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BioGinkgo 27/7BioGinkgo 27/7

A 100 Yr. Old Bonsai Ginkgo Tree

Proprietary extract of ginkgo leaves

Addresses #2 concern among aging baby boomers Loss of

memory

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Ginkgo biloba L. plant: HistoryGinkgo biloba L. plant: History Oldest living plant species, nick named “living

fossil”. In China, it is called “thousand-year-old tree”

Described in the ancient Chinese pharmacopoeia- Shen nown Ben Cao

Since 1960s, Ginkgo biloba extract is the most widely used herb in Europe

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Ginkgo biloba L. leaf: History, Ginkgo biloba L. leaf: History, cont’dcont’d

Pharmanex scientific advisor, Prof. Koji Nakanishi, Columbia University: Discovered a class of unique ginkgolides in ginkgo plant

Ginkgolides can increase blood flow by blocking PAF, a substance that causes platelet clumping

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BioGinkgo 27/7: UniquenessBioGinkgo 27/7: Uniqueness

Pharmanex extraction process enriches for ginkgolides

Only Ginkgo extract that provides for adequate and persistent amounts of ginkgolides in the blood

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Blood concentration of ginkolides after Blood concentration of ginkolides after oral intake of BioGinkgo 27/7 or Ginkobaoral intake of BioGinkgo 27/7 or Ginkoba

Published in Planta Medica

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BioGinkgo 27/7 - AttributesBioGinkgo 27/7 - Attributes

Unique formulation of enriched for levels of ginkgolides

Improved bioavailability compared to competitors

Undesirable Ginkgolic acids removed One of the few companies to

manufacture its own ginkgo product

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Bioginkgo 27/7 process schemeBioginkgo 27/7 process scheme

Finished bulk preparation

Selected leaves

1. crushed

2. aq. Alcohol extract

3. precipitation

4. chromatography

5. remove Ginkgolic acids

6. drying

Flavone-lactone mixture

QA/QC

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Chemical fingerprint of Chemical fingerprint of ginkgolide terpene lactonesginkgolide terpene lactones

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Ginkgo biloba Extract: Cerebral Ginkgo biloba Extract: Cerebral InsufficiencyInsufficiency

Taillander et al. Presse Med. 1986 15 1583-1587 12-month placebo controlled trial of 210 elderly patients Ave. age 82 years End points: Symptoms scale including dizziness, tinnitus, headaches, lack of

energy, and difficulties in memory and concentration at 3, 6, 9, and 12 months

Time of assessment

Treatment 3 6 9 12 months

Placebo 4% 4% 8% 8% Ginkgo 10% 15% 15% 17%

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JAMA clinical studyJAMA clinical study

A Placebo-Controlled, Double-blind, Randomized Trial

A 52-week multi-center study Patients: Outpatients with Alzheimer

disease or multi-infarct dementia, without other significant medical conditions.

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JAMA clinical study: Study JAMA clinical study: Study DesignDesign Complete outcome evaluation at 12, 26,

and 52 weeks. Primary Outcome Measures.

Alzheimer's Disease Assessment Scale-Cognitive subscale (ADAS-Cog), Geriatric Evaluation by Relative's Rating Instrument (GERRI), and Clinical Global Impression of Change (CGIC).

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JAMA clinical study: JAMA clinical study: ConclusionsConclusions

Ginkgo group score better than placebo in ADAS-Cog and GERRI score

No difference in the Clinical Global Assessment Index Ginkgo was safe Appears capable of stabilizing and improving the

cognitive performance and the social functioning of patients for 6 months to 1 year.

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BioGinkgo 27/7: summaryBioGinkgo 27/7: summary

BioGinkgo enhances blood circulation to brain, arms, legs

Mechanism of action believed to be related to flavonoids and ginkgolides

BioGinkgo is recommended to be taken one tablet twice a day

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Introducing…Bio St. John’sIntroducing…Bio St. John’s

Standardized St. John’s wort to 0.3% hypericin(Hypericum perforatum)

PLUSCordyMax Cs-4 [Patent Pending]

(Cordyceps sinensis)

Each capsule of Bio St John’s contains 375 mg of CordyMax and 225 mg St John’s wort extract.

The daily recommended dosage is two capsules twice a day.

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Bio St. John’s : ClaimsBio St. John’s : Claims

Stabilizes mood and promotes a positive outlook

Provides vitality and stamina Reduces fatigue without stimulants

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Bio St. John’s: BenefitsBio St. John’s: Benefits

Bio St. John’s is not a substitute for prescription anti-depressant drugs

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St. John’s Wort: Brit. Medical St. John’s Wort: Brit. Medical Journal StudyJournal Study

Meta-Analysis (BMJ, 1996) 23 randomized trials with 1,757 patients

% patients respond to treatment SJW (55.1%) vs Placebo (22.3%) SJW (63.9%) vs Antidepressant (58.5%)

Test on mild/moderate depression major depression or manic depressive

disorder not tested

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Putative mechanisms of actionPutative mechanisms of action

Monoamine oxidase inhibition Selective serotonin-reuptake inhibition Inhibition of catechol O-methyltransferase GABA and neurokinin receptors

Overall outcome: Effect on neurotransmitters function

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St. John’s wort : Safety/Possible St. John’s wort : Safety/Possible side effectsside effects

Most common adverse effects are: GI symptoms Tiredness/sedation Dizziness/confusion Photosensitivity, but this appears to

occur rarely

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Before St.John’s wortAfter St.John’s wort

Age

Efficacy with ageEfficacy with age

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Bio St. John’sBio St. John’s

A combination of St. John’s wort and CordyMax

The recommended dose for Bio St John’s is 4 capsules daily

It is not a replacement for prescription anti-depressants