Stand nach Drucklegung: November 2018Redaktion: Universitätsklinikum Freiburg | CCILayout: Universitätsklinikum Freiburg | Medienzentrum

13TH FREIBURG IMMUNOLOGY

MEETINGNOVEMBER 28, 2018

VENUE

Albert-Ludwigs-Universität Kollegiengebäude I (KG I), Aula, first floorPlatz der Universität 379098 Freiburg

Kartenausschnitt Google Maps

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BertoldsbrunnenLinie 1, 2, 3, 5 | 27 (Bus)

StadttheaterLinie 1, 3, 5

StadttheaterLinie 1, 3, 5

StadttheaterLinie 27(Bus)

Kollegiengebäude I (KG I) Platz der Universität 379098 Freiburg

10. Regulation and Function of Autophagy in Innate Lymphoid Cells Karolina Ebert (Group Yakub Tanriver) Center for Microbiology and Hygiene, Medical Center – University of Freiburg

11. RASEF enhances γδ T cell receptor signaling Anna Morath (Group Wolfgang Schamel) Bioss Centre, University of Freiburg

12. Cytomegalovirus reprograms macrophages facilitating viral dissemination Sebastian Baasch (Group Philipp Henneke) CCI, Medical Center – University of Freiburg

13. Assessing missense variants of NF-kB1 in immunodeficient patients Nils Klammer (Group Bodo Grimbacher) CCI, Medical Center – University of Freiburg

14. Innate Lymphoid Cells in the female genital tract and their role in chlamydial infection Svenja Barth (Group Georg Häcker) Institute for Microbiology and Hygiene, Medical Center – University of Freiburg

15. Cell death signaling pathways in macrophages upon infection with Modified Vaccinia Virus Ankara (MVA) Lioba Klaas (Group Georg Häcker) Institute for Microbiology and Hygiene, Medical Center – University of Freiburg

16. IFN-λ enhances influenza immunity by stimulating TSLP release during intranasal immunization Liang Ye (Group Peter Stäheli) Institute for Virology, Medical Center – University of Freiburg

17. T-bet+ CD8αα TCRαβ intraepithelial lymphocytes precursors progress through a PD-1 stage and depend on C-myc Jonas Hummel (Group Yakup Tanriver) Institute for Microbiology and Hygiene, Medical Center – University of Freiburg

18. Function of T-bet and Eomes in CTLs – an evolutionary approach using a novel mouse model Jonas Fixemer (Group Yakup Tanriver) Institute for Microbiology and Hygiene, Medical Center – University of Freiburg

SESSION 2 Chair: Wolfgang Schamel

10:45 A role for neutrophils in inflammation and tissue damage during chlamydial infectionSusanne Kirschnek (Group Susanne Kirschnek)Center for Microbiology and Hygiene, Medical Center – University of Freiburg

11:00 Using polyclonal ex vivo expanded γδ T cells for immunotherapy against human breast cancer stem cell-derived xenograftsKatrin Raute (Group Susana Minguet)BIOSS Centre, University of Freiburg

11:15 Novel and distinct interference mechanisms of the Cytomegalovirus gp34 and gp68 glycoproteins with the activation of human Fcү-receptor FcүRlll/CD16A by immune lgGPhilipp Kolb (Group Hartmut Hengel)Institute for Virology, Medical Center – University of Freiburg

11:30 Structural requirements of the proper function of B cell antigen receptor reveal its activation mechanismMelanie Sieder (Group Jianying Yang)BIOSS Centre, University of Freiburg

11:45 The role of tissue stress and damage in contact dermatitisFabian Gendrisch (Group Philipp Eßer/ Stefan Martin)Department of Dermatology, Medical Center – University of Freiburg

12:00 Immune evasion strategies of HCMV: Functional characterization of the highly polymorphic HCMV Fcy receptor RL12/gp95Katja Hoffmann (Group Hartmut Hengel)Institute for Virology, Medical Center – University of Freiburg

12:15 The role of Kidins220 in NKT cells and TCR rearrangementLaurenz Herr (Group Wolfgang Schamel)Bioss Centre, University of Freiburg

12:30 3 Poster Prizes and Closing RemarksWolfgang Schamel

08:00 REGISTRATION AND POSTER SET-UP

08:30 Welcome and Announcement of 3 Poster PrizesStephan Ehl

08:35 Introduction GEFIMichael Reth

08:40 GEFI Prize WinnerNovel insights into germinal center B cell and T follicular helper cell biology – Learning from human primary immunodeficienciesSusanne Unger

SESSION 1 Chair: Stephan Ehl

09:00 Non-canonical binding of the LCK SH3 domain to CD3ε redefines initiation of TCR signalingSusana Minguet (Group Susana Minguet)BIOSS Centre, University of Freiburg

09:15 Optimizing expression of the secreted leukocyte manipulating E3/49K protein of species D adenovirusesHans-Gerhard Burgert (Group Zsolt Ruzsics)Institute for Virology, Medical Center – University of Freiburg

09:30 Both Igα and Igβ bind directly to the mIg to form the BCR complexCornelia Gottwick (Group Jianying Yang)BIOSS Centre, University of Freiburg

09:45 Human MxB protein is a pan-herpesvirus restriction factorSebastian Weigang (Group Georg Kochs)Institute for Virology, Medical Center – University of Freiburg

10:00 COFFEE BREAK AND POSTER PRESENTATION

PROGRAM POSTER PRESENTATION1. A reporter mouse model of cardiac and

vascular macrophages Katja Grotius (Group Ingo Hilgendorf) University Heart Center Freiburg – Bad Krozingen

2. Allele-specific editing of STAT3 mutations with CRISPR-Cas in primary cells of hyper-IgE syndrome patients Saskia König (Group Claudio Mussolino) Institute for Transfusion Medicine and Gene Therapy, Medical Center – University of Freiburg

3. The role of hyper-stabilized β-Catenin in B cell Metabolism, Development and Function Huda Jumaa (Group Julia Jellusova) BIOSS Centre, University of Freiburg

4. Changes in DNA methylation levels at the PI3KCD locus in CVID patients Nadezhda Camacho-Ordonez (Group Bodo Grimbacher) CCI, Medical Center – University of Freiburg

5. The identification of modifiers in CTLA-4 insufficiency by genetic, serological, and molecular analyses Noriko Mitsuiki (Group Bodo Grimbacher) CCI, Medical Center – University of Freiburg

6. Intestinal endoplasmic reticulum stress enhances acute graft-versus-host disease Eileen Haring (Group Petya Apostolova) Department of Medicine I, Medical Center – University of Freiburg

7. The role of protein tyrosine phosphatase 1B in B cell antigen receptor signaling Jennifer Schwarz (Group Bettina Warscheid) Institute of Biology II, University of Freiburg

8. Gene expression profiling meta-analysis reveals novel pathways and mechanisms shared between tuberculosis and rheumatoid arthritis Mohamed Tarek Badr (Group Georg Häcker) Institute for Microbiology and Hygiene, Medical Center – University of Freiburg

9. Novel homozygous mutation in a zinc finger transcription factor causes stat3-like hyper-ige syndrome Theresa Stauß (Group Bodo Grimbacher) CCI, Medical Center – University of Freiburg