Resistenzen bei tierpathogenen Bakterien – ein Update

Seite 2

Die Welt der übertragbaren Resistenzen

Symposium Antibiotikaresistenz in der LM-Kette, Heike Kaspar

Seite 3

Makrolide Penicilline

Polypeptide Fluorchinolone Cephalosporine Aminoglykoside

Diaminopyrimidine Pleuromutiline Lincosamide Sulfonamide Tetrazykline

Fenicole

Carbapeneme Glycopeptide Glycylcycline Monobactame Streptogramine Quinoxaline Ansamycine Zyklische- Lipopeptide Oxazolidinone Ketolide

Veterinärmedizin Humanmedizin

Zugelassene Wirkstoffklassen


Seite 4 Symposium Antibiotikaresistenz in der LM-Kette, Heike Kaspar

Nationales Resistenzmonitoring bei tierpathogenen Erregern in Deutschland Zielstellung Datenbasis für die Abschätzung von Risiken und Ableitung von Managementmaßnahmen Einschätzung des Risikos, das aus dem Tierbereich auf den Menschen einwirken kann Früherkennung von Resistenz (u. a. „empirische“ Therapie) Trends der Resistenzentwicklung erfassen Epidemiologische Zusammenhänge aufklären


Nationales Resistenzmonitoring bei tierpathogenen Erregern in Deutschland Hintergrund • Resistenzen haben einen „One Health“ Bezug, dies gilt für den

Menschen, das Tier und die Umwelt • Resistenzmonitoring auf Basis §77 Abs. 3, AMG regelmäßige Berichtspflicht des BVL zu Resistenzdaten von klinischen

Isolaten • BVL entwickelt jährlich einen dezidierten Stichprobenplan unter Berücksichtigung von aktuellen Entwicklungen • Isolateinsendung von Laboren an BVL zur Resistenzbestimmung


Konzeption Resistenzmonitoring

Antibiotikaresistenzmonitoring GERM Vet

nationales Resistenzmonitoring veterinärpathogener Bakterien seit 2001

ca. 3500 – 4000 Isolate pro Jahr

klinisch erkrankte Tiere

Lebensmittel liefernde Tiere

nicht-Lebensmittel liefernde Tiere (Hobbytiere)

unauffällige Tiere

Lebensmittel tierischer Herkunft

Seite 7

Stichprobenplan (LM liefernde Tiere)

Tierart Indikation Organ Bakterienspzies

Milchrind Mastitis Milch, Euter

Klebsiella spp. Streptococcus spp. Enterococcus spp. E. coli

Kalb, Rind Erkrankungen des Respirationstraktes Bronchien, Lunge Mannheimia spp. Pasteurella multocida

Schwein Enteritis Darm, Kot E. coli

Schwein Hautinfektionen Haut S. aureus S. hyicus

Sammelzeitraum 25.4.2018 – 31.03.2019


Seite 8 Symposium Antibiotikaresistenz in der LM-Kette, Heike Kaspar Seite 8

Quantitative Methode: Bouillon-Mikrodilution

Ampicillin Cephalothin CHL Enrofloxacin Penicillin G Tetracyclin Vancomycin SXT

Wirkstoff [mg/L] MHK

+ +

Bewertung der Ergebnisse

• klinische Grenzwerte gemäß CLSI (VET01 5th. ed, VET08)

• veterinärspezifische GW Adaption humanspezifischer GW

• wenn keine GW verfügbar: Beurteilung des MHK90- Wertes

• Angaben zu Resistenzraten nur bei vorhandenen Grenzwerten


Bewertungskriterien

Begriffsbestimmung – Nomenklatur Klinische Grenzwerte Sensibel

Intermediär bezogen auf die Wahrscheinlichkeit des

Resistent Therapie erfolges

Epidemiologische Cut-off-Werte

Wildtyp im Bereich der Normalverteilung

Nicht-Wildtyp außerhalb der Normalverteilung

Hinweis auf erworbene Resistenz


Grenzwert

0

10

20

30

40

50

60

0,06 0,12 0,25 0,5 1 2 4 8 16 32 64Tetracyclin, MHK [mg/L]

M. haemolytica (n = 131), Rind

Klinischer breakpoint ≥ 16 (CLSI)

Epidemiolog. Cut-off ≥ 4

Auswertung der Ergebnisse


Ergebnisse des Nationalen Resistenzmonitoring

Respiratorische Erkrankungen


APP, Schwein, Indikation: respiratorische Erkrankungen 2008 - 2014

AMP Ampicillin, CEF Cephalothin, XNL Ceftiofur, ENR Enrofloxacin, FFN Florfenicol, TET Tetracyclin, TIA Tiamulin, TIL Tilmicosin

Ergebnisse


APP, Schwein, Indikation: respiratorische Erkrankungen MHK90-Daten 2008 - 2014

Ergebnisse

MHK90 [mg/L]

Studienjahr

Wirkstoffe, für die keine klinischen Grenzwerte vorhanden sind

2008 2009 2010 2011 2012 2013 2014

Cefotaxim 0,015 0,015 0,015 0,25 0,015 0,015 0,015 Cefquinom 0,03 0,03 0,03 0,5 0,03 0,03 0,03 Doxycyclin 1 2 2 8 2 2 1 Gentamicin 16 16 8 8 16 16 16 Nalidixinsäure 4 4 4 4 4 4 4 SXT 0,12 0,25 0,12 0,12 0,12 0,12 0,25 Tulathromycin 32 32 16 16 - 32 32 N = 63 40 58 46 41 102 101


P. multocida, Rind, Indikation: respiratorische Erkrankungen; 2008 - 2017

Ergebnisse

Diagramm1

CeftiofurCeftiofurCeftiofurCeftiofurCeftiofurCeftiofurCeftiofurCeftiofurCeftiofur

EnrofloxacinEnrofloxacinEnrofloxacinEnrofloxacinEnrofloxacinEnrofloxacinEnrofloxacinEnrofloxacinEnrofloxacin

FlorfenicolFlorfenicolFlorfenicolFlorfenicolFlorfenicolFlorfenicolFlorfenicolFlorfenicolFlorfenicol

PenicillinPenicillinPenicillinPenicillinPenicillinPenicillinPenicillinPenicillinPenicillin

TulathromycinTulathromycinTulathromycinTulathromycinTulathromycinTulathromycinTulathromycinTulathromycinTulathromycin

TetracyclinTetracyclinTetracyclinTetracyclinTetracyclinTetracyclinTetracyclinTetracyclinTetracyclin

2008 N=75

2009 N=68

2010 N=25

2011 N=72

2012 N=77

2013 N=48

2014 N=75

2016 N=99

2017 N=64

resistente Stämme [%]

1

0

0

0

0

0

0

0

0

1

0

4

0

0

0

1.3

0

1.6

1

0

0

1.4

1.3

0

0

3

1.6

1.3

3.2

0

5.6

1.3

2.1

0

2

3.1

0

0

0

0

0

0

3

12.7

7

13

4

12.5

5.2

10.4

6.7

15

30.2

Rind

PasteurellaRindalle Produktionsstufen

2008 N=752009 N=682010 N=252011 N=722012 N=772013 N=482014 N=752016 N=992017 N=64

Ceftiofur100000000

Enrofloxacin1040001.301.6

Florfenicol1001.41.30031.6

Penicillin1.33.205.61.32.1023.1

Tulathromycin000000312.7

Tetracyclin713412.55.210.46.71530.2

n=756825727748759964603

Wirkstoffe, für die keine klinischen Grenzwerte vorhanden sindMHK90 [mg/L]

Studienjahr200820092010201120122013201420162017

Ampicillin0.250.50.510.250.250.50.250.5

Cefoperazon0.060.0610.060.0150.060.060.060.06

Cefotaxim0.0150.0150.030.0150.0150.0150.0150.0150.015

Cefquinom0.060.060.060.060.0150.060.060.060.06

Colistin444424284

Doxycyclin12110.51111

Marbofloxacinn.g.n.g.n.g.n.g.0.060.120.060.060.06

Nalidixinsäure42244128222

Neomycinn.g.n.g.n.g.n.g.n.g.163216>64

Streptomycinn.g.n.g.n.g.n.g.n.g.>51264>512>512

Tilmicosin888881688128

Trimethoprim/Sulfamethoxazol0.50.250.250.250.252160.251

Anzahl Isolate (N)756821727748759964

2008 N=752009 N=682010 N=212011 N=722012 N=772013 N=482014 N=752016 N=992017 N=64

Ampicillin0.250.50.510.250.250.50.250.5

Cefotaxim0.0150.0150.030.0150.0150.0150.0150.0150.015

Doxycyclin12110.51111

Marbofloxacinn.g.n.g.n.g.n.g.0.060.120.060.060.06


Tilmicosin888881688128

Trim/Sulf0.50.250.250.250.252160.251

756821727748759964

Rind

2008 N=75

2009 N=68

2010 N=25

2011 N=72

2012 N=77

2013 N=48

2014 N=75

2016 N=99

2017 N=64


Katze

2008 N=75

2009 N=68

2010 N=21

2011 N=72

2012 N=77

2013 N=48

2014 N=75

2016 N=99

2017 N=64

log2 MHK90-Wert

Wirkstoffe, für die keine klinischen Grenzwerte vorhanden sindMHK90 [mg/L]

Studienjahr2010201120122013/201420152016

Ampicillin0.50.510.250.250.25

Amoxicillin/Clavulansäure0.50.50.50.50.50.5

Cefoperazon0.060.060.120.060.060.06

Cefotaxim0.0150.0150.030.0150.0150.015

Cefquinom0.060.060.120.060.0150.06

Ceftiofur0.030.0150.060.060.030.06

Doxycyclin0.50.50.250.250.250.25

Enrofloxacin0.030.030.030.030.030.03

Gentamicin444444

Marbofloxacinn.g.n.g.0.030.060.030.03


Penicillin0.250.250.250.250.250.25

Tetracyclin10.510.50.50.5

Trimethoprim/Sulfamethoxazol0.120.120.12320.060.12

Anzahl Isolate (N)6410918232019


0

5

10

15

20

25re

sist

ente

Stä

mm

e [ %

]

2008 N=217 2009 N=154 2010 N=73 2013 N=151 2015 N=145

P. multocida, Schwein, Indikation: respiratorische Erkrankungen; 2008 - 2015

Diagramm1

AmpicillinAmpicillinAmpicillinAmpicillinAmpicillin

CeftiofurCeftiofurCeftiofurCeftiofurCeftiofur

EnrofloxacinEnrofloxacinEnrofloxacinEnrofloxacinEnrofloxacin

FlorfenicolFlorfenicolFlorfenicolFlorfenicolFlorfenicol

PenicillinPenicillinPenicillinPenicillinPenicillin

TetracyclinTetracyclinTetracyclinTetracyclinTetracyclin

TilmicosinTilmicosinTilmicosinTilmicosinTilmicosin

TulathromycinTulathromycinTulathromycinTulathromycinTulathromycin

2008 N=217

2009 N=154

2010 N=73

2013 N=151

2015 N=145

resistente Stämme [ %]

6.5

5.8

4.1

4

1.4

0

0

2.7

0

0

0.9

0

0

0.7

0.7

0

0.6

1.4

0.7

0

6.9

5.8

8.2

4

1.4

21.7

18.2

17.8

8.7

8.3

0.9

0

4.1

0

0.7

0.5

0

2.7

0

0.7

Pasteurella Schwein

2008 N=2172009 N=1542010 N=732013 N=1512015 N=145Pasteurella Schwein

Ampicillin6.55.84.141.4

Ceftiofur002.700

Enrofloxacin0.9000.70.7

Florfenicol00.61.40.70

Penicillin6.95.88.241.4

Tetracyclin21.718.217.88.78.3

Tilmicosin0.904.100.7

Tulathromycin0.502.700.7

n21715473151145

Pasteurella Schwein

2008 N=217

2009 N=154

2010 N=73

2013 N=151

2015 N=145

resistente Stämme [ %]

Tabelle1



Enteritis


E. coli, Ferkel, Indikation: Enteritis; 2006 - 2017

Ergebnisse

0

10

20

30

40

50

60

70

80

90

100

Ampicillin Amox/Clav Chloramphenicol Gentamicin Tetrazyklin Trimeth/Sulfa

[%] r

esis

tent

e St

ämm

e

2006/2007 N=345 2008 N=240 2009 N=124 2010 N=156 2011 N=183

2012 N=150 2015 N=134 2016 N=133 2017 N=118

Chloramphenicol nur bis 2012 untersucht

Diagramm1

AmpicillinAmpicillinAmpicillinAmpicillinAmpicillinAmpicillinAmpicillinAmpicillinAmpicillin

Amox/ClavAmox/ClavAmox/ClavAmox/ClavAmox/ClavAmox/ClavAmox/ClavAmox/ClavAmox/Clav

ChloramphenicolChloramphenicolChloramphenicolChloramphenicolChloramphenicolChloramphenicolChloramphenicolChloramphenicolChloramphenicol

GentamicinGentamicinGentamicinGentamicinGentamicinGentamicinGentamicinGentamicinGentamicin

TetrazyklinTetrazyklinTetrazyklinTetrazyklinTetrazyklinTetrazyklinTetrazyklinTetrazyklinTetrazyklin

Trimeth/SulfaTrimeth/SulfaTrimeth/SulfaTrimeth/SulfaTrimeth/SulfaTrimeth/SulfaTrimeth/SulfaTrimeth/SulfaTrimeth/Sulfa

2006/2007 N=345

2008 N=240

2009 N=124

2010 N=156

2011 N=183

2012 N=150

2015 N=134

2016 N=133

2017 N=118

[%] resistente Stämme

62

67

69

71.4

75.4

74

57.5

62.4

62.7

3

2

2

11.3

2.2

1.3

3

0

3.4

31

26

27

24.2

32.8

22.7

10

6

11

13

10.9

11.3

2.2

6.8

7.7

80

73

77

78.9

79.2

72.7

59.7

62.4

55.6

50

50

61

55.9

59

56

43.3

51.1

45.3

Kalb

E. coli Kalb

2006/2007 N=1542008 N=1662009 N=1602010 N=1432011 N=1612012 N=2872013 N=2502014 N=2842015 N=1692016 N=1142017 N=114

Ampicillin687076.376.979.776.377.671.568.666.775.4

Amox/Clav18161519.617.41518.821.52610.516.7

Cephalothin443741.348.342.446.439.4424349.1

Chloramph495150.659.455.548.1

Gentamicin2321253539.928.640.437.722.519.324.6

Tetrazyklin717168.169.275.770.474.463.759.86465.8

Trimeth/Sulfa445148.152.449.457.855.647.242.639.544.7

Summe

n=1541661601431732872502841691141142014

2006/2007 N=1542008 N=1662009 N=1602010 N=1432011 N=1612012 N=2872013 N=2502014 N=2842015 N=1692016 N=1142017 N=114

Imipenemn.g.n.g.n.g.n.g.n.g.0.250.250.250.250.250.25

Colistin0.50.50.5121120.50.50.5

Nalidixinsäure256256256256256256256256256256256

Ciprofloxacinn.g.n.g.n.g.n.g.n.g.323232323232

Enrofloxacin3232323232323232323232

Cefotaxim116326464646464646464

Ceftiofur264128128128128128128128128128

Kalb

2006/2007 N=154

2008 N=166

2009 N=160

2010 N=143

2011 N=161

2012 N=287

2013 N=250

resistente Stämme [%]Achsentitel

ESBL

2006/2007 N=154

2008 N=166

2009 N=160

2010 N=143

2011 N=161

2012 N=287

2013 N=250

2014 N=284

2015 N=169

2016 N=114

2017 N=114


Tabelle2

2006/2007 N=154

2008 N=166

2009 N=160

2010 N=143

2011 N=161

2012 N=287

2013 N=250

2014 N=284

2015 N=169

2016 N=114

2017 N=114

log2 MHK90-Wert

Ferkel

ESBL Kalb

JahrKalbSchweinGeflügel

2006/200772.30.2

20081141.4

2009193.81.8

2010183.91.4

201125.410.63.6

2012207.92.3

201329.20.6

2014340.6

201526.75.51

201629.83.73.6

Ferkel

2006/2007

2008

2009

2010

2011

2012

2013

2014

2015

2016

Prävalenz ESBL bildender E. coli [%]

Pute

Masthahn

E. coliFerkel

2006/2007 N=3452008 N=2402009 N=1242010 N=1562011 N=1832012 N=1502015 N=1342016 N=1332017 N=118

Ampicillin62676971.475.47457.562.462.7

Amox/Clav32211.32.21.3303.4

Chloramphenicol31262724.232.822.7

Gentamicin106111310.911.32.26.87.7

Tetrazyklin80737778.979.272.759.762.455.6

Trimeth/Sulfa50506155.9595643.351.145.3

Summe

n=3452401241561831501341331181583

2006/2007 N=3452008 N=2402009 N=1242010 N=1562011 N=1832012 N=1502015 N=1342016 N=1332017 N=118

Imipenemn.g.n.g.n.g.n.g.n.g.0.250.250.250.25

Colistin40.5488880.54

Nalidixinsäure128256256128128256256128128

Ciprofloxacinn.g.n.g.n.g.n.g.n.g.40.50.50.5


Cefotaxim0.120.120.120.120.120.50.120.120.12

Ceftiofur0.50.50.50.50.5110.50.5

Masthahn

2006/2007 N=345

2008 N=240

2009 N=124

2010 N=156

2011 N=183

2012 N=150

2015 N=134

2016 N=133

2017 N=118


Colistin

2006/2007 N=345

2008 N=240

2009 N=124

2010 N=156

2011 N=183

2012 N=150

2015 N=134

2016 N=133

2017 N=118

log2 MHK90-Wert

E. coli PutePutealle Indikationen

2006/2007 N=1662006/2007 N=1662008 N=1332009 N=852010 N=952011 N=1252012 N=1592013 N=1092014 N=1102015 N=1142016 N=962017 N=64

Ampicillin61.961.965.473.542.159.749.7334033.343.845.3

Amoxi/Clav2.42.41.55.31.151.30.91.82.63.10

Cephalothin42.842.836.833.422.1208.314.513.215.626.6

Chloramph14.914.921.126.621.125.818.922

Enrofloxacin334.504.21.51.35.56.46.15.26.3

Gentamicin1.81.82.32.311.613.68.803.72.66.39.4

Tetrazyklin70.270.262.452.836.84827.716.537.315.82523.4

Trimet/Sulfa35.735.721.821.521.122.425.88.330713.510.9

n=166166133859512515910911011496641422

2006/2007 N=1662008 N=1332009 N=852010 N=952011 N=1252012 N=1592013 N=1092014 N=1102015 N=1142016 N=962017 N=64

Imipenemn.g.n.g.n.g.n.g.0.250.250.250.250.250.250.25

Colistin0.50.580.588120.50.50.5

Nalidixinsäure256128128256256256128256128256128

Ciprofloxacinn.g.n.g.n.g.n.g.0.250.50.50.50.50.50.5

Cefotaxim0.120.120.120.120.120.120.120.120.120.120.12

Ceftiofur0.50.50.50.50.50.50.50.50.50.50.5

2006/2007 N=166

2006/2007 N=166

2008 N=133

2009 N=85

2010 N=95

2011 N=125

2012 N=159

2013 N=109

2014 N=110

2015 N=114

2016 N=96

2017 N=64


2006/2007 N=166

2008 N=133

2009 N=85

2010 N=95

2011 N=125

2012 N=159

2013 N=109

2014 N=110

2015 N=114

2016 N=96

2017 N=64

log2 MHK90-Wert

E. coliMasthahn

2006/2007 N=302008 N=212009 N=292010 N=422011 N=742012 N=352013 N=382014 N=312015 N=1092016 N=772017 N=45

Ampicillin6343525035.642.935.838.73335.144.4

Amoxi/Clav1710311.91.411.4001.86.52.2

Cephalothin37242723.825.915.86.56.415.615.6

Chloramph10537.16.88.617.6

Enrofloxacin3539.59.65.75.39.76.42.62.2

Gentamicin3004.89.614.37.93.23.77.82.2

Tetrazyklin40242133.335.634.323.735.516.518.226.7

Trimet/Sulfa4314301916.414.318.425.823.916.920

n=30212942743538311097745531

2006/2007 N=302008 N=212009 N=292010 N=422011 N=742012 N=352013 N=382014 N=312015 N=1092016 N=772017 N=45

Ceftiofur10.50.540.5160.50.50.50.50.5

Cefotaxim0.50.120.1240.12160.120.120.120.250.12

Nalidixinsäure256256256256256256256256256128256

Ciprofloxacinn.g.n.g.n.g.n.g.n.g.0.50.540.50.50.5

Colistin0.50.50.5111110.50.50.5

0.0150.030.060.120.250.51248163264

log2

-6-5-4-3-2-10123456

2006/2007 N=302008 N=212009 N=292010 N=422011 N=742012 N=352013 N=382014 N=312015 N=109

Ceftiofur0-1-12-14-1-1-1

Cefotaxim-1-3-32-34-3-3-3


Ciprofloxacinn.g.n.g.n.g.n.g.n.g.-1-12-1

Colistin-1-1-100000-1

2006/2007 N=30

2008 N=21

2009 N=29

2010 N=42

2011 N=74

2012 N=35

2013 N=38

2014 N=31

2015 N=109

2016 N=77

2017 N=45


2006/2007 N=30

2008 N=21

2009 N=29

2010 N=42

2011 N=74

2012 N=35

2013 N=38

2014 N=31

2015 N=109

2016 N=77

2017 N=45

log2 MHK90-Wert

Tab. 1.6. Anteil mcr-1 positiver Isolate an Colistin-resistenten (E. coli)

SchweinRindGeflügelOthers

2004/050%0%0%0%

2005/060%0%0%0%

2006/076%25%33%0%

20085%0%64%0%

200927%0%92%0%

201047%45%77%0%

201149%0%85%0%

201244%0%95%100%

2013*62%25%0%

2014*45%57%0%

201554%0%50%0%

Table 1.4. Anteil Colistin-resistenter Isolate am Probeneingang


2004/055.1%0.7%0.5%0.0%

2005/063.5%1.1%0.4%0.0%

2006/079.7%2.2%2.7%3.6%

20085.7%4.5%3.3%4.5%

20099.4%3.4%5.5%0.0%

201012.4%2.2%4.5%0.8%

201117.8%1.5%5.3%1.7%

201215.8%0.7%5.2%0.0%

2013*4.9%1.1%0.0%

2014*2.1%2.1%1.1%

201512.3%3.4%0.5%1.0%

Table 1.5. Anteil mcr-1 positiver Isolate am Probeneingang (E. coli)


2004/050.0%0.0%0.0%0.0%

2005/060.0%0.0%0.0%0.0%

2006/070.6%0.5%0.9%0.0%

20080.3%0.0%2.1%0.0%

20092.6%0.0%5.1%0.0%

20105.8%1.0%3.4%0.0%

20118.7%0.0%4.5%0.0%

20126.9%0.0%5.0%1.7%

2013*3.0%0.3%0.0%

2014*0.9%1.2%0.0%

20156.6%0.0%0.3%0.0%

Schwein

Rind

Geflügel

Schwein

Rind

Geflügel

Schwein

Rind

Geflügel


E. coli, MHK90-Daten, Ferkel, Indikation: Enteritis; 2006 - 2017

Ergebnisse

Ciprofloxacin ab 2012 untersucht

Diagramm1

ColistinColistinColistinColistinColistinColistinColistinColistin

NalidixinsäureNalidixinsäureNalidixinsäureNalidixinsäureNalidixinsäureNalidixinsäureNalidixinsäureNalidixinsäure

CiprofloxacinCiprofloxacinCiprofloxacinCiprofloxacinCiprofloxacinCiprofloxacinCiprofloxacinCiprofloxacin

EnrofloxacinEnrofloxacinEnrofloxacinEnrofloxacinEnrofloxacinEnrofloxacinEnrofloxacinEnrofloxacin

CefotaximCefotaximCefotaximCefotaximCefotaximCefotaximCefotaximCefotaxim

CeftiofurCeftiofurCeftiofurCeftiofurCeftiofurCeftiofurCeftiofurCeftiofur

2006/2007 N=345

2008 N=240

2009 N=124

2010 N=156

2011 N=183

2012 N=150

2015 N=134

2016 N=133

log2 MHK90-Wert

4

0.5

4

8

8

8

8

0.5

128

256

256

128

128

256

256

128

0

0

0

0

0

4

0.5

0.5

0.5

1

1

0.5

0.5

8

2

1

0.12

0.12

0.12

0.12

0.12

0.5

0.12

0.12

0.5

0.5

0.5

0.5

0.5

1

1

0.5

Kalb

E. coli Kalb

2006/2007 N=1542008 N=1662009 N=1602010 N=1432011 N=1612012 N=2872013 N=2502014 N=2842015 N=1692016 N=114

Ampicillin687076.376.979.776.377.671.568.666.7

Amox/Clav18161519.617.41518.821.52610.5

Cephalothin443741.348.342.446.439.44243

Chloramph495150.659.455.548.1

Gentamicin2321253539.928.640.437.722.519.3

Tetrazyklin717168.169.275.770.474.463.759.864

Trimeth/Sulfa445148.152.449.457.855.647.242.639.5

Summe

n=1541661601431732872502841691141900

2006/2007 N=1542008 N=1662009 N=1602010 N=1432011 N=1612012 N=2872013 N=2502014 N=2842015 N=1692016 N=114

Imipenemn.g.n.g.n.g.n.g.n.g.0.250.250.250.250.25

Colistin0.50.50.5121120.50.5

Nalidixinsäure256256256256256256256256256256


Enrofloxacin32323232323232323232

Cefotaxim1163264646464646464

Ceftiofur264128128128128128128128128

Kalb

2006/2007 N=154

2008 N=166

2009 N=160

2010 N=143

2011 N=161

2012 N=287

2013 N=250


ESBL

2006/2007 N=154

2008 N=166

2009 N=160

2010 N=143

2011 N=161

2012 N=287

2013 N=250

2014 N=284

2015 N=169

2016 N=114


Tabelle2

2006/2007 N=154

2008 N=166

2009 N=160

2010 N=143

2011 N=161

2012 N=287

2013 N=250

2014 N=284

2015 N=169

2016 N=114

log2 MHK90-Wert

Ferkel

ESBL Kalb


2006/200772.30.2

20081141.4

2009193.81.8

2010183.91.4

201125.410.63.6

2012207.92.3

201329.20.6

2014340.6

201526.75.51

201629.83.73.6

Ferkel

2006/2007

2008

2009

2010

2011

2012

2013

2014

2015

2016


Pute

Masthahn

E. coliFerkel

2006/2007 N=3452008 N=2402009 N=1242010 N=1562011 N=1832012 N=1502015 N=1342016 N=133

Ampicillin62676971.475.47457.562.4

Amox/Clav32211.32.21.330

Cephalothin27191928.623.719.421.1


Gentamicin106111310.911.32.26.8

Tetrazyklin80737778.979.272.759.762.4

Trimeth/Sulfa50506155.9595643.351.1

Summe

n=3452401241561831501341331465

2006/2007 N=3452008 N=2402009 N=1242010 N=1562011 N=1832012 N=1502015 N=1342016 N=133

Colistin40.5488880.5

Nalidixinsäure128256256128128256256128

Ciprofloxacinn.g.n.g.n.g.n.g.n.g.40.50.5


Cefotaxim0.120.120.120.120.120.50.120.12

Ceftiofur0.50.50.50.50.5110.5

Masthahn

2006/2007 N=345

2008 N=240

2009 N=124

2010 N=156

2011 N=183

2012 N=150

2015 N=134

2016 N=133


Colistin

2006/2007 N=345

2008 N=240

2009 N=124

2010 N=156

2011 N=183

2012 N=150

2015 N=134

2016 N=133

log2 MHK90-Wert


2006/2007 N=1662006/2007 N=1662008 N=1332009 N=852010 N=952011 N=1252012 N=1592013 N=1092014 N=1102015 N=1142016 N=96

Ampicillin61.961.965.473.542.159.749.7334033.343.8

Amoxi/Clav2.42.41.55.31.151.30.91.82.63.1

Cephalothin42.842.836.833.422.1208.314.513.215.6

Chloramph14.914.921.126.621.125.818.922

Enrofloxacin334.504.21.51.35.56.46.15.2

Gentamicin1.81.82.32.311.613.68.803.72.66.3

Tetrazyklin70.270.262.452.836.84827.716.537.315.825

Trimet/Sulfa35.735.721.821.521.122.425.88.330713.5

n=166166133859512515910911011496

2006/2007 N=1662008 N=1332009 N=852010 N=952011 N=1252012 N=1592013 N=1092014 N=1102015 N=1142016 N=96

Imipenemn.g.n.g.n.g.n.g.0.250.250.250.250.250.25

Colistin0.50.580.588120.50.5

Nalidixinsäure256128128256256256128256128256

Ciprofloxacinn.g.n.g.n.g.n.g.0.250.50.50.50.50.5

Cefotaxim0.120.120.120.120.120.120.120.120.120.12

Ceftiofur0.50.50.50.50.50.50.50.50.50.5

2006/2007 N=166

2006/2007 N=166

2008 N=133

2009 N=85

2010 N=95

2011 N=125

2012 N=159

2013 N=109

2014 N=110

2015 N=114

2016 N=96


2006/2007 N=166

2008 N=133

2009 N=85

2010 N=95

2011 N=125

2012 N=159

2013 N=109

2014 N=110

2015 N=114

2016 N=96

log2 MHK90-Wert

E. coliMasthahn

2006/2007 N=302008 N=212009 N=292010 N=422011 N=742012 N=352013 N=382014 N=312015 N=1092016 N=77

Ampicillin6343525035.642.935.838.73335.1

Amoxi/Clav1710311.91.411.4001.86.5

Cephalothin37242723.825.915.86.56.415.6

Chloramph10537.16.88.617.6

Enrofloxacin3539.59.65.75.39.76.42.6

Gentamicin3004.89.614.37.93.23.77.8

Tetrazyklin40242133.335.634.323.735.516.518.2

Trimet/Sulfa4314301916.414.318.425.823.916.9

n=302129427435383110977486

2006/2007 N=302008 N=212009 N=292010 N=422011 N=742012 N=352013 N=382014 N=312015 N=1092016 N=77

Ceftiofur10.50.540.5160.50.50.50.5

Cefotaxim0.50.120.1240.12160.120.120.120.25

Nalidixinsäure256256256256256256256256256128

Ciprofloxacinn.g.n.g.n.g.n.g.n.g.0.50.540.50.5

Colistin0.50.50.5111110.50.5

0.0150.030.060.120.250.51248163264

log2

-6-5-4-3-2-10123456

2006/2007 N=302008 N=212009 N=292010 N=422011 N=742012 N=352013 N=382014 N=312015 N=109

Ceftiofur0-1-12-14-1-1-1

Cefotaxim-1-3-32-34-3-3-3



Colistin-1-1-100000-1

2006/2007 N=30

2008 N=21

2009 N=29

2010 N=42

2011 N=74

2012 N=35

2013 N=38

2014 N=31

2015 N=109

2016 N=77


2006/2007 N=30

2008 N=21

2009 N=29

2010 N=42

2011 N=74

2012 N=35

2013 N=38

2014 N=31

2015 N=109

2016 N=77

log2 MHK90-Wert [mg/L]



2004/050%0%0%0%

2005/060%0%0%0%

2006/076%25%33%0%

20085%0%64%0%

200927%0%92%0%

201047%45%77%0%

201149%0%85%0%

201244%0%95%100%

2013*62%25%0%

2014*45%57%0%

201554%0%50%0%



2004/055.1%0.7%0.5%0.0%

2005/063.5%1.1%0.4%0.0%

2006/079.7%2.2%2.7%3.6%

20085.7%4.5%3.3%4.5%

20099.4%3.4%5.5%0.0%

201012.4%2.2%4.5%0.8%

201117.8%1.5%5.3%1.7%

201215.8%0.7%5.2%0.0%

2013*4.9%1.1%0.0%

2014*2.1%2.1%1.1%

201512.3%3.4%0.5%1.0%



2004/050.0%0.0%0.0%0.0%

2005/060.0%0.0%0.0%0.0%

2006/070.6%0.5%0.9%0.0%

20080.3%0.0%2.1%0.0%

20092.6%0.0%5.1%0.0%

20105.8%1.0%3.4%0.0%

20118.7%0.0%4.5%0.0%

20126.9%0.0%5.0%1.7%

2013*3.0%0.3%0.0%

2014*0.9%1.2%0.0%

20156.6%0.0%0.3%0.0%

Schwein

Rind

Geflügel

Schwein

Rind

Geflügel

Schwein

Rind

Geflügel


E. coli, Kalb, Indikation: Enteritis; 2008 - 2017

0

10

20

30

40

50

60

70

80

90

100

Ampicillin Amox/Clav Gentamicin Tetrazyklin Trimeth/Sulfa

[%] r

esis

tent

e St

ämm

e

2006/2007 N=154 2008 N=166 2009 N=160 2010 N=143 2011 N=161 2012 N=287

2013 N=250 2014 N=284 2015 N=169 2016 N=114 2017 N=114

Diagramm1

AmpicillinAmpicillinAmpicillinAmpicillinAmpicillinAmpicillinAmpicillinAmpicillinAmpicillinAmpicillinAmpicillin

Amox/ClavAmox/ClavAmox/ClavAmox/ClavAmox/ClavAmox/ClavAmox/ClavAmox/ClavAmox/ClavAmox/ClavAmox/Clav

GentamicinGentamicinGentamicinGentamicinGentamicinGentamicinGentamicinGentamicinGentamicinGentamicinGentamicin

TetrazyklinTetrazyklinTetrazyklinTetrazyklinTetrazyklinTetrazyklinTetrazyklinTetrazyklinTetrazyklinTetrazyklinTetrazyklin

Trimeth/SulfaTrimeth/SulfaTrimeth/SulfaTrimeth/SulfaTrimeth/SulfaTrimeth/SulfaTrimeth/SulfaTrimeth/SulfaTrimeth/SulfaTrimeth/SulfaTrimeth/Sulfa

2006/2007 N=154

2008 N=166

2009 N=160

2010 N=143

2011 N=161

2012 N=287

2013 N=250

2014 N=284

2015 N=169

2016 N=114

2017 N=114


68

70

76.3

76.9

79.7

76.3

77.6

71.5

68.6

66.7

75.4

18

16

15

19.6

17.4

15

18.8

21.5

26

10.5

16.7

23

21

25

35

39.9

28.6

40.4

37.7

22.5

19.3

24.6

71

71

68.1

69.2

75.7

70.4

74.4

63.7

59.8

64

65.8

44

51

48.1

52.4

49.4

57.8

55.6

47.2

42.6

39.5

44.7

Kalb

E. coli Kalb

2006/2007 N=1542008 N=1662009 N=1602010 N=1432011 N=1612012 N=2872013 N=2502014 N=2842015 N=1692016 N=1142017 N=114

Ampicillin687076.376.979.776.377.671.568.666.775.4

Amox/Clav18161519.617.41518.821.52610.516.7

Gentamicin2321253539.928.640.437.722.519.324.6

Tetrazyklin717168.169.275.770.474.463.759.86465.8

Trimeth/Sulfa445148.152.449.457.855.647.242.639.544.7

Summe

n=1541661601431732872502841691141142014

2006/2007 N=1542008 N=1662009 N=1602010 N=1432011 N=1612012 N=2872013 N=2502014 N=2842015 N=1692016 N=1142017 N=114


Colistin0.50.50.5121120.50.50.5

Nalidixinsäure256256256256256256256256256256256


Enrofloxacin3232323232323232323232

Cefotaxim116326464646464646464

Ceftiofur264128128128128128128128128128

Kalb

2006/2007 N=154

2008 N=166

2009 N=160

2010 N=143

2011 N=161

2012 N=287

2013 N=250


ESBL

2006/2007 N=154

2008 N=166

2009 N=160

2010 N=143

2011 N=161

2012 N=287

2013 N=250

2014 N=284

2015 N=169

2016 N=114

2017 N=114


Tabelle2

2006/2007 N=154

2008 N=166

2009 N=160

2010 N=143

2011 N=161

2012 N=287

2013 N=250

2014 N=284

2015 N=169

2016 N=114

2017 N=114

log2 MHK90-Wert

Ferkel

ESBL Kalb


2006/200772.30.2

20081141.4

2009193.81.8

2010183.91.4

201125.410.63.6

2012207.92.3

201329.20.6

2014340.6

201526.75.51

201629.83.73.6

Ferkel

2006/2007

2008

2009

2010

2011

2012

2013

2014

2015

2016


Pute

Masthahn

E. coliFerkel

2006/2007 N=3452008 N=2402009 N=1242010 N=1562011 N=1832012 N=1502015 N=1342016 N=1332017 N=118

Ampicillin62676971.475.47457.562.462.7

Amox/Clav32211.32.21.3303.4


Gentamicin106111310.911.32.26.87.7

Tetrazyklin80737778.979.272.759.762.455.6

Trimeth/Sulfa50506155.9595643.351.145.3

Summe

n=3452401241561831501341331181583

2006/2007 N=3452008 N=2402009 N=1242010 N=1562011 N=1832012 N=1502015 N=1342016 N=1332017 N=118


Colistin40.5488880.54

Nalidixinsäure128256256128128256256128128



Cefotaxim0.120.120.120.120.120.50.120.120.12

Ceftiofur0.50.50.50.50.5110.50.5

Masthahn

2006/2007 N=345

2008 N=240

2009 N=124

2010 N=156

2011 N=183

2012 N=150

2015 N=134

2016 N=133

2017 N=118


Colistin

2006/2007 N=345

2008 N=240

2009 N=124

2010 N=156

2011 N=183

2012 N=150

2015 N=134

2016 N=133

2017 N=118

log2 MHK90-Wert


2006/2007 N=1662006/2007 N=1662008 N=1332009 N=852010 N=952011 N=1252012 N=1592013 N=1092014 N=1102015 N=1142016 N=962017 N=64

Ampicillin61.961.965.473.542.159.749.7334033.343.845.3

Amoxi/Clav2.42.41.55.31.151.30.91.82.63.10

Cephalothin42.842.836.833.422.1208.314.513.215.626.6

Chloramph14.914.921.126.621.125.818.922

Enrofloxacin334.504.21.51.35.56.46.15.26.3

Gentamicin1.81.82.32.311.613.68.803.72.66.39.4

Tetrazyklin70.270.262.452.836.84827.716.537.315.82523.4

Trimet/Sulfa35.735.721.821.521.122.425.88.330713.510.9

n=166166133859512515910911011496641422

2006/2007 N=1662008 N=1332009 N=852010 N=952011 N=1252012 N=1592013 N=1092014 N=1102015 N=1142016 N=962017 N=64


Colistin0.50.580.588120.50.50.5

Nalidixinsäure256128128256256256128256128256128


Cefotaxim0.120.120.120.120.120.120.120.120.120.120.12

Ceftiofur0.50.50.50.50.50.50.50.50.50.50.5

2006/2007 N=166

2006/2007 N=166

2008 N=133

2009 N=85

2010 N=95

2011 N=125

2012 N=159

2013 N=109

2014 N=110

2015 N=114

2016 N=96

2017 N=64


2006/2007 N=166

2008 N=133

2009 N=85

2010 N=95

2011 N=125

2012 N=159

2013 N=109

2014 N=110

2015 N=114

2016 N=96

2017 N=64

log2 MHK90-Wert

E. coliMasthahn

2006/2007 N=302008 N=212009 N=292010 N=422011 N=742012 N=352013 N=382014 N=312015 N=1092016 N=772017 N=45

Ampicillin6343525035.642.935.838.73335.144.4

Amoxi/Clav1710311.91.411.4001.86.52.2

Cephalothin37242723.825.915.86.56.415.615.6

Chloramph10537.16.88.617.6

Enrofloxacin3539.59.65.75.39.76.42.62.2

Gentamicin3004.89.614.37.93.23.77.82.2

Tetrazyklin40242133.335.634.323.735.516.518.226.7

Trimet/Sulfa4314301916.414.318.425.823.916.920

n=30212942743538311097745531

2006/2007 N=302008 N=212009 N=292010 N=422011 N=742012 N=352013 N=382014 N=312015 N=1092016 N=772017 N=45

Ceftiofur10.50.540.5160.50.50.50.50.5

Cefotaxim0.50.120.1240.12160.120.120.120.250.12

Nalidixinsäure256256256256256256256256256128256


Colistin0.50.50.5111110.50.50.5

0.0150.030.060.120.250.51248163264

log2

-6-5-4-3-2-10123456

2006/2007 N=302008 N=212009 N=292010 N=422011 N=742012 N=352013 N=382014 N=312015 N=109

Ceftiofur0-1-12-14-1-1-1

Cefotaxim-1-3-32-34-3-3-3



Colistin-1-1-100000-1

2006/2007 N=30

2008 N=21

2009 N=29

2010 N=42

2011 N=74

2012 N=35

2013 N=38

2014 N=31

2015 N=109

2016 N=77

2017 N=45


2006/2007 N=30

2008 N=21

2009 N=29

2010 N=42

2011 N=74

2012 N=35

2013 N=38

2014 N=31

2015 N=109

2016 N=77

2017 N=45

log2 MHK90-Wert



2004/050%0%0%0%

2005/060%0%0%0%

2006/076%25%33%0%

20085%0%64%0%

200927%0%92%0%

201047%45%77%0%

201149%0%85%0%

201244%0%95%100%

2013*62%25%0%

2014*45%57%0%

201554%0%50%0%



2004/055.1%0.7%0.5%0.0%

2005/063.5%1.1%0.4%0.0%

2006/079.7%2.2%2.7%3.6%

20085.7%4.5%3.3%4.5%

20099.4%3.4%5.5%0.0%

201012.4%2.2%4.5%0.8%

201117.8%1.5%5.3%1.7%

201215.8%0.7%5.2%0.0%

2013*4.9%1.1%0.0%

2014*2.1%2.1%1.1%

201512.3%3.4%0.5%1.0%



2004/050.0%0.0%0.0%0.0%

2005/060.0%0.0%0.0%0.0%

2006/070.6%0.5%0.9%0.0%

20080.3%0.0%2.1%0.0%

20092.6%0.0%5.1%0.0%

20105.8%1.0%3.4%0.0%

20118.7%0.0%4.5%0.0%

20126.9%0.0%5.0%1.7%

2013*3.0%0.3%0.0%

2014*0.9%1.2%0.0%

20156.6%0.0%0.3%0.0%

Schwein

Rind

Geflügel

Schwein

Rind

Geflügel

Schwein

Rind

Geflügel


Ergebnisse E. coli, Kalb, MHK90-Daten Indikation: Enteritis; 2006 - 2017


Diagramm1

ColistinColistinColistinColistinColistinColistinColistinColistinColistinColistinColistin

NalidixinsäureNalidixinsäureNalidixinsäureNalidixinsäureNalidixinsäureNalidixinsäureNalidixinsäureNalidixinsäureNalidixinsäureNalidixinsäureNalidixinsäure

CiprofloxacinCiprofloxacinCiprofloxacinCiprofloxacinCiprofloxacinCiprofloxacinCiprofloxacinCiprofloxacinCiprofloxacinCiprofloxacinCiprofloxacin

EnrofloxacinEnrofloxacinEnrofloxacinEnrofloxacinEnrofloxacinEnrofloxacinEnrofloxacinEnrofloxacinEnrofloxacinEnrofloxacinEnrofloxacin

CefotaximCefotaximCefotaximCefotaximCefotaximCefotaximCefotaximCefotaximCefotaximCefotaximCefotaxim

CeftiofurCeftiofurCeftiofurCeftiofurCeftiofurCeftiofurCeftiofurCeftiofurCeftiofurCeftiofurCeftiofur

2006/2007 N=154

2008 N=166

2009 N=160

2010 N=143

2011 N=161

2012 N=287

2013 N=250

2014 N=284

2015 N=169

2016 N=114

2017 N=114

log2 MHK90-Wert

0.5

0.5

0.5

1

2

1

1

2

0.5

0.5

0.5

256

256

256

256

256

256

256

256

256

256

256

0

0

0

0

0

32

32

32

32

32

32

32

32

32

32

32

32

32

32

32

32

32

1

16

32

64

64

64

64

64

64

64

64

2

64

128

128

128

128

128

128

128

128

128

Kalb

E. coli Kalb

2006/2007 N=1542008 N=1662009 N=1602010 N=1432011 N=1612012 N=2872013 N=2502014 N=2842015 N=1692016 N=1142017 N=114

Ampicillin687076.376.979.776.377.671.568.666.775.4

Amox/Clav18161519.617.41518.821.52610.516.7

Cephalothin443741.348.342.446.439.4424349.1

Chloramph495150.659.455.548.1

Gentamicin2321253539.928.640.437.722.519.324.6

Tetrazyklin717168.169.275.770.474.463.759.86465.8

Trimeth/Sulfa445148.152.449.457.855.647.242.639.544.7

Summe

n=1541661601431732872502841691141142014

2006/2007 N=1542008 N=1662009 N=1602010 N=1432011 N=1612012 N=2872013 N=2502014 N=2842015 N=1692016 N=1142017 N=114

Colistin0.50.50.5121120.50.50.5

Nalidixinsäure256256256256256256256256256256256


Enrofloxacin3232323232323232323232

Cefotaxim116326464646464646464

Ceftiofur264128128128128128128128128128

Kalb

2006/2007 N=154

2008 N=166

2009 N=160

2010 N=143

2011 N=161

2012 N=287

2013 N=250


ESBL

2006/2007 N=154

2008 N=166

2009 N=160

2010 N=143

2011 N=161

2012 N=287

2013 N=250

2014 N=284

2015 N=169

2016 N=114

2017 N=114


Tabelle2

2006/2007 N=154

2008 N=166

2009 N=160

2010 N=143

2011 N=161

2012 N=287

2013 N=250

2014 N=284

2015 N=169

2016 N=114

2017 N=114

log2 MHK90-Wert

Ferkel

ESBL Kalb


2006/200772.30.2

20081141.4

2009193.81.8

2010183.91.4

201125.410.63.6

2012207.92.3

201329.20.6

2014340.6

201526.75.51

201629.83.73.6

Ferkel

2006/2007

2008

2009

2010

2011

2012

2013

2014

2015

2016


Pute

Masthahn

E. coliFerkel

2006/2007 N=3452008 N=2402009 N=1242010 N=1562011 N=1832012 N=1502015 N=1342016 N=1332017 N=118

Ampicillin62676971.475.47457.562.462.7

Amox/Clav32211.32.21.3303.4


Gentamicin106111310.911.32.26.87.7

Tetrazyklin80737778.979.272.759.762.455.6

Trimeth/Sulfa50506155.9595643.351.145.3

Summe

n=3452401241561831501341331181583

2006/2007 N=3452008 N=2402009 N=1242010 N=1562011 N=1832012 N=1502015 N=1342016 N=1332017 N=118


Colistin40.5488880.54

Nalidixinsäure128256256128128256256128128



Cefotaxim0.120.120.120.120.120.50.120.120.12

Ceftiofur0.50.50.50.50.5110.50.5

Masthahn

2006/2007 N=345

2008 N=240

2009 N=124

2010 N=156

2011 N=183

2012 N=150

2015 N=134

2016 N=133

2017 N=118


Colistin

2006/2007 N=345

2008 N=240

2009 N=124

2010 N=156

2011 N=183

2012 N=150

2015 N=134

2016 N=133

2017 N=118

log2 MHK90-Wert


2006/2007 N=1662006/2007 N=1662008 N=1332009 N=852010 N=952011 N=1252012 N=1592013 N=1092014 N=1102015 N=1142016 N=962017 N=64

Ampicillin61.961.965.473.542.159.749.7334033.343.845.3

Amoxi/Clav2.42.41.55.31.151.30.91.82.63.10

Cephalothin42.842.836.833.422.1208.314.513.215.626.6

Chloramph14.914.921.126.621.125.818.922

Enrofloxacin334.504.21.51.35.56.46.15.26.3

Gentamicin1.81.82.32.311.613.68.803.72.66.39.4

Tetrazyklin70.270.262.452.836.84827.716.537.315.82523.4

Trimet/Sulfa35.735.721.821.521.122.425.88.330713.510.9

n=166166133859512515910911011496641422

2006/2007 N=1662008 N=1332009 N=852010 N=952011 N=1252012 N=1592013 N=1092014 N=1102015 N=1142016 N=962017 N=64


Colistin0.50.580.588120.50.50.5

Nalidixinsäure256128128256256256128256128256128


Cefotaxim0.120.120.120.120.120.120.120.120.120.120.12

Ceftiofur0.50.50.50.50.50.50.50.50.50.50.5

2006/2007 N=166

2006/2007 N=166

2008 N=133

2009 N=85

2010 N=95

2011 N=125

2012 N=159

2013 N=109

2014 N=110

2015 N=114

2016 N=96

2017 N=64


2006/2007 N=166

2008 N=133

2009 N=85

2010 N=95

2011 N=125

2012 N=159

2013 N=109

2014 N=110

2015 N=114

2016 N=96

2017 N=64

log2 MHK90-Wert

E. coliMasthahn

2006/2007 N=302008 N=212009 N=292010 N=422011 N=742012 N=352013 N=382014 N=312015 N=1092016 N=772017 N=45

Ampicillin6343525035.642.935.838.73335.144.4

Amoxi/Clav1710311.91.411.4001.86.52.2

Cephalothin37242723.825.915.86.56.415.615.6

Chloramph10537.16.88.617.6

Enrofloxacin3539.59.65.75.39.76.42.62.2

Gentamicin3004.89.614.37.93.23.77.82.2

Tetrazyklin40242133.335.634.323.735.516.518.226.7

Trimet/Sulfa4314301916.414.318.425.823.916.920

n=30212942743538311097745531

2006/2007 N=302008 N=212009 N=292010 N=422011 N=742012 N=352013 N=382014 N=312015 N=1092016 N=772017 N=45

Ceftiofur10.50.540.5160.50.50.50.50.5

Cefotaxim0.50.120.1240.12160.120.120.120.250.12

Nalidixinsäure256256256256256256256256256128256


Colistin0.50.50.5111110.50.50.5

0.0150.030.060.120.250.51248163264

log2

-6-5-4-3-2-10123456

2006/2007 N=302008 N=212009 N=292010 N=422011 N=742012 N=352013 N=382014 N=312015 N=109

Ceftiofur0-1-12-14-1-1-1

Cefotaxim-1-3-32-34-3-3-3



Colistin-1-1-100000-1

2006/2007 N=30

2008 N=21

2009 N=29

2010 N=42

2011 N=74

2012 N=35

2013 N=38

2014 N=31

2015 N=109

2016 N=77

2017 N=45


2006/2007 N=30

2008 N=21

2009 N=29

2010 N=42

2011 N=74

2012 N=35

2013 N=38

2014 N=31

2015 N=109

2016 N=77

2017 N=45

log2 MHK90-Wert



2004/050%0%0%0%

2005/060%0%0%0%

2006/076%25%33%0%

20085%0%64%0%

200927%0%92%0%

201047%45%77%0%

201149%0%85%0%

201244%0%95%100%

2013*62%25%0%

2014*45%57%0%

201554%0%50%0%



2004/055.1%0.7%0.5%0.0%

2005/063.5%1.1%0.4%0.0%

2006/079.7%2.2%2.7%3.6%

20085.7%4.5%3.3%4.5%

20099.4%3.4%5.5%0.0%

201012.4%2.2%4.5%0.8%

201117.8%1.5%5.3%1.7%

201215.8%0.7%5.2%0.0%

2013*4.9%1.1%0.0%

2014*2.1%2.1%1.1%

201512.3%3.4%0.5%1.0%



2004/050.0%0.0%0.0%0.0%

2005/060.0%0.0%0.0%0.0%

2006/070.6%0.5%0.9%0.0%

20080.3%0.0%2.1%0.0%

20092.6%0.0%5.1%0.0%

20105.8%1.0%3.4%0.0%

20118.7%0.0%4.5%0.0%

20126.9%0.0%5.0%1.7%

2013*3.0%0.3%0.0%

2014*0.9%1.2%0.0%

20156.6%0.0%0.3%0.0%

Schwein

Rind

Geflügel

Schwein

Rind

Geflügel

Schwein

Rind

Geflügel


E. coli, Prävalenzdaten ESBL-bildender (%)

Ergebnisse

Diagramm1

2006/20072006/20072006/20072006/2007

2008200820082008

2009200920092009

2010201020102010

2011201120112011

2012201220122012

2013201320132013

2014201420142014

2015201520152015

2016201620162016

Schwein (2013 und 2014 nicht untersucht)

Kalb

Geflügel

Hund

Prävalenz ESBL E. coli [%]

2.3

7

0.2

0

4

11

1.4

0

3.8

19

1.8

5.4

3.9

18

1.4

3.2

10.6

25.4

3.6

4.7

7.9

20

2.3

1.4

29

0.6

7.8

34

0.6

14.7

5.5

26.7

1

4.4

3.7

29.8

3.6

3.8

Tabelle1

Schwein (2013 und 2014 nicht untersucht)KalbGeflügelHund

2006/20072.370.20

20084111.40

20093.8191.85.4

20103.9181.43.2

201110.625.43.64.7

20127.9202.31.4

2013290.67.8

2014340.614.7

20155.526.714.4

20163.729.83.63.8

Tabelle1

Schwein (2013 und 2014 nicht untersucht)

Kalb

Geflügel

Hund

Prävalenz ESBL E. coli [%]



Mastitis


E. coli, Milchrind, Indikation: Mastitis; 2002 - 2016

Ergebnisse

Diagramm1

AmpicillinAmpicillinAmpicillinAmpicillinAmpicillinAmpicillinAmpicillin

Amoxicillin/ClavulansäureAmoxicillin/ClavulansäureAmoxicillin/ClavulansäureAmoxicillin/ClavulansäureAmoxicillin/ClavulansäureAmoxicillin/ClavulansäureAmoxicillin/Clavulansäure

CeftiofurCeftiofurCeftiofurCeftiofurCeftiofurCeftiofurCeftiofur

GentamicinGentamicinGentamicinGentamicinGentamicinGentamicinGentamicin

TetracyclinTetracyclinTetracyclinTetracyclinTetracyclinTetracyclinTetracyclin

Trimethoprim/SulfamethoxazolTrimethoprim/SulfamethoxazolTrimethoprim/SulfamethoxazolTrimethoprim/SulfamethoxazolTrimethoprim/SulfamethoxazolTrimethoprim/SulfamethoxazolTrimethoprim/Sulfamethoxazol

2002/2003 N=258

2004/2005 N=353

2005/2006 N=534

2010 N=305

2012 N=323

2014 N=240

2016 N=275

resistente Isolate [%]

14

15

13.3

13.1

17

18.7

17.8

0

0

0.9

2.6

2.5

4.1

3.3

0

1.4

1.1

3

8.7

6.6

7.6

2.3

2.5

1.1

2

1.5

5

2.9

11.2

14.5

11.2

11.5

10.5

16.6

16

12

7.5

6.9

5.2

7.4

12.4

12.4

Kalb

2008 N=1662009 N=1602010 N=1432011 N=1612012 N=2872013 N=2502014 N=2842015 N=169

Ampicillin7076.376.979.776.377.671.568.6

Amoxicillin/Clavulansäure161519.617.41518.821.526

CEF3741.348.342.446.439.442

Gentamicin21253539.928.640.437.722.5

Tetrayclin7168.169.275.770.474.463.759.8

Trimethoprim/Sulfamethoxazol5148.152.449.457.855.647.242.6

n=166160143173287250284169

Kalb

ESBL [%]

2006/20077

200811

200919

201018

201125.4

201220

201329.2

201434

201526

201629.8

Kalb

2008 N=166

2010 N=143

2012 N=287

2014 N=284

2015 N=169


Milchrind Mastitis

ESBL [%]

Prävalenz ESBL E. coli Kalb [%]

Schwein

Mastitis E. coli 2016

2002/2003 N=2582004/2005 N=3532005/2006 N=5342010 N=3052012 N=3232014 N=2402016 N=275

Ampicillin141513.313.11718.717.8

Amoxicillin/Clavulansäure000.92.62.54.13.3

Ceftiofur01.41.138.76.67.6

Gentamicin2.32.51.121.552.9

Tetracyclin11.214.511.211.510.516.616


n258353534305323241275

nach CLSI VET01S 3 rd. Ed

Schwein

2002/2003 N=258

2004/2005 N=353

2005/2006 N=534

2010 N=305

2012 N=323

2014 N=240

2016 N=275

resistente Isolate [%]

Schwein 2

E.coli Ferkel Enteritis

2005/2006 N=3322006/2007 N=3452008 N=2402009 N=1242010 N=1602011 N=1832012 N=1502015 N=1342016 N=133

Ampicillin5962676971.474.97457.562.4

Amoxicillin/Clavulansäure132211.32.11.330

Cephalothin2227191928.623.719.421.1

CHL2731262724.2

Gentamicin6106111310.711.32.26.8

Tetracyclin7880737778.979.172.759.762.4

Trimethoprim/Sulfamethoxazol5250506155.958.35643.351.1

n=332345240124160183150134133

Schwein

ESBL [%]

2006/20072.3

20084

20093.8

20103.9

201110.6

20127.9

20155.5

20163.7

Schwein 2

2005/2006 N=332

2008 N=240

2010 N=160

2012 N=150

2015 N=134

2016 N=133


Legehenne

ESBL [%]

Prävalenz ESBL E. coli Schwein [%]

masthahn

E. coliFerkel

2005/20062006/2007200820092010201120122015

AMP5962676971.4

AUG132211.3

CEP2227191928.6

CHL2731262724.2

GEN61061113

TET7880737778.9

SXT5250506155.9

n=332345240124160

E. coliFerkel

2006/2007200820092010

AMP62676971.4

AUG32211.3

CEP27191928.6

CHL31262724.2

GEN1061113

TET80737778.9

SXT50506155.9

n=345240124160

E. coliFerkel

2006/2007 N=3452008 N=2402009 N=1242010 N=1602011 N=116

AMP62676971.470.7

AMC32211.310.7

CEF27191928.631.8

CHL31262724.233.3

GEN106111312

TET80737778.978.6

SXT50506155.957.3

n=345240124160116

masthahn

00000

% resistente Stämme

Pute

0000

% resistente Stämme

Kleintier GIT

00000

% resistant strains

Kleintier UTI

2006/2007 N=1592008 N=1762009 N=722010 N=1032011 N=1622012 N=1962013 N=1952014 N=1762015 N=1662016 N=132

Ampicillin19321721.723.814.414.916.515.720.5

Amoxicillin/Clavulansäure1000.9500.5000

Cephalothin161587.516.74.1464.5

CHL4665.851

Enrofloxacin32014.31.53.61.134.5

Gentamicin6201.93.13.11.50.62.40.8

Tetracyclin27311515.521.714.913.81714.521.2

Trimethoprim/Sulfamethoxazol91537.86.83.63.69.14.83.8

n=15917672103162196195176166132

Kleintier UTI

2006/2007 N=159

2008 N=176

2010 N=103

2012 N=196

2014 N=176

2015 N=166

2016 N=132


Hund UTI

2006/2007 N=302008 N=212009 N=292010 N=422011 N=742012 N=352013 N=382014 N=312015 N=1092016 N=77

Ampicillin6343525035.642.935.838.73335.1

Amoxicillin/Clavulansäure1710311.91.411.4001.86.5

Cephalothin37242723.825.915.86.56.415.6

CHL10537.16.88.617.6

Enrofloxacin3539.59.65.75.39.76.42.6

Gentamicin3004.89.614.37.93.23.77.8

Tetracyclin40242133.335.634.323.735.516.518.2


n=302129427435383110977

Geflügel

ESBL [%]

2006/20070.2

20081.4

20091.8

20101.4

20113.6

20122.3

20130.6

20140.6N=321

20151N=400

20163.6N=305

2010 N=422011 N=742012 N=352013 N=382014 N=31

AMP5035.642.935.838.7

AMC11.91.411.400

CEF23.825.915.86.5

CHL7.16.88.617.6

ENR9.59.65.75.39.7

GEN4.89.614.37.93.2

TET33.335.634.323.735.5

SXT1916.414.318.425.8

n=4274353831

Hund UTI

2006/2007 N=30

2008 N=21

2010 N=42

2012 N=35

2014 N=31

2015 N=109

2016 N=77


Hund GIT

ESBL [%]

Prävalenz ESBL-bildende E. coli Geflügel [%]

Katze GIT

2010 N=42

2011 N=74

2012 N=35

2013 N=38

2014 N=31

resistnat strains [%]

Katze UTI

E. coliPutealle Indikationen

2006/2007 N=1662008 N=1332009 N=852010 N=952011 N=1252012 N=1592013 N=1092014 N=1102015 N=1142016 N=96

Ampicillin61.965.473.542.159.749.7334033.343.8

Amoxicillin/Clavulansäure2.41.55.31.151.30.91.82.63.1

Cephalothin42.836.833.422.1208.314.513.215.6

CHL14.921.126.621.125.818.922

Enrofloxacin34.504.21.51.35.56.46.15.2

Gentamicin1.82.32.311.613.68.803.72.66.3

Tetracyclin70.262.452.836.84827.716.537.315.825

Trimethoprim/Sulfamethoxazol35.721.821.521.122.425.88.330713.5

n=166133859512515910911011496

E. coliPuteSeptikämie

2006/2007 N=1242008 N=982009 N=662010 N=742011 N=632012 N=1292013 N=882014 N=1002015 N=982016 N=78

AMP60666439.263.149.630.73935.747.4

AMC2201.41.50.8023.13.8

CEF43402923256.81414.319.2

CHL13242720.319.717.120.5

ENR2404.11.51.64.577.16.4

GEN12510.812.37023.17.7

TET69645935.143.124.8173516.329.5

SXT36241725.323.125.69.1308.215.4

n=12498667463129881009878

E. coliPuteResp. Symptomatik

2006/200720082009201020112012 N=282013 N=212014 N=11

AMP6355845051.453.642.945.5

AUG7011003.64.80

CEP401837202014.318.2

CHL2092621.122.928.627.3

ENR3905.35.709.50

GEN05015.811.417.909.1

TET70504747.44039.314.363.6

SXT37142626.317.128.64.830

n=3022192035282111

E. coliPuteSeptikämie

2010 N=742011 N=632012 N=1292013 N=882014 N=100

AMP39.263.149.630.739

AMC1.41.50.802

CEF23256.814

CHL20.319.717.120.5

ENR4.11.51.64.57

GEN10.812.3702

TET35.143.124.81735

SXT25.323.125.69.130

n=746312988100

Katze UTI

2006/2007 N=166

2008 N=133

2010 N=95

2012 N=159

2014 N=110

2015 N=114

2016 N=96


2006/2007 N=124

2008 N=98

2009 N=66

2010 N=74

2011 N=63

2012 N=129

2013 N=88

2014 N=100

2015 N=98

2016 N=78


2006/2007

2008

2009

2010

2011

2012 N=28

2013 N=21

2014 N=11


2010 N=74

2011 N=63

2012 N=129

2013 N=88

2014 N=100

resistant strains [%]

E. coliKleintierGIT

2006/2007 N=962008 N=382009 N=252010 N=272011 N=182012 N=182013 N=172014 N=652015 N=472016 N=13

AMP21.926.32018.544.435.338.531.9

AMC2347.4011.107.72.1

CHL1580190

GEN Hund006.604.8011.12.68

GEN Katze04.800012.504.5

TET15292411.128.644.423.521.525.5

SXT1313203.71927.823.521.521.3

n=9638252718181747

Hund 5417151710109258

Katze 42211010888225

alle E. coli

Hund

ESBL [%]

2006/20070

20080

20095.4

20103.2

20114.7

20121.4

20137

201414.7

20154.4

20163.8

2006/2007 N=96

2008 N=38

2009 N=25

2010 N=27

2014 N=65

2015 N=47

resistente Stämme {%]

ESBL [%]

Prävalenz ESBL E. coli Hund [%]

E. coliKleintierUGT

2006/2007 N=632008 N=292009 N=132010 N=242011 N=322012 N=332013 N=372014 N=322015 N=452016 N=59

Ampicillin2735.738.921.731.333.337.828.133.337.3*nicht sensibel (>8)

Amoxicillin/Clavulansäure15.921.428.606.2512.210.818.717.813.6*nicht sensibel (>8)

CEF191126.712.512.516.216.9

CHL5704.218.824.6

Gentamicin/Hund00904.313.601913.34.5

Gentamicin/Katze0004.200006.76.7

Enrofloxacin/Hund21113621.48.722.719.216.116.720.5

Marbofloxacin/Hund*11.122.716.216.116.720.5

Tetracyclin21329.112.521.927.335.112.931.123.7


n=63291324323337324559

Hund 4319112322263044

Katze 2092911111515

2006/2007 N=63

2008 N=29

2009 N=13

2010 N=24

2014 N=32

2015 N=45

2016 N=59


E. coliUGT

2008 N=192010 N=132012 N=332014 N=192015 N=55

AMP31.615.433.336.836.4

AMC15.8012.126.316.4

ENR10.57.721.216.712.7

GEN009.11910.9

MAR21.2012.7

TET26.37.727.31127.3

SXT15.823.118.216.723.6

n=1913331955

alle E. coli

Hund

ESBL [%]

2006/20070

20080

20095.4

20103.2

20114.7

20121.4

20137

2008 N=19

2010 N=13

2012 N=33

2014 N=19

2015 N=55


2006/2007

2008

2009

2010

2011

2012

2013

ESBL [%]


0

0

5.4

3.2

4.7

1.4

7

E. coliGIT

2008 N=172010 N=172013 N=92014 N=382015 N=25

AMP35.511.833.347.432

AMC05.907.94

GEN0011.12.68

TET47.15.922.221.116

SXT0022.226.316

n=22.227181817

alle E. coli

Hund

ESBL [%]

2006/20070

20080

20095.4

20103.2

20114.7

20121.4

20137

2008 N=17

2010 N=17

2013 N=9

2014 N=38

2015 N=25


2006/2007

2008

2009

2010

2011

2012

2013

ESBL [%]


0

0

5.4

3.2

4.7

1.4

7



Studienjahr

MHK90 [mg/L] 2004/ 2005

2005/ 2006 2010 2012 2014 2016

Cefotaxim - 0,12 0,12 8 0,12 0,5

Cefquinom 0,12 0,06 0,12 8 0,12 0,5

Colistin 0,25 0,5 1 1 2 0,5

Doxycyclin 16 8 8 8 16 16

Enrofloxacin 0,06 0,06 0,06 0,06 0,06 0,06

Nalidixinsäure 4 4 4 4 4 8

N = 353 534 305 323 241 275

E. coli, Milchrind, Indikation: Mastitis, MHK90-Daten; 2002 - 2016

Ergebnisse


S. aureus, Milchrind, Indikation: Mastitis; 2008 - 2015

Ergebnisse


Ergebnisse

S. aureus, Milchrind, Indikation: Mastitis, MHK90-Daten; 2008 - 2015

MHK90 [mg/L] Studienjahr


2008 2009 2011 2013 2015

Cefoperazon 2 2 2 2 4

Cefotaxim 2 2 2 4 4

Cefquinom 1 1 1 1 1

Clindamycin 0,12 0,25 0,25 0,25 0,25

Enrofloxacin 0,25 0,25 0,25 0,25 0,5

N = 394 210 346 205 363



Geflügel


E. coli, Pute, verschiedene Indikationen; 2006 - 2017

Ergebnisse

Diagramm1

AmpicillinAmpicillinAmpicillinAmpicillinAmpicillinAmpicillinAmpicillinAmpicillinAmpicillinAmpicillinAmpicillinAmpicillin

Amoxi/ClavAmoxi/ClavAmoxi/ClavAmoxi/ClavAmoxi/ClavAmoxi/ClavAmoxi/ClavAmoxi/ClavAmoxi/ClavAmoxi/ClavAmoxi/ClavAmoxi/Clav

ChloramphChloramphChloramphChloramphChloramphChloramphChloramphChloramphChloramphChloramphChloramphChloramph

EnrofloxacinEnrofloxacinEnrofloxacinEnrofloxacinEnrofloxacinEnrofloxacinEnrofloxacinEnrofloxacinEnrofloxacinEnrofloxacinEnrofloxacinEnrofloxacin

GentamicinGentamicinGentamicinGentamicinGentamicinGentamicinGentamicinGentamicinGentamicinGentamicinGentamicinGentamicin

TetrazyklinTetrazyklinTetrazyklinTetrazyklinTetrazyklinTetrazyklinTetrazyklinTetrazyklinTetrazyklinTetrazyklinTetrazyklinTetrazyklin

Trimet/SulfaTrimet/SulfaTrimet/SulfaTrimet/SulfaTrimet/SulfaTrimet/SulfaTrimet/SulfaTrimet/SulfaTrimet/SulfaTrimet/SulfaTrimet/SulfaTrimet/Sulfa

2006/2007 N=166

2006/2007 N=166

2008 N=133

2009 N=85

2010 N=95

2011 N=125

2012 N=159

2013 N=109

2014 N=110

2015 N=114

2016 N=96

2017 N=64


61.9

65.4

73.5

42.1

59.7

49.7

33

40

33.3

43.8

45.3

2.4

1.5

5.3

1.1

5

1.3

0.9

1.8

2.6

3.1

0

14.9

21.1

26.6

21.1

25.8

18.9

22

3

4.5

0

4.2

1.5

1.3

5.5

6.4

6.1

5.2

6.3

1.8

2.3

2.3

11.6

13.6

8.8

0

3.7

2.6

6.3

9.4

70.2

62.4

52.8

36.8

48

27.7

16.5

37.3

15.8

25

23.4

35.7

21.8

21.5

21.1

22.4

25.8

8.3

30

7

13.5

10.9

Kalb

E. coli Kalb

2006/2007 N=1542008 N=1662009 N=1602010 N=1432011 N=1612012 N=2872013 N=2502014 N=2842015 N=1692016 N=1142017 N=114

Ampicillin687076.376.979.776.377.671.568.666.775.4

Amox/Clav18161519.617.41518.821.52610.516.7

Cephalothin443741.348.342.446.439.4424349.1

Chloramph495150.659.455.548.1

Gentamicin2321253539.928.640.437.722.519.324.6

Tetrazyklin717168.169.275.770.474.463.759.86465.8

Trimeth/Sulfa445148.152.449.457.855.647.242.639.544.7

Summe

n=1541661601431732872502841691141142014

2006/2007 N=1542008 N=1662009 N=1602010 N=1432011 N=1612012 N=2872013 N=2502014 N=2842015 N=1692016 N=1142017 N=114


Colistin0.50.50.5121120.50.50.5

Nalidixinsäure256256256256256256256256256256256


Enrofloxacin3232323232323232323232

Cefotaxim116326464646464646464

Ceftiofur264128128128128128128128128128

Kalb

2006/2007 N=154

2008 N=166

2009 N=160

2010 N=143

2011 N=161

2012 N=287

2013 N=250


ESBL

2006/2007 N=154

2008 N=166

2009 N=160

2010 N=143

2011 N=161

2012 N=287

2013 N=250

2014 N=284

2015 N=169

2016 N=114

2017 N=114


Tabelle2

2006/2007 N=154

2008 N=166

2009 N=160

2010 N=143

2011 N=161

2012 N=287

2013 N=250

2014 N=284

2015 N=169

2016 N=114

2017 N=114

log2 MHK90-Wert

Ferkel

ESBL Kalb


2006/200772.30.2

20081141.4

2009193.81.8

2010183.91.4

201125.410.63.6

2012207.92.3

201329.20.6

2014340.6

201526.75.51

201629.83.73.6

Ferkel

2006/2007

2008

2009

2010

2011

2012

2013

2014

2015

2016


Pute

Masthahn

E. coliFerkel

2006/2007 N=3452008 N=2402009 N=1242010 N=1562011 N=1832012 N=1502015 N=1342016 N=1332017 N=118

Ampicillin62676971.475.47457.562.462.7

Amox/Clav32211.32.21.3303.4

Cephalothin27191928.623.719.421.119.5


Gentamicin106111310.911.32.26.87.7

Tetrazyklin80737778.979.272.759.762.455.6

Trimeth/Sulfa50506155.9595643.351.145.3

Summe

n=3452401241561831501341331181583

2006/2007 N=3452008 N=2402009 N=1242010 N=1562011 N=1832012 N=1502015 N=1342016 N=1332017 N=118


Colistin40.5488880.54

Nalidixinsäure128256256128128256256128128



Cefotaxim0.120.120.120.120.120.50.120.120.12

Ceftiofur0.50.50.50.50.5110.50.5

Masthahn

2006/2007 N=345

2008 N=240

2009 N=124

2010 N=156

2011 N=183

2012 N=150

2015 N=134

2016 N=133

2017 N=118


Colistin

2006/2007 N=345

2008 N=240

2009 N=124

2010 N=156

2011 N=183

2012 N=150

2015 N=134

2016 N=133

2017 N=118

log2 MHK90-Wert


2006/2007 N=1662006/2007 N=1662008 N=1332009 N=852010 N=952011 N=1252012 N=1592013 N=1092014 N=1102015 N=1142016 N=962017 N=64

Ampicillin61.961.965.473.542.159.749.7334033.343.845.3

Amoxi/Clav2.42.41.55.31.151.30.91.82.63.10

Chloramph14.914.921.126.621.125.818.922

Enrofloxacin334.504.21.51.35.56.46.15.26.3

Gentamicin1.81.82.32.311.613.68.803.72.66.39.4

Tetrazyklin70.270.262.452.836.84827.716.537.315.82523.4

Trimet/Sulfa35.735.721.821.521.122.425.88.330713.510.9

n=166166133859512515910911011496641422

2006/2007 N=1662008 N=1332009 N=852010 N=952011 N=1252012 N=1592013 N=1092014 N=1102015 N=1142016 N=962017 N=64


Colistin0.50.580.588120.50.50.5

Nalidixinsäure256128128256256256128256128256128


Cefotaxim0.120.120.120.120.120.120.120.120.120.120.12

Ceftiofur0.50.50.50.50.50.50.50.50.50.50.5

2006/2007 N=166

2006/2007 N=166

2008 N=133

2009 N=85

2010 N=95

2011 N=125

2012 N=159

2013 N=109

2014 N=110

2015 N=114

2016 N=96

2017 N=64


2006/2007 N=166

2008 N=133

2009 N=85

2010 N=95

2011 N=125

2012 N=159

2013 N=109

2014 N=110

2015 N=114

2016 N=96

2017 N=64

log2 MHK90-Wert

E. coliMasthahn

2006/2007 N=302008 N=212009 N=292010 N=422011 N=742012 N=352013 N=382014 N=312015 N=1092016 N=772017 N=45

Ampicillin6343525035.642.935.838.73335.144.4

Amoxi/Clav1710311.91.411.4001.86.52.2

Cephalothin37242723.825.915.86.56.415.615.6

Chloramph10537.16.88.617.6

Enrofloxacin3539.59.65.75.39.76.42.62.2

Gentamicin3004.89.614.37.93.23.77.82.2

Tetrazyklin40242133.335.634.323.735.516.518.226.7

Trimet/Sulfa4314301916.414.318.425.823.916.920

n=30212942743538311097745531

2006/2007 N=302008 N=212009 N=292010 N=422011 N=742012 N=352013 N=382014 N=312015 N=1092016 N=772017 N=45

Ceftiofur10.50.540.5160.50.50.50.50.5

Cefotaxim0.50.120.1240.12160.120.120.120.250.12

Nalidixinsäure256256256256256256256256256128256


Colistin0.50.50.5111110.50.50.5

0.0150.030.060.120.250.51248163264

log2

-6-5-4-3-2-10123456

2006/2007 N=302008 N=212009 N=292010 N=422011 N=742012 N=352013 N=382014 N=312015 N=109

Ceftiofur0-1-12-14-1-1-1

Cefotaxim-1-3-32-34-3-3-3



Colistin-1-1-100000-1

2006/2007 N=30

2008 N=21

2009 N=29

2010 N=42

2011 N=74

2012 N=35

2013 N=38

2014 N=31

2015 N=109

2016 N=77

2017 N=45


2006/2007 N=30

2008 N=21

2009 N=29

2010 N=42

2011 N=74

2012 N=35

2013 N=38

2014 N=31

2015 N=109

2016 N=77

2017 N=45

log2 MHK90-Wert



2004/050%0%0%0%

2005/060%0%0%0%

2006/076%25%33%0%

20085%0%64%0%

200927%0%92%0%

201047%45%77%0%

201149%0%85%0%

201244%0%95%100%

2013*62%25%0%

2014*45%57%0%

201554%0%50%0%



2004/055.1%0.7%0.5%0.0%

2005/063.5%1.1%0.4%0.0%

2006/079.7%2.2%2.7%3.6%

20085.7%4.5%3.3%4.5%

20099.4%3.4%5.5%0.0%

201012.4%2.2%4.5%0.8%

201117.8%1.5%5.3%1.7%

201215.8%0.7%5.2%0.0%

2013*4.9%1.1%0.0%

2014*2.1%2.1%1.1%

201512.3%3.4%0.5%1.0%



2004/050.0%0.0%0.0%0.0%

2005/060.0%0.0%0.0%0.0%

2006/070.6%0.5%0.9%0.0%

20080.3%0.0%2.1%0.0%

20092.6%0.0%5.1%0.0%

20105.8%1.0%3.4%0.0%

20118.7%0.0%4.5%0.0%

20126.9%0.0%5.0%1.7%

2013*3.0%0.3%0.0%

2014*0.9%1.2%0.0%

20156.6%0.0%0.3%0.0%

Schwein

Rind

Geflügel

Schwein

Rind

Geflügel

Schwein

Rind

Geflügel


Ergebnisse

E. coli, Pute, MHK90-Daten, verschiedene Indikationen; 2006 - 2017

0,0625

0,125

0,25

0,5

1

2

4

8

16

32

64

128

256

Imipenem Colistin Nalidixinsäure Ciprofloxacin Cefotaxim Ceftiofur

log2

MHK

90-W

ert

2006/2007 N=166 2008 N=133 2009 N=85 2010 N=95

2011 N=125 2012 N=159 2013 N=109 2014 N=110

2015 N=114 2016 N=96 2017 N=64


Seite 30

E. coli, Broiler, verschiedene Indikationen; 2006 - 2017

Ergebnisse


Diagramm1

AmpicillinAmpicillinAmpicillinAmpicillinAmpicillinAmpicillinAmpicillinAmpicillinAmpicillinAmpicillinAmpicillin

Amoxi/ClavAmoxi/ClavAmoxi/ClavAmoxi/ClavAmoxi/ClavAmoxi/ClavAmoxi/ClavAmoxi/ClavAmoxi/ClavAmoxi/ClavAmoxi/Clav

ChloramphChloramphChloramphChloramphChloramphChloramphChloramphChloramphChloramphChloramphChloramph

EnrofloxacinEnrofloxacinEnrofloxacinEnrofloxacinEnrofloxacinEnrofloxacinEnrofloxacinEnrofloxacinEnrofloxacinEnrofloxacinEnrofloxacin

GentamicinGentamicinGentamicinGentamicinGentamicinGentamicinGentamicinGentamicinGentamicinGentamicinGentamicin

TetrazyklinTetrazyklinTetrazyklinTetrazyklinTetrazyklinTetrazyklinTetrazyklinTetrazyklinTetrazyklinTetrazyklinTetrazyklin

Trimet/SulfaTrimet/SulfaTrimet/SulfaTrimet/SulfaTrimet/SulfaTrimet/SulfaTrimet/SulfaTrimet/SulfaTrimet/SulfaTrimet/SulfaTrimet/Sulfa

2006/2007 N=30

2008 N=21

2009 N=29

2010 N=42

2011 N=74

2012 N=35

2013 N=38

2014 N=31

2015 N=109

2016 N=77

2017 N=45


63

43

52

50

35.6

42.9

35.8

38.7

33

35.1

44.4

17

10

3

11.9

1.4

11.4

0

0

1.8

6.5

2.2

10

5

3

7.1

6.8

8.6

17.6

3

5

3

9.5

9.6

5.7

5.3

9.7

6.4

2.6

2.2

3

0

0

4.8

9.6

14.3

7.9

3.2

3.7

7.8

2.2

40

24

21

33.3

35.6

34.3

23.7

35.5

16.5

18.2

26.7

43

14

30

19

16.4

14.3

18.4

25.8

23.9

16.9

20

Kalb

E. coli Kalb

2006/2007 N=1542008 N=1662009 N=1602010 N=1432011 N=1612012 N=2872013 N=2502014 N=2842015 N=1692016 N=1142017 N=114

Ampicillin687076.376.979.776.377.671.568.666.775.4

Amox/Clav18161519.617.41518.821.52610.516.7

Cephalothin443741.348.342.446.439.4424349.1

Chloramph495150.659.455.548.1

Gentamicin2321253539.928.640.437.722.519.324.6

Tetrazyklin717168.169.275.770.474.463.759.86465.8

Trimeth/Sulfa445148.152.449.457.855.647.242.639.544.7

Summe

n=1541661601431732872502841691141142014

2006/2007 N=1542008 N=1662009 N=1602010 N=1432011 N=1612012 N=2872013 N=2502014 N=2842015 N=1692016 N=1142017 N=114


Colistin0.50.50.5121120.50.50.5

Nalidixinsäure256256256256256256256256256256256


Enrofloxacin3232323232323232323232

Cefotaxim116326464646464646464

Ceftiofur264128128128128128128128128128

Kalb

2006/2007 N=154

2008 N=166

2009 N=160

2010 N=143

2011 N=161

2012 N=287

2013 N=250


ESBL

2006/2007 N=154

2008 N=166

2009 N=160

2010 N=143

2011 N=161

2012 N=287

2013 N=250

2014 N=284

2015 N=169

2016 N=114

2017 N=114


Tabelle2

2006/2007 N=154

2008 N=166

2009 N=160

2010 N=143

2011 N=161

2012 N=287

2013 N=250

2014 N=284

2015 N=169

2016 N=114

2017 N=114

log2 MHK90-Wert

Ferkel

ESBL Kalb


2006/200772.30.2

20081141.4

2009193.81.8

2010183.91.4

201125.410.63.6

2012207.92.3

201329.20.6

2014340.6

201526.75.51

201629.83.73.6

Ferkel

2006/2007

2008

2009

2010

2011

2012

2013

2014

2015

2016


Pute

Masthahn

E. coliFerkel

2006/2007 N=3452008 N=2402009 N=1242010 N=1562011 N=1832012 N=1502015 N=1342016 N=1332017 N=118

Ampicillin62676971.475.47457.562.462.7

Amox/Clav32211.32.21.3303.4

Cephalothin27191928.623.719.421.119.5


Gentamicin106111310.911.32.26.87.7

Tetrazyklin80737778.979.272.759.762.455.6

Trimeth/Sulfa50506155.9595643.351.145.3

Summe

n=3452401241561831501341331181583

2006/2007 N=3452008 N=2402009 N=1242010 N=1562011 N=1832012 N=1502015 N=1342016 N=1332017 N=118


Colistin40.5488880.54

Nalidixinsäure128256256128128256256128128



Cefotaxim0.120.120.120.120.120.50.120.120.12

Ceftiofur0.50.50.50.50.5110.50.5

Masthahn

2006/2007 N=345

2008 N=240

2009 N=124

2010 N=156

2011 N=183

2012 N=150

2015 N=134

2016 N=133

2017 N=118


Colistin

2006/2007 N=345

2008 N=240

2009 N=124

2010 N=156

2011 N=183

2012 N=150

2015 N=134

2016 N=133

2017 N=118

log2 MHK90-Wert


2006/2007 N=1662006/2007 N=1662008 N=1332009 N=852010 N=952011 N=1252012 N=1592013 N=1092014 N=1102015 N=1142016 N=962017 N=64

Ampicillin61.961.965.473.542.159.749.7334033.343.845.3

Amoxi/Clav2.42.41.55.31.151.30.91.82.63.10

Cephalothin42.842.836.833.422.1208.314.513.215.626.6

Chloramph14.914.921.126.621.125.818.922

Enrofloxacin334.504.21.51.35.56.46.15.26.3

Gentamicin1.81.82.32.311.613.68.803.72.66.39.4

Tetrazyklin70.270.262.452.836.84827.716.537.315.82523.4

Trimet/Sulfa35.735.721.821.521.122.425.88.330713.510.9

n=166166133859512515910911011496641422

2006/2007 N=1662008 N=1332009 N=852010 N=952011 N=1252012 N=1592013 N=1092014 N=1102015 N=1142016 N=962017 N=64


Colistin0.50.580.588120.50.50.5

Nalidixinsäure256128128256256256128256128256128


Cefotaxim0.120.120.120.120.120.120.120.120.120.120.12

Ceftiofur0.50.50.50.50.50.50.50.50.50.50.5

2006/2007 N=166

2006/2007 N=166

2008 N=133

2009 N=85

2010 N=95

2011 N=125

2012 N=159

2013 N=109

2014 N=110

2015 N=114

2016 N=96

2017 N=64


2006/2007 N=166

2008 N=133

2009 N=85

2010 N=95

2011 N=125

2012 N=159

2013 N=109

2014 N=110

2015 N=114

2016 N=96

2017 N=64

log2 MHK90-Wert

E. coliMasthahn

2006/2007 N=302008 N=212009 N=292010 N=422011 N=742012 N=352013 N=382014 N=312015 N=1092016 N=772017 N=45

Ampicillin6343525035.642.935.838.73335.144.4

Amoxi/Clav1710311.91.411.4001.86.52.2

Chloramph10537.16.88.617.6

Enrofloxacin3539.59.65.75.39.76.42.62.2

Gentamicin3004.89.614.37.93.23.77.82.2

Tetrazyklin40242133.335.634.323.735.516.518.226.7

Trimet/Sulfa4314301916.414.318.425.823.916.920

n=30212942743538311097745531

2006/2007 N=302008 N=212009 N=292010 N=422011 N=742012 N=352013 N=382014 N=312015 N=1092016 N=772017 N=45

Ceftiofur10.50.540.5160.50.50.50.50.5

Cefotaxim0.50.120.1240.12160.120.120.120.250.12

Nalidixinsäure256256256256256256256256256128256


Colistin0.50.50.5111110.50.50.5

0.0150.030.060.120.250.51248163264

log2

-6-5-4-3-2-10123456

2006/2007 N=302008 N=212009 N=292010 N=422011 N=742012 N=352013 N=382014 N=312015 N=109

Ceftiofur0-1-12-14-1-1-1

Cefotaxim-1-3-32-34-3-3-3



Colistin-1-1-100000-1

2006/2007 N=30

2008 N=21

2009 N=29

2010 N=42

2011 N=74

2012 N=35

2013 N=38

2014 N=31

2015 N=109

2016 N=77

2017 N=45


2006/2007 N=30

2008 N=21

2009 N=29

2010 N=42

2011 N=74

2012 N=35

2013 N=38

2014 N=31

2015 N=109

2016 N=77

2017 N=45

log2 MHK90-Wert



2004/050%0%0%0%

2005/060%0%0%0%

2006/076%25%33%0%

20085%0%64%0%

200927%0%92%0%

201047%45%77%0%

201149%0%85%0%

201244%0%95%100%

2013*62%25%0%

2014*45%57%0%

201554%0%50%0%



2004/055.1%0.7%0.5%0.0%

2005/063.5%1.1%0.4%0.0%

2006/079.7%2.2%2.7%3.6%

20085.7%4.5%3.3%4.5%

20099.4%3.4%5.5%0.0%

201012.4%2.2%4.5%0.8%

201117.8%1.5%5.3%1.7%

201215.8%0.7%5.2%0.0%

2013*4.9%1.1%0.0%

2014*2.1%2.1%1.1%

201512.3%3.4%0.5%1.0%



2004/050.0%0.0%0.0%0.0%

2005/060.0%0.0%0.0%0.0%

2006/070.6%0.5%0.9%0.0%

20080.3%0.0%2.1%0.0%

20092.6%0.0%5.1%0.0%

20105.8%1.0%3.4%0.0%

20118.7%0.0%4.5%0.0%

20126.9%0.0%5.0%1.7%

2013*3.0%0.3%0.0%

2014*0.9%1.2%0.0%

20156.6%0.0%0.3%0.0%

Schwein

Rind

Geflügel

Schwein

Rind

Geflügel

Schwein

Rind

Geflügel

Seite 31

E. coli, Broiler, MHK90-Daten, verschiedene Indikationen; 2006 - 2017

Ergebnisse


Diagramm1

CeftiofurCeftiofurCeftiofurCeftiofurCeftiofurCeftiofurCeftiofurCeftiofurCeftiofurCeftiofurCeftiofur

CefotaximCefotaximCefotaximCefotaximCefotaximCefotaximCefotaximCefotaximCefotaximCefotaximCefotaxim

NalidixinsäureNalidixinsäureNalidixinsäureNalidixinsäureNalidixinsäureNalidixinsäureNalidixinsäureNalidixinsäureNalidixinsäureNalidixinsäureNalidixinsäure

CiprofloxacinCiprofloxacinCiprofloxacinCiprofloxacinCiprofloxacinCiprofloxacinCiprofloxacinCiprofloxacinCiprofloxacinCiprofloxacinCiprofloxacin

ColistinColistinColistinColistinColistinColistinColistinColistinColistinColistinColistin

2006/2007 N=30

2008 N=21

2009 N=29

2010 N=42

2011 N=74

2012 N=35

2013 N=38

2014 N=31

2015 N=109

2016 N=77

2017 N=45

log2 MHK90-Wert

1

0.5

0.5

4

0.5

16

0.5

0.5

0.5

0.5

0.5

0.5

0.12

0.12

4

0.12

16

0.12

0.12

0.12

0.25

0.12

256

256

256

256

256

256

256

256

256

128

256

0

0

0

0

0

0.5

0.5

4

0.5

0.5

0.5

0.5

0.5

0.5

1

1

1

1

1

0.5

0.5

0.5

Kalb

E. coli Kalb

2006/2007 N=1542008 N=1662009 N=1602010 N=1432011 N=1612012 N=2872013 N=2502014 N=2842015 N=1692016 N=1142017 N=114

Ampicillin687076.376.979.776.377.671.568.666.775.4

Amox/Clav18161519.617.41518.821.52610.516.7

Cephalothin443741.348.342.446.439.4424349.1

Chloramph495150.659.455.548.1

Gentamicin2321253539.928.640.437.722.519.324.6

Tetrazyklin717168.169.275.770.474.463.759.86465.8

Trimeth/Sulfa445148.152.449.457.855.647.242.639.544.7

Summe

n=1541661601431732872502841691141142014

2006/2007 N=1542008 N=1662009 N=1602010 N=1432011 N=1612012 N=2872013 N=2502014 N=2842015 N=1692016 N=1142017 N=114


Colistin0.50.50.5121120.50.50.5

Nalidixinsäure256256256256256256256256256256256


Enrofloxacin3232323232323232323232

Cefotaxim116326464646464646464

Ceftiofur264128128128128128128128128128

Kalb

2006/2007 N=154

2008 N=166

2009 N=160

2010 N=143

2011 N=161

2012 N=287

2013 N=250


ESBL

2006/2007 N=154

2008 N=166

2009 N=160

2010 N=143

2011 N=161

2012 N=287

2013 N=250

2014 N=284

2015 N=169

2016 N=114

2017 N=114


Tabelle2

2006/2007 N=154

2008 N=166

2009 N=160

2010 N=143

2011 N=161

2012 N=287

2013 N=250

2014 N=284

2015 N=169

2016 N=114

2017 N=114

log2 MHK90-Wert

Ferkel

ESBL Kalb


2006/200772.30.2

20081141.4

2009193.81.8

2010183.91.4

201125.410.63.6

2012207.92.3

201329.20.6

2014340.6

201526.75.51

201629.83.73.6

Ferkel

2006/2007

2008

2009

2010

2011

2012

2013

2014

2015

2016


Pute

Masthahn

E. coliFerkel

2006/2007 N=3452008 N=2402009 N=1242010 N=1562011 N=1832012 N=1502015 N=1342016 N=1332017 N=118

Ampicillin62676971.475.47457.562.462.7

Amox/Clav32211.32.21.3303.4

Cephalothin27191928.623.719.421.119.5


Gentamicin106111310.911.32.26.87.7

Tetrazyklin80737778.979.272.759.762.455.6

Trimeth/Sulfa50506155.9595643.351.145.3

Summe

n=3452401241561831501341331181583

2006/2007 N=3452008 N=2402009 N=1242010 N=1562011 N=1832012 N=1502015 N=1342016 N=1332017 N=118


Colistin40.5488880.54

Nalidixinsäure128256256128128256256128128



Cefotaxim0.120.120.120.120.120.50.120.120.12

Ceftiofur0.50.50.50.50.5110.50.5

Masthahn

2006/2007 N=345

2008 N=240

2009 N=124

2010 N=156

2011 N=183

2012 N=150

2015 N=134

2016 N=133

2017 N=118


Colistin

2006/2007 N=345

2008 N=240

2009 N=124

Resistenzen bei tierpathogenen Bakterien – ein Update · Symposium Antibiotikaresistenz in der LM...

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