Post on 05-Oct-2018
12. Sachverzeichnis
Acetaldehyd 53 Acetat 13, 14, 54 Acetoacetat 14, 145, 146 Acetoacetyl-CoA 13, 26,
144 Acetylcholin 3, 95, 109, 150 Acetylcholinesterase 125 Acetyl-CoA 13, 19, 26,
144, 147 Acetyl-CoA-Acyltransfe
rase 13, 14, 26 Acetyl-CoA-Carboxy-
lase 147 Acetyl-CoA-Synthetase 13,
26 N-Acetyldopamin 155 N -Acetyl-dopamin-
chinon 155 Acetylgalactosamin 81 Acetylglucosamin 120, 121 N-Acetyllactosamin-Pep-
tid 120, 121 N-Acetyl-5-methoxytrypt
amin --+ Melatonin 2-Acetyl-7 -oxo-dodecahydro
phenanthren 159 Acetylserotonin-Methyltrans-
ferase 95, 125 Acetyltransferase 259 ACTH---> Corticotropin Actin 110 Acyl-CoA-Desaturase 40,
112, 113 Acyl-CoA-Ester 27 Acyl-CoA-Reduktase 113 Addisonsche Krankheit 53 Adenosin-3 ' ,5 '-diphosphat
(pAp) 27 Adenosindiphosphat
(ADP) 77 Adenosin-3 ',5 '-mono
phosphat (cAMP)" 69, 70, 107-111
-, Biosynthese --+ Adenylcyclase
-, Gehalt 108, 174 -,- Kompartimente 74,
75, 82, 90,108,109 - , Rezeptorproteine 110,
253
-, Wirkung 25, 73-76, 78-80,82-84,89,108, 111,114,149,216,261, 263, 264
-, - Antagonism us zum cGMP 108-110, 262, 264
-, - Phosphoproteinphosphatasen 78, 109, 147, 148
-,- Proteinkinasen 76, 78, 79,86,96,107-111, 147,232,253,254
- , - zentral 108 Adenosin-3 ',5' -monophos
phat-Phosphodieste-rase 86, 107, 110, 111
-, Aktivatorprotein 110 -, Inhibitoren 111, 121,
174,261,262 Adenosin-5 '-phosphosulfat
(APS) 171 Adenosintriphosphat
(ATP) 77,108, 171, 210,245,246,250
Adenosintriphospha-tase 153
Adenylcyclase 107 -, Effektoren 104, 108 -, - Aktivator-
protein 110 -,- ca++ 73, 74, 90,
110 -, - hormonelle Stimula
tion 69, 73-75, 79, 83, 86,88-91,96,98,104, 107, 108, 11~ 116, 117, 232,254,261,262
-,- Inhibitor 110 Adenylsulfatkinase 171 Adrenal-Ferredoxin 29,
35-37,51 Adrenal-Ferredoxin-Reduk
tase 29, 35-37, 51 Adrenalin 97, 103, 146, 148 Adrenogenitales Syndrom
(AGS) 52, 57, 267 Adrenosteron 282 Aktiver Sauerstoff 32 Aktives Isopren 16
Akrosin 133 Alanin, Abbau 144, 145,
259 Alaminaminotransfe-
rase 144, 145 Albumin 184, 193, 218,
219,221 Aldehyd-Lyasen 37 Aldose-Reduktase 136 Aldosteron 48 -, Biosynthese 49, 52, 141 -,- Regulation 91-93,
116, 152 -, Gehalt 53, 152 -, Rezeptoren 209, 218,
219 -, Stoffwechsel 189, 190 -, - Halbwertzeit 93,
164, 190 -, Wirkung 141, 142, 151,
241,254 Aldosteron-18-,8-D-glu
curonid 190 Allergische Symptome 149,
150 Allylalkohole 175, 177,192 Alphaxalon 122 a-Amanitin 235 Ameisensaure 20, 259 Amenorrhoe 94 Aminoacyl-Adenylat 245 Aminoacyl-tRNA 245, 246 Aminoacyl-tRNA-Syntheta-
sen 245, 250, 254 p-Aminoglutathimid 43 6-Aminolavulinsaure 121 ,
122, 140 o-Aminolavulinsauresynthe
tase 121, 122, 139, 140 a-(p-Aminophenyl)-a-athyl
glutarimid 43 3,3-bis (p-Aminophenyl)-2-
butanon 43 Aminosauren, Aufnahme
86, 149 -, abbauende Enzyme
144-146 -,Transport 86, 148, 257 Amphenon B 43 Amygdala 102, 209, 215
330
Anabole Wirkung, Androgene 134, 135, 138, 139, 212,214,253
-, d~trogene 123, 133 Aniisthetika_ 122, 258 Androgene 134-140 -, Antiandrogene 57, 58,
158-160,163,260 -, Biosynthese 92, 93 -,- 6 4-Weg 53, 54, 56,
83 -,- 6 5-Weg 51, 54-56,
86,172,261 -,- 5a-Weg 56,57 -, - Regulation 56, 83,
86,88 -,- Inhibitor 57, 158 -, Rezeptoren 85, 87, 202,
207,211-214,257,266 -, - Nuclearakzeptoren
202,211 -, - Plasmarezeptoren
193,219-221 -, - andogenbindendes
Protein (ABP) 85, 221 -, Stoffwechsel 41, 43,
164, 167, 17~ 17~ 175, 177, 190-193
-, Struktur, synthetische Androgene 138, 139
-, - NebennierenrindenAndrogene 49, 53, 57, 59,88,140,221
-, Wirkung 134-140, 158 -,- anabol 134,135,
138,139,212,214,253 -, - Enzym- und Protein
synthese 58, 59, 136-140, 190
-, - NucleinsiiureSynthese 230, 232, 243, 253
-, - Zelldifferenzierung 268-272
-, - ,- Sexualdifferenzierung 135, 137, 264-266
-,- zentral 59, 135, 137 -,- Zielorgane 134-138 -, -, - Akzessorische Ge-
schlechtsorgane 136, 138,260,262
-,-,-Leber 140,212 -, -,- Niere 59, 136,
138,139,160,212,260, 272
-, -,- Testes 83, 136
1,4-Androstadien-3, 17 -dion 179
Androstan 12 5a-Androstan-3, 17 -dion
56,61, 137,190 5fl-Androstan-3, 17 -dion
190 1,4,6-Androstatrien-3,17-
dion 61 5a-Androst-16-en-3-on 193 Androstendiol-> 3fl,17fl-Di
hydroxy-5-androsten 4-Androsten-3,17-dion 34,
41,44,47,53,54,62,63, 135-137, 212, 220
-, Gehalt 140 -, Stoffwechsel 41, 51,
55--60, 179, 190 4-Androsten-3,17-dion-3-
sulfat 191, 192 4-Androsten-3-on-17 fl
carbonsiiure 58 Androsteron (3a-Hydroxy-
5a-androstan-17-on) 49, 56, 135, 136, 140, 187, 190, 191
Angiotensin 91-93 -, Biosynthese 92, 93 -, Gehalt 93 -, Rezeptor 93 -, Stoffwechsel 93 -, Wirkung 52, 70, 91, 93,
108, 152 -,- zentral 91 Angiotensin-Antagonist 93 Angiotensinase 93 Angiotensinogen 92 -, Biosynthese 92, 124,
133, 215 Angulare Methylgruppen 5,
7,8, 10,207 Antiandrogene 158-160 -, 4-Androsten-3-on-17fl-
carbonsiiure 58 -,BOMT 159 -, Corticoide 57, 158 -, Cyproteron 158 -, Cyproteronacetat 57,
158, 159 -, Flutamid 158, 159 -, dstrogene 58, 158, 260 -, Progesteron 58, 158,
260 -, Spirolacton 158, 163 Anticorticoide 162, 163 -, 17a-Methyltesto-
steron 162
Sachverzeichnis
-, dstradiol 162 -, Progesteron 163 -, Testosteron 162 Antigestagene 157 Antihormone 156-163,
200,207 Antiinduktoren 200 Antiinflammatorische Wir
kung 118, 142, 149-151,257
Antikonzeption 131-134 -, Nebenwirkungen--> Ovu
lationshemmer Antikorperbildung 148, 149 Antimineralocorticoid 162,
163 -, Progesteron 163 -, Spirolacton 162, 163 -, Spironolacton 162, 163 Antiostrogene 157,
160-162 -, Clomiphen 160, 161 -, Corticoide 63, 162 -, Dihydrotestosteron 162 -, 2-Hydroxyostradiol 103,
162,165,214 -, MER-25 161 -, Nafoxidin 161 -, Progesteron 161, 162 Apocytochrom P-450 42 Aquatoriale Reste 6, 8, 11 Arachidonsiiure 112-116 Area praeoptica -suprachias-
matica 95, 102, 103, 212,215,265-267
Aren-oxid-Hydratase 40 Arginase 138, 147 Argininosuccinat-Lyase
147 Argininosuccinat-Synthe-
tase 147 Aromatase 60-63 -,Inhibitor 61, 162 Arthritis 149 Arylamin-Acetyltransfe-
rase 155 Arylformylamin-Amidohy
drolase 145 Arylsulfatase 63, 169, 172,
195 -, Inhibitor 172 Ascorbinsiiure 31, 32, 42,
78, 124 Ascorbinsiiure-Cytochrom
b5-Reduktase 31, 42 L-Asparaginsiiure 77, 259 Aspartataminotransferase 145
Sachve rzeichnis
Aspergillus flavus 178 Assoziationskonstante 202,
203 17 a-Athinyl-3,17 tJ-dihydro
xy-lla-methoxy-1,3,5(10)-ostratrien 161
17a-Athinyl-3,17tJ-dihydroxy-1 ,3,5(10)-ostratrien --> Athinylostradiol
17a-Athinyl-3tJ,l7tJ-dihydro-xy-4-ostren-3,17-diacetat 13 2
17a-Athinyl-10tJ,l7tJ-dihydroxy-4-ostren-3-on 17 8
17a-Athinyl-17tJ-hydroxy-4-androsten-3-on 118, 119
17 a-Athinyl-17 P-hydroxy-4-ostren-3-on--> Norethisteron
17 a-Athinyl-17 tJ-hydroxy-5(10)-ostren-3-on 132
17a-Athinyl-3-methoxy-17tJhydroxy-1 ,3,5(1 0)ostratrien 127
17a-Athinyl-18-methyl-17Phydroxy-4-ostren-3-on 132
17a-Athinyl-18-methyl-17P-hydroxy-4,9,11-ostratrien-3-on 157
17 a-Athinylostradiol 125-127, 160,178
Athisteron 118, 119 8-Athoxycarbonyl-10, 11-di
hydroprostaglandin A 117
17a-Athyl-17tJ-hydroxy-4-ostren-3-on 139
Atiocholanolon--> 3a-Hydro-xy-5tJ-androstan-17 -on
Atmungskettenenzyme 74 Autoimmunerkrankung 53 Avidin 119, 120, 124, 268 Axiale Reste 6, 8, 11 Azoospermie 106, 134
Bakterien --> Mikroorga-nismen
Barbiturate 42 Basenpaarung 226 Bastenstapelung 238 Bernsteinsiiure 179, 180 Betamethason 150, 283 Bilirubinglucuronosyltransfe-
rase 122, 261 Bleitetraacetat 38 Blut, Bildung 138, 140
-,Druck 91, 116, 124, 133, 215
-, Steroidabbau 164 -, Volumen 92, 93 Bombyx 154 BOMT 159 Brenztraubensiiure --> Pyruvat 6a-Brom-17tJ-hydroxy-17a-
methyl-4-oxa-5a-androstan-3-on 159
Briickenkopfatome 5, 8, 9 Brustdriise, Ostrogenbil
dung 62 -, Steroidrezeptoren 208,
211,217,218 -, Tumorbildung 62, 88,
127,128,132,196,208, 211
-, - hormonelle Therapie 88, 162, 217
-, Wachstum 87, 119, 123, 130
Brutinstinkte 88, 122
Caeruloplasmin 124 Calcitonin 89-91 -, Biosynthese 90 -, Gehalt 91 -, Halbwertszeit 91 -, Membranrezeptor 90 -, Struktur 90 -, Wirkung 89-91, 152,
153 -, - Adenylcyclase 90,
108 Calcium 77, 152, 153 -, Gehalt 89 -, - Aufnahme durch
Zellen 95 -, - bindendes Protein
153 -,- Mobilisierung 89, 90 -, Wirkung 37, 96 -, - Adenylcyclase 73,
74,90 -, - Aktivatorprotein
110 -, - Cholesterin
transport 28, 3 7 -,- Exocytose 98, 110 -,- !a-Hydroxylase 65,
89 -, - Lutropin 82 -, - Lymphocytentrans-
formation 108 -, - Membranpotential
95, 98, 117
331
-, - Parathormon 90 -, - Sek. Messenger 96 Calliphora 155, 174, 222 cAMP-> Adenosin-3',5'-mo-
nophosphat Carboanhydrase 151 Carotin 129 Casein 87 Catecholamine 3 -, Biosynthese 103 -, Rezeptoren 107 -, Stoffwechsel 103 -, Wirkung 95, 107, 141,
149 Catecholamin-0-Methyltrans
ferase 103, 195, 196 Catecholostrogene 102,
103, 162, 195 Centromer 225 Cerebellum 215 Cerebrum 59 Cervixschleim 132, 133 Cervixtumor 128 Chiasma opticum 71 Chiralitiit 4, 13, 14, 31 Chironomus tentans 253 6-Chlor-17a-hydroxy-1,2a-
methylen-4,6-pregnadien-3,20-dion-17 a-acetat --> Cyproteronacetat
6-Chlor-17 a-hydroxy-4-pregnen-3,20-dion-17-acetat 132
Chlormadinonacetat 132 2,2-bis (2-Chlorphenyl-4-
chlorphenyl)-1, 1-dichlor-iithan 43
6-Chlor-9tJ,lOa-pregna-1,4,6-trien-3,20-dion 120
Cholan 12 Cholecalciferol (Vitamin 0 3)
23,63-65 -, Rezeptor 217,222 8,24-Cholestadien-3-on 21,
26 Cholestan 8, 12 Cholestenol-~-Isomerase
21,26,169 Cholesterin 4, 5 -, Biosynthese 13-27, 66 -, - Regulation 24, 25 -,Carrier 24, 25, 74, 81,
174 -, Gehalt 24, 27 -, Membranwechselwir-
kung 24,25,258 -, Mikrobieller Abbau 179, 273
332
Cholesterin -, Verwertung 13, 27-30,
41,44,47,66,69, 74 -, - Hydroxylierung
29-32,37 -, - Seitenkettenab
spaltung 37-41,69 Cholesterinacetat 66 Cholesterinacyltransferase
25,27 Cholesterinester 27, 78, 79,
114 -, Biosynthese 25, 27, 28 -,Spaltung 25,27,28,69,
74 Cholesterinesterase 25, 27,
28, 114 -,Regulation 25, 69, 78,
83, 111 Cholesterinlinolsiiureester
174 Cholesterinolsiiureester 27 Cholesterinoxidase 180 Cholesterinsulfat 25, 27, 28,
133, 172, 173 Cholesterinsulfatase 25, 27,
133, 173 Cholinacetyltransferase 215 Cholinerge Rezeptoren 95 Cholinphosphotransferase
147,267 Choriongonadotropin
(hCG) 83-85 -, Biosynthese 84 -, Halbwertszeit 85 -, Membranrezeptor 82,
83 -, Struktur 81, 84 -, Wirkung 42, 70, 71,
83-85,232,267 -, - Adenylcyclase 83,
232 -, - Immunsuppression
85 Chromatin 204, 223-226,
233,234,242 -, Bindefiihigkeit fiir Stero
idrezeptoren 202, 205 -, Transkriptionsakti-
vitiit 204, 224, 225, 241, 242
-, - EinfluB von Stero-iden 241, 242
Chromomeren 155 Chromosomen 223, 226, 228 -, Gonosomen 213, 223,
256,257,264,265
-, Lampenbiirstenchromosomen 233
-, Riesenchromosomen 154-156,234,254,258
-, Sequenzen, repetitive 225
-, Transportform 224, 226 Chymotrypsinogen 148 Circadianer Rhythmus 96 -, Aldosteron 53, 93, 152 -,Androgene 59,140 -, Corticoide 53, 152 -,Corticotropin 81 -,DHEA 59 -, Gestagene 183, 184 -, HMG-CoA-Re-
duktase 25 -, Ostrogene 128 -, Prolactin 89 -,Renin 93 Citrat 77, 136 Citronensiiurecyclus 36,
142, 144 Clomiphen 160, 161 Coenzym A 27 Coenzym Q10 58, 169, 175,
191 Collagenase 149 Collagenstoffwechsel 123,
149 Conalbumin 124 Converting enzyme 92 Coprostanol 283 Corney bacterium 150 Corpora allata 156 Corpus luteum 27, 40, 47,
62,70,83,87, 116, 11~ 119, 128-130, 181
Cortexolon (11-Desoxycortisol) 41, 48, 49, 51
Cortexon ( 11-Desoxycorticosteron) 34, 48, 49, 51, 57, 151
Corticoide 47-53, 141-152 -, Biosynthese 27, 44,
47-53,69,70 -,- ~4-Weg 49 -,- ~5-Weg 50, 51 -, - Regulation -> Corti-
coliberin und Corticotropin -, Gehalt 53, 152 -, Rezeptoren 203,
206-209,268 -, - Nuclearakzeptor
203,206-208 -,- Plasmarezeptor 219,
220
Sachverzeichnis
-, Stoffwechsel 184-190 -, Struktur 5, 48, 49 -,- Anticorticoide 162,
163 -, - synthetische Cortico
ide 57, 150, 151, 189, 208,209,219,220
-, Transport 200 -, Wirkung 41-152 -, - Enzym- und Protein-
synthesen 108, 141-149, 207,209,219,244,254, 257,261
-, -, - Gluconeogenese 141-144,147,207,261
-, -,- katabol 141, 144-146,149,208
-, -,- Lipolyse 141, 147-149
-, -,- permissiv 119, 138, 141, 149, 261
-,- an Membranen 257 -, - Nucleinsiiure-
synthese 230, 241, 254, 260
-, - Zelldifferenzierung 141,147,148,207,209, 267,268
-, - Hemmwirkungen 57,62,63,88, 100,106, 141,147-149,205,257, 293
-, -, - Antiinflammatorisch 142, 149-151, 257,258
-, -, - Antisexhormon 158
Corticoliberin (CRH) 81, 96, 99, 100
Corticosteron 34, 41, 48, 49, 52, 91, 96, 142, 151, 152,186,209,218,221, 271
Corticosteron-18-monooxygenase 37, 40, 41, 49, 52, 74,169,176,269
Corticotrophin (ACTH) 72-81
-, Biosynthese 62, 80, 81 -,- Regulation 81, 141 -, Gehalt 53, 81 -, Halbwertszeit 81 -, Rezeptor 73, 74 -, Struktur 72, 73 -, Wirkung 27, 52, 62,
70-80,91,152 -,- Adenylcyclase 73-75
Sachverzeichnis
-, - Cytochrom P-450 42, 74
-,- DNA-Synthese 74 -,- Guanylcyclase 75,
108 -, - Ornithindecarb
oxylase 80 -,- Proteinsynthese 74,
75, 80 -,- rRNA-Synthese 75 -,- Steroidsulfatasen 79,
172 -,- zentral 71, 80 Cortisol 48, 150, 151 -, Biosynthese 49, 50, 141 -, Gehalt 53, 152 -, Stoffwechsel 184, 185 -,- Halbwertszeit 164,
184 -, Wirkung --> Corticoide Cortison 48, 141, 142, 150,
169, 185 Cortol 184, 185, 187 /J-Cortol 184 5a-Cortol 184 Cortolon 184, 185, 187 5/J-Cortolon 185 20~-Cortolon 185 Crustecdyson 154 Cumuluszellen 106 Cushing 100, 149, 158 17a-Cyano-3{J-hydroxy-5-an-
drosten-3-acetat 54 16a-Cyano-3/J-hydroxy-
6, 16/J-dimethyl-5-pregnen-20-on 45
2a-Cyano-17/J-hydroxy-17amethyl-spiro( 5-androsten-4,4' -cyclopropan)-3-on 45
Cyanoketon 45 2a-Cyano-4,4, 17 a-trimethyl-
17 /J-hydroxy-5-androsten-3-on 45
Cyclobutan 16, 18 Cyclohexan 5-7 Cyclooxygenase 113 Cyclopropan 16, 18 Cyclus, weiblicher --> Sexual-
cyclus Cyproteron 158 Cyproteronacetat 158-160 -, Androgenrezeptoren 57,
159,160,212 -, Androgenspiegel 57,
159, 160 -, Corticoide Wirkung 158
-, - EinfluB auf Corticoliberin 100, 159
-, Gestagene Wirkung 158, 159
-, Leberenzymmuster 160, 272
-, Spermiogenese 134 -, Zelldifferenzierung 159,
160,266 Cytidinaufnahme 125 Cytochrom b5 29, 40, 42,
112, 113 Cytochrom b5-Reduktase
31, 40, 42, 112, 113 Cytochrom c-Reduktase 17,
42, 58, 175, 191 Cytochrom P-450 28-44,
50,61,176 -, Biosynthese 42 -, Halbwertszeit 42, 74 -, Mol.-Gewicht 29,42 -, Reaktionscyclus 32-38 -, Vorkommen 40-42,51 --'-, Wechselwirkung mit Sub-
strat 29-32, 34-36, 39, 43 -, - Bindungstypen
32-34,43 -, - EinfluB von Ascorbin
siiure 31, 32, 42 -,- EinfluB von Cal-
cium 37 -, - Inhibitoren 43, 44 Cytochrom P-450-Re
duktase 42 Cytolyse 118
Darm 217,241 -, Calcium-Aufnahme 89 -, Steroidabbau 166, 170 o.p'-DDD 43 Decarboxylierung 19, 20 Dehalogenierung 31, 189 Dehydroascorbinsiiure 78 7-Dehydrocholesterin 23,
24,64-67,169 7-Dehydrocholesterin-Reduk
tase 22, 23, 26, 67 24-Dehydrocholesterin-Re
duktase 22 11-Dehydrocorticosteron
48, 186 21-Dehydrocortisol 188 3-Dehydroecdyson 197 Dehydroepiandrosteron
--> DHEA ~ 1-Dehydrogenase 62, 169,
178, 179
333
14-Dehydrosterinreduk-tase 20, 26
1-Dehydrotestosteron 283 Dekalin 7, 8 Demethylierung 19-21, 24 Desaturase 40, 112, 113 Desmosterin 22, 23, 26, 68 11-Desoxycorticosteron
(Cortexon) 34, 48, 49, 51, 57, 141, 151, 152, 209,218
11-Desoxycortisol (Cortexolon) 41, 48, 49, 51, 152, 186
21-Desoxycortisol 48, 49, 186
21-Desoxycortison 186 2-Desoxy-a-ecdyson 67 22-Desoxy-a-ecdyson 67 2-Desoxyecdysteron 67 11-Desoxy-17-hydroxycor-
tisteron--> 11-Desoxycortisol
Desoxynucleotidkompartiment 230
Desoxyribonucleinsiiure ->DNA
21-Desoxytetrahydrocortisol 186
Dexamethason 57, 100, 149-151,208,220,254
Dextransulfat 201 DHEA 41, 44, 47, 49, 55,
57,5~62,86, 135, 17~ 187,191,220,258
-, Gehalt 140 -, Hemmwirkungen 260 DHEA-Sulfat 55, 56, 62,
172,173 -, Ostrogenvorliiufer 47,
62,63, 70,172,173 -, Plasmabindung 173 DHEA-Sulfatid 173, 174,
260,262 DHT 53, 56, 135-140, 190,
260, 271 -, Gehalt 140 -, Rezeptor 85, 136,
211-214,220,221 -, Wirkung 57-59, 61,
105,136,137,253,258 Diiithylstilbostrol 127, 128,
158,220 2,22-Didesoxy-a-ecdyson
67 22,25-Didesoxy-a-ecdyson
66,67
334
Dienostrol 128 Dienzephalon 94 Differenzierung--> Zelldiffe-
renzierung 6a,9a-Difluor-
11fj,16a,17a,21-tetrahydroxy-1 ,4-pregnadien-3,20-dion-16,17-acetonid 151
20P-Dihydrocortisol 184 Dihydrotestosteron--> DHT Dihydroxyacetonphos-
phat 142, 143 3P,17P-Dihydroxy-3,5-
androstadien 192 3a,17a-Dihydroxy-5a
androstan 136 3a, 17 P-Dihydroxy-5a
androstan 56, 135, 136, 138,172,190,191,220, 230,271
3{3,17P-Dihydroxy-5aandrostan 135, 190, 191,271
3P,16a-Dihydroxy-5aandrostan 192
3{3, 16{3-Dihydroxy-5aandrostan 192
3a,17{3-Dihydroxy-5Pandrostan 190, 191,271
3{3,17{3-Dihydroxy-5{3-androstan 190
3a, 17 {3-Dihydroxy-5a-androstan-3, 17 -disulfat 191, 193
3{3, 17 {3-Dihydroxy-5a-androstan-3,17-disulfat 193
3P, 17 P-Dihydroxy-5a-androstan-17 -sulfat 193
3a, 11{3-Dihydroxy-5aandrostan-17-on 187
3a,11{3-Dihydroxy-5{3-androstan-17 -on 187
3a, 17 {3-Dihydroxy-4-androsten 138, 175, 177, 192
3p, 17 {3-Dihydroxy-4-androsten 138, 177, 192, 193
3P,16a-Dihydroxy-4-androsten 193
3P.17P-Dihydroxy-5-androsten 49, 55-57, 86, 135, 138, 140, 187, 211
3p, 16a-Dihydroxy-5-androsten-17 -on 63, 192
6p, 17 P-Dihydroxy-4-androsten-3-on 193
17 p, 19-Dihydroxy-4-androsten-3-on 60
2P,17 P-Dihydroxy-4-androsten-3-on 193
11p, 17 a-Dihydroxy-4-androsten-3-on-17P-carbonsaure 189
1a,25-Dihydroxy-cholecalciferol 41, 63--65, 70, 89-91, 152-154, 197, 217,218,222,240,241
24,25-Dihydroxy-cholecalciferol 89, 197
25,26-Dihydroxy-cholecalciferol 197
20a,22R-Dihydroxycholesterin 30, 37, 39-41
20a,22R-Dihydroxycholesterin-Aldolase 30, 37, 39, 40
4,4-Dihydroxy-7 ,7 '-diathylstilben --> Diathylstilbostrol
4,4' -Dihydroxy-y,6-diphenyln-hexan 127
2,3-Dihydroxy-1,3,5(10)ostratrien-17-on--> 2-Hydroxyostron
3,4-Dihydroxyphenylathylamin --> Dopamin
{3(3,4-Dihydroxyphenyl)-{Jhydroxyathylamin --> Noradrenalin
P(3,4-Dihydroxyphenyl)-P-hydroxy-N-methylathylamin --> Adrenalin
17a,21-Dihydroxy-1,4-pregnadien-3,11,20-trion 150, 189
3a,20a-Dihydroxy-5a-pregnan 182
3{J,20a-Dihydroxy-5apregnan 182
3a,20P-Dihydroxy-5apregnan 182
3P,20P-Dihydroxy-5apregnan 182
3a,20a-Dihydroxy-5{3-pregnan 181, 182, 195
3P,20a-Dihydroxy-5{3-pregnan 182
3a,20P-Dihydroxy-5Ppregnan 122,182,261
3{J,20{J-Dihydroxy-5{3-pregnan 182
Sachverzeichnis
3a,21-Dihydroxy-5apregnan-11,20-dion 186
3a,21-Dihydroxy-5Ppregnan-11,20-dion 186
3a,20a-Dihydroxy-5p-pregnan-3-{J-D-glu-curonid 182
3a, 17 a-Dihydroxy-5apregnan-20-on 56
3a,6a-Dihydroxy-5apregnan-20-on 183
3{J,6a-Dihydroxy-5apregnan-20-on 183
3{J,6a-Dihydroxy-5Ppregnan-20-on 182
3a,17a-Dihydroxy-5apregnan-20-on 56
3P,20a-Dihydroxy-5-pregnen 172, 183
3{3, 17 a-Dihydroxy-5-pregnen-20-on--> 17aHydroxypregnenolon
3P,21-Dihydroxy-5-pregnen-20-on-3,21-disulfat 172
3{J,20a-Dihydrox-5-pregnen-3,20-disulfat 172
11{3, 17 a-Dihydroxy-4-pregnen-3-on--> 21-Desoxycortisol
11{3,21-Dihydroxy-4-pregnen-3 ,20-dion --> Corticosteron
17 a,21-Dihydroxy-4-pregnen-3,20-dion --> Cortexolon
17 a,21-Dihydroxy-4-pregnen-3,11 ,20-trion --> Cortison
11fj,21-Dihydroxy-4-pregnen-3, 18,20-trion ->Aldosteron
3,4-Dihydroxy-9, 1 0-secoandrosta-1 ,3,5( 1 0)-trien-9,17-dion 179
Dimethylallylpyrophos-phat 15-17,26
Dimethylallyltransferase 16, 17, 26
17 ,21-Dimethyl-19-nor-4, 9-pregnadien-3,20-dion 210
7P,17a-Dimethylte-stosteron 162, 196
Diphenoloxidase 155, 156 2,2-Diphenylvaleriansaure-N
diathylaminoathylester 44 Dipteren 154, 258
Sachverzeichnis
DNA, Biosynthese (Replikation) 226-230, 236
-, - Membranin-itiatoren 223, 226, 227
-, - Okazaki-Stiicke 228 -, - Regulation 223 -, -, - EinfluB von
ACTH 74 -, -, - EinfluB von
cGMP 264 -, -, - EinfluB von Stero
idhormonen 119, 125, 136,138,148,198,222, 223,229,230
-, - Replikations-komplex 227, 228, 230
-, - Replikon 226-228 -,- RNA-Primer 227 -, Struktur 225, 226 -,- Wechselwirkung mit
Steroid-Rezeptoren 201, 206
DNAasen 223, 233 DNA-Methylasen 233 DNA-Polymerase 223, 229 -, Funktion 227, 230 Dopa 155 Dopa-Decarboxylase 155 Dopamin 155 -, Sekretion 88, 101 -, Struktur 99, 155 -, Wirkung 95, 106, 155 Drosophila 154, 156, 222 Durabolin 139 Dydrogesteron 283
a-Ecdyson 66 -, Biosynthese 66--68 -, Rezeptor 222 -, Stoffwechsel 66--68, 197 -, Wirkung 154-156, 244,
258,262 {J-Ecdyson (Ecdyste-
ron) 66--68, 154-156 Ecdysonoxidase 168, 197 a-Ecdysonphosphat 174 Ecdysonsulfat 68 Ehrlich-Ascites-Tumor-
zellen 260 Eidotterproteine 124, 125 Ei-Entwicklung 129-131 Eicosatetraensaure --+ Arachi-
donsaure Eicosatriensaure 112, 114 Eisen, Elektronenspin 33 -, im Cytochrom P-450
29-36,43
-, im Adrenal-Ferredoxin 35,36
ElektronenfluB 35, 36, 38, 42, 103
Elektronentransportkette 31,34-36
Elipten 43 Eminentia mediana 95, 101,
212,215,261 Endometrium 118-120,
123, 129, 131, 183, 217, 222
Endomitose 154 Enolase 142 Entgiftung 181 Entzugsblutung 131 Enzyme, Wechselwirkung mit
Steroiden 159-262 Enzyminduktion 205, 211,
244,255,293 Enzymmuster, geschlechtsab
hangige 59, 138, 160, 175-177,190,191,212, 213,266-272
Epiandrosteron 190, 191 Epididymis 136 Epiphyse 96, 125 Epiphysenfuge 123 Epitestosteron --+ 17 a-Hydro-
xy-4-androsten-3-on Epithelkorperchen 89, 90 Epoxidase 17, 40 Epoxidbildung 17, 19, 30,
39,40,61 20,22-Epoxycholesterin 39,
40 Epoxyhydrase 40 Ergocalciferol 64, 153 Ergosterin 64 Erythrocyten 257 Erythropoietin 138 Ethisteron 283 Ethynodioldiacetat 132 Evolution, von Prolactin 88 -, von Steroid-abhangigen
Systemen 273 Exocytose 96, 98, 110, 250
FAD 36 Faktor X 42 -, bei Sexualdifferenzie
rung 264-266 Farnesylpyrophosphat
15-18,26 Farnesyltransferase 16, 18, 26 Feminisierung, testikulare
213,257
335
Feminisierungsfaktor, hypo-physarer 267, 270
Ferredoxin 29, 35-37, 51 Fetalentwicklung 63, 135 a-Fetoprotein 212, 222,
267 Fettsaureester 25, 27, 79 Fettsauresynthese 123, 141,
147,180,216 Fibroblasten 148 Fiebersenkung 149 Flavinadenindinucleotid 36 Fluocinolonacetonid 151 Fluocortolon 31, 188, 189 9a-Fluorcortisol 189, 209 6a-Fiuor-16a-methyl-llfJ,21-
dihydroxy-1,4-pregnadien-3,20-dion 31, 188, 189
9a-Fiuor-16a-methyl-ll{J, 17 a,21-trihydroxy-1 ,4-pregnadien-3 ,20-dion --+ Dexamethason
p-Fluorphenylalanin 189 9a-Fluor-11{J,16a,l7a,21-te
trahydroxy-1 ,4-pregnadien-3,20-dion--+ Triamcinolon
Flutamid 160 Follikel 81, 102, 116, 129 Follitropin 85-87 -, Gehalt 87, 130 -, Membranrezeptor 86 -, Sekretion 70, 104-106 -, - Halbwertszeit 86 -, - Regulation 86, 87,
95, 104-106 -, Struktur 81, 85 -, Wirkung 71, 74, 85, 86,
129,221,272 N-Formylkynurenin 145 Fructose 136 Fructose-1,6-di-
phosphat 142-144, 147 Fructose-1,6-diphosphat-D
Giycerinaldehyd-3-phosphat-Lyase 142, 143
Fructose- I ,6-diphosphat-1-Phosphohydrolase 142-144
Fructose-6-phosphat 142-144, 147
FSH --+ Follitropin Fucose 81 Fumarsaure 146 4-Fumaryl-acetoessig
saure 146
336
4-Fumaryl-acetoessigsiiureFumarylhydrolase 146
Fusidansaure 10
Galactose 81 Galactosyltransferase 120,
121 Gallenblasenerkran-
kungen 131 Gallensauren 24 Ganglioside 84 Genom 224-226 Geranylpyrophosphat 16,
17, 26 Gerinnungsfaktoren 215 Geschlechtsanlagen 265, 266 Gestagene ---> Progesteron Gewebshormone 3, 117 Globin-mRNA 253 a2.-Globulin 138, 272 Glucagon 149, 273 Glucocorticoide ---> Corticoide Gluconeogenese 141-144,
147,207,261 Glucose 142, 146, 216 -, Transport 148 Glucoseeffekt 108 Glucosefaktor 77 Glucoseoxydation 127, 141,
216 Glucose-1-phosphat 76, 77,
166 Glucose-6-phosphat 76, 77,
111,142-146,174,262 Glucose-6-phosphat-Dehy
drogenase 125, 174, 215,260,262
Glucose-6-phosphat-KetolIsomerase 142, 143
Glucose-6-phosphat-Phosphohydrolase 142-144
Glucose-1-phosphat-U ridylyl-transferase 166
Glucoside 164, 170 Glucosyltransferasen 168 J3-Glucuronidase 124, 138,
160, 169, 170, 190 Glucuronidierung 122, 164,
166- 170, 184 Glucuronosyltransfera-
sen 165, 167, 168, 195, 271
L-Glutamat-Dehydrogenase 259
Glutamin 259 L-Glutaminsiiure 77, 145,
259
Glutaminsynthetase 148, 207,209,268
Glycerinaldehyd 4 D-Glycerinaldehyd-3-phos
phat 142, 143 D-Glycerinaldehyd-3-phos
phat-Dehydrogenase 142, 143
a-Glycerinphosphat 77, 141 Glycerinphosphat-Dehydro
genase 148 Glycerinphosphat-Phosphat
idyltransferase 14 7, 268 Glycerinsiiure-1 ,3-di
phosphat 142, 143 D-Glycerinsaure-2-phos
phat 142, 143 D-Glycerinsiiure-3-phos-
phat 142, 143 Glycoside 170 Glykogen 76, 141, 146 Glykogenphosphorylase 76,
111,259 Glykogensynthetase 146,
147 Glykolyse 142 - , hormonelle Stimula
tion 83, 86, 136 Glykoproteinsialyltransfe-
rase 133 Golgi-Apparat 250 Gonaden---> Ovar bzw. Testes - , LH-Rezeptoren 82 - , Steroidabbau 164 -, Steroidsynthese 83 Gonadoliberin (Gn-RH)
99-106 -, Abbau 101, 105 -, Rezeptor 104 -, Sekretion 96 -, - Kernbereiche 94, 95 -,- Regulation 88, 95,
96, 102,212 -, Struktur 101 -,- Antagonisten 104 -,-Depot-
priiparate 105, 106 -, Wirkung 83, 87, 104,
105, 116 Gonadotropine 81 -, FSH ---> Follitropin -, LH ---> Lutropin -, hCG ---> Choriongonado-
tropin -, PRL---> Prolactin -, Bildung in Neo-
plasmen 63
Sachverzeichnis
-, Sekretion 97, 100-106, 130, 131
-, - Regulation 97, 98, 106
-, Membranrezeptoren 57 Gonosomen 213, 223, 256,
257,264,265 Graafsche Follikel 85, 129 Granulocyten 148, 257 Granulosa-Zellen 86, 129 Guanosindiphosphat
(GOP) 108 Guanosin-3',5' -mono
phosphat (cGMP) 70, 75,107-111,123,254, 262,264
Guanosin-3' ,5 '-monophosphat-Phosphodieste-rase 111
Guanosinpolyphos-phate 181
Guanosintetraphosphat 181, 232
Guanosintriphosphat (GTP) 104, 108, 245-250
Guanylcyclase 1 07 -, hormonelle Stimula-
tion 75, 87, 91, 107, 108
Haarwuchs 135, 138 Halbsesselform 6 Halbwertszeit, biologi-
sche 166 Hiim ---> Protoporphyrin IX Hiimoglobin 29, 140 Hiimoproteine 29 Harnstoffcyclus 14 7 Haut, Vitamin-03-Bil-
dung 65 - , Zielorgan der Andro
gene 57 -, Zielorgan der Corti-
coide 141 hCG ---> Choriongonadotropin Hefe 177,180 HeLa-Zellen 85, 148, 238 Herzgifte 10 Hexahydroaldosteron 189 2J3,3J3, 14a,20J3,22R,25-He-
xahydroxy-5/'1-cholesta-7-en-6-on ---> Ecdysteron
Hexokinase 136 Hierarchie der Hormondrii
sen 98,99, 104,105 Hippocampus 209 Hirnpeptide 98
Sachverzeichnis
Hirsutismus 57, 88, 159, 160,221
Histamin 123, 149 Histone 206, 223-225, 241,
242 -, Modifizierung 111, 223,
224,233,234,242,250 -, Synthese 125, 223, 230 HMG-CoA 13, 14, 25, 26 HMG-CoA-Reduktase 14,
24-26, 111 Hoden -> Testes Hohlweg-Effekt 97, 102,
103, 120, 122, 123, 129, 162,195,266
Homogentisinsaure 145, 146
Homogentisinsaure-1,2-Di-oxygenase 146
Homosexualitat 266, 267 Hormon-Begriff 3 HTC-Zellen 148, 162, 200,
208,254,255,270 17 a-H ydroperoxyproge
steron 54, 55 2a-Hydroxyandrogene 43,
272 2(J-Hydroxyandrogene 41 3-Hydroxy-androsta-1 ,4-
dien-17-on 191, 192 9a-Hydroxy-1,4-androsta
dien-3,17-dion 179 3a-Hydroxy-5(J-androstan-
11,17-dion 187 3a-Hydroxy-5a-androstan-
17 -on -> Androsteron 3a-Hydroxy-5(J-androstan-
17-on 186, 187, 190, 191
3(J-Hydroxy-5a-androstan-17-on 190, 191
3(J-Hydroxy-5(J-androstan-17-on 190
3(J-Hydroxy-5a-androstan-16-on 192
17a-Hydroxy-5a-androstan-3-on 138, 271
17(J-Hydroxy-5a-androstan-3-on-> DHT
17{J-Hydroxy-5(J-androstan-3-on 190, 271
3a-Hydroxy-5a-androst-16-en 193
3(J-Hydroxy-5a-androst-16-en 193
2a-Hydroxy-4-androsten-3,17-dion 272
6(J-Hydroxy-4-androsten-3,17-dion 272
7 a-Hydroxy-4-androsten-3,17-dion 272
19-Hydroxy-4-androsten-3,17-dion 41, 60
ll(J-Hydroxy-4-androsten-3,17-dion 49
16a-Hydroxy-4-androsten-3,17-dion 63
l?(J-Hydroxy-4-androsten-3,19-dion 60
17a-Hydroxy-4-androsten-3-on (Epitestosteron) 13 7, 192,193,271
17 P-Hydroxy-4-androsten-3-on -> Testosteron
3P-Hydroxy-5-androsten-17-on-> DHEA
3-Hydroxyanthranil-saure 145
17(J-Hydroxy-17a-athinyl-18-methyl-4,9,11-ostratrien-3-on 157
3(J-Hydroxy-24-athyl-5-cholesten 66, 68
25-Hydroxycholecalciferol 41, 64, 65, 89, 153
-, Rezeptor 217,218,222 -, Stoffwechsel 197 5,6-trans-25-Hydroxychole
calciferol 153, 154 25-Hydroxycholecalciferol-1-
monooxygenase ->!a-Hydroxylase
3(J-Hydroxy-5, 7 -cholestadien (7-Dehydrocholesterin) 23,24,64-67,169
3(J-Hydroxy-5,20(22)cholestadien 40
3(J-Hydroxy-5 ,24-cholestadien -> Desmosterin
3(J-Hydroxy-5a-cholesta-7,24-dien 22, 23, 26
3(J-Hydroxy-5a-cholesta-8,24-dien -> Zymosterin
Jp-Hydroxy-5-cholesten -> Cholesterin
3{J-Hydroxy-5,7 ,24-cholestatrien 22, 26
3(J-Hydroxy-9, 1 0-seco-cholesta-5, 7 ,9(10)-trien -> Vitamin 0 3
20a-Hydroxycholesterin 30, 37,41
22R-Hydroxycholesterin 30,41
337
18-Hydroxycorticosteron 41,48,51
16a-Hydroxydehydroepiandrosteron 192
16a-Hydroxydehydroepian-drosteronsulfat 63
26-Hydroxy-ecdyson 197 26-Hydroxy-ecdysteron 67 25a-Hydroxy-ergocal-
ciferol 64, 65 3-Hydroxy-L-kynu-
renin 145 Hydroxylierungen 30-32,
41,50,51, 165,166,176 -, bakterielle ->Mikroorga
nismen -, geschlechtsabhangige Hy
droxylasen 176, 272 -, H-Donator 31, 32, 35,
40,42 -, hydroxylierte Positionen
(Spezifitat) 30, 31, 41, 51
-,- !a-Hydroxylase 41, 64,65, 89-91,154,169, 176-178
-,- 2-Hydroxylase 103, 165, 195, 196
-,- 2a-Hydroxylase 43, 176,272
-,- 2(J-Hydroxylase 41, 169,177,178,272
-,- 3a-Hydroxylase -, - 3(J-Hydroxylase -,- 4-Hydroxylase -,- 4a-Hydroxylase
178 178
179 178
-,- 6a-Hydroxylase 41, 178, 182, 196
-,- 6(J-Hydroxylase 41, 169, 177, 178, 185, 189, 192,269,272
-,- ?a-Hydroxylase 169,178,269,272
-,- 7(J-Hydroxylase 178 -,- 8(J-Hydroxylase 178 -,- 9a-Hydroxylase
178, 179 -,- lla-Hydroxylase
41, 169, 178 -,- ll(J-Hydroxylase
29,34,35,39-41,50,51, 57, 74, 169, 176-178
-, -,- Inhibitoren 43, 44 -,- 12a-Hydroxylase
41,178 -,- 12(J-Hydroxylase
41, 178
338
Hydroxylierungen -,- 14a-Hydroxylase
177, 178 -,- 14{3-Hydroxylase
177, 178 -,- 15a-Hydroxylase
20,26,41, 169,177,178 -,- 16a-Hydroxylase
41,62,63, 169,178,182, 196,269,272
-, -,- Inhibitoren 162, 196
-,- 16{3-Hydroxylase 178, 196
-,- 17a-Hydroxylase 41,49-51,54-56,74,82, 86, 169, 178
-, -, - Inhibitoren 44, 51
-,- IS-Hydroxylase 37, 40,41,49,52, 74,169, 176,269
-, -, - Inhibitoren 43 -,- 19-Hydroxylase 41 ,
60, 169, 178 -, -, - Inhibitoren 43 -,- 20a-Hydroxylase
30,41,43 -, -, - Inhibitoren 43 -,- 21-Hydroxylase 41,
49, 50,52,57, 74,169, 178
-, -,- Inhibitoren 43, 52, 121
-,- 22R-Hydroxylase 30,41
-,- 24-Hydroxylase 89, 154, 197
-,- 25-Hydroxylase 42, 64,65
-, -, - Inhibitoren 65 -,- 26-Hydroxylase 66,
169 -, Mechanismus --+ Cyto
chrom P-450 3{3-Hydroxy-24-methyl-
5, 7 ,22-cholestatrien 64 2-Hydroxymethylen-17 a -me
thyl-17{3-hydroxy-5aandrostan-3-on 139
Hydroxymethylglutaryl-CoA 13, 14, 25, 26
Hydroxymethylglutaryl-CoALyase 14
Hydroxymethylglutaryl-CoAReduktase 14, 24--26, 111
H ydroxymethylglutaryl-CoASynthase 14, 26
2-Hydroxyostradiol 103, 137, 162, 165, 195, 196, 214
6a-Hydroxyostradiol 196 6/J-Hydroxyostradiol 196 11a-Hydroxyostradiol 61 17 a-Hydroxyostradiol --+ 17 a-
Ostradiol 17/J-Hydroxy-4-ostren-3-on-
17-phenylpropionat 139 2-Hydroxyostriol 196 6/J-Hydroxyostrogene 196 2-Hydroxyostron 103, 137,
194--196 2-Hydroxyostron-Glutathion-
iither 196 6a-Hydroxyostron 196 6/J-Hydroxyostron 196 16a-Hydroxyostron 196 16/J-Hydroxyostron 196 8( 1-Hydroxy-3-oxopropyl)-
9,12-dihydroxy-5,10-heptadecadien-carbon-siiure 115
p-Hydroxyphenylbrenztraubensiiure 145, 146
p-Hydroxyphenylbrenztraubensiiure-Dioxyge-nase 146
3a-Hydroxy-5a-pregnan-16-en-11,20-dion 122
2/J-Hydroxypregnane 41 17a-Hydroxypregnane 41 3/J-Hydroxy-5a-pregnan-20-
on 182, 183 3/J-Hydroxy-5/J-pregnan-20-
on 182, 183 3a-Hydroxy-5a-pregnan-20-
on 56, 119, 182, 183, 210 3a-Hydroxy-5{3-pregnan-20-
on 121, 182 20a-Hydroxy-5a-pregnan-3-
on 183 17a-Hydroxy-5a-pregnan-
3,20-dion 56 3a-Hydroxy-5{3-pregnan-
6,20-dion 182 16a-Hydroxy-4-pregnen-
3,20-dion 182 17a-Hydi:oxy-4-pregnen-
3,20-dion --+17a-Hydroxyprogesteron
21-Hydroxy-4-pregnen-3 ,20-dion --+ 11-Desoxycorticosteron
Sachverzeichnis
17a-Hydroxypregne-nolon 41, 44, 47, 50, 51, 54--57,86
17 a-Hydroxypregnenolonsulfat 172, 173
21-Hydroxypregnenolon 44 20a-Hydroxy-4-pregnen-3-
on 47, 125, 182, 183 20/J-Hydroxy-4-pregnen-3-
on 182, 183 3a-H ydroxy-5 -pregnen-20-
on 44 3/J-Hydroxy-5-pregnen-20-on
--+ Pregnenolon 17 a-Hydroxy-4-pregnen-
3,11,20-trion--+ 21-Desoxycortison
21-Hydroxy-4-pregnen-3,11,20-trion--+ 11-Dehydrocorticosteron
11a-Hydroxyproge-steron 177
11/J-Hydroxyprogesteron 49 17a-Hydroxyproge-
steron 41, 44, 47, 49, 51,53,54,56, 57, 157
17a-Hydroxyprogesteron-Aldolase--+ C-17,20-Lyase
17a-Hydroxyprogesteron-17-capronat 119
3-Hydroxy-9, 1 0-seco-androsta-1,3,5(10)-trien-9,17-dion 179
3a-Hydroxysteroid-Dehydrogenase 56, 135, 165, 168, 175-177, 182, 185, 186,190,269-271
3/J-Hydroxysteroid-Dehydrogenase 26, 165, 168, 176,177, 182, 190, 269-271
3/J-Hydroxy-A 5 -Steroid-Dehydrogenase 44-47, 50, 54-57,63, 168, 173,180, 183
- , Struktur 4 7, 54 -, Vorkommen 44, 47, 54,
62, 172,213 - , Wirkung 47, 168 -, - EinfluB von LH 83 -,- Inhibitoren 45, 46,
56, 157, 158, 160 6a-Hydroxysteroid-Dehydro
genase 182, 196 6{3-Hydroxysteroid-Dehydro
genase 196
Sachverzeichnis
11#3-Hydroxysteroid-Dehydrogenase 168, 177, 185,269
16a-Hydroxysteroid-Dehydrogenase 168, 196
16P-Hydroxysteroid-Dehydrogenase 196
17a-Hydroxysteroid-Dehydrogenase 168, 192, 193,269,271
17j3-Hydroxysteroid-Dehydrogenase 54-56, 60, 120, 130, 136, 160, 162, 168,177,190,196,213, 220,244,262, 269,270
20a-Hydroxysteroid-Dehydrogenase 125, 168, 177, 182, 183, 185, 186, 270
20j3-Hydroxysteroid-Dehydrogenase 168, 182, 185,211,244
21-Hydroxysteroid-Dehydrogenase 168, 188
3j3-Hydroxysteroid-Sulfo-transferase 27, 171
2j3-Hydroxytestosteron 272 6P-Hydroxytestosteron 61,2 72 lla-Hydroxytestosteron 61 11#3-Hydroxytestosteron 61 16a-Hydroxytesto-
steron 272 19-Hydroxytestosteron 60 17 P-Hydroxy-4,4,17 a-trime
thyl-5-androsten(2,3d)isoxazol 45
3j3-Hydroxy-4,4,14a-trime-thyl-8,24-cholestadien --> Lanosterin
5-Hydroxytryptamin--> Sero-tonin
Hyperandrogenismus 52, 57 Hyperprolactinamie 88 Hypoglykamie 106 Hypogonadismus 105, 158 Hypophyse 70, 71, 94, 95,
230 -, glandotrope Hormone
70,80,81,94,95 -, 5a-Reduktase 58, 59 -, Steroidrezeptoren 96,
105,209,210,215 -, Tripeptidasen 96 Hypophysektomie 58, 74,
80-83,271 Hypophysenstiel 71, 94, 95,
101,261
-, Steroidrezeptoren 96 Hypothalamus 94, 95, 266,
271 -, Androgene 138 -, Kernbereiche--> Nucleus -, Liberine 94-96 -, Neurohormone 94, 95 -, Ostrogenbildung 59, 62,
266 -, 5a-Reduktase 59 -, Steroidrezeptoren 96,
209,210,212,215,266
lkterus 122, 261 Immunsuppressor 85, 149 Induced protein (IP) 123,
124, 126 Informoferen 237,238 Informosomen 238, 247,
251,253 Inhibierungsfaktor, hypotha
lamischer 267, 270 Inhibin 87, 99, 106 Insektenhormone 66-68,
154-156 Insulin 87, 119, 144 Interphase 226, 229 lntersexe 266 Interstitiell-Zellen 82 Isoandrosteron--> 3a-Hydro-
xy-5j3-androstan-17 -on Isocapronaldehyd 30, 37, 40 Isocapronylalkohol 38, 39 Isohexylalkoholdehydro-
genase 39 Isomerase --> Steroidisome
rase Isopentenylpyrophos-
phat 16,17,26 Isopentenylpyrophosphat-Iso
merase 16, 26 Isopren, aktives 16 Isoprenoide 13
Juvenilhormon 66, 156
Kalium 52, 151 -, K+/Na+-Quotient 155,
204,258,259 Kapazitation 133 Kastration 59, 119, 136,
160,230,241,253,254 Katabole Wirkung 118,
141, 144-146, 149 Keimepithel 106, 134 Kernbereiche --> Nucleus Ketogenese 14
339
a-Ketoglutarsaure 77, 145, 259
2-Keto-4-hexensaure 180 Ketosauren 14 17-Ketosteroide 53, 165,
186, 187 P-Ketothiolase 13 Kininase II 92 KIP 124,232,243 Knochen, Bildung 128, 153 -, Calcium-Mobili-
sierung 89, 90, 153 Knochenmark 138, 212,
242 Kobalt 42 Kohlenmonoxid 29 Konformationsbeschrei-
bung 5-11 Konjugatbildung 164-174 Kontrazeptiva--> Ovulations-
hemmer Korpertemperatur 122, 128 Krotengifte 10 Kryptorchismus 106 Kynurenin 145 Kynurenin-Hydrolase 145 K ynurenin-Oxidoreduk-
tase 145
Lac-Operon 205 a-Lactalbumin 121 Lactat 142 Lactatdehydrogenase , 125 Lactose-Synthese 121 -,Regulation 87, 121 Lactosesynthetase 121, 133 Lanosterin 17, 19-21,24,
26 Lampenbiirstenchro
mosom 233 · Larvenhautungen 156 Lathosterinoxidase 21, 22,
26, 169 Lathosterol 284 Laurinsaureester 174 Liivulinsaure 179, 180· Leber, Adenylcyclase 89 -, Angiotensinogen-
Bildung 92, 124 -, Cholesterinbildm'lg 27 -, Enzymmuster, ge-
schlechtsabhangige 138, 160,175-177,190,212, 213,267-272
-, Plasmaproteinbildung 124,219
-, Regeneration 148
340
Leber -, Steroidabbau 164, 170,
175, 176, 190, 192, 196 -, Steroidrezeptoren fiir -,- Androgene 212, 213 -,- Corticoide 208,215 -,- Ostrogene 216,222 -, Tumoren 132, 142,208,
222 -, Zielorgan fiir -,- Androgene 140, 212 -,- Corticoide 142,
144-147,207,208,219 -,- Ostrogene 124,
220-243,254 -, - Proteohormone 88,
89 Lecithin 14 7 Lecithinacyltransferase 27 Leucin 144 -,Transport 121,257 Leukiimie, myeloische 148,
257 Leukocyten 148 Leydigsche Zwischenzel-
len 53, 82, 85, 87, 221 LH -> Lutropin Liberine (RH) 94-106 -, Abbau 96,261 -, Biosynthese 98 -, - Kernbereiche 94, 95 -, Rezeptoren 98, 107 -, Sekretion 95, 96, 102 -, - Regulation 94-96,
118 -, Struktur -> Corticoliberin,
Gonadoliberin bzw. Prolactoliberin
-, Wirkung 94-98, 107 Limbische Hirnbereiche 59,
137 Linolensiiure 112 Linolsiiure 112, 174 Lipid-Granulae 27,79 Lipidphasenbeweglichkeit
-> Membran Lipocyten 148 Lipolyse 133, 139, 141,
147-149 Lipoproteine, LDL 24, 25,
27, 174 -, HDL 25, 27, 174 Liposomen 122 Lipotropin 73 Lipovitellin 120, 124, 125 Lipoxygenase 113 Lumisterin 65
Lunge, Steroidabbau 164, 170
Lungensurfactant 148, 209, 267
Lutealphase 131, 181, 195, 207,214
Luteinisierendes Hormon -> Lutropin
Luteolyse 130, 134 Luteotropes Hormon -> Pro-
lactin Lutropin (LH) 81-83 -, Gehalt 83, 87, 130 -, Halbwertszeit 83 -, Membranrezeptor 82,
85 -, - Hemmpeptid 82 -, Sekretion 83, 104, 105 -,- Regulation 83, 94,
102, 104, 105 -, Struktur 81, 98 -, Wirkung 28, 47, 59, 63,
70,71,81-83,87,101, 129
-, - EinfluB von Cal-cium 82
C-5,10-Lyase 179 C-10,19-Lyase 41, 60,61 C-17,20-Lyase 41, 44,
53-56,83,166,186 -, Inhibitoren 44, 46, 53,
160,260 C-20,22-Lyase 30, 37, 40,
41,54,83 Lymphatisches System 141,
148,149,208,209,293 Lymphoblasten 148, 257 Lymphocyten 230 -, Calcitonin-Rezeptor 90 -,Transformation 108,
230,264 Lymphopenie 148 Lynestrol 284 Lysophosphatidylcholin 27 Lysosomen 198, 204, 258 -, Labilisierung 108, 123,
158,204,257,258,262 -, Stabilisierung 141, 149,
158,205 -, Steroidrezeptoren 199,
204,217 -, Wirkung 129,204,205,
234,242 Lysozym 124, 268
~akrophagen 148,257 Malat 77
Sachverzeichnis
Malat-Dehydrogenase 77, 125,215
Malat-Pyruvat-Shuttle 77 4-Maleyl-acetoessig-
siiure 146 4-Maleyl-acetoessigsiiure-Iso-
merase 146 Mannose 81, 84 Medrogeston 284 Medroxyprogesteronace-
tat 267, 284 Megestrolacetat 132 Meiose 83 Melanocyten 73 Melanotropin (MSH) 53,
73, 100 Melatonin 95-97, 125 Membrane 24, 198, 252 -, Depolarisierung 98, 116 -, Hormonrezeptoren
-> Plasmamembranre-zeptoren
-, Lipidphasenbeweglichkeit 25, 122, 205, 258
-, Potential 95 -, Steroidpassage 200,
205 -, Struktur, Proteine 71,
111, 148, 257 -,- Labilisierung 118,
257 -,- Stabilisierung 133,
141,149,257 -, - Steroidwirkung 252,
257-259,274 -, - EinfluB auf DNA
Synthese 223, 226, 227 Membransyndrom, hya-
lines 148 MER-25 161 Mesenchym 148 Mesterolon 139 Mestranol 127 Metadrenalin 97, 103 Metanephrin 97, 103 Methandrostenolon 139 P(3-Methoxy-4-hydroxyphe-
nyl)-P-hydroxy-N-methyliithylamin -> Metadrenalin
2-Methoxy&tradiol 103, 137, 196
2-Methoxy&triol 103, 196 2-Methoxyostron 103, 137,
196 2-Methoxyostron-3-sulfat
195
Sachverzeichnis
2-Methoxyostron-3-glucuronid 195
Methylasen, DNA-Methylasen 223
-, Proteinmethylasen 98 -, tRNA-Methylasen 125,
243,254 2-Methyl-1 ,2-bis(3-pyridyl)-
1-propanon 43 4a-Methyl-5a-cholesta-8,24-
dien-3-on 23 Methylgruppe, angulare 5,
7,8, 10,207 17a-Methyl-17/)-hydroxy-
1 ,4-androstadien-3-on 139
la-Methyl-17 /)-hydroxy-5aandrostan-3-on 139
1-Methyl-17/)-hydroxy-5aandrosta-1-en-3-on-17-acetat 139
7 a-Methyl-17 {3-hydroxy-5-androsten-3-on 157
3-Methyl-2-hydroxyostradiol 103
17a-Methyl-17 {3-hydroxy-4, 9, 11-ostratrien-3-on 213
7a-Methyl-17{3-hydroxy-5-ostren-3-on 157
7 a-Methyl-17/)-hydroxy-4-ostren-3-on-17 -ace tat 157
6-Methyl-17 a-hydroxy-4-pregnen-3, 20-dion-17-acetat 132
Methylmalonyi-CoA 144 8-Methyl-perhydroindan-1, 5-
dion-4a-carbonsiiure 180
8-Methyl-perhydroindan-1, 5-dion-4a-propionsiiure 180
15-Methylprostaglandin F2a 134
Methylsterinmonooxy-genase 19, 20, 26
17a-Methyltestosteron 162 Methyltrienolon 212, 213 Metopirone (Metyrapon) 43 Mevalonatkinase 15, 26 Mevalonsiiure 13-15 Mevalonsiiurepyrophos-
phat 15,26 Mevalonsiiurepyrophosphat
Kinase 15, 26 Mikrofilamente 110
Mikroorganismen 177-181 -, Cytochrom P-450 29 -, Dehydrogenasen 177,
178 -, Hydroxylasen 177, 178 -, 5a-Reduktase 59, 165,
176, 178 -, Sterine 181, 273 -, Steroidrezeptoren 211,
213,214 Mikrosomen 168-170, 196 -, Cytochrom P-450 31,
40-43,54,62 -, HMG-CoA-Re-
duktase 14 -, Hydroxylasen 40, 41,
51,52,62, 169,176 -, Hydroxysteroid-Dehydro
genasen 168, 176, 177, 269, 270
-, 5a-Reduktase 169, 175, 183, 191
-, Steroidrezeptoren 211 -, Sulfatasen 169, 172 -, UDP-Glucuronosyltrans-
ferasen 167, 168 Mikrotubuli 110, 111 Milchbildung 87, 121, 123 Mineralocorticoide 49, 52,
70, 141, 142, 151, 152 Minipille 132, 133 Mitochondrien 74, 169, 234 -, Cytochrom P-450 28,
30-32,34-36,39-41,54, 65, 74
-, DHEA-Sulfatid-Bildung 173
-, Glucuronosyltransferase 167
-, H-Transfer 77, 78, 262 -, Hydroxylasen 41,176 -, Membran 37, 51, 77 -, NADPH-Kompar-
timent 33, 77 -,Steroid-Transfer 47, 51 Mitose 86, 108, 116,
224-226,230,262,263 Mitoseindex 139 Monodehydroascorbin
siiure 31 Monodehydroascorbinsiiure
Reduktase 78 Monooxygenasen, mischfunk-
tionelle -> Hydroxy Jasen Morbus Addison 53 Miillersche Gange 267 Muskeln, Abbau 141, 149
341
-, Steroidrezeptoren 208, 212
-, Wachstum 137-139 Muskulatur, glatte 116 Myoblasten 139 Myometrium 124, 183 Myopathie 149
Na +, Riickresorption, renale 93, 151
-, Transportsystem 116, 117,141,151,259
-, Wirkung 52, 91, 152 -, - Na + IK +-Quotient
155,204,258,259 NAD+ 20, 21, 45, 47, 166,
167 NADH 18, 59, 77, 78 -, H-Donator fiir Arachi
donsiiurebildung 112, 113
-, - fiir Dehydrogenasen 21, 168, 176, 177, 270
-, - fiir Hydroxylierungen 31,40,42
-,- fiir Reduktasen 169, 175
NADPH 18, 36-40, 76-78 -, H-Donator fiir Choleste
rinsynthese 16-23 -, - fiir Dehydrogena
sen 168, 176, 177, 196, 270
-, - fiir Hydroxylierungen 17, 19, 20, 29, 31, 32, 35-37,39,40,76,169
-, - fiir Peroxidasen 22, 38
-,- fiir Reduktasen 14, 1~22,23,58, 16~ 175
NADPH-Cytochrom c-Reduktase 17, 42, 58, 175, 191
Nafoxidin 161 Nebennierenmark 80, 148 Nebennierenrinde (NNR)
47-49,74,79,80,87,271 -, Adenome und Carci
nome 57 -, Morbus Addison 53 -, Steroidsynthese 27, 28,
47,49,51-53,62,63, 70, 71, 122, 141, 172
-, Oberfunktion 187 Nebenschilddriise 89, 90,
218
342
Neonuclearrezeptor 201, 205,206,216,231
Neoplasmen --+ Tumoren Nervensystem 3 Neugeborenen-Ikterus 122,
261 Neuraminidase 73, 84, 85, 200 Neuraminsiiure 84 Neurohormone 94, 99 Neurotransmitter 3, 95, 96,
115 Nichthistonproteine (NHP)
111,124,156,223,224, 230,233,241,242,250
-, Rolle als Nuclearakzeptoren 201-203,206,225
Nicotinamiddinucleotid --+ NAD+ bzw. NADH
Nicotinamiddinucleotidphos-phat --+ NADPH
Nidation 119, 133, 157 Niere 70, 87,89-93, 160 -, Steroidabbau 164, 170 -, Zielorgan der Andro-
gene 59, 136, 138, 139, 160,212,260,272
-, Zielorgan der Corticoide 148,151,208,209
4 '-Nitro-3 '-trifluormethylisobuttersiiureanilid 160
Nocardia restrictus 176 Non-heme-iron-Protein
(NHI) 29, 35, 36 Noradrenalin 95, 97, 100,
103, 107, 109, 148 Norethynodrel 132 Norethisteron (Noriithin
dron) 132,267,284 Norgestrel 132 24-Nor-25-hydroxy-chole
calciferol 65, 153 19-Nortestosteron 61 Nuclearakzeptoren 201,
203-206,216,231 Nuclease--+ DNAase bzw. Ri
bonuclease Nucleinsiiuren--+ DNA bzw.
RNA Nucleolus 234, 235, 243 Nucleosidtriphosphatase 27 Nucleosomen 224 Nucleotide, cyclische --+ Ade-
nosin-3', 5' -monophosphat bzw. Guanosin-3', 5'-monophosphat
Nucleotidkompartiment 125,234,259
Nucleus dorsomedialis 94 - hypothalamicus ante-
rior 265 - paraventricularis 95 - praemamillaris 94 - suprachiasmaticus 96 - supraopticus 95 - tuberis infundibularis 94 - ventromedialis 94, 102,
265
Ohnos Modell 256 Oocytreifung 83, 124, 129,
264 Orientierung 6, 11 Omithinaminotransfe-
rase 147 Ornithindecarboxylase 232,
243 -, hormonelle Regula
tion 80, 88, 124, 125, 148
Orosomucoid 184, 219 Osteoblasten 148 Osteoide 90 tlstradiol 122-131, 194 -, Biosynthese 41, 44,
59-63, 195 -, - Regulation 63, 267 -, Gehalt 128, 129 -, Rezeptor 160, 200-205,
207,214-217,239,240, 257,261
-, - EinfluB von cAMP 111,261
-, - EinfluB von Prolactin 87,88
-, - EinfluB von Steroiden 120, 125, 127, 129, 207,210,216
-, - Nuclearakzeptor 201,203-205,216,240
-, - Plasmarezeptor 219-222
-, -,- a-Fetoprotein 212,222
-, Stoffwechsel 41, 62, 103, 120, 137, 164
-, - Halbwertszeit 197 -,- Konjugate 167, 169,
171 -, Struktur, synthetische
tlstrogene 125-128 -,- Antiootrogene 157,
160-162 -, Wirkungen, Enzym- und
Sachverzeichnis
Proteinsynthesen 92, 95, 123-126,183,207,210, 215,220,242,244,254, 268
-, - Hemmwirkungen 58,87,97, 101,117,119, 122,123,157,160,175, 258,260
-, - Nucleinsiiuresynthesen 87, 125, 126, 204,230,238-243,251, 254,268
-,- Lysosomen-Labilisierung 123, 204, 257, 258
-, - Prostaglandine 102, 123
-, - Triglycerid-Gehalt 133
-, - Zelldifferenzierung 268
-, Zielorgane, Brustdriise 119
-, - Hypophyse 88, 97, 101-106, 122, 123
-,- Tumoren 128 -,- Uterus 118,
122-125,207,216,259, 261,268
17a-tlstradiol 170, 192 17 ,8-tlstradioldehydroge
nase 177,195 17 a-tlstradiol-1 7-,8-D
glucosid 170 17 a-tlstradiol-3-,8-D-glucu
ronid-17 -,8-D-glucosid 170
17 ,8-tlstradiolsulfat 195 tlstriol 62, 63, 126, 127,
129, 194-197 -, Brusttumoren 127, 162 -, uterotrophe Wir-
kung 126,216 tlstriol-3,16-disulfat 172,
194 tlstriol-16-,8-D-glucosid
170 tlstriol-16-glucuronid 194,
197 tlstriol-3-glucuronid 194,
197 tlstriol-16-sulfat 62, 194 tlstriol-3-sulfat-16-glu
curonid 194 tlstrogene 122-134 -, Biosynthese 60-63,69,
70
Sachverzeichnis
-, Stoffwechsel 62, 164, 165, 167, 177, 178, 194-197
-, Struktur 5, 9 -,- Antiostrogene 157,
160-162 -, Wirkung 122-136 Ostrogenkonjugate 123 Ostron 60, 62, 63, 120, 126,
127, 129, 130, 137, 194-196,220
Ostronglucuronid 167, 194 Ostron-3-glucuronosyltransfe
rase 167 Ostron-3-sulfat 169, 171,
172, 194, 195 Ostronsulfotransferase 171 Ostruscyclus 131 Ovalbumin 120, 124, 240,
268 -, mRNA 239, 240, 244,
253 Ovar, 27, 40, 53, 59, 70,
119,122,123,211,243 -, Cumuluszellen 106 -, Gonadotropin-Rezep-
toren 82, 86 -, Insuffizienz 88 -, Theka-Zellen 62, 86,
129 -,Tumor 57 Ovidukt 119, 120, 124, 138,
209-211,214,216,239, 254,268
Ovomucoid 268 Ovulation 83, 102, 116,
119, 120, 122, 129-131, 160
-, reflektorische 94, 130 Ovulationshemmer 83, 127,
131-134 -, beschleunigter Abbau
176 -, Nebenwirkungen 121,
124,131-133,215 Oxalacetat 77, 142-144 7 -Oxaprostaglandine 117 7-0xaprosta-13-insaure 117 Oxidasen 38 -, Steroid-18-oxidase
49,52 -, Steroid-19-oxidase 60 4{),5{)-0xido-19-oxo
testosteron 61 9{),11{)-0xidopregnan 39,
40 Oxidoreduktasen 166
Oxido-squalen 17, 19,26 Oxido-squalen-Lanosterincy
clase 19, 26 19-0xoandrostendion 60 18-0xocorticosteron---> Aldo
steron 2-0xoglutarsaure 77, 145,
259 6-0xoostradiol 196 16-0xo6stradiol 196 6-0xoostron 196 16-0xo6stron 196 3-0xosteroid-d 1- Dehydro-
genase 62, 169, 178, 179
3-0xosteroid-d 4 -d 5-
Isomerase---> Steroid-dIsomerase
3-0xosteroid-d 4-0xidore-duktasen ---> Reduktasen
19-0xotestosteron 41, 60, 61
3,4-bis(p-Oxyphenyl)-2,4-hexadien 128
3,4-bis(p-Oxyphenyl)-3-hexen ---> Diathylstiloostrol
Pankreas 3, 148,212,268 Parachor 149 Parathormon 89-91 -, Abbau 88, 89 -, Biosynthese 89, 90 -,- Regulation 89-91 -, Gehalt 91 -, Struktur 89 -, Wirkung 65, 70, 71,
89-91, 108, 152, 197 Pentagastrin 116 2(J,3(J,14a,22R,25-Pentahy
droxy-5{J-cholesta-7 -en-6-on---> a-Ecdyson
3a, 11{), 17 a,20a,21-Pentahydroxy-5apregnan 184
3a,11{J,17a,20a,21-Pentahydroxy-S{Jpregnan 184, 185, 187
3a,11{J,17a,20{J,21-Pentahydroxy-5{Jpregnan 184
Pentosephosphatcyclus 76, 77,260
Peptidasen 99, 101 -, hormonelle Aktivie
rung 96,101,106,261 Peptidhormone 107 -,Angiotensin 91-93
343
-, Liberine 94-106 Peptidyl-Dipeptidase 92, 93 Peptidylprolylaminosaure-
carboxypeptidase 93 Peptidyltrimsferase
248-250 Perhydrocyclopentanophen
anthren 4, 7, 10, 16 17a-Perhydroxyproge-
steron 54, 55 Peroxid 32, 33, 38 Peroxidase 22, 26, 38, 40 -, IS-Peroxidase 113 Pfortadersystem 94, 95, 98 Phagocyten 134, 149 Phenobarbital 176 Phenylalaninabbau 145 Phenylalaninhydroxylase
145, 189 Phenylathanolamin-N-Me
thyltransferase 148 Phosphat 89-91 Phosphatase, alkalische 90,
148,174 -, saure 136, 174 3' -Phosphoadenosin-5' -phos
phosulfat 27, 168, 170, 171
Phosphodiesterase ---> Adenosin-3' ,5' -monophosphatPhosphodiesterase
Phosphoenolpyruvat 142, 143, 147
Phosphoenolpyruvatcarboxykinase 142-144, 149
Phosphofructokinase 13 7, 147
Phosphoglucomutase 77 3-Phospho-D-glycerat-1-
Phosphotransferase 142, 143
Phospholipasen 116, 117 -,Phospholipase A1 114 -, Phospholipase A2 200 Phospholipide 27, 37, 114 Phosphomevalonat-Kinase
15,26 5-Phosphomevalonsaure 15, 26 3-Phosphomevalonsaure-py
rophosphat 15, 16, 26 Phosphoproteinphosphatase
78, 109, 120, 147, 148, 151,253
Phosphoribosylpyrophos-phat 260
PhosphoribosylpyrophosphatAminotransferase 259
344
Phosphoribosyltransfera-sen 259,260
Phosphorylase 76, 111, 259 Phosphorylase-Kinase 76 Phosphorylase-Phospha-
tase 76 Phosphoserinphospha-
tase 149 Phosvitin 120, 124, 125 Phytohamagglutinin 230 Phytosterine 66 PIF --> Prolactostatin Pinocytose --> Exocytose Placenta 27, 40, 47, 62, 63,
70,80,83,84,87, 119, 122
Plasmamembran 24, 123, 258
-, Rezeptoren 24, 57, 69, 71, 72,80-82,87,90, 199,217
Plasmaproteine Plasmavolumen Plasmarezeptoren
218-222
124 93
166,
Pleiotypische Regula-tion 111
Polaritatsregel 219 Polyadenylsaure-Polymerase
237,251 Polysomen 239, 252, 255 Porphyrinsynthese 121, 122 Porphyrie, intermittierende
121, 122, 140 Portalgefiillsystem 94, 95, 98 Potenzstorungen 94 Pracalciferol 65 Praputialdriise 59, 137 Prasqualenpyrophosphat 16,
18,26 Prednisolon 148, 150, 151,
158,189,257 Prednison 150, 189 9{J,10a-Pregna-4,6-dien-3,20-
dion 120 Pregnan 10, 12 Pregnandiol-> 3a,20a-Dihy
droxy-5{J-pregnan 5a-Pregnan-3,20-dion 47,
53,56, 119,182,210,271 5{3-Pregnan-3,20-dion 182 4-Pregnen-3,20-dion --> Pro
gesteron 5-Pregnen-3,20-dion 45, 46 Pregnenolon, Biosynthese
27-30,37-41,69,79,81, 82
-, Verwertung zur Steroidsynthese 44, 47, 50, 53-55,69,86,183
Pregnenolon-3-sulfat 28, 172, 173
Pregnenolonsynthetase 28-30,36,37,74,78
-, Inhibitoren 43 -, Phosphorylierung 80,
111 -, ungewohnliche Substrate
39, 79 Prenylpyrophosphat --> Dime-
thylallylpyrophosphat Pressinonsaure 100 Primobolan 139 Primordialfollikel 129 PRL --> Prolactin Proandrogene 191 Proangiotensin 92 Progesteron 118-122 -, Biosynthese 27,44-47,
69, 70, 122, 141, 183 -,- Regulation 47, 83,
87 -, Gehalt 122, 130 -, Rezeptoren 125, 201,
203,205,207,209-211, 217,264
-, - Nuclearakzeptoren 203
-, - Plasmarezeptoren 184,219,220,222
-, -, - Uteroglobin 119, 120, 130
-, Stoffwechsel 121, 122, 181-184,210
-,- Halbwertszeit 184 -, Struktur, Antigesta-
gene 157 -, - synthetische Gesta
gene 120-122,132,210, 219
-, -, - androgene Nebenwirkung 267
-, Wirkung 119-122 -, - aniisthetische Wir-
kung 122 -, - Brustdriisenent
wicklung 119 -,- DNA-Synthese 119 -, - Enzym- und Protein-
synthese 119, 120, 222, 268
-, - Hemmwirkungen 53,56, 58, 87,100,101, 117, 119-121, 123, 129,
Sachverzeichnis
132, 133, 157, 161, 162, 207,216,257,258,260, 261
-, - Hypophysenhormone 103, 119
-,- Oocyt-Reifung 121, 264
-,- Ovulation 120 -,- RNA-Synthese 205,
241 -,- Uterus-Entwicklung
119 -,- Verwertung zur Stero
idsynthese 41, 49-51, 54,56,57
-,- zentral 103, 122 Progesteronmonooxygenase
41,54 Prolactin (PRL) 87-89 -, Gehalt 89, 106 -, Rezeptoren 87 -, Sekretion 88, 106 -, - Regulation 88, 96,
106, 119 -, Struktur 87, 98 -, Wirkung 87, 88, 107,
211 -, - Enzym- und Protein
synthese 87, 88, 120 -, - Hemmwirkungen
88, 120 -, - Steroidrezeptor
Bildung 87, 88, 211, 215 -,- Steroidsynthese 47,
59, 70, 71,83,87,88 -, Zielorgane, Leber 271 -,-Mamma 88 -, - Nebennierenrinde
271 -, - Prostata 87 -,- Vesikulardriise 87 -,- ZNS 71, 88 Prolactoliberin 88, 97, 99,
106 Prolactostatin (PIF) 88, 96,
97,99,106 Prolinhydroxylase 149 Propionaldehyd 180 Propionsaure 31, 180 Propionyi-CoA 144 Prostaglandine 3, 112-117 -, Abbau 114, 117, 134 -, Biosynthese 112-115,
117 -, - Regulation 82, 88,
91,95, 117,123,141,149 -, Rezeptor 116, 117,258
Sachverzeichnis
-, Struktur, Antagonisten 117
-,- PG AI 52, 114, 115, 117, 152
-,- PG B 114, 115 -,- PG C 114, 115 -,- PG 0 2 113, 115 -,- PG E1 114-116,258 -, - PG E2 82, 83, 88,
91, 96, 101, 102, 113, 115, 116
-,- PG F2a 88, 91, 102, 107,113,115,116,258
-,- PG G2 113-115 -,- PG H 2 113-115,
117 -,- 15-Methyl
prostaglandin F2a 134 -, Wirkung 112, 115-117 -, - Adenylcyclase 88,
112, 114, 116, 117 -, - Guanylcyclase 88,
107 -,- Luteolyse 116, 134 -,- Muskulatur 116 -, - Oocytreifung 83 -,- Ovulation 116 -, - Proteohormonse-
kretion 88, 96, 101, 112, 116
-, - Steroidsynthese 70, 82, 116
-,- Synapsen 95,112 Prostaglandinisomerase
113,114 Prostaglandinsynthetase 113 Prostata 136, 190, 241 -, Steroidrezeptoren 211,
212,215,220 -, Tumoren 134, 136, 158 -, Wachstum 87, 128, 135,
136,230 Prostatahypertrophie 158,
160 Proteinasen 149, 198, 234,
242,252 Proteinkinasen 76, 78, 79,
86,96,107- 111,147, 232,253,254
Proteinmethyltransfe-rasen 98
Proteinreifung 250-252 Proteinsynthese 238,
244-257,259 -, Elongationsfak
toren 248, 250, 254 - , EinfluB von Hormo-
nen 74, 118, 125, 141, 198,239,250-257
-, Startfaktoren 125, 245, 246,250,252,253
-, Terminationsfak-toren 249, 250
-, Translationsre-pressor 253, 256
Proteohormone ---+ Gonadotropine
-, Gehalt 3, 81, 83, 87, 89, 91
-, Rezeptoren 57, 69, 72, 107
-, Wirkung 24, 69-93, 107 Prothoraxdriise 66, 68, 154 Protocollagenhydroxy-
lase 123 Protolanosterin 17, 19 Protoporphyrin IX 29-31 -, Biosynthese 42 -, EinfluB auf 11-Aminolavu-
linsauresynthetase 121, 140
-,- auf Globin-Messenger 253
Proviron 139 Pseudohermaphroditis
mus 206,213,264 Pseudomonas testostero-
ni 211, 213, 244 Pupertat 104 Puffing 155, 156, 234, 253 Purinnucleosidtriphos-
phate 181 Purinnucleotidbiosynthese
259,260 Pyknose 148 Pyrogalloostrogene 196 Pyroglutaminsaure 101 Pyrophosphat-Phosphohydro-
lase 171 Pyrophosphomevalonat-De
carboxylase 16, 26 Pyruvat 77, 142-145, 180,
259 Pyruvatcarboxylase 142-144 Pyruvatkinase 147
Rebound-Effekt 97 Redox-Potentiale 36 Reduktasen 169, 175, 176 -, bakterielle 59, 165, 169,
175, 176 -, 5a-Reduktase 58, 59,
61, 166, 169, 174-176, 185
345
-, - Wirkung, Rolle von Coenzym 0 10 58, 169, 175,191
-,- H-Donatoren ---+ NADH bzw. NADPH
-, - Geschlechts-abhangig 59, 175, 191, 266,269-271
-,- Inhibitoren 47, 58, 119,158,160,175,260
-,- Regulation 58, 59, 83
-,- bei Porphyrie 121, 139
-, - bei Progesteronreduktion 47, 56, 119, 183, 271
-, - bei Testosteronreduktion 58, 136, 160, 190-'192, 213, 266
-, 5~-Reduktase 58, 164, 166, 169,174-176,182, 185, 186, 190, 191
-, - Geschlechtsabhiingig 190, 269, 271, 272
-,- Inhibitoren 158, 175,189
Relaxin 128 Releasing Hormone ---+ Libe-
rine Renin 52, 91-93 -, Biosynthese 91, 92 -, Gehalt 93 -, Halbwertszeit 93 Replikation-+ DNA-Syn
these Replikon-+ DNA-Synthese Reticulum, endoplasmati
sches 252 Retinal-Differenzie-
rung 148,207,209,268 Retrodifferenzierung 70, 80 Retroprogesteron 120 Retro-Steroide 7, 120 Rezeptoren -+ Steroidrezep-
toren, Proteohormonrezeptoren, Plasmarezeptoren, Plasmembranrezeptoren
Rheuma 149, 150 Rhizopus arrhizus 177 Rhythmus, circadianer---+ Cir-
cadianer Rhythmus Ribonuclease 181, 204,
237,241,242,251 Ribonucleinsaure-+ RNA
346
Ribonucleoproteine 201, 206,211,216,238,251
Ribosephosphatpyrophosphatkinase 260
Ribosomen 231, 240, 243, 245,246-250,254
-, ribosomale Proteine 111, 250, 254
Riesenchromosomen 154-156,234,254,258
Rifamycin 176 Ringkonformation 5-11 Ringverkniifgung 7-10, 12 RNA 236 -, Biosynthese 224,
227-238,241 -, - Regulation durch
Hormone 86, 89, 111, 138, 141, 148, 155, 156, 198, 205, 230-234, 238-244
-, - Transkriptionseinheit 236
-, Messenger-RNA 238-244,246-250
-, - Biosynthese 234, 237,251
-, -, - Regulation durch Hormone 125, 239, 241-243,251
-,- Struktur, Cap-Sequenz 238,247
-, -, - Informosomen 238,247,251,253
-, -,- Poly A-Seg-ment 237, 238,240,251
-, -, - Stabilitat 238, 244,253-255
-,Nuclear-RNA 223, 237, 251
-, - Biosynthese 234, 235,237
-, -, - Regulation durch Hormone 86, 126, 199, 205,240,242,253
-,- Reifung 198,204, 237, 238,243,251,253
-, Ribosomale RNA 250 - , - Biosynthese 156,
204,231 , 232, 234,235, 243,256
-,- Reifung 237,243, 251
-, Transfer-RNA 236, 245-254
-, - Biosynthese 234, 235,237,243,252,254
-,- Methylierung 125, 243,252,254
RNase --> Ribonuclease RNA-Polymerase I 214, 215,
231,232,234-236,243 -, Hormonrezeptor 214,
243,256 -, Inhibitorproteine 156 -, Regulation durch Hormo-
ne 232,240,243,256 - II 126, 225, 227, 231,
234-236 -, EiweiBfaktoren 232 -, Phosphorylierung 111,
232 -, Regulation durch Hormo-
ne 126,153,240 -III 234,235 -, mitochondriale 234 Riickkopplung 99, 102 -, kurze 99 -,negative 94, 96, 123,
131,261 -,positive--> Hohlweg-Ef
fekt -, ultrakurze 96, 99
Salvage-Pathway 111, 260 Samenblase --> Vesikulardriise Samenkanalchen 85 Sauerstoff, aktiver 3 2 Schilddriise 96 Schilddriisenzellen, parafolli-
kulare 90 Schmerz 116 Schwangerschaft 119, 123,
128,267 -, Abbruch 133, 134 -, Serumproteine 133,
218,220,221 -, Steroidstoffwechsel 122,
181, 182, 196 Second-Messenger-Hypothe-
se 72,76 Sekretin 3 Seminalplasma 106 Serin-Pyruvat-Aminotransfe-
rase 149 Serotonin 95-97, 106, 148 Sertolizellen 62, 85, 221 Sesselform 5-8 Sexhormon-bindendes Globu-
lin (SBG) 124, 136, 158, 193,213,219-221
Sexprotein 138, 272 Sexualcyclus 102, 104, 119,
122, 129- 131
Sachverzeichnis
-, EinfluB auf Korpertemperatur 122, 128
-, - auf Membranrezeptoren 82
-, - auf Plasmahormonspiegel 83, 119, 120, 122, 129, 130, 183
-, - auf Steroidausscheidung 181
-, - auf Uterusproteine 120,171,183,207
-, Phasen --> Lutealphase Sexualhormone 3, 69 -, --> Androgene bzw. Ge-
stagene bzw. dstrogene Sexualtrieb 134, 160 Sexualverhalten--> Verhalten Sexualzentrum, Differenzie-
rung 53, 135, 137, 264-267
-, Erotisierungszentrum 265
- , Organisationsgesetz 265 Sialinsaure 73, 81, 82,
84-86 Sichelzellenanamie 257 Sitosterin 66, 68 SKF-525A 44 Sklerotisierung 155 Sofa-Konformation 6 Somatomedin 88, 123 Somatotropin--> Wachstums-
hormon Sorbitdehydrogenase 136 Spermatozoen-Entwick
lung 106 Spermatozyten-Oberflachen-
antigene 134 Spermidin 232 Spermien, kapazitierte 133 Spermiogenese 85, 87,
134-137,263 Spin der Einzelelek-
tronen 33 Spinnbarkeit --> Cervixschleim Spirolacton 158, 162, 163 Spironolacton 162 Squalen 16-19, 23, 24, 26,
68 Squalen-Epoxidase (Squalen-
Monooxygenase) 17,26 Stammzellen 263, 268 Statine 95, 96, 107, 118 Stearinsaureester 17 4 Stein-Leventhal-Syn-
drom 57 Steran 4-7, 9, 12
Sachverzeichnis
Sterilitat 105 Sterin 4-7, 9, 10, 13, 19,
23,181,273 Sterincarbonsaure-Decarb
oxylase 19-21, 26 Sterin-Carrier-Proteine
(SCP) 24 A5-Sterin-A24-Reduktase 26 Sterinsulfatase 25, 56, 169,
172, 173 -, EinfluB von Corticotro
pin 79, 172 -, Inhibitoren 172, 260,
261 Steroide, Biosynthese
13-68, 172 -,- Regulation 69-117 -, - ektopisch ~ Tumoren -, Rezeptoren 96, 157,
199-218,231 -, - Plasmare-
zeptoren 218-222 -, Stoffwechsel 164-197 -,- Halbwertszeit 218 -, Struktur 4-12 -, Transport 200, 205 -, Wirkung, biologisch 3,
118-163, 264-272 -, - molekularbio
logisch 198-262 Steroidacetate 164 Steroiddehydrogenasen ~ Hydroxysteroid-Dehydrogenasen
Steroid-4,5-Dioxy-genase 179
Steroidglucoside 164 Steroidglucuronide 164,
167, 170, 184, 187, 190, 192,194,219
Steroidhydroxylierung ~ Hydroxylierung
Steroid-A-Isomerase 46, 50, 53,55,56,63, 160,169, 172, 173, 183, 213
Steroidkonjugate ~ Konju-gate
Steroidmonooxygenasen ~ Hydroxylasen
Steroidoxidasen ~ Oxidasen Steroidphosphate 164, 174 Steroidreduktasen ~ Reduk-
tasen Steroidresistenz 206 Steroidrezeptoren ~ Steroide Steroidsulfatasen --+ Sterinsul-
fatasen
Steroidsulfate 164, 171-173,184,219,271
Steroidsulfatide 164 Streptomyces spec. 177 - hydrogenans 181, 211,
214,244 Stress 81, 100 Stroma 62, 125 Strophantidin 10 Strukturgen 225, 226, 236 Succinat 77 Succinyl-CoA 144 Sulfat-Adenylyl-Transfe-
rase 171 Sulfatbildung 164, 170-173,
271 Sulfatasen ~ Sterinsulfatasen
bzw. Arylsulfatase Sulfatide 164 Sulfotransferasen (Sulfokina
sen) 27, 165, 168, 170, 171, 191, 195
Superinduktion 255, 256 Superoxid-Anion 32 Synaptosomen 96, 215
Tachysterin 65 Testes 27, 40, 53, 57, 59,
62, 70,82,99, 106,136, 173,221,264
-, EinfluB von Follitropin 85, 86, 138, 221
Testosteron 134-140 -, Biosynthese 41, 44, 49,
53-59,63,140,177 -,- Regulation 59,83 -, Gehalt 59, 140 -, Rezeptoren 136, 211,
212 -, - Nuclearakzeptoren
211 -, - Plasmarezeptoren
193,219-221 -, Stoffwechsel 137, 190 -, - Halbwertszeit 193 -,- Ring A-Reduktion
-+DHT -, - Aromatisierung
59-62, 105, 123, 128, 137,139,193,212,266
-, Struktur synthetischer Androgene 138, 139
-, Wirkung 105, 134-140, 258,265
-,- anabol 135, 137-139 -,- DNA-Synthese 136,
230
347
-, - Enzym- und Protein-synthese 136-139
-,- Glykolyse 136 -,- Membranen 257 -,- RNA-Synthese
241-243,257 -,- zentral 59, 135, 137 -, Zielorgane, akzessorische
Geschlechtsorgane 136, 138,260,262
-,-Leber 140,212 -,- Muskeln 208, 212 -,- Niere 59, 136, 138,
139,160,212,260,272 -,- Testes 83, 136 Testosteronacetat 41, 54 Testosteron-17 P-Dehydro-
genase~ 17(3-Hydroxysteroid-Dehydrogenase
Testosteronfettsaure-ester 174
Testosteron-17 (3-glucu-ronid 58, 191, 271
Testosteronsulfat 173 . Tetrahydroaldosteron . 189 Tetrahydrocortico-
steron 186 Tetrahydrocortisol 184 Tetrahydro-11-dehydrocorti
costeron 186 Tetrahydro-11-desoxycor
tisol 186 Tetrahydropteridine 31 3a, 11(3,20(3,21-Tetrahydroxy-
5a-pregnan 186 3a, 17a,20a,21-Tetrahydroxy-
5{3-pregnan 186 3a, 11(3,20(3,21-Tetrahydroxy-
5{3-pregnan-18-on 189, 190
3a,17a,20a,21-Tetrahydroxy-5(3-pregnan-11-on 184, 185, 187
3a, 17 a,20{3,21-Tetrahydroxy-5(3-pregnan-11-on 185
3a, 11(3, 17 a,21-Tetrahydroxy-5{3-pregnan-20-on 184, 185
11{3,17a,20(3,21-Tetrahydroxy-4-pregnen-3-on 184
3(3,11{3,17a,21-Tetrahydroxy-5-pregnen-20-on 50
tfm-Syndrom 213, 257 Thekaluteinzellen 62 Thekazellen 62 Theophyllin 111
348
Thermosensitive Neuro-nen 122, 128
Thromboembolische Erkran-kungen 131, 215
Thromboxan B2 115 Thymidineinbau 229 Thymidinkinase 111, 149,
230,259 Thymocyten 148 Thymus 208, 209, 257 Thyreotropin 81, 85, 106 Thyroliberin 88, 106 Thyroxin 87, 96 Thyroxin-bindendes Glo-
bulin 124 Tomkins' Modell 254-256 Transcalciferin 222 Transcortin 124, 184, 189,
193,210,219-221 Transfer-Ribonucleinsiiure
-->RNA Transhydrogenase, energieab
hiingige 77, 78 Transkription--> RNA-Syn
these Translation --> Proteinsyn-
these Transportprozesse 77 -, Aminosiiuren 86, 148, 257 -, Glucose 148, 257 -,Natrium 116, 117, 141,
151,259 -, Nucleoside 257 -, Steroide 200, 205 -, Thymidin 230 Trengeston 120 Triamcinolon 150 Triamcinolonacetonid 151 Tricarbonsiiurecyclus 36,
142, 144 2,22,25-Tridesoxy-a
ecdyson 67 Triglyceridfreisetzung --> Li
polyse 3a,16a,17{3-Trihydroxy-5a
androstan 192 3a,16a,17{3-Trihydroxy-5{3-
androstan 192 3a, 17 {3, 18-Trihydroxy-5a
androstan-3-on 193 3{3,16a,17{3-Trihydroxy-5-
androsten 192 3{3,5, 14-Trihydroxy-(5{3, 14{3)
card-20(22)-enolid-19-on 10
2{3,3{3,14a-Trihydroxy-5{3-cholesta-7-en-6-on 67
3,16a,17{3-Trihydroxy-1 ,3,5(10)-ostratrien --> Ostriol
1a,3{3,25-Trihydroxy-9,10-seco-cholesta-5,7 ,10(19)trien -->1a,25-Dihydroxycholecalciferol
11{3,17a,21-Trihydroxy-1,4-pregnadien-3,20-dion --> Prednisolon
3a,6a,20a-Trihydroxy-5{3-pregnan 182
3{3,16a,20a-Trihydroxy-5{3-pregnan 182
3{3,16a,20a-Trihydroxy-5apregnan 183
3a,11{3,21-Trihydroxy-5apregnan-20-on 186
3a,11{3,21-Trihydroxy-5{3-pregnan-20-on 186
3a,11{3,17a-Trihydroxy-5{3-pregnan-20-on 186
3a, 17 a,20a-Trihydroxy-5{3-pregnan-11-on 186
3a, 17 a,21-Trihydroxy-5{3-pregnan-20-on 186
3a, 17 a,21-Trihydroxy-5{3-pregnan-11 ,20-dion 185
3a, 11{3,21-Trihydroxy-5{3-pregnan-18,20-dion 189, 190
3{3, 11{3,21-Trihydroxy-5{3-pregnan-18,20-dion 190
3a, 11{3,21-Trihydroxy-5apregnan-18,20-dion 190
3{3,17a,21-Trihydroxy-5-pregnen-20-on 50
11{3,17a,21-Trihydroxy-4-pregnen-3,20-dion --> Cortisol
11{3,18,21-Trihydroxy-4-pregnen-3,20-dion 52
2,2, 17 a,-Trimethyl-17 -hydroxy-4,9,11-ostratrien-3-on 159
Triosephosphatisomerase 142, 143
Tropine --> Proteohormone Tryptophanabbau 144, 145 Tryptophan-2,3-dioxy-
genase 144, 145 Tryptophan-5-monooxyge-
nase 148 Tubulin 110 Tubulus-Apparat 85, 86 Tumoren 70, 217, 251, 260 -, Membranrezeptoren 57,80
Sachverzeichnis
-, Proteohormon-bil-dende 63, 70,80,84,85
-, Steroid-bildende 27, 57, 62,80
Tyrosin 155 -, Abbau 145, 146 -, Bildung 145 Tyrosinaminotransferase
145, 146, 149, 162, 254-256,261
Tyrosin-3-monooxyge-nase 150, 155
UDP-Galactose 146 UDP-Giucose 166-168 UDP-Giucose-Dehydro-
genase 166, 167 UDP-Giucosyltransfe
rase 168 UDP-Giucuronosyltrans
ferase 167, 168 UDP-Giucuronsiiure
166-168 UDP-Xylose Urocortisol Urocortison Uteroglobin
222
170 184, 185 185 119, 120, 130,
Uterus, Muskulatur 116 -,RNA 240 -, Schleimhaut 119, 122,
129 -, Steroidmetabolite 177,
183 -, Steroidrezeptoren 207,
210,214-216,222 -, Wachstum 123, 138, 212 Utilisationstherorie 164
Vagina, Schleimhaut 125, 126, 138, 212
-, Steroidrezeptoren 211 -, Tumoren 128 Valinverwertung zur Gluco-
neogenese 144 Vasodilatation 116, 123 Vasokonstriktion 116 Vasopressin 100 Verhalten, EinfluB von An-
drogenen 137,138,212 -, EinfluB von Cortico-
iden 141, 151, 152 -,- von Ostradiol 128,215 -, - von Peptiden 80 -,- von Progesteron 122 -, sexuelles 137, 212, 215,
264,265
Sachverzeichnis
Vermeideverhalten, aktives 80
Vesikulardriise 59, 115, 133,137,260,262
-, Testosteronbindung 212 -, tRNA-Synthese 243 -, Wachstum 87, 128, 135,
136, 138 Virilisierung 193, 221 -, Adrenogenitales Syn-
drom 52, 57, 267 -, p-Aminoglutiithimid 43 -, Anabolika 139 -, synthetische Gesta-
gene 267 Vitamin C -> Ascorbinsiiure Vitamin 0 2 -> Ergocalciferol Vitamin 0 3 -> Cholecalciferol
·vitellogenin 124, 156
Wachstumshormon 87, 88, 106, 138
Wannenform 5-8, 10 Wasserstoffbriicken-Bin
dung 226,238
Xyloside 170 Xylosyltransferase 170
Zellcyclus 108, 139, 229, 230,255,264
Zelldifferenzierung 3, 70, 82, 85, 108, 118, 135, 141,209,263-272
Zellteilung 264 Zellwachstum 108 Zentrales Nervensystem
(ZNS) 94
349
-, Steroidrezeptoren 96 -, Wirkung, Corticotro-
pin 71,80 -, - cyclische Nucleo-
tide 108 -, - Peptide 80 -,- Prolactin 71, 88 -,- Prostaglandine 95,
112 -, - Proteohormone 71 -,- Steroide 118, 152 Zink 59,92 Zona fasciculata 48, 49, 51,
74 - functionalis 123 - glomerulosa 48, 49, 51,
74,93 - reticularis 48, 49, 51, 74 Zymosterin 21, 26
P. v. Sengbusch Einfiihrung in die Allgemeine Biologie Hochschultext 221 Abbildungen und 64 Schemata. VI, 475 Seiten. 1974 DM 29,80; US$ 12.30 ISBN 3-540-06810-4 Inhaltsiibersicht: Organisationsebenc: Zelle. - Organisationsebene: Vielzeller. - Organisationsebene: Gesellschaften. -Evolution.
Biologie Ein Lehrbuch ftir Studenten der Biologie Gemeinschaftlich verfaBt von zahlreichen Fachwissenschaftlem Herausgeber: G. Czihak, H. Langer,H. Ziegler 957 Abbildungen, 2 Falttafeln. XXIII, 837 Seiten. 1976 Gebunden DM 58,- ; US S 23.80 ISBN 3-540-05727-7 Jnhaltsiibersicht: Bau und Leistungen der Zellen: Cytologie. - Strukturen und Funktionen derOrganismen: Genetik. F ortpflanzung und Sexualitiit. Entwicklung. Bau und Funktion pflanzlicher und tierischer Organe. Strukturelle und funktionelle Integration im Gesamtorganismus. Verhalten. - Die Organismen in Population en: Okologie. Biogeographie: Verbreitung der Pflanzen und Tiere. Evolution. Grundlagen und Ziele der biologischen Systematik. Stammbaume der Pflanzen und Tiere. Sachverzeichnis
Physiologische Chemie Eine Einft.ihrung in die medizinische Biochemie ft.ir Studierende der Medizin und A.rzte Von H. A. Harper, G. Li:iffier, P. E. Petrides, L. Weiss. 644 Abbildungen, 189 Tabellen. XI, 940 Seiten. 1975 DM 88,-; US$ 36.10 ISBN 3-540-07490-2 Inhaltsiibersicht: Teil A: Stoffe und Stoffwechsel der Zelle. Stoffe: Bausteine der Zelle: Wasser- und Bioelemente. Kohlenhydrate. Lipide. Nucleotide und Polynucleotide (Nucleinsauren). Aminosauren und Polyaminosauren (Proteine). Stoffwechsel: Energie- und Materieumsatz der Zelle: Mechanismus und Regulation der Proteinbiosynthese. Enzyme. Bioenergetik und biologische Oxidation. Citratcyclus. Stoffwechsel der Kohlenhydrate. Stoffwechsel der Lipide. Stoffwechsel der Aminosauren. Stoffwechsel der Purine und pyrimidine. - Porphyrine und Gallenfarbstoffe. Grundlagen der Emahrung. Wasserund Elektrolyt-Haushalt. Spurenelemente und Vitamine. - Teil B: Struktur und Stoffwechsel der Gewebe: Hormone. Gastrointestinaltrakt. Leber. Blut. Muskelgewebe. Binde- und Stiitzgewebe. Nervengewebe. Immunsystem. Nieren und Urin. - Hinweisindex zum Gegenstandskatalog Physiologische Chernie. - Sachverzeichnis.
C. Bresch, R. Hausmann Klassische und Molekulare Genetik 3. erweiterte Auflage. Zahlreiche Abbildungen, 32 Tafeln. XI, 415 Seiten. 1972 DM 42,- ; US$ 17.30 ISBN 3-540-05802-8
Springer-Verlag Berlin Heidelberg New York
Grundrill der Sinnesphysiologie Herausgeber: R. F. Schmidt Mit Beitragen von H. Altner et al. 2. Auflage. 122 Abbildungen, 109 Testfragen zur Selbstkontrolle. X, 249 Seiten. 1976. (Heidelberger Taschenbi.icher, 136. Band. Basistext Medizin) DM 18,80; US S 7.80 ISBN 3-540-07587-9 Inha/tsiibersicht: Allgemeine Sinnesphysiologie. - Somato-viscerale Sensibilitat. - Physiologie des Sehens. - Physiologie des Horens. -Physiologie des Gleichgewichtssinnes.- Physiologie des Geschmacks.Physiologie des Geruchs. - Durst und Hunger: Allgemeinempfindungen. - Antwortschli.issel. - Sachverzeichnis.
W. F. Ganong Lehrbuch der Medizinischen Physiologie P.ie Physiologie des Mensch en ftir Studierende der Medizin und A.rzte. Ubersetzt, bearbeitet und erganzt von W. Auerswald in Zusammenarbeit mit B. Binder, A. Haidenthaler, J. Mleczoch 3., vollig neu bearbeitete und erweiterte Auflage. 545 Abbildungen, 150 Tabellen, 1 Anhang, XVIII, 811 Seiten. 1974 DM 48,-; US S 19.70 ISBN 3-540-06440-0 Inhaltsiibersicht: Physiologie der Nerven- und Muskelzellen. Funktionen des Nervensystems. Endokrinologie und Zwischenstoffwechsel. Gastrointestinale Funktionen. Zirkulation. Atmung. Nierenfuktion, Wasser- und Elektrolyt-Haushalt.
J. van Lancker Molecular and CeUular Mechanisms in Disease 411 figures, 68 tables. XX, 1168 pages. 1976 Cloth DM 362,-; US S 148.50 (in 2 parts, not available separately) ISBN 3-540-06932-1 Contents: Cellular Sources of Energy. - Determination of Cellular Specificity. -Inborn Errors of Metabolism. -Malnutrition. -Calcium and Phosphorus Metabolism. - Iron and Bile Pigment Metabolism. -Blood Coagulation. - Hormones. - Alterations of Body Fluids and Electrolyte Metabolism. - Cellular Death and Degeneration. - Blood Lipids in Arteriosclerosis and Hyperlipidemia. - Radiation. - Inflammation. -Immunopathology. -Regeneration, Hypertrophy, and Wound Healing.- Cancer.
E. Gurpide Tracer Methods in Hormone Research 35 figures. XI, 188 pages. 1975 Cloth DM 72,-; US$ 29.60 ISBN 3-540-07039-7 Contents: Rates in Open System in the Steady State: Definitions and Relations. -Infusion of Tracers at a Constant Rate. -Rapid Injection of Tracers. - Tracer Kinetics in Compartmental Models. - Interpretation of Isotopic Data from Blood-Borne Compounds. - Rates of Secretion and Metabolism of Hormones Estimated from Specific Activities of Urinary Metabolites. - In vitro Tracer Superfusion Experiments.
Springer-Verlag Berlin Heidelberg New York