FINAL PROGRAMME 1 · JOINT 12TH EBSA 10TH ICBP-IPAP Boyss Conress MADRID 20-24 JL 2019 BIOPHSICS...

1F I N A L P R O G R A M M E

JOINT 12TH EBSA10TH ICBP-IUPAP Biophysics Congress

MADRID20-24 JULY 2019

BIOPHYSICS FOR LIFE AND TECHNOLOGY

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C O M M I T T E E SOrganizing Committee

ChairJesús Pérez-Gil, UCM

Co-ChairJuan Manuel Parrondo, UCM

Jorge Alegre, CNICSaúl Ares, UCIIILaura Arriaga, UCMAntonio Cruz, UCMMercedes Echaide, UCMBegoña García Álvarez, UCMLucía García Ortega, UCMJuan Hermoso, IQFR-CSICFrancisco Monroy, UCMGermán Rivas, CIB-CSICJosé María Valpuesta, CNB-CSICMarisela Vélez, ICPQ-CSIC

Scientific Committee

ChairJesús Pérez-Gil, Madrid

Ana Azuaga, GranadaMark Baldus, UtrechtFrançoise Brochard, ParisChristian Eggelin, OxfordAntonio Ferrer-Montiel, ElcheVadim Frolov, BilbaoMaria Garcia-Parajo, BarcelonaJordi Garcia-Ojalvo, BarcelonaRamin Golestanian, OxfordStephan Grill, DresdenJuan Hermoso, MadridHerbert Levine, HoustonAndrea Liu, PennsylvaniaJuan Manuel Parrondo, MadridManuela Pereira, LisbonSriram Ramaswamy, BengaluruFelix Ritort, BarcelonaClaudia Steinem, GottingenMasaki Sasai, NagoyaIlpo Vattulainen, Helsinki




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EBSA Council

President Prof. Anthony Watts, UK

Vice President Prof. Jesus Perez-Gil, Spain

Past President Prof. Helmut Grubmüller, Germany

Secretary Prof. John M. Seddon, UK

Treasurer Prof. Anthony J. Wilkinson, UK

EBJ Editor Prof. Robert Gilbert, UK

Member Prof. José L. Carrascosa, Spain

Member Prof. Jacqueline Cherfils, France

Member Prof. André Matagne, Belgium

Member Prof. Pavol Miskovsky, Slovakia

Member Prof. Mauro Dalla Serra, Italy

Co-opted member Prof. László Mátyus, Hungary

Co-opted member Prof. Pierre-Emmanuel Milhiet, France

Co-opted member Elena Pohl, Austria

Co-opted member Prof. Ilpo Vattulainen, Finland

C6 IUPAP ComissionOfficers

Chair Ramin Golestanian, Germany (2011) (2014) (2017)

Vice-Chair Jeff Gore, USA (2017)

Secretary Masaki Sasai, Japan (2014) (2017)

MembersMing Li, China (2014) (2017)Françoise Brochard Wyart, France (2014) (2017)Suliana Manley, Switzerland (2017)Hans-Joachim Galla, Germany (2017)Vladimir Nekorkin, Russia (2017)Mohammad Reza Ejtehadi, Iran (2017)Bryan Trevor Sewell, South Africa (2014) (2017)Debashish Chowdhury, India (2017)Juan Manuel Rodríguez Parrondo, Spain (2017)Joanna Trylska, Poland (2017)Marcia Barbosa, Brazil (2017)




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G E N E R A L I N F O R M A T I O N Technical Secretariat

VIAJES PACÍFICO S.A. Calle Castello, 128- 7ª planta - 28006; MadridPh. +34 91 383 60 00 [email protected]

Venue

IFEMA Palacio Municipal de Congresos de MadridIFEMA Municipal Conference Centre

Av. de la Capital de España Madrid, s/n28042 Madrid (Spain)www.ifema.es/convencionesycongresos_01/IFEMAPalacioMunicipal/index.htm

Language

The official language of the congress is English. No simultaneous translation will be provided.

Wifi

NETWORK: EBSA_2019PASSWORD: madrid19

Poster Session

» All posters will be presented in paper format » Posters should be 90 cm (width) x 120 cm (height) Portrait type, and they should

be displayed by the authors in the poster area at the slot corresponding to the code number provided in the confirmation letter.

Presenting authors are expected to be in front of their posters one of the day of the block session they have been assigned, (during the poster session slot) as follows:

» Sunday Poster Session: Sunday 21st July, from 12:45 to 15:00h. Authors with odd poster numbers (ex: P-001, P-003, P-005…)

» Monday Poster Session: Monday 22nd July, from 12:45 to 15:00h. Authors with even poster numbers (ex: P-002, P-004, P-006...)

» Tuesday Poster Session: Tuesday 23rd July, from 12:45 to 15:00h. Authors with odd poster numbers (ex: P-401, P-403, P-405…)

» Wednesday Poster Session: Wednesday 24th July, from 12:45 to 15:00h. Authors with even poster numbers (ex: P-402, P-404, P-406...)




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Setting-up and taking down times: » The posters should be fixed on the corresponding board on

Sunday 21st from 10:00h, and must be removed on Monday 22nd before 20:00h.Tuesday 23rd from 10:00h, and must be removed on Wednesday 24th before 20:00h.

Fixing tape to set up the posters will be provided by the organization.The Technical Secretariat is not responsible for those posters that will not be removed at the end of the Congress

Congress badges

All participants, accompanying persons and exhibitors must wear the Congress identification badges. Entrance to meeting rooms, posters and exhibition area will not be allowed to any person without badge.

Certificate of Attendance

A certificate of attendance will be sent by email to each delegate at the end of the congress sessions. For special requirements, please ask to the Technical Secretariat.

Liability

Upon registration, participants agree that neither the Organizing Committee nor the Technical Secretariat assume any liability. Participants should, therefore, organize their own health and travel insurance.

Rooms directory

AUDITORIUM

EXHIBITION & POSTERSAREA / COFFEE BREAKS

ENTRANCE RIGHT SIDELEFT SIDE

2nd FLOOR

3rd FLOOR

1st FLOOR

GROUND FLOORHALL CAFETERIA

LUNCH AREAHALL ESTRASBURGOLUNCH AREA

ROMAREIJKIAVIK

DUBLIN

MADRIDPARIS

MÓNACOBONN

PREVIEW ROOM-LUXEMBURGO

2nd FLOOR

3rd FLOOR

1st FLOOR

GROUND FLOOR




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C L O S E D A N D O P E N M E E T I N G SMEETING CLOSED/ OPEN DAY TIME ROOM

First EBSA EC meeting closed Saturday 20th

July 15:00-17:00 Room Monaco- 1st floor left side

SBE Meeting open Sunday 21st July 14:00 -15:00 Room Monaco- 1st floor left side

Nanotemper workshop open Monday 22nd July 14:00 -15:00 Room Paris -

1st floor left side

SEBM National Assembly open Monday 22nd July 19:15-20:15 Room Madrid -

1st floor left side

SFB (Société Française de Biophysique)

National Assembly

open Monday 22nd July 19:15-20:15 Room Roma- 2nd floor left side

SBfP (Sociedade

Portuguesa de Biofísica) National

Assembly

open Monday 22nd July 19:15-20:15 Room Paris- 1st floor left side

EBSA Presidents’ meeting closed Monday 22nd July 13:00 -15:00 Room Berlin-

1st floor left side

CPL meeting closed Tuesday 23rd July 13:00-15:00 Room Monaco- 1st floor left side

ERC Information open Tuesday 23rd July 14:00-15:00 Room Paris - 1st floor left side

EBSA General Assembly closed Tuesday 23rd July 19:00-20:00 Room Paris-

1st floor left side

Second EBSA EC meeting closed Wednesday 24th

July 14:00-15:00 Room Monaco- 1st floor left side




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E B S A D E T A I L E D P R O G R A MS a t u r d a y 2 0 J u ly AUDITORIUM

17:30 WELCOME ADDRESS

18:00 PLENARY LECTURE Harnessing evolution to create new medicines Sir Gregory Paul Winter Chair: Anthony Watts, President of EBSA, UK

S u n d a y 2 1 J u lyAUDITORIUM

09:00 PLENARY LECTURE Eukaryotic organelles: deciphering their interdependency, structure and dynamics with new imaging technologies Jennifer Lippincott-Schwartz, USA Chair: María García-Parajo, Spain

10:00-12:45 PROTEIN FOLDING Chairs: Ana Azuaga, Spain Jacqueline Cherfils, France

Invited speakers

10:00 Understanding alpha-synuclein amyloid self-assembly and its associated toxicity Nunilo Cremades, Spain

10:30 Dodging the crisis of folding proteins with non-trivial topology - new challenges Joanna Sulkowska, Powland

11:00 – 11: 30 COFFEE BREAK

11:30 The structural determinants of the toxicity of misfolded protein oligomers associated with neurodegenerative diseases Fabrizio Chiti, Italy

Short Talks

12:00 Prion soft amyloid core driven self-assembly of globular proteins into bioactive nanofibrils Weiqiang Wang, Spain




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12:15 Unravelling the details of the conformational cycle of the Hsp90 chaperone Katarzyna Tych, Germany

12:30 Strategically positioned slow codons support protein folding Michal Perach, Israel

MADRID

10:00-12:45 DNA ARCHITECTURE AND GENE REGULATION Chairs: Masaki Sasai, Japan Helmut Schiessel, Netherlands

Invited speakers

10:00 DNA release from histones in nucleosome core particles: measurements and models Lois Pollack, USA

10:30 Gene control with a “twist”: Exploring the dynamic chromatin landscape Beat Fierz, Switzerland

11:00- 11:30 COFFEE BREAK

11:30 Chromosome organization in living human cells revealed by single nucleosome imaging Kazuhiro Maeshima, Japan

Short Talks

12:00 Non-specific action of polyamines leads to specific changes in structure and function of DNA Takashi Nishio, Japan

12:15 Simulating the binding of pioneer transcription factors to the nucleosome Jan Huertas, Germany

12:30 Dependence of DNA persistence length on ionic strength and ion type Catherine Tardin, France

S u n d a y 2 1 J u ly




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ROMA

10:00-12:45 MECHANOBIOLOGY Chairs: Malgorzata Lekka, Poland Pere Roca-Cusachs, Spain

Invited speakers

10:00 Mechanically and biochemically induced pathways regulating integrin-dependent cell adhesion Nico Strohmeyer, Switzerland

10:30 Molecular to cellular mechanics at short timescales Felix Rico, France


11:30 Mechanosensitive actomyosin network dynamics and migration plasticity in 3D environments Verena Ruprecht, Spain

Short Talks

12:00 Activation of human aortic valve interstitial cells by local stiffness in calcific aortic valve disease Loredana Casalis, Italy

12:15 Role of Rab8A and Caveolin-1 in the interplay between cell mechanotransduction and cholesterol trafficking Giulio Fulgoni, Spain

12:30 The mechanical work of vinculin binding to talin regulates vinculin activation Rafael Tapia Rojo, USA

PARIS

10:00-12:45 BIOPHYSICS OF CYTOSKELETON Chairs: Marisela Velez, Spain Andreas Janshoff, Germany

Invited speakers

10:00 Mind the gap: polyampholytes meet the neuronal skeleton Roy Beck, Israel




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10:30 Reconstitution of basic mitotic spindles in cell-like confinement Marleen Dogterom, the Netherlands

11:00 – 11:30 COFFEE BREAK

11:30 The spindle is a composite of two permeating polar gels Jan Brugués, Germany

Short Talks

12:00 Structure dissection of a contractile phage tail tube Birgit Habenstein, France

12:15 Ultrafast tracking reveals the function of structural domains of single proteins Kristýna Holanová, Czech Republic

12:30 Nucleotide and osmolyte induced folding of FtsZ from staphylococcus aureus Sonia Huecas, Spain 12:45-14:30 LUNCH AND POSTER SESSION

AUDITORIUM

14:30 PLENARY LECTURE Shaping membranes with proteins and cytoskeleton: deciphering mechanisms with reconstituted systems Patricia Bassereau, France Chair: John Seddon, UK

15:15 AVANTI-EBSA MEMBRANE BIOPHYSICS AWARD Control of organelle dynamics by membrane curvature and lipid unsaturation Bruno Antonny, France Chair: Anthony Watts, President of EBSA

16:00-16:30 EBSA YOUNG INVESTIGATOR AWARD Sensing the matrix: transducing mechanical signals from integrins to the nucleus. Pere Roca-Cusachs, Spain Chair: Anthony Watts, President of EBSA






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17:00-19:15 MEMBRANE STRUCTURE AND DYNAMICS Chairs: Claudia Steinem, Germany Felix Goñi, Spain

Invited speakers

17:00 Lessons learned from complex mimics of biological membranes Georg Pabst, Austria

17:30 Regulating the dynamic interactions between herpes simplex viruses and cell-surface glycosaminoglycans Marta Bally, Sweden

18:00 IQGAP1 links phosphoinositide signaling to the cytoskeleton and promotes cytoskeletal reorganization Arne Gericke, USA

Short Talks

18:30 Adsorption kinetics of pulmonary surfactant complexes purified from bronchoalveolar lavages of porcine lungs and human amniotic fluid José Carlos Castillo-Sánchez, Spain

18:45 Microfluidic platforms for the handling, manipulation, and analysis of model cells Tom Robinson, Germany

19:00 Quantified efficiency of membrane leakage events relates to antimicrobial selectivity Maria Hoernke, Germany

MADRID

17:00-19:15 CELLULAR PROLIFERATION Chair: Juan M. R. Parrondo, Spain

Invited speakers

17:00 Dynamics of bacterial swarms and biofilms Knut Drescher, Germany

17:30 Biophysical concepts applied to tumor progression Herbert Levine, USA

18:00 How molecular forces shape bacterial biofilms Berenike Maier, Germany





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Short Talks

18:30 A nonequilibrium phase transition theory for the formation of diverse homeostasis and the emergence of systematic aging in multicellular systems Yuting Lou, Japan

18:45 Molecular architecture of bacterial amyloids in Bacillus biofilms Nadia El Mammeri, France

19:00 Microviscosity of bacterial biofilm matrix characterized by fluorescence correlation spectroscopy and single particle tracking Valentin Dunsing, Germany

ROMA

17:00-19:15 TRAFFICKING AND SIGNALLING Chair: Carlo Manzo, Spain

Invited speakers

17:00 Systematic superresolution analysis of endocytosis reveals an actin nucleation nano-template that drives efficient vesicle formation Jonas Ries, Germany

17:30 Shedding new light on the nanoscale organization of GPCR signalling Davide Calebiro, UK

18:00 Cryo-EM structural analysis of focal adhesion machinery Naoko Mizuno, Germany

Short Talks

18:30 TANGO1 regulates membrane tension to mediate collagen export from the endoplasmic reticulum Felix Campelo, Spain

18:45 Facile membrane flow and tension equilibration at a presynaptic nerve terminal Erdem Karatekin, USA

19:00 Allosteric regulation of small GTPases at the surface of membranes Jacqueline Cherfils, France





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PARIS

17:00-19:15 NON-EQUILIBRIUM PHYSICS Chairs: Jeff Gore, USA a Udo Seifert, Germany

Invited speakers

17:00 How rotating ATP synthases can modulate membrane structure Ivan Lopez-Montero, Spain (Premio Enrique Pérez-Paya SBE)

17:30 Quantifying and modelling active motion in biological systems Timo Betz, Germany

18:00 Dynamics of nanoparticle and virus uptake at cell membranes Ulrich Schwarz, Germany

Short Talks

18:30 Non-equilibrium processes in proteins triggered by light: excited states molecular dynamics perspective Wieslaw Nowak, Poland

18:45 1/f noise in ion channels formed by the Classical Swine Fever Virus (CSFV) p7 protein Antonio Alcaraz, Spain

19:00 Biophysical models of mRNA translation applied to ribosome profiling data Juraj Szavits-Nossan, UK





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M o n d a y 2 2 J u ly

AUDITORIUM

09:00 PLENARY LECTURE Overcoming the multiscale simulation challenge for biomolecular systems Gregory Voth, USA Chair: Ilpo Vattulainen, Finland

10:00-12:45 BIOMOLECULAR SIMULATION I Chairs: Claudio Soares, Portugal Ilpo Vattulainen, Finland

Invited speakers

10:00 Deep learning for molecular biophysics Frank Noe, Germany

10:30 Sculpting cell membranes by protein nanomachines Andela Saric, UK


11:30 Pentameric ligand-gated ion channels: new crystal structures and MD simulations Marc Delarue, France

Short Talks

12:00 Automated cryo-EM structure refinement using correlation-driven molecular dynamics Maxim Igaev, Germany

12:15 Aβ peptides and β-sheet breakers. A coarse grained molecular dynamics approach using GO-Martini Aishwarya Dhar, Italy

12:30 Effect of pH on the influenza fusion peptide structure and activity: A constant-pH molecular dynamics approach Diana Lousa, Portugal




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MADRID

10:00-12:45 MACROMOLECULAR COMPLEXES Chairs: Tony Wilkinson, UK Irene Diaz-Moreno, Spain

Invited speakers

10:00 Recent insights into the peptide-loading complex machinery Simon Trowitzch, Germany

10:30 LUBAC and linear ubiquitin chains: novel tools to study immune signalling Katrin Rittinger, UK


11:30 Analysing cryoEM data quality in the post resolution revolution era: Validity criteria José M. Carazo, Spain Short Talks

12:00 Histone tails in nucleosome: fuzzy interaction with DNA Sevastyan Rabdano, Russia

12:15 New protein-protein interaction modulators for the therapeutic regulation of synapse dysfunction in neurodevelopmental disorders and neurodegeneration María José Sánchez, Spain

12:30 Structural characterisation of tissue-derived, disease-associated polymers of alpha-1-antitrypsin using conformation-selective antibodies and single-particle reconstructions from electron microscopy images James Irving, UK

ROMA

10:00-12:45 BIOPHYSICS OF MEMBRANE OXIDATION Chairs: Manuel Prieto, Portugal Rosangela Itri, Brazil





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Invited speakers

10:00 Photosensitized oxidation of lipid membranes: yields and rates of chemical and physical changes Mauricio da Silva, Brazil

10:30 Achievements, challenges and hopes in the biophysical analysis of oxidized (phospho)lipids Ana Reis, Portugal

11:00-11:30 COFFEE BREAK

11:30 Oxysterols and truncated oxidized phospholipids in model membranes Martin Hof, Czech Republic

Short Talks

12:00 Lipids as substrates and dynamic activators: pro-apoptotic lipid peroxidation at the mitochondrial membrane surface Patrick Van Der Wel, Netherlands

12:15 The effect of oxidized cholesterol on model red blood cell membranes Paul Smith, UK

12:30 Lipid curvature modulates function of mitochondrial membrane proteins Olga Jovanovic, Austria

PARIS

10:00-12:45 EVOLUTIONARY DYNAMICS Chairs: Susanna Manrubia, Spain Liedewij Laan, Netherlands

Invited speakers

10:00 Eco-evolutionary dynamics during Escherichia coli colonization of the mouse gut Isabel Gordo, Portugal

10:30 Evolutionary biology of cell division: integrating quantitative genetics and cellular biophysics Daniel Needelman, USA






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11:30 Universal properties of genotype-phenotype maps Sebastian Ahnert, UK

Short Talks

12:00 ScarTrace: CRISPR/Cas9-mediated clonal tracing in zebrafish embryonic development and regeneration Anna Alemany, Netherlands (Premio Antalgenics SBE)

12:15 Rare beneficial mutations cannot halt Muller’s ratchet in spatial populations Su-Chan Park, South Korea

12:30 Exploring phenotypic variability of bacteria using microfluidic cell traps Ágnes Ábrahám, Hungary

12:45-15:00 LUNCH AND POSTER SESSION

13:00-15:00 MEETING OF EBSA Presidents

AUDITORIUM

15:00 PLENARY LECTURE Cryo-EM to visualize structure and dynamics of complex biological macromolecular assemblies Eva Nogales, USA Chair: Jose Carrascosa, Madrid

15:45 IUPAP Young Scientist Prize in Biological Physics 2019 Bacterial collective behaviors Knut Drescher, Germany Chair: Ramin Golestanian, Chair C6-IUPAP

16:00 IUPAP Young Scientist Prize in Biological Physics 2018 Thermodynamics of biological active matter Nikta Fakhari, USA Chair: Jeff Gore, Vice-Chair C6-IUPAP

16:30-19:15 PROTEIN STRUCTURE AND FUNCTION Chairs: Mark Baldus, Netherlands Juan Hermoso, Spain

Invited speakers

16:30 Unraveling the role of SepF in the early actinobacterial divisome Pedro Alzari, France




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17:00 Molecular basis for the extra-mitochondrial roles of cytochrome C in cell life and death Miguel Angel de la Rosa, Spain


18:00 Atomistic simulation of biomolecular function: ribosomal translation and ligand binding heterogeneity Helmut Grubmueller, Germany

Short Talks

18:30 Campylobacter jejuni Tlp3 dCache sensing domain specifically recognises hydrophobic amino acids Mohammad Firoz Khan, Australia

18:45 Dynamics of intrinsically disordered and unfolded proteins: investigations using neutron spin-echo spectroscopy Andreas Stadler, Germany

19:00 Side chain to main chain hydrogen bonds stabilize a polyglutamine helix in the activation domain of a transcription factor Albert Escobedo, Spain

MADRID

16:30-19:15 CELL MEMBRANE BIOPHYSICS (CPL Symposium) Chairs: Pierre Emmanuel Milhiet, France Gemma Fabries, Spain

Invited speakers

16:30 Cholesterol modulation of nicotinic acetylcholine receptor single molecule and nanocluster trajectories Francisco Barrantes, Argentina

17:00 Morphology of membrane contact sites contributes to the regulation of the phosphatidylinositol cycle Richard Epand, Canada


18:00 Redox lipidomics deciphers phospholipid signals of programmed cell death Edgard Koijmann, USA





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Short Talks

18:30 Linking structure, stability and function in the anti-measles virus action of tocopherol-derivatized peptide nanoparticles Tiago N. Figueira, Portugal (Prize SBfP)

18:45 Antimicrobial peptides impair bacteria cell structure within seconds Enrico F. Semeraro, Austria

19:00 Elucidating the nanoscale architecture of the plasma membrane with super-resolution spectroscopy Erdinc Sezgin, UK

ROMA

16:30-19:15 NEW FRONTIERS IN BIOIMAGING Chairs: Laszlo Matyus, Hungary Silvia Caponi, Italy

Invited speakers

16:30 Faster and gentler optical nanoscopy for brain cell imaging Ilaria Testa, Sweden

17:00 The mesolens: a new instrument for 3d optical imaging of large biological specimens with sub-cellular resolution throughout Gail McConnell, UK


18:00 Brillouin Microscopy for cell and tissue biomechanics Giuliano Scarcelli, USA

Short Talks

18:30 Wavefront shaping for low background, high resolution STED-FCS in three dimensions Aurélien Barbotin, UK

18:45 High density single particle tracking reveals nano- and meso-scale dynamic organization of plasma membrane receptors in living cells Nicolas Mateos Estevez, Spain

19:00 Photophysics and engineering of transgene labels for optoacoustics Andre C. Stiel, Germany





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PARIS

16:30-19:15 GENE NETWORK DYNAMICS AND SIGNALING Chairs: Marta Ibañez, Spain Jan Brugues, Germany

Invited speakers

16:30 Stochastic Turing patterns in the development of a one-dimensional organism Joel Stavans, Israel

17:00 Human time vs. mouse time: in vitro segmentation clock as a model system Miki Ebisuya, Spain


18:00 Distinguishing dormant from dead by triggering life in spores Hyun Youk, Netherlands

Short Talks

18:30 A nonequilibrium phase transition theory for the formation of diverse homeostasis and the emergence of systematic aging in multicellular systems Yuting Lou, Japan

18:45 Post-transcriptional regulation, noise and spatial transcript localization of small RNA-controlled genes in an Escherichia coli stress response network Rinat Arbel-Goren, Israel

19:00 Modeling cytoneme guidance for Hedgehog signaling Adrián Aguirre-Tamaral, Spain

19:15-20:15 NATIONAL ASSEMBLIES





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T u e s d a y 2 3 J u ly

AUDITORIUM

09:00 PLENARY LECTURE 6Titin folding powers muscle contraction

Julio Fernández, USA Chair: Jorge Alegre-Cebollada, Spain

10:00-12:45 MECHANISMS OF MEMBRANE PROTEINS Chairs: Elena Pohl, Austria Antonio Ferrer, Spain

Invited speakers

10:00 Factors affecting ion permeation through K+-Channels Carmen Domene, UK

10:30 The first human lacking functional TRPV1 channel: Implications on TRPV1 functions in nociception Baruk Minke, Israel

11:00-11:30 COFFEE BREAK

11:30 Optoelectrical dynamics of BK channel activation Teresa Giraldez, Spain

Short Talks

12:00 Structural insight into TRPV5 channel function and modulation Jenny Van Der Wijst, Netherlands

12:15 Biophysical insights into membrane fission mediated by ESCRT III Vasil Georgiev, Germany

12:30 Ion transport, interfacial effects and scaling behavior in protein channels Vicente Aguilella, Spain

MADRID

10:00-12:45 SINGLE MOLECULE BIOPHYSICS Chairs: Nuno Santos, Portugal David Rueda, UK




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Invited speakers

10:00 The mechanical stability of proteins regulates their translocation rate into the cell nucleus Sergi Garcia-Manyes, UK10:30 Mechanosensitive states of the giant muscle protein titin Miklos Kellermayer, Hungary

11:00 – 11:30 COFFE BREAK

11:30 Single-molecule live-cell imaging of mRNA life cycle María Carmo-Fonseca, UK

Short Talks

12:00 ParB dynamics and the critical role of the C-terminal domain in DNA condensation unveiled by combined magnetic tweezers and TIRF microscopy Julene Madariaga-Marcos, Spain

12:15 A folding nucleus and minimal ATP binding domain of Hsp70 identified by single-molecule force spectroscopy Gabriel Zoldak, Slovakia

12:30 Single-molecule dissection of the dihydrofolate reductase reaction revealed multiple conformers leading to a catalytic product release Nicole Galenkamp, Netherlands

ROMA

10:00-12:45 BIOPHYSICS OF IMMUNE RESPONSE Chairs: Jean Marie Ruysschaert, Belgium Mario Castro, Spain

Invited speakers

10:00 Membrane sensing and remodelling during the immune synapse. A spatiotemporal adaptive tale of lipid packing dynamics and collective assembly Jorge Bernardino de la Serna, Spain

10:30 Mechanosensing via immunoreceptors Cheng Zhu, USA






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11:30 The role of oligomeric scaffolds in inflammatory signal transduction through Toll-like receptors and MyD88 Nick Gay, UK

Short Talks

12:00 Insights into the molecular mechanism of lipids/Toll-Like receptors interaction Malvina Pizzuto, Spain

12:15 Super-resolution microscopy analysis of molecular interactions between epithelial cells and tissue-resident T cells in mouse epidermis Dmitry Ushakov, UK

12:30 Shape matters: Towards a molecular understanding of the innate immune response to microbial lipids Andra Schromm, Germany


AUDITORIUM

15:00-16:15 NEW AND NOTABLE Chairs: Anthony Watts, UK Maria Garcia-Parajo, Spain

15:00 A molecular mechanism for transthyretin amyloidogenesis Trevor Forsyth, France

15:25 Cryo-EM of helical polymers at near atomic resolution yields surprises: from microbial nanowires to indestructible pili Edward H. Egelman, USA

15:50 To spread or not to spread: the mechanosensitive dilemma of T cells Kheya Senguptaa, France

16:15-19:00 BIOMOLECULAR SIMULATION II Chairs: Claudio Soares, Portugal Ilpo Vattulainen, Finland Invited speakers

16:15 Advances in multiscale simulation of DNA Modesto Orozco, Spain




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16:45 Nanoparticle-bio interactions: the role of interface composition, conformation and softness Giulia Rossi, Italy


17:45 Lipid regulation of structure, dynamics, energetics, and function of membrane proteins Emad Tajkhorshid, USA

Short Talks

18:15 The catalytic mechanism of MB-COMT: new drug design paradigm? Alex Bunker, Finland

18:30 Combining theoretical and experimental approaches to understand the mechanism of antibiotic permeation: implications on the fight against bacterial resistance Carla F. Sousa, Portugal

18:45 Exploring conformational transitions and free energy profiles of proton coupled oligopeptide transport Mariana Batista, Brazil

MADRID

16:15-19:00 LIVE IMAGING AND OPTICAL MICROSCOPY Chair: Susanne Fenz, Germany

Invited speakers

16:15 Faster and better: taking localisation microscopy into live cells Susan Cox, UK

16:45 A Multi Messenger microscope to paint chromatin in cells Alberto Diaspro, Italy


17:45 Looking into the nursery of platelets: Imaging of the bone marrow in vivo, in vitro and in silico Katrin Heinze, Germany





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Short Talks

18:15 Strong cytoskeleton activity on millisecond timescales upon particle binding revealed by ROCS microscopy Felix Jünger, Germany

18:30 Multiplexed single-molecule fluorescence imaging by FRET PAINT Nina Deußner-Helfmann, Germany

18:45 In vivo single-molecule imaging of DNA gyrase Ji-Eun Lee, UK

ROMA

16:15-19:00 ACTIVE MATTER AND BIOLOGICAL SELF-ORGANIZATION Chairs: Sriram Ramaswamy, India Ramin Golestanian, Germany

Invited speakers

16:15 Active polymers and membranes Gerhard Gompper, Germany

16:45 The microtubule/kinesin system: A versatile realization of an active nematic Francesc Sagues, Spain


17:45 Spontaneous tension cable generation and convergence-extension flows in the gastrulating chick embryo Silke Henkes, UK

Short Talks

18:15 Design principles for robust self-assembly of multiple biological structures from limited resources Deb Sankar Banerjee, UK

18:30 Active phase separation in mixtures of chemically-interacting particles Jaime Agudo-Canalejo, UK

18:45 Self-organization of ciliary beats in bronchial epithelium Simon Gsell, France





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PARIS

14:00-15:00 INFORMATION SESSIONThe European Research Council – Funding for frontier research in Europe

Janne Salo, Research programme officer, European Research Council Executive Agency

Andela Šarić, UK, Starting grantee

Cait MacPhee, UK, Advanced Grant panel chair 2018

16:15- 19:00 IONIC LIQUIDS AND BIOMOLECULES Chairs: Hans-Joachim Galla, Germany Pietro Ballone, Ireland

Invited speakers

16:15 Ionic liquids in bio-systems: from model biomembranes to living cells Antonio Benedetto, Ireland

16:45 Aqueous ionic liquids: consequences for biological stabilities Jens Smiatek, Germany


17:45 Studying fundamental role of ionic interactions to connect structure and properties of ionic liquids with biological activity Valentine Ananikov, Russia

Short Talks

18:15 Probing the effect of a room temperature ionic liquid on self assembled structure of phospholipid membranes Saheli Mitra, India

18:30 The effect of imidazolium-based ionic liquids on human insulin aggregation/amyloid fibrillization Vladimir Vanik, Slovakia

18:45 Effect of Ionic Liquids on the mechanoelasticity of biomembranes: from model phospholipid bilayers to living cells Pallavi Kumari, Ireland

19:00-20:00 EBSA GENERAL ASSEMBLY





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W e d n e s d a y 2 4 J u ly

AUDITORIUM

09:00 PLENARY LECTURE Nonequilibrium stresses and fluxes: compositional organization at the cell surface and organelle morphodynamics Madan Rao, India Chair: Juan M. R. Parrondo, Spain

10:00-12:45 LIPID AND LIPIDOME Chairs: John Seddon, UK Francisco Monroy, Spain

Invited speakers

10:00 Membrane remodeling by the amyloidogenic peptide IAPP: surface crowing relevance Manuel Prieto, Portugal

10:30 How the globoside Gb3 partitions in phase-separated membranes Claudia Steinem, Germany


11:30 Curvature rigidity of asymmetric and differentially stressed membranes Markus Deserno, USA

Short Talks

12:00 Formation of membrane domains: insight from simulations on different scales Andreas Heuer, Germany

12:15 Monte Carlo and molecular dynamics simulations to explain biomembrane meso-patterning by a composition-curvature coupling mechanism Julie Cornet, France

12:30 Biophysical properties of 1-deoxyceramides in ordered and disordered bilayers Felix M Goñi, Spain




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MADRID

10:00-12:45 BIG DATA IN BIOPHYSICS Chairs: Remy Monasson, France Alfonso Valencia, Spain

Invited speakers

10:00 A systems approach to understanding the allosteric mechanism of pyruvate kinase M2 Franca Fraternali, UK

10:30 Statistical mechanics of protein evolution: From models to algorithms Ugo Bastolla, Spain


11:30 Combining imaging and gene expression data in mathematical models for immuno-oncology Vera Pancaldi, France

Short Talks

12:00 Real-time dynamic changes in serum metabolome during the anticancer treatment by means of NMR-based metabolomics Lukasz Boguszewicz, Poland

12:15 Decrypting interaction fingerprints in protein molecular surfaces Bruno Correia, Switzerland

12:30 Bayesian inference and machine learning approaches to determine protein copy number from localization microscopy Carlo Manzo, Spain

ROMA

10:00-12:45 INSTRUCT-ERIC: INTEGRATING ACCESS TO BIOPHYSICS AND STRUCTURAL BIOLOGY IN EUROPE Chair: Ray Owens, UK

Invited speakers

10:00 Structure and mechanism of bactericidal mammalian perforin-2, an ancient agent of innate immunity Rob Gilbert, UK





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10:30 NMR-based hybrid approaches for cellular structural biology Marc Baldus, Netherlands


11:30 Towards High Throughput cryoEM data acquisition and processing, assuring reproducibility Jose-Maria Carazo, Spain

Short Talks

12:00 Access to structural biology and biophysics technologies through Instruct-ERIC Naomi Gray, UK

12:15 Crystal structures of bacteriophage receptor binding proteins Mark J. Van Raaij, Spain

12:30 The Cryo-EM structure of a non-toxic greek key oligomer of alpha synuclein Ritobrita Chakraborty, India

PARIS

10:00-12:45 LIQUID-LIQUID PHASE SEPARATION IN BIOLOGICAL SYSTEMS Chair: Mauro della Serra, Italy

Invited speakers

10:00 Bacterial division protein phase-separated condensates: biochemical and functional consequences German Rivas, Spain (Bruker Manuel Rico SBE Prize)

10:30 Light controlled cytoplasmic transport to probe cellular organization Mortiz Kreysing, Germany


11:30 Multivalency of proteins in cellular phase separation Samuel Safran, Israel

Short Talks

12:00 General sol to gel transition of liquid-liquid phase separated protein under shear Yi Shen, UK




30

12:15 Recapitulation of nucleocytoplasmic transport with phase separation of engineered protein repeats Sheung Chun Ng, Germany

12:30 Protein phase transition: from biology towards new dynamic protein materials Paolo Arosio, Switzerland


14:00-15:00 EBSA EC SECOND MEETING

AUDITORIUM

15:00-17:45 MOLECULAR MOTORS Chairs: Christoph Schmidt, USA José Carrascosa, Spain

Invited speakers

15:00 Cooperative functions of molecular motor assemblies Shin’Ichi Ishiwata, Japan

15:30 A molecular hurdle race: How does DNA polymerase deal with SSBs stably bound to the template? Borja Ibarra, Spain


16:30 A ratchet mechanism governs load adaptation by branched actin networks Peter Bieling, Germany

Short Talks

17:00 Kinesin-2 stepping reflects its heteromeric nature Willi L. Stepp, Germany

17:15 Reverse stroke of cardiac myosin revealed by single molecule microscopy is essential for heart function Yongtae Hwang, Japan

17:30 Artificial assembly of the bacterial flagella motor on DNA scaffolds Sophie Hertel, Australia





31

MADRID

15:00-17:45 TISSUE BIOPHYSICS AND MORPHOGENESIS Chair: Françoise Brochard-Wyart, France

Invited speakers

15:00 Forming, watching and stressing organoids Pierre Nassoy, France

15:30 Physics of epithelial folds and flows Guillaume Salbreux, UK


16:30 Bacterial colonies as active droplets - from single cells to continuum theory Vasily Zaburdaev, Germany

Short Talks

17:00 Biomimetic emulsions probe the mechanics of tissues Lea-Laetitia Pontani, France

17:15 Mechano-transduction and coordination of epithelial cells during Drosophila morphogenesis Matthias Häring, Germany

17:30 A hydraulic instability underlies oocyte size selection in C. elegans Arghyadip Mukherjee, Germany

ROMA

15:00-17:45 EMERGING BREAKTHROUGH MOLECULAR-SCALE BIOPHYSICS METHODOLOGIES (ARBRE-MOBIEU COST Action) Chairs: Patrick England, France Isabel Alves, France

Invited speakers

15:00 Adventures with dynamic and disordered systems Perdita Barran, UK

15:30 Access to atomic resolution structural information of homo repeats: The huntingtin case Pau Bernado, France






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16:30 Investigating the bacterial translocon at the single molecule level Peter Hinterdorfer, Austria

Short Talks

17:00 Correlative μ-Brillouin and μ-Raman spectroscopy: emerging tool for simultaneous mechanical and chemical analysis of cells and tissues Silvia Caponi, Italy

17:15 Revisiting the structure-function relationship with mass photometry Gavin Young, UK

17:30 Hierarchical micro- and nanostructured surface architectures for label-free spectroscopic and microscopic protein interrogation Julia Flesch, Germany

AUDITORIUM

18:00 CLOSING PLENARY LECTUREMINFLUX Nanoscopy: Superresolution post Nobel

Stefan Hell, Germany Chair: Jesús Pérez-Gil, President (Elect) EBSA

19:00 CLOSING CEREMONY

21:00 CONGRESS DINNER





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Biophysical Society–IOP SeriesThe official publishing partner of the Biophysical Society

Expand your reach and engagement

Publish your textbook, monograph, review or handbook in this exciting new series. As the Biophysical Society’s own publishing series your book will benefit from exposure to your peers at conferences, member newsletters and much more.

We welcome proposals in all areas of biophysics research, applications, education, methods, computational tools and techniques.

Choose the right publisher for you

Come along to booth 28 on Tuesday 23 July between 2.00–3.00 p.m. for some refreshments and to find out more about this growing book series.

Alternatively e-mail [email protected] for more information.

Benefits of choosing a digital-first publisher

Rapid publication times

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Full-color print copies

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A dedicated, hands on editor

35

Biophysical Society–IOP SeriesThe official publishing partner of the Biophysical Society

Expand your reach and engagement

Publish your textbook, monograph, review or handbook in this exciting new series. As the Biophysical Society’s own publishing series your book will benefit from exposure to your peers at conferences, member newsletters and much more.

We welcome proposals in all areas of biophysics research, applications, education, methods, computational tools and techniques.

Choose the right publisher for you

Come along to booth 28 on Tuesday 23 July between 2.00–3.00 p.m. for some refreshments and to find out more about this growing book series.

Alternatively e-mail [email protected] for more information.

Benefits of choosing a digital-first publisher

Rapid publication times

Multimedia content

Full-color print copies

No Digital Rights Management

E-reader compatibility

A dedicated, hands on editor

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FINAL PROGRAMME 1 · JOINT 12TH EBSA 10TH ICBP-IPAP Boyss Conress MADRID 20-24 JL 2019 BIOPHSICS...

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