aerts, M., Faes, C., Dewulf, J. and Mintiens, K. (2008). Dose-illness models for

human salmonellosis based on outbreak data. In: Proceedings of 23rd International

Workshop on Statistical Modelling. P. Eilers (ed.), Utrecht, the Netherlands, pp.1245-130.

Jacobs, T., Straetemans, R., Rossenu, S., Dunne, A., Molenberghs, G., Bijnens, L. (2008). A

new convolution-based approach to develop a level a in-vitro-in-vivo correlation (IVIVC)

for an extended-release oral dosage form. 2007 Proceedings of the American Statistical

= NS

Association, Biopharmaceutical Section [CD-ROM], Alexandria, VA: American Statistical

Association, p.141-144.

Lin, D., Shkedy, Z., Burykowski, T., Aets, M., Göhlmann, H.W.H., De Bondt, A., Perera, T.,

Geerts, T., Van den Wyngaert, I., Bijnens, L. (2008). Information theory based marker

evaluation 2007 Proceedings of the American Statistical Association, Biopharmaceutical

Section [CD-ROM], Alexandria, VA: American Statistical Association, p.472-479.

Aerts, M., Bollaerts, K., Ribbens, K., Van der Stede, Y., Boone, I. and Mintiens, K. (2008).

Semi-parametric regression to identify farms with high Salmonella infection burden. In:

Proceedings of the 23rd International Workshop on Statistical Modelling, P. Eilers (ed.).

Utrecht, pp.89-92.

Leuridan, E., Hens, N. Ieven, G., Aerts, M., Van Damme, P. (2008). Maternal antibodies

against measles after natural infection or vaccination in parturient women. Proceedings

of the 26th Annual meeting of the European Society for Paediatric Infectious Diseases

ESPID, Graz, Austria, 14-16 May 2008.

Hens, N., Wienke, A., Aerts, M. and Molenberghs, G. (2008). On the correlated frailty model

for bivariate current status data. Proceedings of the workshop on composite likelihood

methods. Warwick, UK, 15-17 April 2008.

Goeyvaerts, N., Hens, N., Ogunjimi, B., Aerts, M., Van Damme, P. and Beutels, P. (2008).

Estimating transmission parameters using social contact data and serological data.

Proceedings of the 24th International Biometric Conference, Dublin, July 13-18, 2008.

Creemers, A., Hens, N., Aerts, M., Molenberghs, G., Verbeke, G., Kenward, M.G. Shared-

parameter models and missingness at random. Proceedings of the 24th International

Biometric Conference, Dublin, July 13-18, 2008. ISBN 978-0-9821919-0-3.

Hens, N., Aerts, M., Melagaro, A., Gay, N., Edmunds, J. Elucidation of the factors producing

any observed differences in the epidemiological patterns of airborne infections across

Europe. Proceedings of the 24th International Biometric Conference, Dublin, July 13-18

2008. ISBN 978-0-9821919-0-3.

Lejeune, O., Hens, N., Bilcke, J. and Beutels, P. Proceedings of the International workshop

facing the challenge of Infectious Diseases – Integrating mathematical modeling,

computational thinking and ICT applications, ISI Foundations, Turin (Italy), October 13-

18, 2008.

Molenberghs, G., Aerts, M., Beunckens, C., Creemers, A., Hens, N., Kenward, M.G., Sotto, C.

and Verbeke, G. Missing not at random models and their missing at random counterparts,

in various modelling frameworks in livro in ACTAS do XVI Congresso da SPE, UTAD – Vila

REAL, 2008.

Hens, N. (2008). Exploiting data for risk evaluation. In: Scientific exploitation of databases

within the framework of food safety risk assessment. Federal Food Safety Authority.

Brussels, Belgium.

Massonnet, G., Janssen, P. and Duchateau, L. (2008). Using copulas to model four-

dimensional udder enfection data. Programme and abstract book 29th Annual conference

of the International Society for Clinical Biostatistcs, Copenhagen, Denmark.

Leanen, A., Alonso, A., Molenberghs, G. and Vangeneugden, T. (2008). Reliability of a

longitudinal sequence of scale ratings. Proceedings of the 24th International Biometric

Conference, Dublin, Ireland. ISBN 978-0-9821919-0-3.

Faes, C., Geys, H. and Catalano, P. (2008). Joint models of discrete and continuous

longitudinal data. In: Handbooks of Modern Statistical Methods: Longitudinal Data

Anlysis. Fitzmaurice, G., Davidian, M., Molenberghs, G. and Verbeke, G. (Eds.) London:

Chapman Hall/CRC, pp.327-348.

NT

Buntinx, F., Aertgeerts, B., Aerts, M., Bruyninckx, R., Knottnerus, J.A., Van den Bruel, A., Van

den Ende, J. (2008). Multivariable analysis in diagnostic accuracy studies. What are the

possiblities? In: The evidence base of clinical diagnosis. J.A. Knottnerus and F. Buntinx

(eds.) John Wiley and Sons (ISBN 1405157879 / 9781405157872), pp. 146-167.

Moons, E., Wets, G. and Aerts, M. (2008). Investigating the Performance if rule-based models

with increasing complexity on the prediction of trip generation and distribution. In:

Frontiers in Brain, Vision and AI. C. Rossi (ed), pp.167-182. ISBN 978-953-7619-04-6

27 Uitgaven van publicaties of proceedings als editor

Fitzmaurice, G., Davidian, M., Molenberghs, G. and Verbeke, G. (2009). Longitudinal Data

Analysis. Handbooks of Modern Statistical Methods. New York: Chapman & Hall/CRC.

Burzykowski, T. Guest editor for Statistical Methods in Medical Research (volume 17, issue 5,

2008)

Duchateau, L. and Janssen, P. (2008). Frailty models. Springer: Statistics for Biology and

Health. ISBN 978-0-387-72834-6.

3 Congressen en voordrachten

31 Organisatie van internationale wetenschappelijke congressen of zomerschool

Tomasz Burzykowski

Cursus ‘Survival Analysis’ georganiseerd door MSOURCE Medical Development and the Polish

Group of the International Society for Clinical Biostatistics, Warsaw, Poland. (17-18 juni 2008)

Censtat

Celebration 20th Anniversary Master in Biostatistics, 10th Anniversary Center for Statistics,

Interuniversity Honorary Doctorate Prof. Normal Breslow, Kick-Off IB2. Universiteit Hasselt.

(10-11 september 2008)

Ziv Shkedy

- One-day Workshop on ‘Dengue in Cuba’. Universiteit Hasselt, 25 april 2008

- One-day Workshop on “HIV/AIDS in developing countries’. Universiteit Hasselt, 27 mei

2008.

- Short course in R and infections diseases. Jimma University, Ethiopia, december 2008.

Workgroup Competing Risks

Seminars on competing Risks

(20/11/2007, 17/1/2008, 19/3/2008, 9/6/2008)

Members: Richard Sylvester and Murielle Maurer (EORTC), Ingrid Van Keilegom, Catherine

Legrand (UCL), Luc Duchateau, Els Goetghebeur, Bart Van Rompaye (UGent), Noël

Veraverbeke, Roel Braekers, Auguste Gaddah, Goele Massonnet, Paul Janssen (UHasselt)

= NU

PO= sççêÇê~ÅÜíÉå=çé=áåíÉêå~íáçå~äÉ=ïÉíÉåëÅÜ~ééÉäáàâÉ=ÅçåÖêÉëëÉå

Noël Veraverbeke

4-8 november 2008. International Seminar on Nonparametric Inference ISNI2008, Vigo,

Spain. Empirical likelihood for non-smooth criterion functions (7 november 2008).

Geert Molenberghs

4-7 maart 2008. 8th German Open Conference on Probability and Statistics, Aachen,

Germany. Every missing not at random model has got a missing at random counterpart with

equal fit (5 maart 2008)

16-19 maart 2008. International Biometric Society Eastern North American Region, Chrystal

City, Virginia. Unified approaches for surrogate marker evaluation from multiple randomized

trials (18 maart 2008)

13-16 april 2008. 2nd Annual FDA/DIA Statistics Forum, Bethesda, Maryland, USA.

Incomplete data in clinical studies: analysis and sensitivity analysis (16 april 2008)

16-17 april 2008. AdvaMed/FDA Statistics Conference on Statistical Issues for Medical

Devices and Diagnostics, Bethesda, Maryland, USA. Incomplete data in clinical studies:

analysis and sensitivity analysis (16 april 2008).

14-17 april 2008. Workshop on Composite Likelihood, University of Warwick, Coventry, UK.

Pseudo-likelihood methodology for marginally, conditionally and hierarchically specified

models (17 april 2008).

6 juni 2008. Johns Hopkins School of Public Health, Baltimore, Maryland, USA. Model

assessment and sensitivity analysis when data are incomplete.

11-13 juni 2008. Graybill Conference VII, Colorado State University, Fort Collins, Colorado,

USA. Eevery missing not at random model has got a missing at random counterpart with

equal fit. (12 juni 2008).

10-11 juli 2008. Epidemiology and Biometry 2008: Recent statistical methods in

epidemiology, Paris, France. Surrogate markers: hopes and perils (10 juli 2008).

13-18 juli 2008. XIV International Biometric Conference, Dublin, Ireland. Publishing in

Biometrics: a journal of the International Biometric Society (14 juli 2008)

13-18 juli 2008. XIV International Biometric Conference, Dublin, Ireland. Every missing not at

random model has got a missing at random coutnerpart with equal fit (14 juli 2008).

13-18 juli 2008. XIV International Biometric Conference, Dublin, Ireland. Recent

developments in longitudinal data analysis (15 juli 2008).

29 juli – 2 augustus 2008. Eleventh Meting of new researchers in statistics and probability.

Institute for Mathematical Statistics. University of Colorado, Boulder, Colorado, USA.

Publishing in Biometrics: a journal of the International Biometric Society (2 augustus 2008).

NV

2-7 augustus 2008. Joint Statistical Meetings, Denver, Colorado, USA. Roundtable discussion

leader on “Is there a future for surrogate marker evaluation in randomized clinical studies” (4

augustus 2008).

23-25 september 2008. Non-clinical statistics conference 2008, Leuven, Belgium. Unified

approaches for surrogate marker evaluation from multiple randomized trials (24 september

2008).

1-4 oktober 2008. Congreso Anual da Sociedade Portuguesa de Estatistica, Villa Real,

Portugal. Every missing not at random model has got a missing at random counterpart with

equal fit (3 oktober 2008).

4-7 november 2008. International Seminar on Nonparametric Inference ISNI 2008, Vigo,

Spain. Every missing not at random model has got a missing at random counterpart with

equal fit (6 november 2008).

10 november 2008. Centraal Bureau voor Statistiek, Voorburg, Nederland. Every missing not

at random model has got a missing at random counterpart with equal fit.

26 november 2008. Hans van Houwelingen Symposium, Leiden, Nederland. Surrogate

markers: hopes and perils.

Roel Braekers

16-19 juni 2008. 22nd Nordic Conference on Mathematical Statistics (NORDSTAT), Vilnius,

Lithuania. A homoscedastic regression model with a copula for the depdency.

Auguste Gaddah

16-19 juni 2008. 22nd Nordic Conference on Mathematical Statistics (NORDSTAT), Vilnius,

Lithuania. An extension of the Koziol-Green model under dependent censoring.

Niel Hens

13-18 juli 2008. 24th International Biometric Conference, Dublin, Ireland. Elucidation of the

factors producing any observed differences in the epidemiological patterns of airborne

infections across Europe.

Cristina Sotto

13-18 juli 2008. 24th International Biometric Conference, Dublin, Ireland. Marginalizing

pattern-mixture models for categorical data subject to monotone missingness.

Annouschka Laenen

13-18 juli 2008. 24th International Biometric Conference, Dublin, Ireland. Reliability of a

longitudinal sequence of scale ratings.

An Ceemers

13-18 juli 2008. 24th International Biometric Conference, Dublin, Ireland. Shared-parameter

models and missingness at random.

= OM

Christel Faes

23-25 september 2008. Non-Clinical Statistics Conference, Leuven. Modeling spatial learning

in rats based on Morris water maze expriments.

Marc Aerts

16-19 maart 2008. International Biometric Society Eastern North American Region, Arlington,

USA. Flexible modelling of age-dependent infectious disease parameters using seroprevalence

data in combination with social contact data.

Caroline Beunckens

12-18 juli 2008. 24th International Biometric Conference, Dublin, Ireland. Stochastic EM

algorithm for incomplete longitudinal data.

Ivy Jansen

12-18 juli 2008. 24th International Biometric Conference, Dublin, Ireland. An algorithm to find

co-regulated gene clusters: important improvements.

12-18 juli 2008. 24th International Biometric Conference, Dublin, Ireland. Pattern-mixture

models for categorical outcomes with non-monotone missingness.

Tomasz Burykowski

19-20 juni 2008. Seventh International Seminar on Statistics in Clinical Practice, Warsaw,

Poland. The use of the isotopic distribution in high-resolution maldi-tof mass spectrometry

data.

16-19 maart 2008. IBS/ENAR2008 Meeting, Arlington Virginia, USA. A model for the analysis

of proteolytic 180 stable-isotope labeled peptides in MALDI-TOF mass spectra.

13-18 juli 2008. XXIVth International Biometrics Conference, Dublin, Ireland. An algorithm to

find co-regulated gene clusters: important improvements.

Kaatje Bollaerts

23-25 januari 2008. 10th European Symposium on Statistical Methods in the Food Industry.

Louvain-la-Neuve. Development of a modular quantitive microbial risk assessment to

evaluate zoonotic risks in Belgium: Salmonellosis through consumption of porc as an example.

7-11 juli 2008. 23rd International Workshop on Statistical Modelling, Utrecht, Nederland.

Dose-illness models for human salmonellosis based on outbreak data.

Tetyana Kadankova

16-19 juli 2008. Second International Conference on Mathematics and Staitstics, Athens,

Greece. A two-sided exit problem for a difference of a compound Poisson process and a

compound renewal process with a discrete phase space (invited talk).

Saskia Litière

13-18 juli 2008. 24th International Biometric Conference, Dublin, Ireland. Diagnostic tools for

misspecification in mixed models.

ON

17-21 augustus 23008. 29th Annual Conference of the International Society for Clinical

Biostatistics, Copenhagen, Denmark. Diagnostic tools for misspecification in mixed models.

Nele Goeyvaerts

12-18 juli 2008. 24th International Biometric Conference, Dublin, Ireland. Estimating infectious

disease parameters from data on social contacts and serological status.

21-25 oktober 2008. DIMACS/ECDC Workshop on spatio temporal and network modeling of

infectious deseases, Tübingen, Germany. Parovirus B19 in five European Countries:

disentagling the sociological and microbiological mechanisms underlying infectious disease

transmission.

Dan Lin

29 juni – 2 juli 2008. First symposium on biopharmaceutical statistics. Shanghai, China.

Selection and evaluation of genomic biomarkers for depression in a microarray setting.

24-28 augustus 2008. 29th International Symposium on Clinical Biostatistics, Copenhagen,

Denmark. Selection and evaluation of genomic biomarkers for depression in a microarray

setting.

Suzy Van Sanden

13-18 juli 2008. International Biometric Conference, Dublin, Ireland. Genomic biomarkers for

a categorical response variable in early drug development microarray experiment.

23-25 september 2008. Non Clinical Statistics Conference, Leuven. Genomic biomarkers for a

binary response in early drug development microarray experiments.

Kasim Adetayo

13-18 juli 2008. International Biometric Conference, Dublin, Ireland. Using baseline gene

expression for multi-compound secreening in early drug development experiments.

23-25 september 2008. Non Clinical Statistics Conference, Leuven. Order restricted

clustering for dose-response microarray experiments.

Kristien Wouters

13-18 juli 2008. International Biometric Conference, Dublin, Ireland. Multivariate functional

linear discriminant analysis based on pairwise pseudo-likelihood modeling combined with

splines.

Tom Jabobs

23-25 september 2008. Non Clinical Statistics Conference, Leuven. Clinical relevance of

dissolution specifications.

Ziv Shkedy

13-18 juli 2008. International Biometric Conference, Dublin, Ireland. Testing procedures on

comparisons of several treatments with one control in a microarray setting.

= OO

Pryseley Assam

13-18 juli 2008. International Biometric Conference, Dublin, Ireland. Using earlier measures

in a longitudinal sequence as a potential surrogate for a later one.

Goele Massonnet

17-21 augustus 2008. 29th Annual Conference of the International Society for Clinical

Biostatistics, Copenhagen, Denmark. Using copulas to model four-dimensional udder infection

data.

Ariel Alonso

13-18 juli 2008. International Biometric Conference, Dublin, Ireland. Random-effects

distribution in generalized linear mixed models: perception and problems.

Harriet Namata

13-18 juli 2008. International Biometric Conference, Dublin, Ireland. Model averaging in

quantitative risk assessment.

33 Voordrachten in het buitenland op uitnodiging van instellingen of organisaties

=Noël Veraverbeke

2-3 april 2008. Charles University, Prague, Czech Republic. Copulas in survival analysis (2

april 2008). =Geert Molenberghs

31 januari – 2 februari 2008. Erasmus Medical Center, Rotterdam, Nederland. Missing values

in clinical research. =21 februari, 27 maart, 24 april 2008. Webinar for Learn Stat, American Statistical Association.

The statistical evaluation of surrogate endpoints in clinical trials (3 sessions of 2 hours)

9-11 april 2008. Erasmus University, NIHES, Rotterdam, Nederland. Longitudinal and

incomplete data.

28-29 april 2008. KULeuven. Numerical techniques for statisticians.

7-9 mei 2008, Graduate Program in Statistics, Neuchatel, Switzerland. Introduction to

longitudinal data analysis.

29 juni 2008. International meeting of the Psychometric Society (IMPS2008), Durham.

Methods for analyzing continuous, discrete and incomplete longitudinal data.

4 augustus 2008. Joint Statistical Meetings, Denver, Colorado, USA. Models for discrete

repeated measurements.

17 augustus 2008. International Society for Clinical Biostatistics, Copenhagen, Denmark

Discrete longitudinal data.

1 september 2008. Conference of the Royal Statistical Society, Nottingham, UK. Models for

discrete repeated measurements.

OP

=7-10 oktober 2008. Congreso Latinoamericano de Sociedades de Estadistica, Montevideo,

Uruguy. Continuous, discrete and incomplete longitudinal data.

13-14 oktober 2008. National University of Cordoba, Argentina. Longitudinal and incomplete

data.

21-22 oktober 2008. Copenhagen, Denmark. Longitudinal and incomplete data.

28 oktober 2008. Royal Statistical Society. Professional Development Center, London, UK.

The statistical evaluation of surrogate endpoints in clinical trials.

17-20 november 2008. ESALQ Course on Models for longitudinal and incomplete data.

ESALQ, Piraciaba, Saõ Paulo, Brasil. Missing values in clinical trials.

Tomasz Burzykowski

7 juli 2008. Department of Statistics, University of Milano Bicocca, Italy. An overview of the

meta-analytic approach to validation of surrogate endpoints in clinical trials.

Marc Aerts

15-17 april 2008. Workshop on composite likelihood methods, Warwick, UK. Pseudo-

likelihood methodology for marginally, conditionally and hierarchically specified models.

22 augustus 2008. Human Sciences Research Council, Pretoria, South Africa. Flexible

modelling of age-dependent infectious disease parameters using seroprevalence data in

combination with social contact data.

23 mei 2008. Instituto de Medicina Tropical ‘Pedro Kouri’ (IPK), La Habana, Cuba. Pseudo-

likelihood methodology for marginally, conditionally and hierarchically specified models.

José Cortiñas

5-6 maart 2008. Meeting of the working Group on the analysis of baseline survey on

Salmonella in Turkeys. Parma, Italië. Statistical considerations for the analysis of survey

data.

Niel Hens

15-17 april 2008. Workshop on composite likelihood methods, Warwick, UK. On the

correlated frailty model for bivariate current status data.

17 januari 2008. Martin-Luther Universität, Halle-Wittenberg. Estimating the association and

heterogeneity in the acquisition of varicella zoster virus and parovirus B19 for five different

European countries.

23 mei 2008. Instituto ‘Pedro Kouri’, Havana, Cuba. Measuring social mixing patterns and

their impact on modelling the spread of airborne infections among humans.

30 juli 2008. University of Washington, USA. Measuring social mixing patterns and their

predictiveness for observed epidemiological patterns.

= OQ

Ziv Shkedy

2 januari 2008. Gertner Institute for Epidemiology and Health Policy Research, Israel.

Identification of genetic biomarkers.

7-8 oktober 2008. European monitoring Center of drug and drug addiction (EMCDDA) expert

meeting on drug related infectious diseases, Lisboa, Portugal. Modeling HVC/HIV: longitudinal

analysis of time series data from Italy.

7-8 oktober 2008. European monitoring Center of drug and drug addiction (EMCDDA) expert

meeting on drug related infectious diseases, Lisboa, Portugal. Modeling subject heterogeneity

from cross-sectional individual data.

5-6 februari 2008. Meeting of the European study Group for mathematical modeling and

epidemiological analysis of drug related infectious diseases, Amsterdam. Modeling the

transition parameters of hepatitis C in injecting drug users.

6-7 november 2008. ESF Workshop, Utrecht. Model averaging for the skyline plot.

Dirk Valkenborg

1 april 2008. Philips Research, Eindhoven. A strategy for the prior preprocessing of high-

resolution mass spectrometry data in the application of peptide-centric proteomics.

Paul Janssen

7-10 mei 2008. Universidad Carlos III, Spain. Contributions to frailty and copula models.

Harriet Namata

23 april 2008. Utrecht, Nederland. Modeling the transmission parameters of Hepatitis C

among injecting drug users.

34 Presentatie van posters op internationale wetenschappelijke congressen

Dan Lin

23-25 september 2008. Non Clinical Statistical Conference, Leuven. Selection and evaluation

of genomic biomarkers for depression in a microarray setting.

Kasim Adetayo

23-25 september 2008. Non Clinical Statistics Conference, Leuven. A latent response

approach to multi-compound screening using baseline gene expression: application to cancer

cell lines.

Tomasz Burzykowski

13-18 juli 2008. 24th International Biometric Conference, Dublin, Ireland. A model for the

analysis of 18O stable-isotope labeled peptides in MALDI-TOF mass spectra.

Marc Aerts

7-11 juli 2008. 23rd International Workshop on Statistical Modelling, Utrecht, NL. Semi-

parametric regression to identify farms with high salmonella infection burden.

OR

Arthur Gitome

23-25 september 2008. Non Clinical Statistics Conference, Leuven. Classification of call lines

based on the response to treatment using PAMSHIPS.

15-17 oktober 2008. 16th Annual Meeting of the Belgian Statistical Society, Wépion-Namur.

Classification of cell lines based on the response to treatment using PAMCHIPS.

Setia Pramana

23-25 september 2008. Non Clinical Statistics Conference, Leuven. Gene expression analysis

in striatum after acute treatment with antipsychotics.

15-17 oktober 2008. 16th Annual Meeting of the Belgian Statistical Society, Wépion-Namur.

Gene expression analysis in striatum after acute treatment with antipsychotics.

Tom Jabobs

23-25 september 2008. Non Clinical Statistics Conference, Leuven. Therapeutic relevance of

bioequivalence acceptance limits.

23-25 september 2008. Non Clinical Statistics Conference, Leuven. An ordinal multinomial

nonlinear model for the effects of investigational compounds on Taxol-induced mechanical

neuropathy.

José Cortiñas

17-21 augustus 2008. 29th Annual Conference of the International Society on Clinical

Biostatistics, Copenhagen, Denmark. Alternative methods to evaluate trial level surrogacy.

25-28 oktober 2008. 48th Annual ICAA/IDSA 46th Annual Meeting, Washington, DC.

Evaluation of chromogenic media for MRSA detection using a combined Bayesian – penalized

likelihood approach.

Harriet Namata

13-18 juli 2008. International Biometric Conference, Dublin, Ireland. Prevalence and

persistence of salmonella in Belgian boiler chicken flocks. An identification of risk factors.

Abel Tilahun

23-25 september 2008. Non Clinical Statistics Conference, Leuven. Measuring associations

using surrogate marker methodology.

13-18 juli 2008. 24th International Biometric Conference, Dublin, Ireland. Investigating

association between CORT heart rate, blood pressure using surrogate marker methodology.

Niel Hens

14-16 mei 2008. 26th Annual Meeting of the European Society for Paediatric Infectious

Diseases – ESPID, Graz, Austria. Maternal antibodies against measles after natural infection

or vaccination in parturient women.

= OS

Dirk Valkenborg

22-26 september 2008. ECCB, Cagliari, Italy. A model-based method estimating the relative

abundance in 18O-labeld mass spectra.

15-16 december 2008. Maastricht, Nederland. Estimating the ion ratio of proteolytic 18O-

isotope labeled peptides.

4 Expert- en referee-opdrachten

41 Lidmaatschappen van editorial board van internationale tijdschriften

Noël Veraverbeke

- Associate editor of South African Statistical Journal (2009- )

- Nationaal correspondent voor International Association for Statistical Education (IASE)

Roel Braekers

- Associate editor ‘Statistica Neerlandica’ (2009- )

Geert Molenberghs

- Wiley Series in Probability and Statistics Editor (Editors: David J. Balding, Noel A.C.

Cressie, Nicholas I. Fisher, Iain M. Johnstone, J.B. Kadane, Geert Molenberghs, Louise M.

Ryan, David W. Scott, Adrian F.M. Smith, Jozef L. Teugels) (2003- )

- Co-editor of Biometrics (2007-2009)

Paul Janssen

- Associate editor “Statistica Neerlandica’ (2003-2008)

Marc Aerts

- Associate editor of Biometrics

- Associate editor of Statistical Modelling: An international journal

Ziv Shkedy


Tomasz Burzykowski

- Member of editorial board of Advances in Medical Sciences


42 Referee-opdrachten van publicaties op aanvraag van editorial board van

internationale tijdschriften

Noël Veraverbeke

• Computational Statistics and Data Analysis

• Journal of Statistical Planning and Inference

• Statistics and Probability Letters

• Mathematical Reviews (25)

• Annals of the Institute of Statistical Methematics

• Journal of Nonparametric Statistics

OT

• Journal of the American Statistical Association

• South African Statistical Journal

Geert Molenberghs

• Biometrics (Editor: 230)

• Biostatistics

• Biometrika

• Statistical Science

• Statistics in Medicine

• Journal of the Royal Statistical Society C

• Book Chapter (Springer)

• Book Proposal (Wiley, as advisor, 27)

• Book Proposal (Springer)

Paul Janssen

• Scandinavian Journal of Statistics

• South African Journal of Statistics

Marc Aerts


• Communications in Statistics: Simulation and Computation

• Statistica Sinica

• Journal of Applied Statistics

Roel Braekers

• Computational Statistics and Data Analysis

• Computational Statistics

• Journal of Multivariate Analysis

• Annals of the Institute of Statistical Mathematics

• Lifetime Data Analysis

Ariel Alonso

• Statistical Modelling

• Journal of the Royal Statistical Society-Series A

• Biometrics


Kaatje Bollaerts

• Risk Analysis

• Statistica Sinica

• Journal of Nonparametric Statistics

Tomasz Burzykowski

• Statistics in Medicine (2)

• STATA Journal (2)

• Biometrics (7)

• Clinical Trials (1)

= OU

Niel Hens

• American Journal of Epidemiology

• Biometrics

• Biometrika

• Statistical Modelling

Goele Massonnet

• International Journal of Biostatistics


Christel Faes

• Biometrics (2)

• Journal of Agricultural, Biological and Ecological Statistics (3)

• Biometrical Journal

Herbert Thijs

• Computational Statistics and Data Analysis (4)

Ziv Shkedy

• Statistical Applications in Molecular Biology

• Biometrics

Ivy Jansen

• Annals of Statistics

43 Referee-opdrachten vanprojecten, ingediend bij internationale onderzoeks-

programma’s

Noël Veraverbeke

• Jurylid voor de Belgian American Educational Foundation (BAEF), Alumni Award in Exact

Sciences (2 juni 2008)

• Grant referee for grant Agency of the Academiy of Sciences of the Czech Republic

• Grant referee for the National Research Foundation (NRF) South Africa

Geert Molenberghs

• Faculty member appointment (Denmark: 1)

• Faculty member appointment (Turkey: 1)

• Faculty member promotion (US: 1)

• Panellid by accreditatieaanvraag nieuwe opleiding (NVAO, Nederland: 1)

• Steering committee member of the European Science Foundation Research Networking

Programme on “Quantive Methods in the Social Sciences 2” (QMSS2)

• Grant application (Canada: 1)

• International Statistical Institute (ISF). Life Sciences, Committee Chair (2007-2009)

Marc Aerts

• Scientific expert for the European Food Safety Agency

• Reviewer for FWO-Vlaanderen

OV

Paul Janssen

• Lid van de VLIR werkgroep onderzoek

• Lid van de FWO werkgroep onderzoeksbeleid

• Lid Stuurgroep Onderzoek en Ontwikkeling

• Lid van de Vlaamse Raad voor Wetenschapsbeleid

• UHasselt promotor voor het Steunpunt OOI (lid van de stuurgroep en het dagelijks

bestuur)

• Lid van het Bureau en stuurgroep Universitaire Ontwikkelingssamenwerking

• Vice rector onderzoek (2008-2012)

44 Lidmaatschappen van scientific committee van internationale congressen

Noël Veraverbeke

• AF Math Conference: Actuarial and Financial Mathematics Conference (international

conference), Brussel 5-6 februari 2009. Member of the scientific committee.

• IAP Workshop on Missing Information in Survival Data beyond Right Censoring, Gent, 18-

19 september 2008. Member of the scientific committee.

• 58th ISI Conference, Dublin, 21-27 augustus 2011. Chairman of the General Topics

Committee

• International Seminar on Nonparametric Inference ISNI2008, Vigo, Spain. Member of the

scientific committee

Geert Molenberghs

• XXX Conference of the International Society for Clinical Biostatistics, ISCB30, Prague,

Czech Republic, 23-27 augustus 2009. Chair of the Scientific Program Committee

• International Seminar on Nonparametric Inference, ISNI2008, Vigo, Spain, Member of the

scientific committee

Paul Janssen

• IAP Worshop on Missing Inforamtion in Survival Data beyond Right Censoring, Gent, 18-19

september 2008. Member of the scientific committee and local co-organizer.

Ziv Shkedy

• NSC2008: Statistical Methods for Pharmaceutical Research and Early Development,

Leuven, 23-25 september 2008. Member of the organising committee

45 Referee-opdrachten t.a.v. internationale congressen

/

46 Lidmaatschappen van wetenschappelijke commissies in binnen- en buitenland

Noël Veraverbeke

• Lid van de Hoge Raad voor Statistiek (benoemd op 8 november 1998)

• Lid van het Wetenschappelijk Comité van de enquête 2001 (2001- )

• Lid van de Scientific Council van Eurandom, Eindhoven, Nederland (2004-2010)

• Lid van de stuurgroep van de FWO Wetenschappelijke Onderzoeksgemeenschap Wiskunde

(1996- )

• Lid van de jury van de Vlaamse Wiskunde Olympiade (1985- ) Voorzitter (2007- )

= PM

• Vertegenwoordiger van FWO-Vlaanderen in de vergaderingen van Mathematics

Representatives of the European Union (Paris 2003, Stockholm 2004, Berlin 2005, London

2006, Oslo 2007, Valencia 2008)

• Jurylid Prijs Ontwikkelingssamenwerking (2005- )

• Verantwoordelijke voor het Outreach Programme van de Bernoulli Society (2005- )

• Lid van de VLIR werkgroep Internationalisering (2006- )

Geert Molenberghs

• Lid van de Wetenschappelijke Commissie Wiskunde van het FWO (2003-2009)

• Lid van de Commissie voor International Wetenschappelijke Contacten van het FWO (2003-

2009)

Ziv Shkedy

• President of the Three County Corner Club of the Royal Statistical Society

Paul Janssen

• President van de Belgische Vereniging voor Statistiek

Herbert Thijs

• Independent Data Monitoring Committee for Sanofi Aventis (2008-2009)

• Independent Data Monitoring Committee for J&JPRD (2008-2009)

5 Verwerving van extern gefinancierde onderzoeksprojecten

51 Verwerving van onderzoeksprojecten als projectleider met internationale

participatie

Geert Molenberghs

VLIR Eigen Initiatief Cuba: Biostatistics and Bioinformatics Education and Research (2006-

2010)

Marc Aerts

Project leader “Biostatistics and Modelling”, IUC VLIR Partner Programme, Mondlane

University, Mozambique (UEM)

Paul Janssen

Project leader “Epidemiology and Modelling of Infectious Diseases”, IUC VLIR Partner

Programme, Jimma University, Jimma, Ethiopia.

Ziv Shkedy

Project Leader VLIR-UOS North-South-South Cooperation Programme.

PN

52 Verwerving van onderzoeksprojecten als deelnemer met internationale

participatie

Noël Veraverbeke

Spanish Ministry of Education

Title: Flexible statistical inference: methodological advances and new applications in

engineering, economics, and biomedical sciences (FSI-EEB) (2008-2011). Reference MTM

2008-03129.

Principal investigator: Jacobo de Uña Alvarez, University of Vigo, Spain

Co-investigator: Noël Veraverbeke

Niel Hens

Methusalem grant Vaxinfectio (UAntwerpen) and Censtat (UHasselt)

Christel Faes

• EPIZONE “Epidemiology and surveillance of bluetongue virus serotype 8 in Europe” (1 year

– for networking) Promotor: Koens Mintiens

• EFSA “Request for assistance in statistical analysis of the 2008 EU-wide baseline surveys on

broiler flocks and broiler carcasses”

• Project title: Generalized additive modelling in studies of association, prediction, and

classification. Applications in medicine and biology. Reference MTM2008-01603. Financed

by the Spanish Ministry of Science for the period 2008-2011.

53 Verwerving van binnenlandse (nationaal of regionaal) onderzoeksprojecten

Christel Faes

FWO Nieuw onderzoeksproject “A flexible method for modelling non-normal hierarchical data

structures (promotor: Geert Molenberghs; co-promotor: Christel Faes)

Herbert Thijs

UHasselt IOF Grant

Marc Aerts

Co-promotor of the SBO-IWT (Strategisch Basisonderzoek) grant “Simulation models of

infectious disease transmission and control processes (SIMID), with applications to five major

health policy issues in Flanders, “January 1, 2007 – December 31, 2010.

Geert Molenberghs

Censtat dienstverlening: In 2008 werd met volgende instellingen/bedrijven samengewerkt:

Amsterdam Molecular Therapeutics (AMT), Belgian Association for Cardio-Thoracic Surgery

(BACTS), Boehringer Ingelheim GmbH, Bristol-Myers Squibb International Corporation,

Caridian BCT Europe, Centraal Bureau voor de Statistiek van Nederland (CBS), Centrum voor

Alcohol- en andere drugproblemen (CAD), Centrum voor Huisartsgeneeskunde (UA), CODA-

CERVA, Eli Lilly, European Academy for Gynecological Surgery vzw, European Food Safety

Authority (EFSA), Federale Diensten voor Wetenschappelijke, Technische en Culturele

aangelegenheden (DWTC), IM Associates, International Drug Development Institute (IDDI),

Janssen Pharmaceutica NV, Johnson & Johnson Pharmaceutical Research and Development

L.L.C., KULeuven, LOOA (Limburgs Overleg Onderwijs Arbeid), Mars Belgium, Mars UK

Limited, NYCOMED Belgium, Openbare Vlaamse afvalstoffen Maatschappij (OVAM), Pierre

= PO

Fabra Médicament, Provinciale Hogeschool Limurg (PHL), Provincie Limburg, Rekenhof, Sanofi-

Aventis Recherche & Développement, Schwarz Biosciences, Tibotec bvba, UCB Pharma sa,

Universitair Ziekenhuis Maastricht, Virga Jesse Ziekenhuis, Vlaams Agentschap Zorg en

Gezondheid, Vlaams Instituut voor Technologisch Onderzoek (VITO), Vlaamse

Interuniversitaire Raad (VLIR), Vrije Universiteit Brussel (VUB), Ziekenhuis Oost-Limburg

(ZOL)

6 Prijzen, vermeldingen, gerealiseerde toepassingen

61 Behaalde wetenschappelijke prijzen

Geert Molenberghs

2009 Excellence in Continuing Education Award of the American Statistical Association for

Course on Discrete Londigitudinal Data, presented by Verbeke, G. and Molenberghs, G.

at the Joint Statistical Meetings, Denver, Colorado (04/08/2008). Awarded at the

Joint Statistical meetings in Washintgon, District of Columbia, XX/08/2009.

2008-2009: Belgian Francqui Chair, Universiteit Antwerpen.

Dan Lin

Quetelet prize for the best master thesis biostatistics, UH, 2007

Kaatje Bollaerts

Prize of the best International Workshop on Statistical Modelling 2008 Student presentation

7 Samenwerking met andere wetenschappelijke instellingen en onderzoekers

72 Verblijf van buitenlandse onderzoekers aan de UHasselt

Jeanine Houwing-Duistermaat, Universiteit Leiden, Nederland

1 december 2009 – 9 januari 2008; genetic epidemiology; onderwijs

Financiering: UHasselt

Lizet Sánchez Valdés, Tropical Institute ‘Pedro Kouri’, Havana, Cuba

17 maart – 31 mei 2008; infectious diseases; onderzoek

Financiering: VLIR - Cuba

Fasil Tessema, Jimma University, Ethiopia

1 februari – 31 maart 2008; onderzoek

Financiering: VLIR – Jimma

Yehenew Getachew, Jimma University, Ettiopia

1 februari – 31 maart 2008; onderzoek survival analysis


Wondwossem Kassahun, Jimma University, Ethiopia

1 februari – 31 maart 2008; onderzoek


Clarice Demétrio, Sao Paulo State Unviersity, Brasil

1 mei – 30 juni 2008; biometry; onderwijs en onderzoek

Financiering: VLIR

PP

Marek Omelka, Charles University, Prague, Czech Republic

15 april – 14 oktober 2008; copulas; onderzoek

Financiering;: IUAP project

Afriano Marcio Correia Vieira, University of Brasilia

1 maart – 30 september 2008; onderzoek

Financiering: eigen financiering

Dani Yekutieli, Tel Aviv University, Israel

27-29 maart 2008; Bayesian inference; onderzoek


Liset Oropesa Gonzalez, Tropical Institute ‘Pedro Kouri’, Havana, Cuba

25 april 2008; infections diseases; onderzoek


Dimitris Karlis, Athens University, Greece

18 april 2008; missing data; onderzoek


Khangelani Zuma, Human Sciences Research Council, Pretoria, South Africa

22 mei – 1 juni 2008; HiV research; onderzoek


Marta Fiocco, Leiden University, Nederland

19 juni 2008; onderzoek composite likelihood


Hector de Arazoa, University of Habana, Cuba

12 juni 2008; HiV research; onderzoek

Financiering; UHasselt

Bennet Kato, King’s Collega, London, UK

8-12 augustus 2008; microarray data; onderzoek


Ricardo Cao, University of La Coruna, Spain

7-11 september 2008; survival analysis; onderzoek

Financiering: IUAP project

Andreas Wienke, Universität Halle – Wittenberg, Germany

7-9 september 2008; frailty models; onderzoek


James Steven Marron, University of North Carolina, Chapel Hill, USA

8-11 september 2008; object oriented data analysis; onderzoek


Norman Breslow, University of Washington, Seattle, USA

8-13 september 2008; Wilms Tumor Study; onderzoek


Dhammika Amaratunga, Johnson and Johnson Pharmaceutical Research and Development,

Raritan, New Jersey, USA

9-13 september 2008; classification methods; onderzoek


Michal Kulich, Charles University, Prague, Czech Republic

9-12 september 2008; regression; onderzoek


Dimitris Rizopoulos, Universiteit Rotterdam, Nederland

10-11 september 2008; Laplace approximation; onderzoek


= PQ

Jelle Goeman, Universiteit Leiden, Nederland

10 september 2008; onderzoek


Dan Kajungu, Uganda Malaria Surveillance Project, Kampala, Uganda

15-28 september 2008 ; infectious diseases ; onderzoek

Financiering : IUAP Project

Bart Mertens, University Leiden, Nederland

12 september 2008 ; onderzoek


Carmen Cadarso Suarez, Unviersity of Santiago de Compostela, Spain



Anastasios Tsiatis, North Carolina State University, Raleigh, USA



Marie Davidian, North Carolina State University, Raleigh, USA



Garret Fitzmaurice, Harvard School of Public Health, Boston, USA

12-14 december 2008; longitudinal data; onderzroek


Yehenew Getachew, Jimma Univeristy, Ethiopia

1 september – 31 december 2008; onderzoek


73 Gemeenschappelijk verricht onderzoek

Jan Swanepoel (North-West University, Potchefstroom, Zuid Afrika)

Paul Janssen en Noël Veraverbeke

Resampling, modified bootstrap and goodness-of-fit

Bilateral Scientific and Technological Cooperation

21-30 januari 2008: P. Janssen en N. Veraverbeke in Potchefstroom

BOF bilaterale samenwerking

Stéphane Loisel (Université de Lyon 1, France) and Claudio Macci (University of Rome, Tor

Vergata)

Noël Veraverbeke

Risk Theory

Individueel akkoord

13-15 februari 2008: Noël Veraverbeke in Lyon

Ingrid Van Keilegom (UCL)

Noël Veraverbeke

Empirical likelihood with non smooth criterion function

Individueel akkoord

Ingrid Van Keilegom (UCL)

Roel Braekers

Copulas in regression

Individueel akkoord

PR

Elisa Molanes (University Carlos III Madrid, Spain)

Noël Veraverbeke

Empirical likelihood

Individueel akkoord

Irène Gijbels (KULeuven) en Marek Omelka (Charles University, Prague)

Noël Veraverbeke

Copula estimation

IAP Network

15 april – 14 otober 2008: Marek Omelka in UHasselt

Paul Markel (Minot State University, USA)

Roel Braekers

Zero inflated Cox regression model for left-censored data

Individueel akkoord

Ricardo Cao and Ignacio Lopez de Ullibarri (University of La Coruña, Spain)

Paul Janssen

Frailty models

Individueel akkoord

Luc Ducateau (UGent)

Paul Janssen, Goele Massonnet

Frailty models

Individueel akkoord

Jimma University, Jimma, Ethiopia

Paul Janssen, Noël Veraverbeke, Ziv Shkedy

IUS samenwerking

8-14 december 2008: Paul Janssen en Ziv Shkedy in Jimma

VLIR-UOS

Pierre Van Damme, Philippe Beutels, Heidi Theeten, Koen Van Herck, Elke Leuridan, Gaelle

Boulet, John-Paul Bogers, Kris Vestreken, Joke Bilcke, Oliver Lejeune, Benson Ongunjimi

(UA), Koen Mintiens, Stefan Roels, Yves Vanderstede, Estelle Méroc (Centrum voor

Onderzoek in Diergeneeskunde en Agrochemie), Dirk Berkvens, Nico Speybroeck

(Instituut voor Tropische Geneeskunde), Patrick Cras (UA), Claude Saegerman (Un

Liège), Peter Teunis en Jaco Wallinga (RIVM, Bilthoven, NL)

Marc Aerts, Ziv Shkedy, Geert Molenberghs, Christel Faes, Niel Hens, José Cortiñas,

Kaatje Bollaerts, Harriet Namata, Nele Goevaerts, Yovanna Amparo Castro Sanchez

Modelling infectious diseases

FWO, Polymod, SBOSIMID

Methusalem Project on Vaccine and Infectious diseases (UH and UA): Herman Goossens, Greet

Ieven, Vanessa Vankerckhoven, Katherine Loens

Patrick Cras, Bart Van Everbroeck, Pierre Van Damme, Philippe Beutels, Koen Van Herck

(Universiteit Antwerpen), Dirk Berkvens (Instituut voor Tropische Geneeskunde), Claude

Saegerman (Universiteit Luik), Koen Mintiens, Stefan Roels (Centrum voor Onderzoek in

de Diergeneeskunde en Agrochemie).

Marc Aerts

FWO

= PS

Koen Mintiens, Ides Boone, Yves Van der Stede (Centrum voor Onderzoek in de

Diergeneeskunde en Agrochemie), Georges Daubes, Laurent Delhalle (Universiteit Luik),

Jeroen Dewulf, Dominiek Maes (Universiteit Gent), Koen Grijspeerdt (Instituut voor

Landbouw- en Visserijonderzoek)

Marc Aerts

Project FOD Volksgezondheid

Frank Buntinx, Ann Van der Bruel (KULeuven)

Marc Aerts

Europees project POLYMOD: Pierre Van Damme, Philippe Beutels (Universiteit Antwerpen),

Peter Teunis, Jacco Wallinga (RIVM) + 14 European partner research institutes

Marc Aerts

Europees project Polymod

Jeffrey Simonoff (New York University, USA)

Marc Aerts, Niel Hens

Model selection

Individueel akkoord

Mike Kenward (London School of Hygiene and Tropical Medicine, UK)

Marc Aerts, Geert Molenberghs, Herbert Thijs, Niel Hens, Ivy Janssen, An Creemers

Incomplete clinical trial data

IAP Network and ESRC Grant

Diverse bezoeken

Marc Van Ranst, Pieter Maes (KULeuven), Ignace Glorieux (VUB) Niel Hens, Marc Aerts,

Christel Faes

Modelling pandemic influenza : the impact on Flanders

Individueel akkoord

Kristel Van Steen, Els Goetghebeur, Stijn Vansteelandt (UGent), Mike Kenward (London),

Dimitris Rizopoulos, Sypridoula Tsonoka, Geert Verbeke (KULeuven)

Geert Molenberghs, Marc Aerts, Herbert Thijs, Ivy Janssen, Caroline Beunckens, An

Creemers, Cristina Sotto

Missing data and sensitivity analysis

Individueel akkoord

Didier Renard (Novartis), Tony Vangeneugden, Geert Molenberghs, Tomasz Burzykowski,

Helena Geys, José Cortiñas, Ariel Alonso, Ziv Shkedy, Abel Tilahun, Pryseley Assam

Surrogate markers

Individueel akkoord

Paul Eilers (Universiteit Utrecht, Nederland)

Kaatje Bollaerts, Marc Aerts, Niel Hens

Splines

15-19 december: NH in Utrecht

Universiteit Utrecht

John Edmunds and Nigel Gay, Alessia Melagro (Health Protection Agency, London, UK)

Niel Hens, Nele Goeyvaerts

Elucidation on differences in the sero-epidemiology of VZV and B19 in five European

Countries

Polymod project

PT

Geert Verbeke, Iven Van Mechelen, Francis Tuerlinckx, Paul De Boeck, Dirk Smits (KULeuven)

Geert Molenberghs

Logistic models in item response theory

Individueel akkoord

Michael Kenward (London), Raymond Caroll (Texas A&M University), Craig Malinckrodt (Eli

Lilly, Indianapolis, USA)

Geert Molenberghs, Caroline Beunckens, Ivy Jansen, Cristina Sotto

Missing data in clinical trials

Individueel akkoord

Carmen Cadarso Suarez (Santiago de Compostela, Spain)

Geert Molenberghs, Helena Geys, Ariel Alonso, Christel Faes

Neuro synchronization

Grant BMF2005-00818 (Spain)

Peter Boyen, Frank Neven (Infolab, UHasselt)

Ivy Jansen

Protein-protein interaction networks

Individueel akkoord

P. Manfredi (Pisa), G. Scalia Tomba (Rome), Mirjam Kretzschmar (Utrecht), Peter Theunis

(Bilthoven), Emanuele del Fava, Ziv Shkedy

Infectious deseases

Individueel akkoord

University of Michigan (Ann Arbor, Michigan, USA)

Tomasz Burzykowski

FWO

9-16 augustus 2008: TB in Ann Arbor

Gail Potter en Ira Longini (University of Washinton)

Niel Hens

Egocentric data

21 juli – 21 augustus: Niel Hens in Washington

Individueel akkoord

Jacco Wallinga (Utrecht), Teel Tamme (formerly UHasselt)

Niel Hens, Ziv Shkedy

Epidemic trees

Individueel akkoord

Didier Renard (Vovartis, Belgium), Christelle Darstein (Eli Lilly, USA)

Ariel Alonso, Saskia Litière, Annouschka Laenen, Geert Molenberghs

Biomarkers

Individueel akkoord

Luc Bijnens (Janssen Pharma), Luc Wouters (Barrier Therapeutics)

Dan Lin

Microarray data

Individueel akkoord

Individueel akkoord

George Daube (UL), Lieven De Zutter (UG), Koen Grijspeerdt (CLO), Koen Mintiens (CODA),

Herman Van Oyen (WIV)

Kaatje Bollaerts, Marc Aerts, Ziv Shkedy

Individueel akkoord

Koen Kras (Pronota)

= PU

Dirk Valkenborg, Tomasz Burzykowski

Microarray data

Individueel akkoord

Dani Yekutieli, (Tel-Aviv University, Israel)

Dan Lin, Tomasz Burzykowski, Ziv Shkedy

Microarray experiments

Individueel akkoord

Roel Straetemans (Janssen Pharma) en A. Dunne (University College, Dublin)

Tom Jacobs, Geert Molenberghs

Mixed effects modeling

Individueel akkoord

University of Havana, Cuba

Geert Molenberghs, José Cortiñas, Niel Hens

Training and Research program in medical statistics and bioinformatics

20-30 juni 2008: José Cortinas in Cuba

19-29 mei 2008: Niel Hens in Cuba

VLIR-UOS

Edward Ip (Wake Forest Univeristy, Winston-Salem, USA)

Geert Molenberghs

Logistic models in item response theory

Individueel akkoord

Yuri Goegebeur (University of Southern Denmark, Odense)

Geert Molenberghs

Item response theory

Individueel akkoord

Clarice Demétrio en Afriano Vieira (Sao Paulo State University, Brasil)

Geert Molenberghs, Tony Vangeneugden, Geert Verbeke

Combined longitudinal-overdispersed models

Individueel akkoord

Andreas Wienke (Martin-Luther Universität Halle-Wittenberg)

Niel Hens, Marc Aerts, Geert Molenberghs

Current status data

16-17 januari: NH in Halle-Wittenberg

Individueel akkoord

Janne Lehtiö (Karolinska Institutet, Stockholm)

Tomasz Burzykowski, Dirk Valkenborg

Bioinformatics: Mass-spectrometry data

Individueel akkoord

Andrea Kvitkovicova, Daniel Hlubinka (Charles University, Prague)

Niel hens, Marc Aerts Modelling seroprevalence data

Individueel akkoord

Koen Matthijs (KULeuven) en Bart Van de Putte (UGent)

Christel Faes

Historische demografie

FWO-WOG

PV

Peter Ekamper en Frans van Poppel (Netherlands Interdisciplinary Demographic Institute)

Christel Faes

Historische demografie

FWO-WOG

Koen Mintiens (Vose Consulting Belgium), Yves Van der Stede (VAR Belgium), Estalle Méroc

(VAR, belgium), Armin Elbers (CVI, the Netherlands), Alinde de Koeijer (CVI, the

Nederlands), Christoph Staubach (FLI, Germany), Franz Conraths (FLI, Germany), Helène

Guis (CIRAD, France)

Christel Faes

Spatio-temporal spead of infectious diseases

EPIZONE

27-28 oktober 2008: Christel Faes in Berlin (EPIZONE meeting)

Estelle Méroc, Yves van der Stede and Koen Mintiens (Veterinary and Agrochemical Research

Centre, Belgium)

Christel Faes

Bluetongue infection

Consulting en FWO

Wim Talloen, Anne De Bondt, Hinrich Goehlmann, Luc Bijnens (Janssen Pharmaceutica)

Arthur Gitome, Setia Pramana, Suzy Van Sanden, Ziv Shkedy, Dan Lin, Adetayo Kassim

Microarrays

Individueel akkoord

Dhammika Amaratunga (Johnson & Johnson, Raritan, New Jersey, USA)

Philippe Haldermans

Microarray analysis

Individueel akkoord

11-22 augustus 2008: Philippe Haldermans in Raritan

= QM

Activiteitenverslag - Voordrachten op nationale of regionale congressen, studiedagen, symposia,

workshops Herman Callaert - 8-15-22 oktober 2008. Vliebergh-Sencie, Leuven. Nascholing voor leerkrachten

wiskunde van het secundair onderwijs (derde graad). Kansmodellen en betrouwbaarheidsintervallen.

- 12-19-26 november 2008. CNO, UAntwerpen. Nascholing voor leerkrachten wiskunde van het secundair onderwijs (derde graad). Kansmodellen en betrouwbaarheidsintervallen.

Noël Veraverbeke - 16 mei 2008. Université catholique de Louvain. Copulas in survival models. - 31 oktober 2008. Katholieke Universiteit Leuven. Coloquiumvoordracht. Half a

century of Kaplan-Meier estimation in survival analysis (1958-2008). Geert Molenberghs - 22 maart 2008. UHasselt. Pseudo-likelihood methodology for marginally, conditionally

and hierarchically specified models. - 22 mei 2008. UHasselt. Incomplete data in clinical studies: analysis and sensitivity

analysis. - 4 september 2008. UAntwerpen. Clinical trials and surrogate markers. - 4 september 2008. UAntwerpen. Closing remarks First Joint Scientific Meeting –

Methusalem Consortium. - 30 september 2008. KULeuven. Medical Statistics and Epidemiology. - 23 oktober 2008. Paneldiscussie. Research Careers “Kennismakers” Symposium for

the 80th Anniversary FWO Vlaanderen, Brussel. - 9 december 2008. UAntwerpen. Statistical methods in (pre)clinical trials. Roel Braekers - 9 juni 2008. Universiteit Gent. Overview dependent censoring. Auguste Gaddah - 18-19 september 2008. UGent. IAP Workshop Missing information in survival analysis

beyond right censoring. An extension of the Koziol-Green model under dependent censoring.

José Cortiñas - 18-19 september 2008. UGent. IAP Workshop Missing information in survival analysis

beyond right censoring. Modelling strategies for surrogate validation for multivariate failure time data.

- 4 september 2008. First Joint Scientific Meeting – Methusalem Consortium: Vaccine and Infectious Disease Institute (Vaxinfectio), UA and UH, UHasselt Statistical tools to evaluate diagnostic tests in medical microbiology.

QN

Niel Hens - 18-20 september 2008. UGent. IAP Workshop Missing information in survival analysis

beyond right censoring. A simulation – based assessment of the correlated frailty model for bivariate current status data.

- 16-17 oktober 2008. 16th Annual Meeting of the Belgian Statistical Society, Wépion-Namur. Identifying missing links in pneumonic plague epidemics using a prior-based EM algorithm.

Ivy Jansen - 3 november 2008. Leuven. Statistics Seminar. Identifying overlapping peptides in

mass spectra. Marc Aerts - 12 december 2008. Workshop on Infectious Disease Epidemiology for Decision Making

– Belgian Association of Public Health, Brussel. Seroprevalence studies as methods for public health decisions.

- 4 september 2008. First Joint Scientific Meeting Methusalem Consortium, Antwerpen. Ten years of collaboration on estimating infectious disease parameters for simulation models.

- 9 juni 2008. Workshop on estimating contact patterns and their implications for infectious disease modelling. POLYMOD Final Meeting, Antwerpen. Estimating the force of infection directly from antibody levels.

Christel faes - 15-17 oktober 2008. 16th Annual Meeting of the Belgian Statistical Society, Wépion-

Namur. Young Statisticians Afternoon. Joint models for continuous and discrete longitudinal data.

- 15-17 oktober 2008. 16th Annual Meeting of the Belgian Statistical Society, Wépion-Namur. A high-dimensional joint model for longitudinal endpoints of different type.

- 4 december 2008. Gent. Dag van de historische demografie (WOG). Tijd- en ruimteeffecten in de afstand tussen huwelijkspartners.

Nele Goeyvaerts - 9 juni 2008. UAntwerpen. Estimating transmission parameters using social contact

data and serological data on the varicella zoster virus in Belgium. Suzy Van Sanden - 20 juni 2008. UHasselt. Genomic biomarkers for a binary clinical outcome in early

drug development microarray experiments. Adetayo Kasim - 13 oktober 2008. Janssen Pharmaceutica, Beerse. Order restricted clustering for

dose-response microarray experiments. Qi Zhu - 15 februari 2008. BSMS. BBC Conference Identifiability of 16O-18O labeled mass

spectra: a simulation study (poster) - 17 otkober 2008. 16th Annual Meeting of the Belgian Statistical Society, Wépion-

Namur. A Bayesian approach to identify overlapping peptides in a mass spectrum.

= QO

Arthur Gitome - 15-17 oktober 2008. 16th Annual Meeting of the Belgian Statistical Society, Wépion-

Namur. Classification of cell lines based on the response to treatment using PAMCHIPS.

Setia Pramana - 15-17 oktober 2008. 16th Annual Meeting of the Belgian Statistical Society, Wépion-

Namur. Testing for trend in dose-response microarray experiments. Cristina Sotto - 10-11 september 2008. Censtat Anniversary Celebration, UHasselt. MCMC-based

estimation methods for continuous longitudinal data with monotone and non-monotone missingness.

- 18-20 september 2008. IAP Workshop Missing Information in survival data beyond right censoring, UGent. A simulation study comparing weighted estimating equations and multiple imputation based estimating equations for longitudinal binary data.

Goele Massonnet - 13 juni 2008. Seminars in Statistics. UHasselt. Using copulas to model multivariate

survival data. - 2 oktober 2008. Statistics Seminar. KULeuven. Contributions to frailty and copula

modelling with applications to clinical trials and dairy cows data. - 14 november 2008. Statistics Seminar UCL. Louvain-la-Neuve. Contributions to

frailty and copula modelling with applications to clinical trials and dairy cows data.

= QP

Congressen (passieve deelname) Herman Callaert - National Council of Teachers of Mathematics Conference. Salt Lake City and Oklahoma

City. Noël Veraverbeke - Symposium 10 years Eurandom ‘A random tour through a decade of research.

Eindhoven, 26-28 augustus 2008. - IAP Workshop Missing information in survival data beyond right censoring. UGent, 18-

19 september 2008. - 16th Annual Meeting of the Belgian Statistical Society. Wépion-Namur, 16-17 oktober

2008. - International Workshop FMSR 2008, Flexible Modelling: smoothing and robustness.

KULeuven, 12-14 november 2008. - Bijeenkomst Stochastici. Lunteren, Nederland, 17-19 november 2008. Kaatje Bollaerts - International Workshop FMSR 2008. Flexible Modelling: smoothing and robustness.

KULeuven, 12-14 november 2008. Roel Braekers - IAP Workshop Missing information in survival analysis beyond right censoring. UGent,

18-19 september 2008. Qi Zhu - 3rd Conference on Proteome Analysis. Antwerpen, 18-19 december 2008. Arthur Gitome - 15 september 2008. Statistical Genetics Conference. ULiège. - 16-18 september 2008. Course in Statistics in gene-mapping studies & SAS JMP

genomics, UCL-Bruxelles. - 23-25 september 2008. Non Clinical Statistics Conference, Leuven. - 13 oktober 2008. The 10th Johnson and Johnson Pharmaceutical Conference in

Statistics, Beerse. - 15-17 oktober 2008. 16th Annual meeting of the Belgian Statistical Society, Wépion-

Namur. Setia Pramana - 15 september 2008. Statistical Genetics Conference. ULiège. - 16-18 september 2008. Course in Statistics in gene-mapping studies & SAS JMP

genomics, UCL-Bruxelles. - 23-25 september 2008. Non Clinical Statistics Conference, Leuven. - 13 oktober 2008. The 10th Johnson and Johnson Pharmaceutical Conference in

Statistics, Beerse. - 15-17 oktober 2008. 16th Annual meeting of the Belgian Statistical Society, Wépion-

Namur.

= QQ

Emanuele del Fava - 9-11 juni 2008. Final Meeting of the European project POLYMOD, Antwerpen Niel Hens - 12 december 2008. Workshop on Infectious Disease Epidemiology for Decision

Making. Brussel. Ivy Jansen - 15 februari 2008. Beerse. Annual Meeting of the Belgian Society for Mass

Spectrometry. - 15 september 2008, ULiège. Mini-Conference: Aspects of Statistical Genetics. - 22-26 september 2008. Cagliari, Sardinia. 7th European Conference on

Computational Biology (ECCB08) - 16-17 oktober 2008. 16th Annual Meeting of the Belgian Statistical Society, Wépion-

Namur. - 15-16 december 2008. Maastricht. Benelux. Bioinformatics Conference. - 18-19 december 2008. Maastricht, 3rd Symposium on Proteome Analysis. Ziv Shkedy - 16-17 oktober 2008. 16th Annual Meeting of the Belgian Statistical Society, Wépion-

Namur. Goele Massonnet - 18-20 september 2008. IAP Workshop Missing information in survival data beyond

right censoring. UGent. Paul Janssen - 29 maart – 6 april 2008. Conference of the Flemish rectors in Cuba. - 31 mei – 6 juni 2008. Launch of the IUC programme at Anton de Kom University,

Paramaribo, Suriname. - 8-14 december 2008. Jimma University en University of Addis Ababa, Ethiopia (IUC

and NSS, VLIR-UOS Development Cooperation). - 16-17 oktober 2008. 16th Annual meeting of the Belgian Statistical Society, Wépion-

Namur. Christel Faes - 24 oktober 2008. VEE Studiedag. Leuven. Binnenlandse bezoekers (seminarie) Dimitris Rizopoulos (KULeuven), 4 april 2008 Olivier Thas (UGent), 10-11 september 2008 Ingrid Van Keilegom (UCL), 10-11 september 2008 Tony Van Geneugden (Tibotec), 10-11 september 2008 Koen Kas (VIB, Gent), 12 september 2008

Jaarverslag2008Statistiek - Universiteit Hasselt · transmission: an illustration for variacella...

Documents

Transcript of Jaarverslag2008Statistiek - Universiteit Hasselt · transmission: an illustration for variacella...