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Page 1: Fabian Weber - Gesellschaft Deutscher Chemiker · Top 200 drugs by worldwide sales 2011 according to data collected by IMS Health in 59 countries (Source: IMS Health, IMS MIDAS Quantum

Top 200 Drugs by Worldwide Sales 2011 Fabian Weber[a] and Gottfried Sedelmeier*,[b]

[a] Dipl.-Chem. Fabian Weber, Institut für Organische Chemie und Biochemie, Albert-Ludwigs-Universität Freiburg, Albertstraße 21, 79104 Freiburg, Germany, e-mail: [email protected]; [b] Prof. Dr. Gottfried Sedelmeier, Chemical & Analytical Developement, Novartis Pharma AG, Forum 1, Novartis Campus, 4056 Basel, Switzerland, e-mail: [email protected]

Top 200 drugs by worldwide sales 2011 according to data collected by IMS Health in 59 countries (Source: IMS Health, IMS MIDAS Quantum MAT December 2011). All data on this poster may only be used purely for academic purposes. All logos, brands, and trademarks represented on this poster are property of the respective copyright owner. Another representation of the top 200 drugs by worldwide sales in 2008 & 2009 was developed by the Njardarson-group: http://cbc.arizona.edu/njardarson/group/top-pharmaceuticals-poster. a Monoclonal immunoglobulin G1 antibodies. Picture: Human immunoglobulin G1 (L. W. Guddat, J. N. Herron, A. B. Edmundson, Proc. Natl. Acad. Sci. 1993, 90, 4271-4275).– b Fusion Protein of the human tumor necrosis factor receptor and human immunoglobulin G1. Picture: Extracellular domain of the 55 kDa human tumor necrosis factor (J. H. Naismith, T. Q. Devine, T. Kohno, S. R. Sprang, Structure 1996, 4, 1251-1262).– c Monoclonal immunoglobulin G1 antibody. Picture: Crystal structure of the rituximab FAB fragment with a protein epitope (J. Du, H. Wang, C. Zhong, B. Peng, M. Zhang, B. Li, S. Huo, Y. Guo, J. Ding, J. Biol. Chem. 2007, 282, 15073-15080).– d Insulin Glargin is an analog of human insulin with prolongued activity. The difference to human insulin is glycin instead of asparagin in position A21 and and the B-chain is elongated by two arginins. Picture: Human Insulin (V. I. Timofeev, A. V. Lyashenko, Y. A. Kislitsyn, A. N. Baidus, I. P. Kuranova, to be published according to the RCSB protein data bank).– e PEGylated recombinant human granuleucyte colony-stimulating factor analog filgrastim. Picture: Human granuleucyte colony-stimulating factor (T. Zink, A. Ross, K. Lueers, Ch. Cieslar, R. Rudolph, T. A. Holak, Biochemistry 1994, 33, 8453–8463).– f Insulin Aspart is a fast acting analog of human insulin. The difference to human insulin is aspartic acid instead of prolin in position B28. Picture: see footnote d.– g Epoetins are recombinant forms of the human erythropoetin with identical amino acid sequences and disulide bridges but different glycosylation patterns. Picture: NMR structure of human erythropoetin (J.C. Cheetham, D.M. Smith, K.H. Aoki, J.L. Stevenson, T.J. Hoeffel, R.S. Syed, J. Egrie, T.S. Harvey, Nat. Struct. Biol. 1998, 5, 861-866).– h Recombinant human interferone. Picture: Human Iinterferone beta (M. Karpusas, M. Nolte, C.B. Benton, W. Meier, W.N. Lipscomb, S. Goelz, Proc. Natl. Acad. Sci. 1997, 94, 11813-11818).– i Synthetic erythropoetin. Picture: see footnote g.– j Insulin Lispro is a fast acting analog of human insulin. The difference to human insulin is the exchange of proline and lysin in position B28 and B29. Picture: see footnote d.– k Insulin Detemir is a long acting analog of human insulin. The difference to human insulin is a fatty acid bound to lysin in position B29. Picture: see footnote d.– l Picture: Crystal structure of the Fab-Fragment of Cetuximab (S. Li, K.R. Schmitz, P.D. Jeffrey, J.J.W. Wiltzius, P. Kussie, K.M. Ferguson, Cancer Cell 2005, 7, 301-311). m Recombinant human granuleucyte colony-stimulating factor analog filgrastim. Picture: see footnote e. n PEGylated recombinant human interferone. Picture: Human interferone Alfa-2A (W. Klaus, B. Gsell, A.M. Labhardt, B. Wipf, H. Senn, J. Mol. Biol. 1997, 274, 661-675).– o Recombinant human coagulation factor VIII. Picture: Crystal structure of the human coagulation factor VIII (B.W. Shen, P.C. Spiegel, C.H. Chang, J.W. Huh, J.S. Lee, J. Kim, Y.H. Kim, B.L. Stoddard, Blood 2008, 111, 1240-1247).– p Recombinant human growth hormone somatotropin. Picture: Crystal structure of somatotropin (L. Chantalat, N.D. Jones, F. Korber, J. Navaza, A.G. Pavlovsky, Protein Pept. Lett. 1995, 2, 333-340).– q Recombinant human parathyroid hormone. Picture: Crystal structure of the human parathyroid hormone (L. Chantalat, N.D. Jones, F. Korber, J. Navaza, A.G. Pavlovsky, Protein Pept. Lett. 1995, 2, 333-340).– r Recombinant humanized immunoglobulin G1. Picture: Crystal structure of of the FAB fragment of Omalizumab (C.H. Huang, F.H.A. Hung, C. Lim, T.W. Chang, C. Ma, to be published according to the RCSB protein data bank).– s Recombinant fusion protein of Oncostatin, CLTA-4 and a fragment of the IgG heavy chain. Picture: Left: Crystal structure of Oncostatin M (M.C. Deller, K.R. Hudson, S. Ikemizu, J. Bravo, E.Y. Jones, J.K. Heath, Structure Fold. Des. 2000, 8, 863-874), right: NMR solution structure of CTLA-4 (W.J. Metzler, J. Bajorath, W. Fenderson, S.Y. Shaw, K.L. Constantine, J. Naemura, G. Leytze, R.J. Peach, T.B. Lavoie, L. Mueller, P.S. Linsley, Nat. Struct. Biol. 1997, 4, 527-531).– t Recombinant human coagulation factor VIIa. Picture: Crystal structure of the human coagulation factor VIIa (A.C. Pike, A.M. Brzozowski, S.M. Roberts, O.H. Olsen, E. Persson, Proc. Natl. Acad. Sci. 1999, 96, 8925-8930).– u Recombinant human insulin. Picture: see footnote d.– v Recombinant humanized immunoglobulin G1. Picture: Crystal structure of the FAB fragment of Ustekinumab (J. Luo, S.-J. Wu, E.R. Lacy, Y. Orlovsky, A. Baker, A. Teplyakov, G. Obmolova, G.A. Heavner, H.-T. Richter, J. Benson, to be published according to the RCSB protein data bank).– w Synthetic version of the hormone exendin-4. Picture: Crystal structure of exendin-4 (J.W. Neidigh, R.M. Fesinmeyer, K.S. Prickett, N.H. Andersen, Biochemistry 2001, 40, 13188-13200).–

1. Atorvastatin

2. Clopidogrel

3. Fluticasone + Salmeterol

4. Rosuvastatin 5. Esomeprazole 6. Quetiapine 7. Adalimumaba 8. Infliximaba 9. Etanerceptb 10. Aripiprazole 11. Montelukast 12. Olanzapine 13. Rituximabc 14. Insulin Glargind 15. Bevacizumaba 16. Trastuzumaba 17. Duloxetine 18. Tiotropium Bromide

19. Pegfilgrastime 20. Imatinib

Lipitor® Plavix® Seretide® Crestor® Nexium® Seroquel® Humira® Remicade® Enbrel® Abilify® Singulair® Zyprexa® Mabthera® Lantus® Avastin® Herceptin® Cymbalta® Spiriva® Neulasta® Glivec®

Sales: 12.539 Mrd $

HMG-CoA reductase inhibitor

Sales: 9.293 Mrd $

P2Y12‘ inhibitor

Sales: 8.738 Mrd $

Corticosteroid + 2-adrenergic receptor agonist

Sales: 7.986 Mrd $

HMG-CoA reductase inhibitor

Sales: 7.940 Mrd $

Proton pump inhibitor

Sales: 7.587 Mrd $

Atypical antipsychotic

Sales: 7.281 Mrd $

TNF inhibitor

Sales: 6.887 Mrd $

TNF inhibitor

Sales: 6.758 Mrd $

TNF inhibitor

Sales: 6.289 Mrd $

Atypical antipsychotic

Sales: 6.137 Mrd $

Leukotriene receptor antagonist

Sales: 5.718 Mrd $

Atypical antipsychotic

Sales: 5.685 Mrd $

Cluster of differentiation CD20 antibody

Sales: 5.486 Mrd $

Insulin analogon

Sales: 5.312 Mrd $

Angiogenesis inhibitor

Sales: 4.718 Mrd $

Interacts with the HER2/neu receptor

Sales: 4.684 Mrd $

Serotonin-norepinephrine reuptake inhibitor

Sales: 4.670 Mrd $

Muscarinic receptor antagonist

Sales: 4.231 Mrd $

Granulocyte colony-stimulating factor

Sales: 4.142 Mrd $

Inhibits certain tyrosin kinases

21. Pioglitazone 22. Valsartan 23. Pregabalin 24. Glatiramer 25. Ranibizumaba 26. Tenofovir + Emtricitabine + Efivarenz

27. Oxycodone 28. Enoxaparin Sodium

29. Budesonide + Formoterol

30. Sitagliptin 31. Tenofovir + Emtricitabine

32. Insulin Aspartf 33. Escitalopram 34. Celecoxib 35. Valsartan + Hydrochlorothiazide

36. Epoetin Alfag 37. Ezetimibe 38. Donepezil 39. Interferon Beta-1Ah

40. Darbepoetin Alfai

Actos® Diovan® Lyrica® Copaxone® Random polymer of:

Lucentis® Atripla® OxyContin® Lovenox® Symbicort® Januvia® Truvada® Novorapid® Lexapro® Celebrex® Co-Diovan® Epogen® Zetia® Aricept® Avonex® Aranesp®

Sales: 4.091 Mrd $

Stimulates PPAR- and PPAR-

Sales: 4.086 Mrd $

Angiotensin II receptor antagonist

Sales: 4.067 Mrd $

Binds to the voltage-dependent calcium channel

Sales: 3.897 Mrd $

May serve as decoy for the immune system

Sales: 3.894 Mrd $

Binds to the endothelial growth factor

Sales: 3.654 Mrd $

Reverse transcriptase inhibitors

Sales: 3.593 Mrd $

2b-opioid agonist

Sales: 3.396 Mrd $

Binds to antithrombin III

Sales: 3.369 Mrd $

Glucocorticoid steroid + 2-agonist

Sales: 3.362 Mrd $

Dipeptidyl peptidase-4 inhibitor

Sales: 3.348 Mrd $

Reverse transcriptase inhibitors

Sales: 2.891 Mrd $

Insulin analogon

Sales: 2.869 Mrd $

Selective serotonin reuptake inhibitor

Sales: 2.751 Mrd $

COX-2 inhibitor

Sales: 2.725 Mrd $

Angiotensin II receptor antagonist + diuretic

Sales: 2.713 Mrd $

Controles erythropoiesis

Sales: 2.670 Mrd $

Decreases cholesterol absorption in the intestine

Sales: 2.598 Mrd $

Actetylcholinesterase inhibitor

Sales: 2.539 Mrd $

Activates immune system

Sales: 2.520 Mrd $

Controles erythropoiesis

41. Sildenafil 42. Pemetrexed 43. Rabeprazole 44. Risperidone 45. Interferon Beta 1Ah

46. Insulin Lisproj 47. Simvastatin + Ezetimibe

48. Zoledronic acid 49. Tacrolimus 50. Epoetin Alfag 51. Tadalafil 52. Glucose blood Test

53. Pneumococcal Conjugate

54. Olmesartan Medoxmil

55. Candesartan Cilexetil

56. Bortezomib 57. Mometasone Furoate

58. Telmisartan 59. Oxaliplatin 60. Insulin Aspart + Insulin Aspart Protaminef

Viagra® Alimta® Pariet® Risperdal® Rebif® Humalog® Vytorin® Zometa® Prograf® Erypo® Cialis® One touch ultra® Prevnar® Benicar® Blopress® Velcade® Nasonex® Micardis® Eloxatine® Novomix®

Sales: 2.502 Mrd $

cGMP-specific phospho-diesterase type 5 inhibitor

Sales: 2.271 Mrd $

Folate antimetabolite

Sales: 2.259 Mrd $

Proton pump inhibitor

Sales: 2.200 Mrd $

Dopamine antagonist

Sales: 2.116 Mrd $

Activates immune system

Sales: 2.047 Mrd $

Insulin analogon

Sales: 2.044 Mrd $

HMG-CoA reductase inhibitor + decreases cholesterol absorption in the intestine

Sales: 2.031 Mrd $

Inhibits bone resorption

Sales: 2.029 Mrd $

Calcineurin inhibitor

Sales: 2.023 Mrd $

Controles erythropoiesis

Sales: 2.019 Mrd $

cGMP-specific phospho-diesterase type 5 inhibitor

Sales: 1.954 Mrd $

Glucose blood test

Sales: 1.827 Mrd $

Vaccine

Sales: 1.807 Mrd $

Angiotensin II receptor antagonist

Sales: 1.758 Mrd $

Angiotensin II receptor antagonist

Sales: 1.673 Mrd $

Proteasome inhibitor

Sales: 1.661 Mrd $

Glucocorticosteroid

Sales: 1.653 Mrd $

Angiotensin II receptor antagonist

Sales: 1.610 Mrd $

Inhibits DNA synthesis

Sales: 1.605 Mrd $

Insulin analogon

61. Insulin Detemirk 62. Levetiracetam 63. Cetuximabl 64. Fluticasone Propionate

65. Lenalidomide 66. Atazanavir 67. Diclofenac 68. Ziprasidone 69. Memantine 70. Amlodipine 71. Capecitabine 72. Palivizumaba 73. Solifenacin 74. Docetaxel 75. Interferon Beta-1Bh

76. Fenofibrate 77. Enoxaparin Sodium

78. Filgrastimm 79. Octreotide 80. Raltegravir

Levemir® Keppra® Erbitux® Flixotide® Revlimid® Reyataz® Voltaren® Zeldox® Namenda® Norvasc® Xeloda® Synagis® Vesicare® Taxotere® Betaferon® Tricor® Enoxaparin Sodium Neupogen® Sandostatin® Isentress®

Sales: 1.601 Mrd $

Insulin analogon

Sales: 1.571 Mrd $

Binds to synaptic vesicle Protein SV2A

Sales: 1.547 Mrd $

Epidermial growth factor inhibitor

Sales: 1.539 Mrd $

Corticosteroid

Sales: 1.519 Mrd $

Multiple modes of action

Sales: 1.518 Mrd $

Protease inhibitor

Sales: 1.503 Mrd $

Cyclooxygenase inhibitor

Sales: 1.477 Mrd $

Atypical antipsychotic

Sales: 1.476 Mrd $

NMDA-type gultamate receptor blocker

Sales: 1.470 Mrd $

Calcium channel blocker

Sales: 1.399 Mrd $

Inhibits DNA synthesis

Sales: 1.365 Mrd $

Antibody against F protein in respiratory syncytial virus

Sales: 1.356 Mrd $

Competitive muscarinic acetyl-choline receptor antagonist

Sales: 1.348 Mrd $

Binds to micrtubules

Sales: 1.336 Mrd $

Activates immune system

Sales: 1.331 Mrd $

Activates the peroxisome proliferator-activated receptor

Sales: 1.318 Mrd $

Binds to antithrombin III

Sales: 1.313 Mrd $

Granulocyte colony-stimulating factor

Sales: 1.308 Mrd $

Glucagon inhibitor

Sales: 1.303 Mrd $

Integrase inhibitor

81. Lisdexamfe- Tamine

82. Peginterferon Alfa-2An

83. Bubrenophine + Naloxone

84. Sitagliptin + Metformin

85. Methylphenidate 86. Linezolid 87. Erlotinib 88. Lansoprazole 89. Varicella Vaccine 90. Lidocaine 91. Ipratropium Bromide + Salbutamol

92. Modafinil 93. Escitalopram 94. Leuprorelin 95. Darunavir 96. Nicotinic acid 97. Testosterone 98. Raloxifene 99. Sunitinib 100. Rivastigmine

Vyvanse® Pegasys® Suboxone® Janumet® Concerta® Zyvox® Tarceva® Takepron® Varivax® Lidoderm® Combivent® Provigil® Cipralex® Enantone® Prezista® Niaspan® Androgel® Evista® Sutent® Exelon®

Sales: 1.301 Mrd $

Prodrug to dextroamphetamine

Sales: 1.294 Mrd $

Activates immune system

Sales: 1.292 Mrd $

Opioid receptor agonists

Sales: 1.285 Mrd $

Dipeptidyl peptidase-4 Inhibitor + AMPK activator

Sales: 1.270 Mrd $

Norepinephrine-dopamine reuptake inhibitor

Sales: 1.265 Mrd $

Protein synthesis inhibitor

Sales: 1.256 Mrd $

Tyrosine kinase inhibitor

Sales: 1.233 Mrd $

Proton pump inhibitor

Sales: 1.208 Mrd $

Vaccine

Sales: 1.186 Mrd $

Blocks voltage gated sodium channels

Sales: 1.175 Mrd $

Muscarinic acetylcholine receptor blocker + 2-adrenergic receptor agonist

Sales: 1.158 Mrd $

Mode of action unclear

Sales: 1.152 Mrd $

Selective serotonin reuptake inhibitor

Sales: 1.152Mrd $

Pituitary GnRH receptor antagonist

Sales: 1.151 Mrd $

Protease inhibitor

Sales: 1.151 Mrd $

Vitamine; stimulates a G-protein-coupled receptor

Sales: 1.132 Mrd $

Human hormone with many functions

Sales: 1.117 Mrd $

Selective estrogen receptor modulator

Sales: 1.105 Mrd $

Multi-targeted receptor tyrosine kinase inhibitor

Sales: 1.105 Mrd $

Cholinesterase inhibitor

101. Octocog Alfao 102. Dutasteride 103. Salbutamol 104. Latanoprost 105. Mycophenolate Mofetil

106. Natalizumaba 107. Epoetin Betag 108. Abacavir + Lamivudine

109. Amphetamine + Dexamphetamine

110. Valsartan + Amlodipine

111. Liraglutide 112. Ibandronic acid 113. Letrozole 114. Tolterodine 115. Entecavir 116. Salbutamol 117. Glucose blood tests

118. Risedronic Acid 119. Lamotrigine 120. Pantoprazole

Recombinate® Avodart® Ventolin® Xalatan® Cellcept® Tysabri® Neorecormon® Epzicom® Adderall® Exforge® Victoza® Bonviva® Femara® Detrusitol® Baraclude® Salamol® Ascensia Contour® Actonel® Lamictal® Pantozol®

Sales: 1.095 Mrd $

Essential blood clotting protein

Sales: 1.093 Mrd $

Dual 5-a reductase inhibitor

Sales: 1.090 Mrd $

2-adrenergic receptor agonist

Sales: 1.077 Mrd $

analog of prostaglandin F2

Sales: 1.063 Mrd $

Inosine monophosphate dehydrogenase inhibitor

Sales: 1.049 Mrd $

Antibody against 4-integrin

Sales: 1.028 Mrd $

Controles erythropoiesis

Sales: 1.018 Mrd $

Nucleoside analog reverse transcriptase inhibitors

Sales: 1.018 Mrd $

Release dopamine and norepinephrine

Sales: 1.017 Mrd $

Angiotensin II receptor antagonist + calcium channel blocker

Sales: 1.013 Mrd $

Glucagon-like peptide-1 receptor agonist

Sales: 1.013 Mrd $

Inhibits bone resorption

Sales: 1.009 Mrd $

Aromatase inhibitor

Sales: 1.006 Mrd $

Muscarinic receptor antagonist

Sales: 1.004 Mrd $

Nucleoside analog

Sales: 0.991 Mrd $

2-adrenergic receptor agonist

Sales: 0.988 Mrd $

Glucose blood test

Sales: 0.988 Mrd $

Inosine monophosphate dehydrogenase inhibitor

Sales: 0.983 Mrd $

Sodium channel blocker

Sales: 0.982 Mrd $

Proton pump inhibitor

121. Esterified Fish Oils

122. Goserelin 123. Mesalamine 124. Somatropinp 125. Ketoprofen 126. Teriparatideq 127. Budesonide 128. Amoxicillin + Clavulanic acid

129. Levofloxacin 130. Omalizumabr 131. Venlafaxine 132. Losartan 133. Glucose Blood Test

134. Candesartan Cilexetil

135. Temozolomide 136. Iohexol 137. Cyclosporin A 138. Abatacepts 139. Fexofenadine 140. Tenofovir Disoproxil

Lovaza® Zoladex® Asacol® Genotropin® Sector® Forteo® Pulmicort® Augmentin® Levaquin® Xolair® Venlafaxine Cozaar® Accu-Chek Aviva® Atacand® Temodal® Omnipaque® Sandimmun® Orencia® Telfast® Viread®

Sales: 0.979 Mrd $

Omega-3-fatty acids as ethyl esters

Sales: 0.974 Mrd $

Gonadotropin releasing hormone superagonist

Sales: 0.964 Mrd $

Multiple modes of action

Sales: 0.923 Mrd $

Growth hormone

Sales: 0.917 Mrd $

Cyclooxygenase inhibitor

Sales: 0.916 Mrd $

Parathyroid hormone

Sales: 0.912 Mrd $

Glucocorticoid steroid

Sales: 0.909 Mrd $

-Lactam antibiotics

Sales: 0.909 Mrd $

Antimicrobial agent with multiple modes of action

Sales: 0.905 Mrd $

Binds to human immunoglobuline IgE

Sales: 0.902 Mrd $

Serotonin-norepinephrine reuptake inhibitor

Sales: 0.898 Mrd $

Angiotensin II receptor Antagonist

Sales: 0.892 Mrd $

Glucose blood test

Sales: 0.885 Mrd $

Angiotensin II receptor antagonist

Sales: 0.8857 Mrd $

Interfers with DNA replication

Sales: 0.873 Mrd $

Contrast agent (iodine atoms!)

Sales: 0.869 Mrd $

Calcineurin inhibitor

Sales: 0.868 Mrd $

Inhibits the co-stimulation of T-cells

Sales: 0.868 Mrd $

Selective H1 receptor antagonist

Sales: 0.859 Mrd $

Reverse transcriptase inhibitor

141. Lopinavir + Ritonavir

142. Bosentan 143. Rizatriptan 144. Telmisartan + Hydrochlorothiazide

145. Eptacog Alfat 146. Budesonide 147. Estrogenic Substances

148. Moxifloxacin 149. Telaprevir 150. Venlafaxine 151. Omeprazole 152. Human Papillo-mavirus vaccine

153. Anastrozole 154. Dabigatran Etexilate

155. Nifedipine 156. Immunoglobulin Basea

157. Somatropinp 158. Eszopiclone 159. Leuprorelin 160. Travoprost

Kaletra® Tracleer® Maxalt® Micardis HCT® Novoseven® Budesonide Premarin® Avelox® Incivek® Effexor® Losec® Gardasil® Arimidex® Pradaxa® Adalat® Privigen® Norditropin® Lunesta® Lupron® Travatan®

Sales: 0.854 Mrd $

HIV protease inhibitor + cytochrome P450 3A4 inhibitor

Sales: 0.851 Mrd $

Endothelin receptor antagonist

Sales: 0.837 Mrd $

Serotonin 5-HT1 receptor agonist

Sales: 0.831 Mrd $

Angiotensin II receptor antagonist + diuretic

Sales: 0.818 Mrd $

Blood clotting protein

Sales: 0.818 Mrd $

Glucocorticoid steroid

Sales: 0.816 Mrd $

Replacement of estrogenic Hormones

Sales: 0.814 Mrd $

Broad-spectrum antbiotic

Sales: 0.813 Mrd $

NS3.4A serine protease inhibitor

Sales: 0.812 Mrd $

Serotonin-norepinephrine reuptake inhibitor

Sales: 0.812 Mrd $

Proton pump inhibitor

Sales: 0.812 Mrd $

Vaccine

Sales: 0.796 Mrd $

Aromatase inhibitor

Sales: 0.796 Mrd $

Direct thrombin inhibitor

Sales: 0.794 Mrd $

Dihydropyridine calcium channel blocker

Sales: 0.789 Mrd $

Pooled, polyvalent IgG of over 1000 blood donors

Sales: 0.788 Mrd $

Growth hormone

Sales: 0.782 Mrd $

GABAA receptor agonist

Sales: 0.782 Mrd $

Pituitary GnRH receptor antagonist

Sales: 0.781 Mrd $

Synthetic prostaglandine analog

161. Zolpidem 162. Levothyroxine Sodium

163. Cyclosporin 164. Methyl-phenidate

165. Acetylsalicylic Acid

166. Minocycline 167. Varenicline 168. Insulin Lispro + Insulin Lispro Protaminei

169. Octocog Alfao 170. Immunoglobulin Basea

171. Levonorgestrel 172. Atomoxetine 173. Irbesartan + Hydrochlorothiazide

174. Drospirenone + Ethinylestradiol

175. Olmesartan Medoxomil + HCT

176. Ethinylestradiol + Etonogestrel

177. Voriconazole 178. Irbesartan 179. Fentanyl 180. Piperacillin + Tazobactam

Stilnox® Synthroid® Restasis® Methylphenid® Aspirin® Solodyn® Champix® Humalog Mix® Kogenate® Gamunex® Mirena® Strattera® Coaprovel® Yasmin® Benicar HCT® NuvaRing® Vfend® Aprovel® Duragesic® Tazocin®

Sales: 0.774 Mrd $

GABAA receptor agonist

Sales: 0.769 Mrd $

Synthetic thyroid hormone

Sales: 0.766 Mrd $

Calcineurin inhibitor

Sales: 0.765 Mrd $

Norepinephrine-dopamine reuptake inhibitor

Sales: 0.763 Mrd $

Cyclooxygenase inhibitor

Sales: 0.762 Mrd $

Tetracycline antibiotic

Sales: 0.759 Mrd $

Nicotinic receptor partial agonist

Sales: 0.753 Mrd $

Insulin analogon

Sales: 0.746 Mrd $

Essential blood clotting protein

Sales: 0.746 Mrd $

Pooled, polyvalent IgG of over 1000 blood donors

Sales: 0.737 Mrd $

Synthetic progestogen

Sales: 0.736 Mrd $

Selective norepinephrine reuptake inhibitor

Sales: 0.731 Mrd $

Angiotensin II receptor antagonist + diuretic

Sales: 0.730 Mrd $

Estradiol derivative + synthetic Progestin

Sales: 0.730 Mrd $

Angiotensin II receptor antagonist + diuretic

Sales: 0.725 Mrd $

Synthetic estrogen + progestin

Sales: 0.724 Mrd $

Antifungal medication

Sales: 0.724 Mrd $

Angiotensin II receptor antagonist

Sales: 0.717 Mrd $

Opioid receptor agonist

Sales: 0.714 Mrd $

-Lactam antibiotics

181. Bimatoprost 182. Mesalamine 183. Loxoprofen 184. Paroxetine 185. Insulin Human + Insulin Human Isophaneu

186. Human Papillo-mavirus Vaccine

187. Losartan + Hydrochlorothiazide

188. Pramipexole 189. Dasatinib 190. Cilostazol 191. Ustekinumabv 192. Irbesartan 193. Darbepoetin Alfai

194. Perindopril 195. Exenatidew 196. Desloratadine 197. Tamsulosin 198. Amphetamine + Dexamphetamine

199. Levofloxacin 200. Desvenlafaxine

Lumigan® Pentasa® Loxonin® Seroxat® Actraphane® Cervarix® Hyzaar® Sifrol® Sprycel® Pletaal® Stelara® Karvea® Darbepoetin Alfa Coversyl® Byetta® Aerius® Harnal® Amphetamine/ Dexamphetamine

Cravit® Pristiq®

Sales: 0.714 Mrd $

Prostaglandin analog

Sales: 0.712 Mrd $

Multiple modes of action

Sales: 0.709 Mrd $

Cyclooxygenase inhibitor

Sales: 0.708 Mrd $

Selective serotonin reuptake inhibitor

Sales: 0.708 Mrd $

Human insulin + neutral protamine insulin

Sales: 0.706 Mrd $