Post on 06-Sep-2020
Zur Frage 1: Wo liegt der Ursprung der somatischen Stammzellen?
1Georg Weitzer
4. Doppelstunde ESF II WS2016
, WT1
2Department für Medizinische BiochemieGeorg Weitzer
1.5.1.Wie entsteht das Herz während der frühe Embryogenese der Maus und des Menschen?1.5.1.2. Was geschieht nach dem Einnisten des Embryos?
1.5.1.1.Entstehung des Epiblasten siehe 3.Doppelstunde
Ao. Univ. Prof. Dr. Georg Weitzer ESF-II/4 WS12
Developmental Biology page 354
Sagittal / Medianebene
cranial /rostral
caudal
mediallinks lateralrechts lateral
Dorsal, posterior
ventral, anterior
Siehe auch: https://de.wikipedia.org/wiki/Anatomische_Lage-_und_Richtungsbezeichnungen
Frontal Ebene
Transverse Ebene
Georg Weitzer
Department für Medizinische BiochemieGeorg Weitzer
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DOI: http://dx.doi.org/10.1093/cvr/cvs270
doi: 10.1242/dev.01248
E7.5 N2 Mouse Heart
doi:10.1006/dbio.1996.0046
E13.5
doi: 10.1073/pnas.0609628104
Hyperplasia
DOI 10.1002/dvdy.22449
E8.5E8.0
doi:10.1016 /S0008-6363(03)00246-3
1.5.1.3. Wo, wann und wie kommt es zur Kardiogenese während und nach der Gastrulation?
somatic
splanchnic
Georg Weitzer
Organisational unitPresentation title / topic OR Presenter's name
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From http://dingbatland.tumblr.com/post/141110542932/physio-fact-of-the-day-3-acrobatic
Ao. Univ. Prof. Dr. Georg Weitzer ESF-II/4 WS12
Ao. Univ. Prof. Dr. Georg Weitzer ESF-II/4 WS12
File:Gray19 with color.pnghttp://en.wikipedia.org/wiki/File:Gray19_with_color.png
Ao. Univ. Prof. Dr. Georg Weitzer ESF-II/4 WS12
doi: 10.1101/cshperspect.a013847
Georg Weitzer
12Department für Medizinische BiochemieGeorg Weitzer
Heart DEvelopment
Ao. Univ. Prof. Dr. Georg Weitzer ESF-II/4 WS12
Contributions from the second heart field
Ao. Univ. Prof. Dr. Georg Weitzer ESF-II/4 WS12
Entwicklung des Herzens während der Embryogenese
Nat Rev Mol Cell Biol. 2013 Aug;14(8):529-41. doi: 10.1038/nrm3619. Epub 2013 Jul 10.Mending broken hearts: cardiac development as a basis for adult heart regeneration and repair.Xin M1, Olson EN, Bassel-Duby R.
Aus MolMed2016
The multifaceted role of Notch in cardiac development and diseaseFrances A. High & Jonathan A. EpsteinNature Reviews Genetics 9, 49-61 (January 2008)doi:10.1038/nrg2279
Overview of cardiac development
Ao. Univ. Prof. Dr. Georg Weitzer ESF-II/4 WS12
Organisational unitPresentation title / topic OR Presenter's name
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Illustrations depict cardiac development with colour coding of morphologically related regions, seen from a ventral view. Cardiogenic precursors form a crescent (left-most panel) that is specified to form specific segments of the linear heart tube, which is patterned along the anterior–posterior axis to form the various regions and chambers of the looped and mature heart. Each cardiac chamber balloons out from the outer curvature of the looped heart tube in a segmental fashion. Neural crest cells populate the bilaterally symmetrical aortic arch arteries (III, IV and VI) and aortic sac (AS) that together contribute to specific segments of the mature aortic arch, also colour coded. Mesenchymal cells form the cardiac valves from the conotruncal (CT) and atrioventricular valve (AVV) segments. Corresponding days of human embryonic development are indicated. A, atrium; Ao, aorta; DA, ductus arteriosus; LA, left atrium; LCC, left common carotid; LSCA, left subclavian artery; LV, left ventricle; PA, pulmonary artery; RA, right atrium; RCC, right common carotid; RSCA, right subclavian artery; RV, right ventricle; V, ventricle.
doi:10.1038/35025190
Organisational unitGeorg Weitzer
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1.5.2. Morphologie und Funktionsweise des adulten Säugetierherzens.
Fig. 1. The adult mammalian heart. The adult mammalian heart is made up offour chambers: the right and left ventricles (RV and LV) and right and left atria(RA and LA). The ventricles are separated by the interventricular septum (IS).The vena cava and the aorta carry the flow of blood to and from the heart,respectively. Blood low in oxygen (blue arrows) from the different tissues iscollected into the right atrium via the superior and inferior vena cava and flowsto the lungs through the right ventricle. Oxygenated blood (red arrows) from thelungs flows into the left atrium and is pumped into the aorta by the left ventricle.This system allows oxygenated and non-oxygenated blood to be completelyseparate.
Georg Weitzer
Nat Rev Mol Cell Biol. 2013 Aug;14(8):529-41. doi: 10.1038/nrm3619. Epub 2013 Jul 10.Mending broken hearts: cardiac development as a basis for adult heart regeneration and repair.Xin M1, Olson EN, Bassel-Duby R.
Aufbau des Säugetierherzens und die darin vorkommenden wichtigsten Zelltypen
SinusknotenAtrio-Ventriklärknoten
Reizleitungssystem:
Hiss-Bündel
Purkinje-Fasern
EpikardiumMyokardiumEndokardiumHerzklappen (4)
Erstes Herzfeld = Laterales MesodermZweites Herzfeld = Rachen MesodermCraniale Neuralleistenzellen Proepicardiales OrganMesangioblasten der Aorta
SchrittmacherzellenAtriale KardiomyozytenVentrikuläre KardiomyocytenKardiale FibroblastenEndothelzellen, glatte Muskelz.Telozyten, PerizytenMastzellen, Makrophagen, …Herzstammzellen
Aus MolMed2016
Department für Medizinische BiochemieGeorg Weitzer
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DOI: http://dx.doi.org/10.1093/cvr/cvs270
E7.5
1.5.3. Zelluläre Stadien im Laufe der Kardiogeneses
https://www.researchgate.net/figure/224929158
Organisational unitGeorg Weitzer
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Alessandra Morettis Homepage: http://www.med1.mri.tum.de/ru/node/169
Cardiogenesis in mammals at the cellular level II
Cardiacstemcells
Endocardialprogenitors
Department für Medizinische BiochemieGeorg Weitzer
Department für Medizinische BiochemieGeorg Weitzer
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Detaillierte Übersicht über die Kardiomyogenese
DOI: http://dx.doi.org/10.1093/cvr/cvs270
Cardiogenesis in mammals at the cellular level III
• The heart is composed of some 20 different cell types,
• but of only ~ 20% cardiomyocytes, occupying ~ 80% of the space,
• and of > 50% cardiac fibroblasts, occupying only ~ 20% of the space.
• Prevalence of cardiac stem cells: 1:30.000 -1:500.000
Organisational unitGeorg Weitzer
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1.5.4. Molekulare Aspekte der frühen Kardiogenese (Teil 1)
Department für Medizinische BiochemieGeorg Weitzer
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DOI: http://dx.doi.org/10.1093/cvr/cvs270
E7.5
1.5.4. Molekulare Aspekte der frühen Kardiogenese (Teil 1)
Organisational unitGeorg Weitzer
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Detailliertere Beschreibung der Gastrulation:
http://www.sciencedirect.com/science/article/pii/S0959437X10000973
http://www.sciencedirect.com/science/article/pii/S0925477397001238
http://www.nature.com/nrg/journal/v8/n5/full/nrg2084.html
Sehr gute Bilder zur Herzentstehung:
http://circres.ahajournals.org/content/111/10/1323.long