45. Internationaler MEDICHEM Kongress 2017 · 2017 eingereicht werden, diese werden anschließend...

45. InternationalerMEDICHEMKongress 2017

13.–15. September 2017Wien | Österreich

2 45. Internationaler MEDICHEM Kongress 13.–15. September 2017 · Wien | Österreich 3

HERZLICHWILLKOMMEN

ALLGEMEINEINFORMATION

Liebe Kolleginnen und Kollegen!Sehr geehrte MEDICHEM-Mitglieder!

Wir freuen uns, Sie zum 45. Inter-nationalen MEDICHEM Kongress vom 13. bis 15. September 2017 in Wien willkommen heißen zu dürfen. MEDICHEM ist eine inter-nationale wissenschaftliche Ge-sellschaft, beschäftigt sich seit 45 Jahren mit arbeits medizini-schen und umweltmedi zinischen Fragestellungen, die in Zusam-menhang mit der Produktion und Weiterverarbeitung von Chemi-kalien stehen. Als Kongressauftakt ist der Abend empfang am Mittwoch, 13. September 2017, gedacht. In den darauffolgenden zwei Ta-gen, Donnerstag, 14., und Freitag, 15. September 2017, erwarten Sie zahlreiche interessante Vorträge, Diskussionen und Möglichkeiten, neue Kontakte zu knüpfen und sich fachlich auszutauschen.Die MEDICHEM ist eine einzigartige Informations- und Kommunika-tionsplattform für Spezialisten der Arbeitsmedizin und ein hervor-ragendes Forum, um sich mit Kol - legInnen der Toxikologie, Psycholo-gie, Ökologie und anderen Diszipli-nen austauschen zu können.Zu unserem Kongressthema „Ar-beitsbedingte Krebserkrankun-gen“ werden Vortragende aus dem universitären Bereich und auch der Industrie aktuelle The-men und Daten vorstellen. Wenn-

TAGUNGSBÜROAustropa InterconventionVerkehrsbüro Kongress Management GmbHLassallestraße 3, 1020 WienTel.: +43 1 588 00 534Mail: [email protected]: www.medichem2017.eu

TAGUNGSGEBÜHREN

Early Bird Tagungsgebühr 1-Tages-Pass/Tag 1.12.2016–15.5.2017 16.5.–15.9.2017

MEDICHEM-Mitglieder EUR 400 EUR 450 EUR 150

Nicht-Mitglieder * EUR 450 EUR 500 EUR 150

Nur Pre-conference Workshop EUR 120

Begleitperson ** EUR 100 EUR 120

Pre-conference Empfangund Kongress Dinner ** inkludiert inkludiert nicht inkludiert

* Nicht-Mitglieder können eine MEDICHEM Mitgliedschaft für 40 EUR pro Jahr oder 100 EUR für 3 Jahre beantragen (individuelle Mitgliedschaft), um von der vergünstigten Tagungsgebühr zu profitieren.

** Die Gebühr inkludiert: Führung durch das Technische Museum und Empfang im Austria Trend Hotel Park Royal Palace, sowie das Konferenz Dinner im Restaurant Rathauskeller

Offene Vorträge: Sie sind herzlich eingeladen, eine Präsentation zu einem arbeitsmedizinisch bezogenen Thema bzw. zum Thema Umwelttoxikologie einzureichen. Die Beitragsannahme ist abhängig vom zeitlichen Einlangen der Einreichung. Beitragsvorschläge können bis 30. März 2017 eingereicht werden, diese werden anschließend vom Wissenschaftlichen Komitee beur-teilt. Wird Ihr Beitrag angenommen, so erhalten Sie bis Ende April 2017 eine Rückmeldung.

Weitere Informationen entnehmen Sie bitte auf: http://medichem2017.eu

MEDICHEM Preis, Stipendien und das „Young Professional“ Programm: Der MEDICHEM ist die berufliche Weiterentwicklung von ArbeitsmedizinerInnen ein besonderes Anliegen. Daher gibt es die Möglichkeit eines Stipendiums für Studenten und andere Interessenten. Weitere Informatio-nen finden Sie auf unserer Website im Bereich „Medichem Prize and Scholarships“. Ihren Antrag für ein Stipendium richten Sie bitte an:Prof. Dr. Kenneth A. MundtRamboll Environ28 Amity Street, Suite 2AAmherst, MA 01002 (USA)Phone: +1 413 835 4360 oder +1 413 885 [email protected]

UNTERKUNFT: Wien ist sehr einfach per Flugzeug, Zug und Auto zu erreichen. Jedoch könnte das Parken eine Schwierigkeit darstellen, da es vor allem im Stadtbereich sehr häufig nur kos-tenpflichtige Parkplätze gibt. Im Rahmen der Tagung ist für Sie ein Kontingent an Hotelzimmern von Austropa vorreserviert. Mehr Informationen dazu finden Sie auf unserer Kongress-Website.

DIPLOM-FORTBILDUNGSPROGRAMM DER ÖSTERREICHISCHEN ÄRZTEKAMMER (DFP)Insgesamt können Sie 20 DFP-Punkte für den Besuch der Veranstaltung erhalten. Die Veranstal-tung wird bei der Österreichischen Ärztekammer mit 15 DFP und der Workshop am Mittwoch mit 5 DFP eingereicht. Sie erhalten nach dem Kongress eine Teilnahmebestätigung.

gleich sich durch die ver besserten Arbeitsbedingungen viele Gefähr-dungen bereits reduziert haben, so bleiben nach wie vor Risiken in der Arbeitswelt bestehen. Die geschätzte Zahl an ungemelde-ten Fällen von arbeitsbedingten Krebserkrankungen – bedingt durch vermeidbare Karzinogen-exposition – ist nach wie vor sehr hoch. Ein weiterer Schwerpunkt liegt auf potentiel len Einflüssen anderer arbeitsbezogener Fakto-ren wie z.B. Schichtarbeit auf das Krebsrisiko.Ein eigener Teil des Kongresses wird freien Vorträgen gewidmet, welcher Mitgliedern von MEDI-CHEM und anderen Interessier-ten die Möglichkeit geben wird, Ideen zu diskutieren und neueste Erkenntnisse mit der MEDICHEM Community zu teilen.

Wir freuen uns sehr auf Ihre ge-schätzte Teilnahme an der MEDI-CHEM 2017.

Mit herzlichen Grüßen aus Wien beziehungsweise aus Südafrika

Dr. Murray CoombsPräsident der MEDICHEM

Prim. Priv.-Doz. Dr. Robert Winker Vorsitzender des Organisationskomitees


RAHMENPROGRAMM

PROGRAMMMITTWOCH13. SEPTEMBER

ABENDEMPFANG

Mittwoch13. September 201717.00–20.00 Uhr

Führung durch das Technische MuseumMariahilfer Straße 2121140 Wien17.00–18.00 Uhrwww.technischesmuseum.at

AbendempfangAustria Trend HotelPark Royal Palace Vienna Schlossallee 8, 1140 Wien18.00–20.00 Uhr www.austria-trend.at/de/ hotels/park-royal-palace

http://medichem2017.eu

KONFERENZ DINNER

Donnerstag14. September 201718.30 Uhr – open end

Restaurant„Wiener Rathauskeller“Rathaus Rathausplatz 1 1010 WienTel. +43 (0) 50876-1001 www.wiener-rathauskeller.at

Empfang durch den Bürgermeister der Stadt Wien

U-Bahn Station U2 „Rathaus“ oder ca. 10 Minuten zu Fuß vom Tagungsort

PRE-CONFERENCE WORKSHOP

12.00–16.00 UhrProf. Dr. Kenneth A. Mundt,Generalsekretär MEDICHEM Environment and Health;Ramboll Environ, Inc.Amherst, Massachusetts, (USA) Prof. Dr. Paolo Boffetta,Icahn School of Medicine at Mount Sinai, New York (USA)

„Arbeitsbedingte Karzinogene“ in 3 Themenblöcken: 1. Einführung in epidemio-

logische Konzepte und Methoden

2. Etablierung von Kausal-zusammenhängen

3. Methoden zur Gefährdungs-beurteilung

Separate Registrierung, mit zusätzlichen Kosten verbunden. Kein Englisch-Deutsch-Dolmetsch beim Workshop.

ABENDEMPFANG

17.00–18.00 UhrFührung durch das Technische Museum Wien,Mariahilfer Straße 212,1140 Wien

18.00–20.00 Uhr Empfang im Austria Trend Hotel Park Royal Palace Vienna, Schlossallee 8, 1140 Wien

Bustransfer vom Tagungsort zum Technischen Museum um 16.15 Uhr, Abfahrtsort Hotel de France.


PROGRAMMDONNERSTAG

14. SEPTEMBER

PROGRAMMDONNERSTAG14. SEPTEMBER

8.30 Uhr Tagungseröffnung

Musikalischer Empfang: Camerata Medica Wien

Begrüßung durch den Präsidenten der MEDICHEM Dr. W. Murray Coombs, Health Director, The Dow Chemical Company, Südafrika

Begrüßung durch Younion – Die Daseinsgewerkschaft Ing. Christian Meidlinger, Vorsitzender der Younion, Vizepräsident der KFA

Begrüßung durch die AUVA DI Georg Effenberger, AUVA-Hauptstelle, Leiter der Abteilung für Unfallverhütung und Berufskrankheitenbekämpfung

Begrüßung durch die Ärztekammer für Wien a.o. Univ.-Prof. Dr. Thomas Szekeres, Präsident der Österreichischen Ärztekammer (ÖÄK)

VORMITTAG | TAG 1 Vorsitz: Dr. Martin Kuster, Head Corporate Health & Biosafety Novartis Business Services, Basel (Switzerland)Dr. Dirk Pallapies, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr-Universität Bochum (IPA), Germany

Risk classification and global burden09:00–09:15 Overview and introduction into the topic Prim. Priv.-Doz. Dr. Robert Winker Head of Health- & Prevention Center of the KFA, Vienna (Austria)09:15–10:00 Occupational carcinogens: approaches for Professor Dr. Paolo Boffetta hazard identification and risk assessment Icahn School of Medicine at Mount Sinai, New York (USA) 10:00–10:45 The global burden of disease due to Professor Dr. Marilyn Fingerhut occupational carcinogens Vice President ICOH, Alexandria (USA), Consultant to NIOSH in Washington, DC (USA)10:45–11:00 PAUSERisk assessment lung11:00–11:35 Mesothelioma biomarkers Dr. Avi Wiener Faculty of Civil and Environmental Engineering, Technion – Israel Institute of Technology, Haifa (Israel)11:35–12:10 Risk assessment: Early detection of Prim. Dr. Barbara Machan mesotheliomas in case of asbestosis Medical director of the Department for Occupational Diseases and Occupational Medicine of the Rehabilitation clinic Tobelbad, Graz (Austria)

12:10–14:00 MITTAGSPAUSE

NACHMITTAG | TAG 1 Vorsitz: Dr. Andreas Flückiger, Chief Occupational Health Officer, Roche, Basel (Switzerland)Prof. Dr. Kenneth A. Mundt, Environment and Health, Ramboll Environ, Inc., Amherst, Massachusetts (USA)

Risk assessment: exposure scenarios for cancer14:00–14:35 Nanotechnology and cancer risk Dr. Maren Beth-Hübner BG RCI (German Social Accident Insurance Institution for the Raw Materials and Chemical Industry), Heidelberg (Germany)14:35–15:10 Potential health effects of shift work – Dr. Dirk Pallapies current evidence Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr-Universität Bochum (IPA), Germany15:10–15:30 PAUSE15:30–16:05 Shift work and cancer – Dr. Michael Nasterlack overview and BASF example Formerly Occupational Medicine & Health Protection at BASF SE, Ludwigshafen (Germany)16:05–16:40 Causality for occupational cancer Professor Dr. Tee L. Guidotti, MD, MPH in fire fighters Occupational + Environmental Health & Medicine, Washington (USA)

16:40–17:00 Summary of day 1 – Announcements Dr. W. Murray Coombs Health Director, The Dow Chemical Company (South Africa)17:00–18:00 General Assembly Dr. W. Murray Coombs Health Director, The Dow Chemical Company (South Africa)

18:30 h – open end Konferenz-Dinner Empfang durch den Bürgermeister der Stadt Wien im „Wiener Rathauskeller“

Posterbeiträge13:00–13:30 Occupational health and safety risk Bekir Bulut et.al. (presenter and author analysis in a pathology laboratory: Nazim Ercument Beyhun, MD, Assoc. Prof.) Chemical hazards and risks Karadeniz Technical University (Turkey)

Cancer risk assessment of formaldehyde Li Keyong, MSc exposure in a zipper plant Shanghai Institute of Occupational Disease for Chemical Industry (China)

Arsenicosis and skin cancer Dr. Palash Kumar Sanyal Department of Health, Govt. Of Puducherry (India)

Synthetic cannabinoids detected Hulya Savas et.al. (presenter and author in biological samples: Six case reports Nazim Ercument Beyhun, MD, Assoc. Prof.) Karadeniz Technical University (Turkey)

A description of the profile of narcotics and Sinan Zazoglu et.al. (presenter and author new generation psychoactive substances Nazim Ercument Beyhun, MD, Assoc. Prof.) sent by the judical authorities to the Turkish Karadeniz Technical University (Turkey) council of forensic medicine trabzon group chairmanship between 2010–2014

The current activities in Japan to control Ass. Prof. Dr. Keiichi Fujimoto hazardous chemical substances after the Department of hygiene and public Health, case report of bile duct cancer in a printing Osaka (Japan)

factory in Osaka

Während des gesamten Kongresses Simultan-Dolmetsch vorhanden.



PROGRAMMFREITAG15. SEPTEMBER

Medichem Young Professional Award14:00–14:10 Occupational cadmium exposure and Dr. Sandra Wonisch renal cancer: the latest Austrian notified AUVA Rehabilitationsklinik Tobelbad (Austria) occupational cadmium renal cancer14:10–14:20 Occupational exposure to ultrafine Dr. Galateja Jordakieva particles in police officers: No evidence Medical University Vienna (Austria) for adverse respiratory effects 14:20–14:30 Medichem Young Professional Award ceremonyStipendien14:30–14:40 Academia versus industry: variances at chemistry Dr. Elana Venter research laboratories University of Johannesburg (South Africa)14:40–14:50 Obstructive sleep apnea in patients with cancer: Amir Radfar, MD, MPH Is there any link? A case of a quantitative Babol university of Medical sciences (Iran) descriptive (cross-sectional) study14:50–15:00 Study of social, economic and adverse health Dr. Palash Kumar Sanyal effects of chronic arsenic poisoning in Department of Health, Purbasthali 1 Block, Burdwan District, West Bengal Govt. of Puducherry (India)

15:00–15:10 Risk assessment on inhalation exposure Assoc. Prof. Dr. Sunsia Chaiklieng to benzene among gasoline station workers Khon Kaen University (Thailand)15:10–15:20 Could sputum eosinophilia act as a predictive Dr. Mehrzad Ebrahemzadih test for diagnosis of high risk bakery workers Kurdistan University of Medical Sciences, to asthma? Sanandaj (Iran)

15:20–15:35 PAUSEFreie Vorträge15:35–15:45 Comparison of FibroScan® and Fatty Liver Index Mag. Manuela Teufelhart, Bakk., BSc. (FLI) to screen for fatty liver disease in a large Health- & Prevention Center of the KFA, cohort of employees: Where is the optimal cut off? Vienna (Austria)

15:45–15:55 Is there an occupational exposure limit Martin Kuster, MD, MOH for laboratory animal allergens? Novartis Business Services, Basel (Switzerland) 15:55–16:05 Literature review of occupational Wang Jie, MSc benzene-induced leukemia Shanghai Institute of Occupational Disease for Chemical Industry (China)

16:05–16:15 The ACGIH biological exposure index for urinary Dr. Greg Kew arsenic: to adjust for urinary creatinine or not? EOH Workplace Health and Wellness, Cape Town (South Africa)

16:15–16:25 Genetic toxicology testing in drug Stephan Kirchner, PhD development: Relevance of MoA information FA Hofmann-La Roche Ltd, Basel (Switzerland)16:25–16:35 Training occupational safety and health Prof. Dr. Katja Radon (presenter: Luisa Merz) in Latin America University of Munich (Germany)16:35–16:45 Research progress on the health of the body Huang Huato, MSc damage of dimethylformamide poisoning Shanghai Institute of Occupational Disease for Chemical Industry (China)

16:45–16:55 Breaking a vicious circle in chronic migraine Faro T. Owiesy, MD and craniofacial neuralgia treatment: Corona Doctor’s Medical Clinics, Corona, CA (USA) Advantages of De-Novo treatment in reduction of loss of man-hours at work place16:55–17:05 Chemical hazards and risks in hazelnut Gamze Can et.al. (presenter and author and tea agriculture Nazim Ercument Beyhun, MD, Assoc. Prof.) Karadeniz Technical University (Turkey)

PROGRAMMFREITAG

15. SEPTEMBER

VORMITTAG | TAG 2 Vorsitz: Dr. Michael Nasterlack, Formerly Occupational Medicine & Health Protection at BASF SE, Ludwigshafen (Germany)Dr. Evelyne Wohlschläger-Krenn, Deputy Head of Health- & Prevention Center of the KFA, Vienna (Austria)

Risk management: exposure scenarios for cancer09:00–09:35 Management of exposure to genotoxic and Dr. Andreas Flückiger carcinogenic agents in the pharma industry Chief Occupational Health Officer, Roche Basel (Switzerland) 09:35–10:10 Low level exposure to wood dust – Priv.-Doz. R-Ing. Dr. Georg Wultsch introduction of an Austrian study and Scientific Director, risk management of wood exposure AMEZ – Occupational medical center, Graz (Austria) MedUni Graz, Graz (Austria)

10:10–10:45 Risk management in the Prof. Dr. Kenneth Mundt semiconductor industry Environment and Health, Ramboll Environ, Inc. Amherst, Massachusetts (USA)10:45–11:05 PAUSE

NACHMITTAG | TAG 2 Vorsitz: Prof. Dr. Michael Kundi, Head of the Institute for Environmental Hygiene, Medical University Vienna (Austria)Dr. Hans Mooshammer, Institute for Environmental Hygiene, Medical University Vienna (Austria)

Environmental carcinogenicity11:05–11:40 Hexachlorobenzene: Prof. Dr. Michael Kundi Is there a carcinogenicity issue? Head of the Institute for Environmental Hygiene, Medical University Vienna (Austria)11:40–12:15 The effects of environmental pollutants Dr. Avi Wiener on animals and humans Faculty of Civil and Environmental Engineering, Technion – Israel Institute of Technology, Haifa (Israel)12:15–12:50 Bladder cancer screening Dr. Dr. MSPH BS Thomas Bender in an occupational cohort Associate Health Services Director & Epidemiologist at The Dow Chemical Company, Midland, Michigan (USA)12:50–14:00 MITTAGSPAUSE

Vorsitz:

Prim. Dr. Erich Pospischil Head of the Occupational- and Social Medicine Center Mödling (Austria)

OA. Priv.-Doz. Dr. Thomas Scherzer Health- & Prevention Center of the KFA, Vienna (Austria)

FREIE VORTRÄGE · STIPENDIEN · PREISE



Faculty of Civil and Environmental Engineering, Technion – Israel Institute of Technology, Haifa (Israel)


ABSTRACTSABSTRACTS

14. September 2017, 9:00

Overview and introduction into the topic

Prim. Priv.-Doz. Dr. Robert Winker Head of Health- & Prevention Center of the KFA, Vienna (Austria)

The presentation will mainly focus on recent hu-man literature of occupational carcinogens and ex-posures scenarios. As a starting point an appraisal order for a case of death that was assigned by the Austrian General Accident Insurance Company will be presented. The case reveals the difficulty of establish ing a causal connection between work and disease in general. Then occupational cancer frequencies will be related to cancer frequencies in Austria and a subsequently discrepancy to inter-national publications will be addressed. Although some hazards may have been removed others may remain and the estimated number of unreported cases of occupational cancers due to occupational literature still continues to be high. Recent ILO estimates indicate that approximately 666.000 fatal work-related cancers occur every year. At the end of the talk reasons for the high number of unknown cases and improvement potentials for the future will be identified.

14. September 2017, 9:15

Occupational carcinogens: approaches for hazard identification and risk assessment

Professor Dr. Paolo Boffetta Icahn School of Medicine at Mount Sinai, New York (USA)

The evaluation of the carcinogenic potential of oc-cupational chemical exposures has the ultimate ob-jective of preventing cancers. This generally requires several steps, including hazard evaluation and risk assessment on which interventions may be based that reduce exposures to acceptable levels of risk. To determine whether a chemical is a cancer hazard, i.e., capable of causing human cancers, the totality of published evidence is critically reviewed and

synthesized, and a causal determination made. The paradigm of risk assessment is based on the inte-gration of hazard identification, models of carcino-genesis and exposure levels to produce estimates of cancer risks for specific exposure circumstances. In some instances, however, a classification of a chem-ical as a human carcinogen may not be followed by considerations of the risk under different exposure situations, leading to possible misconception among regulatory authorities and the general public. In other instances, the risk assessment may not fully consider the conclusions of hazard identification have not been integrated by risk assessment, es-pecially where carcinogenicity is uncertain. We will provide a multidisciplinary overview of established and novel approaches for hazard identification and risk assessment of occupational carcinogens, as well as their integration, and discuss challenges in relevant methodological research.

14. September 2017, 10:00

The global burden of disease due to occupational carcinogens

Professor Dr. Marilyn FingerhutVice President ICOH, Alexandria (USA),Consultant to NIOSH in Washington, DC (USA)

This presentation provides an overview of major research activities analyzing the Global Burden of Disease (GBD) due to Occupational Carcinogens, be-ginning with the World Health Organization (WHO) Comparative Risk Assessment effort using 2000 data. The leaders of that effort are now the GBD Team at the Institute of Health Metrics and Evalua-tion (IHME) and an external expert group advises regarding occupational risks. Their GBD 2015 results are available from the IHME site (http://vizhub.healthdata.org/gbd-compare). The main occupa-tional risk factors in terms of deaths were asbestos, diesel, second-hand smoke and silica. Lung cancer was the predominant cancer type, with mesotheli-oma and laryngeal cancer the next most common.

The 2014 ILO fatality estimates indicate that approx-imately 666,000 work-related cancer deaths occur every year, and the 2015 GBD estimate is 489,000 fatalities, while the 2002 WHO estimate is 146,000. The differences appear to be due to criteria for inclusion of risk factors and associated outcomes, but also to some differences in methodology and data sources. Recent EU, national and regional burden analyses provide insights regarding possible improved meth-ods that could be used for global burden analyses. It is highly desirable to assess the methodological differences and possible new approaches for esti-mates of work related deaths and Disability Adjust-ed Life Years (DALYs). This presentation will describe efforts that are currently underway.

14. September 2017, 11:00

Mesothelioma biomarkers

Dr. Avi WienerFaculty of Civil and Environmental Engineering, Technion – Israel Institute of Technology, Haifa (Israel)

Malignant mesothelioma (MM) is a rare, highly ag-gressive, neoplasm arising primarily from serosal cells of the pleural, peritoneal and pericardial cav-ities. MM incidence rate is increasing throughout the world. Asbestos inhalation is the predominant cause and it accounts for near about 80% of cases of malignant pleural mesothelioma (MPM). Epide-miologists predict that in the coming 20 years there will be a dramatic increase incidence rate of MPM due to the extensive exposure to asbestos fibers during the second half of the 20thcentury. Until re-cently the prognosis of patients suffering from MPM was extremely poor: nearly all of them succumbed 6-8 months after diagnosis. Two main reasons were related to this poor outcome: late diagnosis and lack of curing treatment. Nowadays, the prognosis has been improved to some extent, as physicians became more active in enhancing diagnostic pro-cedures to identify patients at earlier stages of the disease, and because of the application of ad-

vanced chemotherpy modalities. Moreover, some surgeons published encouraging data about better survival time after extra pulmonary pneumonec-tomy performed in patients with stage I MPM. The difficulty in such an aggressive procedure has been to differentiate patients most likely to benefit from those destined to die at early stages of the disease. The use of biological exposure indices (BEIs), and especially osteopontin, mesothelin, megakaryocyte potentiating factor, and fibulin has been suggested to screen workers exposed in the past to asbestos. In this lecture, the benefits and disadvantages of routine screening of the population at risk by means of mesothelioma biomarkers will be discussed.

14. September 2017, 11:35

Early detection of lung cancer in asbestos exposed workers

Prim. Dr. Barbara MachanMedical director of the Department for Occupational Diseases and Occupational Medicine of the Rehabilitation clinic Tobelbad, Graz (Austria)

Asbestos was banned in Austria in 1990, about the same time as in our neighbour countries Germany and Switzerland. But in the previous decades, there was a widespread industrial use of asbestos. Be-cause of the long latency between asbestos expo-sure and the outbrake of the malignant diseases the number of asbestos related cancers is still in-creasing in western industrial countries, whereas the use of asbestos was forbidden more than 25 years ago.This development, which was already evident a couple of years ago, led to reflexions about the con-ception of a program destined to former asbestos workers. In 2004 the Austrian Program for Asbestos exposed workers, initiated by the Austrian workers’ compensation board started.The primary medical objective of the program is the detection of lung cancer and the assessment of lung cancer prevalence in asbestos workers. LDCT scans


ABSTRACTSABSTRACTS

socio economic factors. Therefore, evidence is often limited regarding associations between shift sched-ules and health impact as well as with respect to specific recommendations for prevention in shift workers.

14. September 2017, 15:30

Shift work and cancer overview and BASF example

Dr. Michael NasterlackFormerly Occupational Medicine & Health Protection at BASF SE, Ludwigshafen (Germany)

In December 2007, an expert Working Group con-vened by the IARC Monographs programme has concluded that shift work that involves circadian disruption is probably carcinogenic to humans (Group 2A). Since the IARC assessment, several new studies have been published, still with inconclusive results. Hetero geneity of study exposures and out-comes and emphasis on positive but non-significant results make it difficult to draw general conclusions. Also, several reviews and commentaries, which have been published meanwhile, came to equivocal re-sults. Published evidence is widely seen as sugges-tive but not conclusive for an adverse association between night work and breast cancer, and limited and inconsistent for cancers at other sites and all cancers combined. Against this background BASF epidemiologists scru-tinized available data from a large cohort of shift workers and compared them to an equally large control population of dayworkers with similar socio- economic status and workplace exposures. The results of these studies, which covered both cancer mortality and incidence, did not support the IARC ruling. While it cannot be ruled out that some forms of shift work including night work may increase the risk for some cancers in those who perform it, this appears not to be the case in the BASF cohort. Expla-nations for these “non-findings” and possible conse-quences for the organization and management of shiftwork will be discussed.

14. September 2017, 16:05

Causality for occupational cancer in firefighters

Professor Dr. Tee L. GuidottiOccupational + Environmental Health & Medicine, Washington (USA)

Firefighters are exposed to many cancer-causing chemicals generated in fire smoke, diesel exhaust, and other sources incidental to firefighting opera-tions. Inhalational exposures is reduced but not to-tally controlled by self-contained breathing appara-tus (SCBA), which is not typically used in the overhaul phase of firefighting. Skin absorption is also signifi-cant for many chemical hazards. The source of the most potentially carcinogenic chemical exposures is fire combustion, including lignocellulosic mate-rial (wood and paper) but particularly of synthetic polymers. Other products of combustion include: polycyclic aromatic hydrocarbons, some of which are known carcinogens; volatile organic compounds, including benzene, a potent carcinogen, dioxins and furans, halogenated hydrocarbon compounds more familiar as solvents, and 1,3-butadiene. Nitroarene analogues or PAHs come predominantly from die-sel emissions. Fine particulate matter is produced by both fire and diesel exhaust. Other hazardous materials with carcinogenic potential, such as as-bestos and polychlorinated biphenyl compounds (PCBs) may be encountered during particular sit-uations. The cancers most often accepted under presumption legislation as being associated with firefighting are kidney, bladder, testicular, leukemia, non-Hodgkin lymphoma (itself actually a family of cancers), brain, colon and rectum, and prostate. The latter three present particular problems of interpre-tation. The evidence for elevated risk in these and other cancers is mostly epidemiological, with some supportive animal studies. Risk to firefighting may be underestimated because baseline risk is reduced (for example because of low smoking rates).

are performed annually in a high risk group. An im-portant part of the program is a psychosocial care system (case management) for the former exposed persons, for cancer and mesothelioma patients and their families, coordinated by the BBRZ. This program is still unique in Europe in terms of the combination of medical testing, psychological ad-vice, smoking cessation programmes and medical rehabilitation . The program for asbestos exposed workers and the results of the lung cancer screening are content of this presentation.

14. September 2017, 14:00

Nanotechnology and cancer risk

Dr. Maren Beth-HübnerBG RCI (German Social Accident Insurance Institution for the Raw Materials and Chemical Industry), Department of Hazardous Substances and Biological Agents at Work, Heidelberg, (Germany)

Nanotechnology is the design and use of particles as small as one-billionth of a meter. Materials at nano-size can have completely different properties from larger versions, such as unusual strength or the ability to conduct electricity. Nanotechnology holds promise for a vast range of products, including new medicines to treat diseases or delivery systems to get drugs to body parts now hard to reach. It has the potential to provide society with great benefits.However, due to the relative infancy of this field there are many issues that have yet to be resolved. What are the impacts to human health? There may be short, medium and long term effects and the latter can take many years to emerge. Are workers exposed to nanomaterials in its manufacture and industrial use, and if so what are the characteris-tics and levels of exposure? How do nanoparticles interact with the body’s systems? Could nanotech-nologies harm workers’ health and even could cause occupational cancer?

The lecture aims to provide an up-to-date view on the standardization and physical-chemical charac-terization of nanoparticles in the light of cell-particle interactions and toxicological effects, on pulmonary and systemic toxicity, on the mechanisms of toxicity and evaluation of hazards to humans, as well as on the assessment and prevention of exposure to nano particles at the workplace and on the question whether existing regulation can cope with nano-technology.

14. September 2017, 14:35

Potential health effects of shift work current evidence

Dr. Dirk PallapiesInstitute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University (IPA), Bochum (Germany)

IARC’s (International Agency for Research on Cancer) classification of “shiftwork that involves circadian disruption” as probably carcinogenic to humans provided a stimulus for intense shiftwork-related research during the last ten years, especially on the potential association with breast cancer. While it is clear that shiftwork often impairs sleep duration and quality and might be related to various health problems, the most recent large cohort studies on shiftwork and breast cancer do not support the hy-pothesis that shiftwork itself would be a risk factor for cancer. Focussing on the available large cohort studies, the current evidence for shiftwork-related breast cancer will be presented in the context of an overview of the potential impact of shiftwork upon obesity, diabetes, cardiovascular and gastro-intestinal diseases, and upon the accident risk. The potential use of health-related interventions will also be addressed. However, many studies suffer from methodological limitations such as imprecise characterization of shiftwork exposures / circadian disruption, heterogenous endpoint assessment, potential confounding, e.g. by nutrition, smoking,


ABSTRACTSABSTRACTS

15. September 2017, 10:10

Risk management in the semiconductor industry

Prof. Dr. Kenneth MundtEnvironment and Health, Ramboll Environ, Inc. Amherst, Massachusetts (USA)

Moore’s Law, that the number of integrated circuit components doubles biennially, is paralleled by the exponential growth of the semi-conductor indus-try. Employing over a million workers worldwide, semi-conductor manufacturing includes wafer fabri-cation (circuits etched onto silicon wafers); integrated circuit assembly (preparing and testing chips); print-ed circuit board fabrication (etching metal-laminated resin boards) and assembly (cleaning and soldering components). Each step may involve chemicals (e.g., hydrogen fluoride, solvents and cleaners) or metals (e.g., lead, nickel and arsenic). Semiconductor chips and components are fabricated in well controlled environments that protect processes from worker contamination and workers from exposures. Never-theless, occupational exposures in this industry have been claimed to cause cancers, reproductive effects and other problems. These claims generally have not been supported by the epidemiological lit-erature, although relatively few studies have been published. This presentation will provide an over-view of the potential occupational health effects associated with the semiconductor manufacturing process, and health risk management opportunities. While traditional health risk management requires accurate identification and control of exposures, the importance of addressing risk perception and public fears will be highlighted. Ongoing and transparent research, stakeholder participation and precise com-munication are recommended.

15. September 2017, 11:05

Hexachlorobenzene: Is there a carcinogenicity issue?

Prof. Dr. Michael KundiDepartment of Environmental Health, Center for Public Health, Medical University of Vienna (Austria)

There is sufficient evidence that hexachlorobenzene (HCB) causes carcinoma in experimental animals (rats, mice, and hamsters). In humans no consistent evidence has been provided for any cancer to be related to HCB exposure. Consequently, U.S.EPA has classified HCB as a Group B2 carcinogen (prob-able human carcinogen with little or no human data), and IARC as possibly carcinogenic to humans (Group 2B). The different types of cancers observed and differences in dose-response between species and between genders indicate that differences in metabolism or efficiency of metabolic pathways could be responsible. HCB is metabolized in only a small percentage mainly along two metabolic pathways, the oxidative pathways and the gluta-thione conjugation pathway. In animals the most prominent metabolic product is pentachloro phenol, which is, however, only detected in small amounts in humans. Studies in animals suggest that car-cinogenicity may be due to tissue damage (from phenols?) causing inflammation and cell prolifera-tion. This mechanism can be considered as having a threshold since the carcinogenic process cannot take place without the upstream tissue damage. Also porphyria, which is associated with a highly in-creased cancer risk, occurs only at very high levels of circulating HCB, and has only rarely been detected in occupational and never in environmental or alimen-tary exposures except for the incident in Anatolia in the 1950s, is therefore likely not relevant for human cancer.

15. September 2017, 9:00

Exposure of workers in the pharmaceutical industry to occupational carcinogens

Dr. Andreas FlückigerF. Hoffmann-La Roche Ltd, Basel (Switzerland), Group Occupational Health Department

Workers in the pharmaceutical industry may be exposed to carcinogens or potential carcinogens. Such substances can be process chemicals used in the manufacture of active pharmaceutical ingre-dients (APIs), or the APIs themselves may have such characteristics. This presentation focuses on carcino-genetic and potentially carcinogenic APIs and how the pharmaceutical industry manages exposures to such substances.The risk of an adverse effect due to chemical exposure occurring can be expressed by the simple formula: Risk = Hazard x Exposure.The pharma industry applies this formula by basing its risk assessment on both a rigorous hazard assess-ment and exposure assessment. For each API, an oc-cupational exposure limit (OEL) is established that is protective for basically all workers, with exception of OELs for allergens which are not always low enough to avoid elicitation of symptoms in those already sen-sitised. For all carcinogens, regardless of mechanism of action, the paradigm is that there is a threshold below which no additional cases of cancer will occur. If this threshold is not known for a given substance, a TTC-based threshold of 1.5 mcgr/day is assumed for all potential carcinogens that do not belong to the so-called cohort of high concern (e.g. aflatoxin-like-, N-nitroso-, and alkyl-azoxy compounds).These limits values are set in a transparent way and for each limit, a criteria document is established. Workplaces are designed that guarantee that expo-sures are kept below these limit values by technical means with personal protective equipment only used as a back-up for the case of failure of the engineering controls.

15. September 2017, 9:35

Low level exposure to wood dust – introduction of an Austrian study and risk management of wood exposure

Priv.-Doz. R-Ing. Dr. Georg WultschAMEZ Graz, MedUNI Graz, MedUNI Wien

Wood dust was classified by the IARC as a human car-cinogen which causes sinonasal tumours. However, the exposure in different industries varies strongly and the risks of workers depend on the specific situa-tion which can be assessed by the use of biomonitor-ing methods. The aim of this study was to investigate the workers who are exposed to low dust levels (be-low the permitted concentrations) with cytogenetic and biochemical methods. Micronuclei (MNi) which are indicative for genomic damage, nuclear buds which reflect gene amplification, binucleated cells which are caused by mitotic disturbances and acute cyto toxicity parameters (pyknosis, karyorrhexis, condensed chromatin, karyolysis) were monitored in buccal and nasal cells of workers of a veneer factory (n=51) who are exposed to volatile wood-derived com-pounds, in carpenters of a furniture factory which use no synthetic chemicals (n=38) and in a control group (n=65). Additionally, markers were measured in blood plasma which reflect inflammations (C-reactive pro-tein, CRP) and the redox status, namely malondial-dehyde (MDA) and oxidised low density proteins (oxLDL). No induction of micronucle-ated cells was observed in both epithelia in the two exposure groups while all other nuclear anomalies except pyknosis were increased; also one health- related biochemical marker (MDA) was significantly elevated in the workers. Taken together, the results of our study show that exposure to low levels of wood dust does not cause formation of MNi indicating that the cancer risks of the workers are not increased as a consequence of genetic damage while positive re-sults were obtained in earlier studies with workers who are exposed to high dust levels. However, our findings indicate that wood dust causes cytotoxic effects which may lead to inflammations.


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FREIE VORTRÄGE · STIPENDIEN · PREISE

Medichem Young Professional Award

15. September 2017, 14:00

Occupational cadmium exposure and renal cancer: the latest Austrian notified occupational cadmium renal cancer

Dr. Sandra WonischAUVA Rehabilitationsklinik Tobelbad (Austria)

Cadmium and its inorganic compounds are known as malleable metals. Today the major usage of cad-mium is in the production of batteries. A significant occupational exposure also arises from incineration processes like converting of cadmium yielding waste materials.For internal human exposure the most important role plays absorption by inhalation. Absorbed cad-mium is bound to metallothionein and plasma pro-teins and is mainly accumulated in the kidneys. The biological half-life period runs up to 10–30 years. Cadmium and its inorganic compounds were classi-fied by the IARC as a human carcinogen group I in 1993 for lung cancer but not for renal cancer (2012), although there has been sufficient evidence. In 2004 the DFG affirmed the causal connection also based on the classification by the MAK committee for cad-mium being a human carcinogen for lung and renal cancer.In Austria an occupational disease due to cadmium and its compounds is defined in the list for acclaimed occupational diseases as BK 6. Recently one case of renal cancer was accepted caused by earlier 10 years lasting high occupational exposure as a welder 20 years ago. In the present talk established information regard-ing the carcinogenicity of cadmium and its inorganic compounds will be reviewed and the case will be intro duced.

15. September 2017, 14:10

Occupational exposure to ultrafine particles in police officers: No evidence for adverse respiratory effects

Dr. Galateja Jordakieva Medical University Vienna (Austria)

Inhalation exposure to ultrafine particles (UFPs) has been associated with respiratory diseases. Still, there are still open questions regarding quality, threshold levels and concentration of UFPs causing adverse health effects. The impact of occupational exposure to high levels of UFPs (3.34x105 to 7.58x105 particles/cm³) was assessed in 30 healthy police shooting instructors by clinical investigation, self- assessment questionnaire, sputum and spirometry and compared to a control group. General laboratory chemistry parameters, circulating cytokines (inter-leukin [IL]-2, IL-4, IL-5, IL-6, IL-8, interferon-gamma [IFN-y]), and granulocyte macrophage colony-stimu-lating factor (GM-CSF) in serum were measured. UFP exposure was recorded by Scanning Mobility Particle Sizer. Short term exposure (4h) to high levels of UFPs caused an increase of IFN-y in exposed subjects (p = 0.022). 24h after exposure a significant decrease of IgG, albumin fibrinogen and factor VII was found. Neither directly after 4h of higher levels UFPs expo-sure nor 24 h after exposure subjective complaints or objective measurements indicating adverse res-piratory effects in exposed subjects were found.Practical implications: Exposure to high levels of UFPs is not necessarily associated with adverse res-piratory effects in healthy young men.

15. September 2017, 11:40

The effects of environmental pollutants on animals and humans

Dr. Avi WienerFaculty of Civil and Environmental Engineering, Technion – Israel Institute of Technology, Haifa, Israel

Environmental Toxicology deals with the deleterious effects of anthropogenic pollutants and ionizing radiation on plants, animals, and humans. Spillage of industrial and agricultural chemicals in the environ-ment may result in bio-accumulation of toxic xeno-biotics in animals’ tissues with bio-magnification of their concentrations along the food chain. These processes might interfere with the delicate balances prevailing in the community of the ecosystem result-ing in the extinction of species. To avoid these man-made irreversible damages one should be aware of the fate of the emitted pollutants in air, soil and wa-ter, and recognize the mechanisms by which they in-toxicate animals of all sorts, from microorganisms to the most developed mammals. Rachel Carson was the first to draw our attention to the harmful effect to non-target victims of what was considered to be a harmless pesticide. In her book “The Silent Spring” she described the endocrine disruptive effect of DDT to birds causing thinning of their eggs and cessation of the chicks’ maturation. Then after, it was revealed that DDT is an animal carcinogen and its use was banned in 1975. Nevertheless, its remnants are still found nowadays in seals in San Francisco Bay and in white bears in the North Pole. DDT and many other chemicals are considered to be persistent organic pollutants, surviving in the environment for many years, and still active far away from the site where they were first spread. Investigations of ecological catastrophes have given us the opportunity to explore the toxicological impacts of harmful xeno-biotics on animals and humans. In our lectures some of the most illustrative examples will be discussed with emphasis on carcinogenic pollutants and ra-diation. Interestingly, in some cases the causative relationship between exposure to industrial toxi-cants or ionizing radiation and specific deleterious

effects on animals can be proved by the identifica-tion of specific biological exposure indices, and even by genetic markers. The importance of our ability to disclose cause-effect relationship in cases of anthro-pogenic pollution will also be discussed.

15. September 2017, 2:15

Bladder cancer screening in an occupational cohort

Dr. Dr. MSPH BS Thomas BenderAssociate Health Services Director & Epidemiologist at The Dow Chemical Company, Midland, Michigan (USA)

Workers employed at a specialty chemical facility in Paterson, New Jersey, USA, for ≥30 days during 1946–2001 (N=507) have been eligible to participate in a bladder cancer screening program which began in 2001 and will continue thru 2030. These workers are at increased risk of developing bladder cancer because of opportunities for exposure to known and suspected bladder cancer carcinogens, including ortho-toluidine, benzidine, and 2-naph thylamine. Urine concentrations of ortho-toluidine among workers deemed probably exposed were 8 times higher post-shift vs pre-shift. The screening program aims to limit morbidity and mortality by using the most effective, accurate, and sensitive testing avail-able. Participants may submit urine for testing every 6 months. Abnormal screening results trigger urolog-ical referral and evaluation as appropriate. To date, 6 workers have been diagnosed with bladder cancer, which was the cause of death for one. Adoption of fluorescent in situ hybridization (FISH) for screening in 2007 likely contributed to false positive results and unnecessary urological procedures. Among 69 participants with abnormal FISH results, there have been at least 98 cystoscopies, 71 CT urograms, 10 ureteroscopies, 2 emergency department visits for complications, and 4 diagnoses of bladder can-cer. A revised testing protocol, such as using mRNA- based testing to risk stratify participants with micro hematuria, might help curb screening program morbidity.


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15. September 2017, 14:50

Study of social, economic and adverse health effects of chronic arsenic poisoning in Purbasthali 1 Block, Burdwan District, West Bengal

Dr. Palash Kumar SanyalDepartment of Health, Govt. Of Puducherry (India)

Introduction: The eastern districts of the state of West Bengal (India) are affected by groundwater contamination by arsenic. This has had profound implications for the social, economic and health as-pects of the populations concerned. The manage-ment of environmental toxicity by arsenic, therefore is not just limited to clinical management but also social and economic rehabilitation of the population it has affected. This study aims to study not only the adverse out-comes on health of the affected population but also the social, economic implications.Aims and Objectives: 1. To evaluate the health impact of chronic arsenicosis 2. To study the social, economic parameters or

arsenic affected patients.Study Area: Purbasthali 1 block of Burdwan District of West Bengal (India)Conclusions: From our study which included field based survey of households and camp based study of various adberse health effects of chronic arsenic poisponing, we concluded that poverty, lack of educa tion, poor socio-economic status compound-ed the adverse health effects of chronic arsenicosis. Limitations of the study: Due to limited resources it was not feasible to screen the entire population surveyed , for adverse health effects. This leaves the room for a more extensive study. It is proposed to organise a more detailed study in near future once sufficient resources are available. Acknowledgement: The author acknowledges the contribution of Sunam Chatterjee, PhD, who had participated in field survey related to this study and who helped in screening the patients.

15. September 2017, 15:00

Risk assessment on inhalation exposure to benzene among gasoline station workers

Assoc. Prof. Dr. Sunsia ChaikliengKhon Kaen University (Thailand)

Benzene is human carcinogen presented as a com-ponent in gasoline (1% by volume), which can be evaporated into ambient air during the fueling pro-cess at gasoline stations. The aim of this study was to assess health risk on inhalation exposure to ben-zene among gasoline stations workers. The ambient benzene concentration was measured by personal sampling from 150 workers in gasoline stations (137 fueling workers and 13 cashiers) and analyzed by gas chromatography with a flame ionization detector. Additional data was collected via subject interviews and observation. Risk assessment on inhalation ex-posure was determined following U.S.EPA (2009) for non-cancer risk and cancer risk of benzene exposure. The results showed that non-cancer health risk from exposure to benzene was found (hazard quatient; HQ >1) in 51.33% of gasoline station workers. The sig-nificant differences of HQ between fueling workers and cashiers and among three located zones (urban, suburban, and rural) of gasoline stations were indi-cated. The cancer risk range was between 1.345E-08 and 1.518E-04, that affected 70.67% of those workers for lifetime cancer risk (>IUR; 2.20E-6). These risk estimations considered at 50% inhalation uptake of inhaled air benzene without the respirator use of gasoline workers. Therefore, the health surveillance program is recommended for gasoline workers by further monitoring of ambient benzene concentra-tion and the biomarker of benzene exposure. More-over, the employers should optimise eight working hours/day with the use of P25 respirator for inhala-tion protection of benzene exposure.

15. September 2017, 14:20

Medichem Young Professional Award ceremony

Stipendien

15. September 2017, 14:30

Academia versus industry: variances at chemistry research laboratories

Dr. Elana Venter University of Johannesburg (South Africa)

Compared to chemistry research laboratories in in-dustry, a limited number of studies has been conduct-ed at such laboratories in academic settings. The rising number of incidents associated with aca-demic chemistry research laboratories sharply con-trasts with the decline in such incidents in the chemi-cal manufacturing industry. Safety programmes for research environments are further lacking compared to industry. The unique nature of universities sanctions independ-ent research interventions and its associated occupa-tional health and safety hazards. Complexity of aca-demic research implies a multitude of chemicals and discovery of new substances with new hazards.Hazmat laboratory incidents monitored via Google Reader found that academic research laboratories were more at risk than teaching laboratories.The ILO postulates the integrated approach to the sound management of chemicals, covering the entire life cycle of chemicals. The U.S. Occupational Safety and Health Administration found that ‘a strong safety culture is the best approach to preventing incidents’. Progression from a mind-set of safety compliance to that of a safety culture is advised.Findings from literature and a previous study by this researcher echo the occupational health and safety hazards and risks linked to chemicals present in chemistry research laboratories at one South African public university. An expanded study is being under-taken.

15. September 2017, 14:40

Obstructive sleep apnea in patients with cancer: Is there any link? A case of a quantitative descriptive (cross-sectional) study

Amir Radfar, MD, MPHBabol university of Medical sciences (Iran)

Background: Due to a high prevalence of sleep dis-orders in patients with cancer, assessment of ob-structive sleep apnea (OSA) has clinical significance and contributes to improved quality of life.Design: In this a quantitative descriptive study, the association and demographics of (OSA) in cancer patients from the Caspian Sea was assessed.Results: (52.2%) of patients had positive sleep ap-nea scores and 29% showed increased daytime sleepiness. As sign of OSA, Snoring rate in patients was exceeding than the average rates of the gener-al population .More than half of the snorers (51.11%) were positive for OSA. BMI in women was a strong predictor for OSA. More females were obese (20%) and overweight (57.7%). Although no temporal as-sociation between RLS and cancer occurrence was observed, RLS was associated with severe sleep dis-turbance in patients.Conclusion: Treatment of sleep disorders and its determinants will improve patient outcomes and decrease morbidity and mortality in patients with cancer.


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15. September 2017, 15:45

Is there an occupational exposure limit for laboratory animal allergens?

Martin Kuster, MD, MOHNovartis Business Services, Basel (Switzerland)

Laboratory Animal Allergy (LAA) is a frequent occu-pational illness. Depending on the source, up to 30% of people handling laboratory animals might devel-op LAA in any given year. Of those handling animals, about 70% will develop LAA in the first three years. If progressing to Asthma, LAA might be the cause for a person needing to leave a given workplace. The way animals are housed, transported and handled and how their cages are handled are the cru-cial elements to review in case of LAA risk reduction. The common goal is to reduce dust formation or to capture such dust at the source. The patho-physiology of sensitization against such allergens is complex, with scientists and laboratory technicians at higher risk for LAA, due to their inter-mittent high exposures.The case is made to have a systematic risk assess-ment along all the different tasks of handling ani-mals. The UK HSE GN EH76 (Prevention of Laboratory Animal Allergy) is suggested as program document. In addition data are presented on the use of the benchmark value of 5 ng/m3 of rat urine allergen. While not an OEL by definition, this value proved em-pirically protective in our case. There were no new cases of LAA since introduction of the program and using the benchmark-value in a Novartis site since 2011. We were able to keep allergic associates (exter-nally sensitized) at their workplaces.

15. September 2017, 15:55

Literature review of occupational benzene-induced leukemia

Wang Jie, MSc Shanghai Institute of Occupational Disease for Chemical Industry (China)

Abstract Objective: To investigate the features of occupational benzene-induced leukemia in China.Methods: The cases of leukemia due to occupa-tional benzene exposure were searched in Chinese databases (CNKI,VIP,Wanfang) and the information including leukemia type, age of onset, sex, type of work, duration of exposure, latent period, benzene air concentration were analyzed.Results: There were twenty five articles published from 2000 to 2016, and 105 cases altogether. All cases are made up of 56 cases of AML (53.3%), 16 cases of ALL (15.2%), 31 CML (29.5%) and 2 other types of leu-kemia. The cases of AML comprised 23 of M1 or M2, 22 of M3,3 of M4,4 of M5 and 2 of M6. Male cases were ac-counted for 56.2% and female were 43.8%.The age of onset is from 19 to 66, 20~40 years old with a total of 86 cases (81.9%). The duration of benzene exposure was from 5 months to 31 years. The duration of less than 5 years was accounted for 59%, 5–<10 years was 20.0%, 10–<20 years was 15.2%. Benzene air concen-tration in workplace was from<0.5 to 1196.2 mg/m3. The concentration was below 3.25 mg/m3 for 26 cases (30.2%), <6 mg/m3 for 31 (36.0%); <100 mg/m3 for 56 (65.1%); <300 mg/m3 for 83 (96.5%). Paint Spraying (or production) was the primary type of work (n=27, 25.7%), shoe production (n=21, 20%) and printing (n=10, 9.5%) were also common.Conclusion: AML was the most part of benzene- induced leukemia (53.3%) and CML was accounted for a considerable proportion (29.5%). The propor-tion of cases exposure to low concentration (<3.25 mg/m3) was close to one third. The asso ciation between low-level benzene exposure and leukemia is worthy following.

15. September 2017, 15:10

Could sputum eosinophilia act as a predictive test for diagnosis of high risk bakery workers to asthma?

Dr. Mehrzad EbrahemzadihKurdistan University of Medical Sciences, Sanandaj (Iran)

The aim of this study examined the relationship between occupational wheat flour inhalation in bakery and supermarket employees with pulmo-nary functions, respiratory symptoms, and sputum eosinophilia to determine hyper-responsiveness in a cross-sectional study in Iran. 122 subjects from tra-ditional bakeries and 137 subjects from supermarket employees were enrolled in the study. Flour expo-sure concentrations, respiratory signs, sputum anal-ysis, and respiratory volumes and capacities were measured based on the standard methods. Respir-able concentration of flour in the bakery workers was two- to four-fold of ACGIH’s threshold limit value in which bread-bakers with 2.2 mg/m3 experienced maximum exposures. The respiratory volumes in both bakery and supermarket employees were in the normal range. However, the median of volumi-nal percentage in bakery workers except Forced Vital Capacity (FVC) decreased (p<0.001). The mean respiratory volume of bread-bakers was reduced compared to supermarket employees (p<0.05). In addition, we observed increased respiratory symp-toms in the bakery workers, again more prevalent in the bread-bakers. There was a significant correlation between flour exposure concentration and sputum eosinophilia in which the percentage of eosinophilia in the bread-bakers was more than other bakery and supermarket employees. Sputum eosinophilia might be a suitable screening method to detect air-way hyper-responsiveness in workers exposed to known asthmogens.

Freie Vorträge

15. September 2017, 15:35

Comparison of FibroScan® and Fatty Liver Index (FLI) to screen for fatty liver disease in a large cohort of employees: Where is the optimal cut off?

Mag. Manuela Teufelhart, Bakk., BSc.Health- & Prevention Center of the KFA, Vienna (Austria)

Background: Aim of this study is to screen Austrian employees with FibroScan® for liver diseases (fibrosis/ steatosis). Furthermore we evaluate the accuracy of FLI compared to Fibroscan®CAP to detect NAFLD. FLI was developed as a simple predictor of steatosis (Bedogni, 2006). A cut-off value ≥60 ruled in (positive likelihood ratio [LR+] 4.3) steatosis in Italians diag-nosed with ultrasound. FibroScan®CAP is more sensi-tive to diagnose steatosis than ultrasound. Methods: More than 1000 Austrian bank employees are screened for NAFLD with FibroScan®. A kPa value ≥7.9 (M-probe) and ≥7.2 (XL-probe) indicates fibro-sis. Moreover FibroScan®CAP with a cut-off value ≥248 dB/m is defined as steatosis, ≥300 dB/m as high-grade steatosis. Heavy drinkers are identified with AUDIT and SIAC questionnaires. Results: To date 482 employees [age 45.9±8.7 (mean±SD)] are included in this analysis. 14/482 (2.9%) employees had signs of liver fibrosis and re-ceived further investigations. FibroScan®CAP values ≥248 dB/m are shown in 156/482 (32.4%) employees (m: 91, f: 65), 56/482 (11.6%) had CAP values ≥300 dB/m. Furthermore 15/156 (9.6%) patients with steatosis are heavy drinkers. FLI significantly predicts Fibro-Scan®CAP values (adj. R2=0.544, t (249)=17.3, p<0.001). In this study population, a FLI cut-off value ≥40 (CAP ≥248 dB/m) and ≥50 (CAP ≥300 dB/m) rules in fatty liver disease with a LR+ of 4.7 (SN: 84%; SP: 75%) and 4.3 (SN: 82%; SP: 78%), respectively. Conclusion: FibroScan® represents an eligible tool to diagnose liver diseases in Austrian employees. Com-pared to previous work (Bedogni, 2006) FLI predicts fatty liver at a lower cut-off level. This difference may be due to the fact that FibroScan®CAP detects steatosis at an earlier stage than ultrasound.


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15. September 2017, 16:25

Training occupational safety and health in Latin America

Prof. Dr. Katja Radon (presenter: Luisa Merz) University of Munich (Germany)

Background: In many Latin American countries work places change because of economic growth. How ever, in many sectors occupational safety and health (OSH) are still not priority. To improve the situ-ation we aimed at educating OSH professionals who might act as multipliers. Methods: We developed a blended learning Master program which includes onsite courses, project work and interactive online modules. The students learn to evaluate working conditions and to carry out a successful intervention based on international knowledge. Results: Since 2012, 43 experts from 11 Latin Ameri-can countries graduated from the program. Overall, graduates evaluate the master program with 9.1 on a 10-point Likert scale from poor to excellent. Graduates work in executive positions and higher education in OSH. Alumni form a strong network offering training for future trainers. Conclusion: The results of the program suggest that the train the trainer concept might contribute to face OSH challenges in Latin America.

15. September 2017, 16:35

Research progress on the health of the body damage of dimethylformamide poisoning

Huang Huato, MScShanghai Institute of Occupational Disease for Chemical Industry (China)

Dimethylformamide (DMF) is an important chemical raw material and excellent solvent, widely used in industrial enterprises. DMF can be through the res-piratory tract and skin into the body, resulting in the most prominent liver, kidney, heart and other organs of the damage, the occurrence of acute poisoning or

chronic injury. This article reviews the progress of DMF poisoning, including the current situation of DMF poisoning exposure, latency, the clinical mani-festations of various organs (system) damage and the treatment, in order to improve the clinical under-standing of dimethylformamide poisoning.

15. September 2017, 16:45

Breaking a vicious circle in chronic migraine and craniofacial neuralgia treatment: Advantages of De-Novo treatment in reduction of loss of man-hours at work place

Faro T. Owiesy, MDCorona Doctor’s Medical Clinics, Corona, CA (USA)

Importance: Migraines are a worldwide problem which reduces workplace productivity due to Ab-senteeism and Presentism.Objective: New approach to chronic migraine and craniofacial neuralgia which simplify long term cu-rative measure and decrease loss of productivity among workforce.Design, setting, and participants: An ongoing single center, randomized, patient centered pilot study by diagnosing chronic craniofacial and migraine pa-tients. Patients with previous medical interventions and treatment modalities age 12–87 are selected. Main outcome and measures: A modified MIDASQ (Migraine Disability Assessment Questionnaire) is used to measure the impact of headaches on the patients work environment and disability before after DE-NOVO treatment. Data obtained from questionnaire was analyzed to evaluate the effect of DE-NOVO treatment on this group of patients. Results: Our data showed that nearly 95% patients re sponded with complete relief after being treated with combined Dexamethasone, Lidocaine, and Thiamine mixture (DE-NOVO treatment). 2–5% of patients experienced major relief in frequency and intensity of their migraine attacks. As of now, among

15. September 2017, 16:05

The ACGIH biological exposure Index for urinary arsenic: to adjust for urinary creatinine or not?

Dr. Greg KewEOH Workplace Health and Wellness, Cape Town (South Africa)

Employees at a copper smelter in Tsumeb, Namibia are exposed to inorganic arsenic as a contaminant of metallurgically complex ore concentrates smelted. Mandatory biological monitoring comprises urinary arsenic (uAs). The relationships between uncorrected uAs, urinary creatinine (uCr) and creatinine corrected uAs (uAsCr) were examined in relation to the ACGIH Biological Exposure Index for arsenic (ACGIH, 2001).Spot urine samples were obtained from 4313 em-ployees at the end of a working shift at the end of a working week. These were representative of the entire workforce between 2012 to 2015. Samples were analysed for total arsenic (inorganic, methylated (MMA & DMA), and arsenobetaine), and creatinine concentration. Analysis was by ICP/MS in an accredited pathology laboratory (Goulle et al., 2005) and uCr values between 0.34 to 3.4 g/l were considered valid. The work involves exposure to heat from the smelting process, and the weather, particularly in the summer months, can be very hot with temperatures reaching 40 degrees Celsius, with low to moderate humidity. The work is physically arduous for many, particularly in hot working environments, where adequate hydra-tion is important.Overall there is a highly significant positive correlation between uAs and uCr (r=0.34, n=4313, p <0.0001). uAsCr provides a higher numerical value than uAs at uAs values below 25 μg/l, and a lower numerical value compared with uAs values above 25 μg/l, complicating comparisons with the uncorrected uAs ACGIH stand-ard. The use of uncorrected uAs as required by the (ACGIH) can be misleading in both high and low exposure settings.We conclude that the ACGIH BEI documentation of 2001 has not sufficiently characterized the relation-ship between uAs and uAsCr. This has particular relevance for high exposure environments typical

of a copper smelter on the one hand, and for hot working conditions within warm climatic zones such as Namibia on the other. These environments are typically associated with more concentrated urine. For low level exposure environments (below 25 μg/l uAs) without high heat stress and where urine is not concentrated, correcting for creatinine will result in a more conservative (preventive) exposure estimation.

15. September 2017, 16:15

Genetic toxicology testing in drug development: Relevance of MoA information

Stephan Kirchner, PhDFA Hofmann-La Roche Ltd, Basel (Switzerland)

Testing for genotoxic potential is an integral part of the non-clinical safety assessment of new pharma-ceuticals and data are also relevant to set health- based exposure limits.The induction of gene mutations is generally as-sessed by a bacterial reverse mutation test on Sal-monella typhimurium, known as the Ames test. For the detection of chromosome damage, in vitro and in vivo Micronucleus (MN) assays are generally used. Chromosome damage might either result from direct DNA reactivity or indirect mechanisms interfering with the physiology or regulation of the chromosome replication cycle (e.g. inhibition of cell cycle kinases) and cytotoxicity mechanisms. For in-direct mechanisms, thresholds that would allow for safety margins might exist. Therefore mechanistic knowledge on the origin of chromosomal damage is highly important to assess the possibility of existing thresholds and the biological relevance of poten-tial chromosome damage. The value of including additional cytotoxicity endpoints in chromosome damage testing (especially time course measure-ment of apoptosis induction) for an improved and more holistic understanding of chromosome damaging activity will be shown and discussed.


workforce-related migraine cases who revealed loss of work hours or become disabled due to their chronic migraine headaches and underwent DE-NOVO treat-ment (36 patients) almost 100% reported conse-quent steady work performance without interrup-tion of their performance or loss of work hours. Conclusion and relevance: Patients with chronic craniofacial neuralgia and migraine headaches who received simultaneous bilateral administration of Dexamethasone, lidocaine and thiamine, showed more effective and superior results compare to the most current abortive and surgical modalities. This DE-NOVO treatment is cost effective, safe and does reduce need for multi pharmacy treatment for com-plicated chronic migraine headache and craniofacial pain. The component of this DE-NOVO treatment are widely available, in expensive, and its administration is safe and practical by all medical specialties with minimal training. This treatment facilitates patients return to their work environment without interrup-tion, and would benefit major corporates in saving of work hour loss.Keywords: occupational medicine, work hour loss, migraine headache, absenteeism, presentism

15. September 2017, 16:55

Chemical hazards and risks in hazelnut and tea agriculture

Gamze Can et.al. (presenter and author Nazim Ercument Beyhun, MD, Assoc. Prof.)Karadeniz Technical University (Turkey)

Although the hazelnut and tea agriculture includes chemical hazards and risks for workers, there are very limited studies because of its unindustrialized nature. The results of this presentation is one of the part of a project “Risk assessment of Occupational Health and Safety in Hazelnut and Tea Agriculture Workers and Development of Guidebook” which was funded by TUBITAK (Project No: 115S921). The aim of this presentation is to demonstrate chemi-cal hazards and risks occurred during hazelnut and tea agriculture. The study was conducted between 2015–2017 (Workshop, Observational field study, Develop ment of handbook). Chemical hazards-risks were defined and measures to minimize them were determined. The chemical hazards and possible risks were observed during trimming, cleaning wild grass, shelling, fertilizer, pesticide-herbicide and lime implementation processes. The hazards observed were exhaust gas of patoz vehicle, motorized saw, use of flammable, explosive chemicals like oils and gas for motorized saw and hoe vehicle, inadequately and unlabeled chemical use, preparation and use of motorized vehicles in indoor places, use of fertilizers, pesticides and lime. The risks that were determined were intoxications, fire, explosion, dermal, gastro-intestinal and respiratory system diseases and death. The major chemical hazard was use of fertilizers, pesticides-herbicides and lime during hazelnut and tea agriculture.

Posterbeiträge 14. September 2017, 13:00–13:30

Occupational health and safety risk analysis in a pathology laboratory: Chemical hazards and risks

Bekir Bulut et.al. (presenter and author Nazim Ercument Beyhun, MD, Assoc. Prof.)Karadeniz Technical University (Turkey)

The aim of this study which was conducted be-tween 2014–2016 was to determine the chemical hazards and risks with a risk analysis in Karadeniz Technical University (KTU) Farabi Hospital Pathology Laboratory. The hazards and risks were clarified by job safety analysis and L type (5×5) matrix method. The level of (Stel) formaldehyde (mg/m3), xylene was analysed with Gillian BDX Air Sampling Pump (NIOSH 3500). The former analysis of the pathology laboratory (June 2015) that were done by the hos-pital management were collected. This study was funded by Scientific Reserch Projects Unit of KTU (TTU-2015-93). The results showed that the level of formaldehyde at all 26 localizations were <0.0025 mg/m3 (Max- matrix score=5). The highest levels for o-xylene and m, p-xylene were 2.98 and 21.23 mg/m3 in the electron microscopy room (Max- matrix score=5). The second highest levels were found in histopathology room with 2.13 and 15.38 mg/m3 (Max- matrix score=10). According to former anal-yses, 3.125 mg/m3 formaldehyde was found for a worker during transforming pure formaldehyde to 10% solution and 2.5 mg/m3 for a worker during emptying full formaldehyde pots. TWAs (time weighted averages) were between 0.05–0.325 mg/m3 for formaldehyde. The levels for formaldehyde were below OSHA but over NIOSH border levels and over ATSDR minimal risk level. The levels for xylene were below OSHA and NIOSH but over minimal risk level for ATSDR.

Cancer risk assessment of formaldehyde exposure in a zipper plant

Li Keyong, MScShanghai Institute of Occupational Disease for Chemical Industry (China)

Objective: The Cancer risk of formaldehyde exposure in a Zipper Plant was assessment.Methods: According to the national guideline, the concentration of formaldehyde in the workplace was determined, and the cancer risk of the exposed workers was assessed by using EPA inhalation risk model.Results: The risk values of formaldehyde exposure in injection modeling, assembling and resin cutting were 5.14–79.7) ×10–5.Conclusion: The cancer risk induced by formaldehyde in the zipper plant was highly increased especially in resin cutting post.

Arsenicosis and skin cancer

Dr. Palash Kumar SanyalDepartment of Health, Govt. Of Puducherry (India)

Introduction: Environmental poisoning of human population with arsenic has been documented among the people living in the eastern parts of West Bengal (India). The spectrum of arsenic poisoning has been studied by various authors and includes skin diseases, hepatic diseases, pulmonary diseases etc. This study was undertaken to explore the spectrum of dermatological manifestations of chronic arsenic poisoning in a resource poor field based approach.Aim and objectives: The principal aim of this study was to explore the varied spectrum of skin manifes-tations of chronic arsenic poisoning in Purbasthali 1 block of Burdwan district of West Bengal (India) using simple clinical criteria.Study area: Nadanghat village under Purbasthali 1 blockEach patient was clinically examined by a team of doctors experienced in the detection of chronic

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arsenic poisoning. Demographic paramenters were noted in the proforma. Each patient underwent a thorough general physical examination and this was followed by focused physical examination of the skin to look for the different clinical manifestations of chronic arsenic toxicity. Routine investigations feasible at the point of study which included Blood Glucose, Lipid Profile etc. were also carried out.Discussion: In this short study it was noted that a sig-nificant number of patients with chronic arsenicosis had evidence of premalignant skin lesion in the form of Bowen’s disease and two patients were clinically diagnosed with skin cancer. It may be noted that hyperpigmentation of skin was the most common clinical finding and this agrees with a previous study by Guha majumdar et al. Skin cancer was diagnosed in two patients with chronic arsenicosis and one patient who attended the study had already under-went surgery for skin cancer as evident from his treatment records.Conclusions: The dermatological manifestations of chronic arsenicosis are varied. Skin cancers are common in chronic arsenicosis. They evolve from pre-malignant lesions such as Bowen’s disease. Early diagnosis in a community level is the key to reduce morbidity and mortality.

Synthetic cannabinoids detected in biological samples : Six case reports

Hulya Savas et.al. (presenter and author Nazim Ercument Beyhun, MD, Assoc. Prof.) Karadeniz Technical University (Turkey)

The aim of this study was to discuss possible rela-tionships between synthetic cannabinoid (SC) use, histopathological and autopsy findings of six death cases. Toxicological analyses were performed on biological specimens obtained after autopsy of six death cases referred to the Council of Forensic Medicine Trabzon Group Chairmanship between Jan–July 2014. SCs that might be present in blood, urine, vitrous humor and bile samples were analysed

using liquid chromatography-mass spectroscopy/mass spectroscopy (LC-MS/MS) following enrichment by solid phase extraction (SPE). SCs and their meta-bolites (JWH018, JWH018-n pentanoic acid, JWH018-5 hydroxypentil, JWH073, JWH073-4 hydroxybutyl, JWH073-n butanoic acid) and also other substances (MDA, MDMA, THC) were detected at toxicological analyses of six death cases with different histories. As a conclusion, SCs may cause bleeding in lungs and may trigger myocardial infarction even in young age.

A Description of the profile of narcotics and

new generation psychoactive substances

sent by the judical authorities to the Turkish

council of forensic medicine trabzon group

chairmanship between 2010–2014

Sinan Zazoglu et.al. (presenter and author Nazim Ercument Beyhun, MD, Assoc. Prof.) Karadeniz Technical University (Turkey)

The research data were obtained through retrospec-tive examination of narcotic substance files archived at The Turkish Council of Forensic Medicine Trabzon Group Chairmanship Chemistry Specialization De-partment between 01.05.2012–31.04.2014 (4 years). A total of 1454 applications made to the Chairman-ship and 1571 substances were sent for narcotic ex-amination. Cannabis was the most common of the substances (n=1301, 82.8%), followed by the hashish (n=85, 5.4%), methylenedioxy-methamphetamine (MDMA) (n=78, 5.0%), synthetic cannabinoids (n=58, 3.7%), amphetamine (n=16, 1.0%) and heroine (n=16, 1.0%). The most common identified synthetic can-nabinoid was AM-2201 (n=23), constituting approx-imately half of the synthetic cannabinoids (39.7%). This research reveals that cannabis is still the most commonly identified substance, but that the num-ber of stimulant tablets and synthetic cannabinoids are increasing on an annual basis.

The current activities in Japan to control hazardous chemical substances after the case report of bile duct cancer in a printing factory in Osaka

Ass. Prof. Dr. Keiichi FujimotoDepartment of hygiene and public Health, Osaka (Japan)

There have been growing interest and concern about the elevated risk of developing carcinogens in the workplaces of treating chemical substances in Japan. In May 2012, in a printing factory in Osaka, Japan, 8 of the cases died of bile duct cancer out of 17 identified proof-printing workers. The Ministry of Health, Labor and Welfare of Japan organized a com-mittee to investigate the causes of bile duct cancer and concluded that chemicals (1,2-dichloropropane, dichloromethane) were the most likely causes. In response to the survey, the International Agency for Research on Cancer (IARC) of the World Health Organization (WHO) classified 1,2-dichloropropane as Group 1 carcinogenic risks to humans. Now that our industrial working environment is controlled by the occupational safety and health law or various related legislations and guidelines, however, there is still a blind spot or loophole in the established and matured system.After the first case-series were reported with regard-ed to a printing factory in Osaka, the Cabinet of Japan issued the Order for the Enforcement of the partial amendments of the Act and chemical substance manufacturers were required to apply hazard labels and issue Safety Data Sheets (SDS) regarding all haz-ardous chemical substances according to the Global-ly Harmonized System (GHS) classification. Based on the ILO International Chemical Control Toolkit, the control banding can be used to manage workplace risks as an assessment method on the website. Also, in some companies, new products and appliances were developed to promote working environmental management.For instance, new toxic gas detector and alarms were invented by NEW COSMOS ELECTRIC CO, LTD. Volatile organic compounds (VOCs) in the workplace environ-ment can be measured at real time with continuing

monitoring. When the gas concentration is exceed-ed the certain standard, the warning sound will go off and alert the workers to step away the spot. This new gas alarm device is compact and portable gas detector with easy operation. It helps to raise the workers awareness of risk assessment for hazard-ous chemical substances and will also be the meas-uring and monitoring system enabling the visualiza-tion of reducing the exposure of hazardous chemical substances. Workers can easily understand where and when the toxic gas is detected and what kind of line operation can be recognized to wear protec-tive equipment on an individual basis. Each year new chemical substances are introduced to workplaces without clarifying its toxicity to humans. In case the concentration of VOCs can affect the quality of the products, the real time measuring and always moni-toring system will be useful to maintain the process of manufacturing products.

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45. Internationaler MEDICHEM Kongress 2017 · 2017 eingereicht werden, diese werden anschließend...

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