University Hospital Regensburg SYMPOSIUM Performance for ...

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SYMPOSIUM Biomolecular Imaging Meets Immuno-Oncology Kolpinghaus Regensburg, Kongress- & Kulturzentrum July 15-16, 2019 SPITZE IN DER MEDIZIN. MENSCHLICH IN DER BEGEGNUNG. ukr.de General Information Organizing Committee Marina Kreutz Department of Internal Medicine III University Hospital Regensburg Gerhard Liebisch Clinical Chemistry and Laboratory Medicine University Hospital Regensburg Peter Oefner Institute of Functional Genomics University of Regensburg Petr Simek Analytical Chemistry and Metabolomics Biology Centre CAS Budweis Venue Kolpinghaus Regensburg, Kongress- & Kulturzentrum Adolph-Kolping-Straße 1 93047 Regensburg Congress Management Britta Haseneder UK3 Congress Management University Hospital Regensburg Franz-Josef-Strauß-Allee 11 93053 Regensburg Germany Phone +49 (0)941 944 4232 Fax +49 (0)941 944 4233 [email protected] Date July 15-16, 2019 Congress Fee Regular Participation 300 € Students 100 € Registration under: www.congress-registration.ukr.de Sponsors Pfizer Pharma GmbH 1.500 € Performance for booth fee and advertising purposes. Speakers and Session Chairs Nadine Assmann Department of Biomedicine University and University Hospital Basel Basel, Switzerland Luciana Berod Institute of Infection Immunology TWIN CORE, Centre for Experimental and Clinical Infection Research Hannover Medical School and Helmholtz Centre for Infection Research Hannover, Germany Tobias Bopp Institute for Immunology Johannes Gutenberg-University Mainz Mainz, Germany Jürgen Burhenne Department of Clinical Pharmacology and Pharmacoepidemiology University Clinic Heidelberg Heidelberg, Germany Rita Casadonte Proteopath GmbH, Trier, Germany Hayo Castrop Institute of Physiology University of Regensburg Regensburg, Germany Guoliang Cui Deutsches Krebsforschungszentrum Heidelberg Heidelberg, Germany Katja Dettmer Institute of Functional Genomics University of Regensburg Regensburg, Germany Christina Ferreira Bindley Bioscience Center Purdue University West Lafayette, IN, USA Isabelle Fournier Laboratoire Protéomique Université de Lille Lille, France Wolfram Gronwald Institute of Functional Genomics University of Regensburg Regensburg, Germany Karsten Gülow Department of Internal Medicine I University Hospital Regensburg Regensburg, Germany Jörg Hanrieder Department of Psychiatry and Neurochemistry Sahlgrenka Academy at Gothenburg University Mölndal, Sweden Sina-Franziska Heimer Department of Oral and Maxillofacial Surgery University Hospital Regensburg Regensburg, Germany Mathias Holpert NanoString Technologies, Inc. Seattle, WA, USA Marcus Höring Institute of Clinical Chemistry and Laboratory Medicine University Hospital Regensburg Regensburg, Germany Jonathan Jantsch Institute of Microbiology und Hygiene University Hospital Regensburg Regensburg, Germany Uwe Karst Institute of Inorganic and Analytical Chemistry University of Münster Münster, Germany Mary King Department of Chemistry University of Texas at Austin Austin, TX, USA Marina Kreutz Department of Internal Medicine III University Hospital Regensburg Regensburg, Germany Dieter Kube Department of Haematology and Oncology University Medical Center Göttingen Göttingen, Germany Gerhard Liebisch Institute of Clinical Chemistry and Laboratory Medicine University Hospital Regensburg Regensburg, Germany Jason Locasale Department of Pharmacology and Cancer Biology Duke University School of Medicine Durham, NC, USA Rémi Longuespée Department of Clinical Pharmacology and Pharmacoepidemiology University Clinic Heidelberg Heidelberg, Germany Martina Marchetti-Deschmann Institute of Chemical Technologies and Analytics Vienna University of Technologies Vienna, Austria Liam McDonnell Center for Proteomics and Metabolomics Leiden University Medical Center Leiden, The Netherlands Peter Oefner Institute of Functional Genomics University of Regensburg Regensburg, Germany Kathrin Renner-Sattler Department of Internal Medicine III University Hospital Regensburg Regensburg, Germany Colinda Scheele Division of Molecular Pathology, Oncode Institute The Netherlands Cancer Institute Amsterdam, The Netherlands Almut Schulze Department of Biochemistry and Molecular Biology Theodor-Boveri-Institute University of Würzburg Würzburg, Germany Kristina Schwamborn Institute of Pathology Technical University Munich Munich, Germany Andrej Shevchenko Max Planck Institute of Molecular Cell Biology and Genetics Dresden, Germany Peter Siska Department of Internal Medicine III University Hospital Regensburg Regensburg, Germany Astrid Slany Department of Analytical Chemistry University of Vienna Vienna, Austria Rainer Spang Chair of Bioinformatics University of Regensburg Regensburg, Germany Tim Sparwasser Department of Medical Microbiology and Hygiene Johannes Gutenberg University Mainz Mainz, Germany Bernhard Spengler Institute of Inorganic and Analytical Chemistry Justus Liebig University Giessen Giessen, Germany Iain Styles School of Computer Science University of Birmingham Birmingham, UK Zoltan Takats Imperial College London London, UK Michael Witting Department of Environmental Sciences (DES) Helmholtz Zentrum München Neuherberg, Germany Photo and rights: UKR June 2019 Registration conditions After your successful registration you will receive an invoice for your participation by email. Once registered your registration is binding. All payments must be made prior to the conference. Par- ticipation fees are due upon receipt of invoice without deduction. Please transfer the invoice amount before the event date. In case of a cancellation the cancellation statement must be in writing. The following processing fees apply: 8-3 working days before the event 50% of participa- tion fee. In case of too late cancellation or absence without written cancellation the entire fee will be charged. A substitute participant may be submitted at any time.

Transcript of University Hospital Regensburg SYMPOSIUM Performance for ...

SYMPOSIUM Biomolecular Imaging Meets Immuno-OncologyKolpinghaus Regensburg, Kongress- & KulturzentrumJuly 15-16, 2019

SPITZE IN DER MEDIZIN. MENSCHLICH IN DER BEGEGNUNG.

ukr.de

General Information

Organizing Committee Marina Kreutz Department of Internal Medicine III University Hospital RegensburgGerhard Liebisch Clinical Chemistry and Laboratory Medicine University Hospital RegensburgPeter Oefner Institute of Functional Genomics University of RegensburgPetr Simek Analytical Chemistry and Metabolomics Biology Centre CAS Budweis

Venue Kolpinghaus Regensburg, Kongress- & Kulturzentrum Adolph-Kolping-Straße 1 93047 Regensburg

Congress Management Britta Haseneder UK3 Congress Management University Hospital Regensburg Franz-Josef-Strauß-Allee 11 93053 Regensburg Germany Phone +49 (0)941 944 4232 Fax +49 (0)941 944 4233 [email protected]

Date July 15-16, 2019

Congress Fee Regular Participation 300 € Students 100 €

Registration under: www.congress-registration.ukr.de

Sponsors

Pfizer Pharma GmbH 1.500 €

Performance for booth fee and advertising purposes.

Speakers and Session ChairsNadine Assmann Department of Biomedicine University and University Hospital Basel Basel, SwitzerlandLuciana Berod Institute of Infection ImmunologyTWIN CORE, Centre for Experimental and Clinical Infection Research Hannover Medical School and Helmholtz Centre for Infection Research Hannover, GermanyTobias Bopp Institute for Immunology Johannes Gutenberg-University Mainz Mainz, GermanyJürgen Burhenne Department of Clinical Pharmacology and Pharmacoepidemiology University Clinic Heidelberg Heidelberg, GermanyRita Casadonte Proteopath GmbH, Trier, GermanyHayo Castrop Institute of Physiology University of Regensburg Regensburg, GermanyGuoliang Cui Deutsches Krebsforschungszentrum Heidelberg Heidelberg, GermanyKatja Dettmer Institute of Functional Genomics University of Regensburg Regensburg, GermanyChristina Ferreira Bindley Bioscience Center Purdue University West Lafayette, IN, USAIsabelle Fournier Laboratoire Protéomique Université de Lille Lille, FranceWolfram Gronwald Institute of Functional Genomics University of Regensburg Regensburg, GermanyKarsten Gülow Department of Internal Medicine I University Hospital Regensburg Regensburg, GermanyJörg Hanrieder Department of Psychiatry and Neurochemistry Sahlgrenka Academy at Gothenburg University Mölndal, SwedenSina-Franziska Heimer Department of Oral and Maxillofacial Surgery University Hospital Regensburg Regensburg, GermanyMathias Holpert NanoString Technologies, Inc. Seattle, WA, USAMarcus Höring Institute of Clinical Chemistry and Laboratory Medicine University Hospital Regensburg Regensburg, GermanyJonathan Jantsch Institute of Microbiology und Hygiene University Hospital Regensburg Regensburg, GermanyUwe Karst Institute of Inorganic and Analytical Chemistry University of Münster Münster, GermanyMary King Department of Chemistry University of Texas at Austin Austin, TX, USAMarina Kreutz Department of Internal Medicine III University Hospital Regensburg Regensburg, Germany

Dieter Kube Department of Haematology and Oncology University Medical Center Göttingen Göttingen, GermanyGerhard Liebisch Institute of Clinical Chemistry and Laboratory Medicine University Hospital Regensburg Regensburg, GermanyJason Locasale Department of Pharmacology and Cancer Biology Duke University School of Medicine Durham, NC, USARémi Longuespée Department of Clinical Pharmacology and Pharmacoepidemiology University Clinic Heidelberg Heidelberg, GermanyMartina Marchetti-Deschmann Institute of Chemical Technologies and Analytics Vienna University of Technologies Vienna, AustriaLiam McDonnell Center for Proteomics and Metabolomics Leiden University Medical Center Leiden, The NetherlandsPeter Oefner Institute of Functional Genomics University of Regensburg Regensburg, GermanyKathrin Renner-Sattler Department of Internal Medicine III University Hospital Regensburg Regensburg, GermanyColinda Scheele Division of Molecular Pathology, Oncode Institute The Netherlands Cancer Institute Amsterdam, The NetherlandsAlmut Schulze Department of Biochemistry and Molecular Biology Theodor-Boveri-Institute University of Würzburg Würzburg, Germany Kristina Schwamborn Institute of Pathology Technical University Munich Munich, GermanyAndrej Shevchenko Max Planck Institute of Molecular Cell Biology and Genetics Dresden, GermanyPeter Siska Department of Internal Medicine III University Hospital Regensburg Regensburg, GermanyAstrid Slany Department of Analytical Chemistry University of Vienna Vienna, AustriaRainer Spang Chair of Bioinformatics University of Regensburg Regensburg, GermanyTim Sparwasser Department of Medical Microbiology and Hygiene Johannes Gutenberg University Mainz Mainz, GermanyBernhard Spengler Institute of Inorganic and Analytical Chemistry Justus Liebig University Giessen Giessen, GermanyIain Styles School of Computer Science University of Birmingham Birmingham, UKZoltan Takats Imperial College London London, UKMichael Witting Department of Environmental Sciences (DES) Helmholtz Zentrum München Neuherberg, Germany

Photo and rights: UKR June 2019

Registration conditionsAfter your successful registration you will receive an invoice for your participation by email. Once registered your registration is binding. All payments must be made prior to the conference. Par-ticipation fees are due upon receipt of invoice without deduction. Please transfer the invoice amount before the event date. In case of a cancellation the cancellation statement must be in writing. The following processing fees apply: 8-3 working days before the event 50% of participa-tion fee. In case of too late cancellation or absence without written cancellation the entire fee will be charged. A substitute participant may be submitted at any time.

Dear colleagues,

the „Bavarian-Bohemian-Metabolism-Network“, a Euro-pean Union funded collaboration between the Institutes of Functional Genomics and Clinical Chemistry at the University of Regensburg and the Laboratory of Analytical Biochemistry and Metabolomics at the Biology Center CAS in Budweis, and the „Else Kröner Research College for Interdisciplinary Translational Immuno-Oncology“ are pleased to announce their joint symposium „Biomolecular Imaging Meets Immuno-Oncology“, which will be held in Regensburg from July 15-16, 2019.

The symposium will bring together national and inter-national leaders in the field of in situ analysis of bio-molecules, drugs and cells to explore the application of imaging techniques in advancing the understanding, diagnosis and therapy of immune and cancer diseases.

We are grateful to the colleagues, who have accepted our invitation to come to Regensburg to present their research. The symposium promises to deliver a compre-hensive review of the current status and potential of bio-molecular imaging in the life sciences and biomedicine.

We hope that you will join us in Regensburg for an exciting exchange of data and ideas, to which you may contribute by poster presentations. We will be happy to assist you in making arrangements for your visit.

Looking foward to seeing you in Regensburg.

Peter Oefner

Welcome Address

Monday, July 15, 201908:25 Opening Remarks

Peter OefnerSession I The Nuts and Bolts of Imaging Biomolecules Session Chairs: Isabelle Fournier, Kristina Schwamborn08:30 Imaging Mass Spectrometry in Bioanalysis

Uwe Karst09:00 Desorption Electrospray Ionization Mass Spectrometry Imaging:

Recent Developments and Perspectives Christina Ferreira

09:30 High Performance MALDI Mass Spectrometry Imaging in the Biomedical Field Bernhard Spengler

10:00 Coffee BreakSession II Cancer and Immune Cell Metabolism Session Chairs: Marina Kreutz, Liam McDonnell10:30 Glucose and Amino Acid Metabolism in Health and Cancer

Jason Locasale11:00 Targeting Cancer Metabolism

Almut Schulze11:30 Metabolic Communication in the Tumor Microenvironment:

New Perspectives on Macrophage Polarization Tobias Bopp

12:00 Metabolic Control of Treg Differentiation Luciana Berod

12:30 Metabolic Checkpoints Controlling Immune Cell Function Tim Sparwasser

13:00 LunchSession III Imaging Mass Spectrometry in Diagnostic Medicine Session Chairs: Christina Ferreira, Uwe Karst14:00 Imaging Mass Spectrometry - Applications in Pathology

Kristina Schwamborn14:30 Imaging Mass Spectrometry Utility in the Area of

Diagnostic Medicine Rita Casadonte

15:00 Molecular Imaging Mass Spectrometry to Probe Neuro-degenerative Disease Pathology Jörg Hanrieder

15:30 Coffee BreakSession IV Cancer and Immune Cell Metabolism Session Chairs: Kathrin Renner-Sattler, Tobias Bopp16:00 T Cell Metabolic Editing in Cancer and Infection

Guoliang Cui16:30 The Citrate-Malate Shuttle is Central to the Metabolic Pheno-

type of Cytokine Activated NK Cells Nadine Assmann

17:00 Cooperation of Jak/STAT and NF-κB Signaling Pathways - Aberrant GOT2 Expression and Glutamine Addiction in Aggressive Lymphoma Dieter Kube

17:30 Glycolytic Insufficiency and Mitochondrial Dysregulation Impair Function of Tumor Infiltrating CD8 T Cells Peter Siska

17:45 Inhibition of Tumor Growth and Metastasis Formation by Energy Depletion Karsten Gülow

18:15 Modulation of the Mitochondrial Pathway of Apoptosis by Hyperosmotic Stress Sina-Franziska Heimer

18:30 O2 in infected tissues and its impact on antimicrobial macro-phage defense mechanisms Jonathan Jantsch

19:00 - 22:00 Networking

Program Program

Tuesday, July, 16, 2019Session V From Imaging Biomolecules to Cells Session Chairs: Isabelle Fournier, Rita Casadonte08:30 Multimodal Imaging

Martina Marchetti-Deschmann09:00 Desorption Electrospray Ionization MS Imaging for Cancer

Diagnosis and Clinical Research Mary King

09:30 Intravital Microscopy Reveals Dynamics of Tissue Homeostasis and Tumor Progression Colinda Scheele

10:00 Deep Insights: New Applications of Intravital Multiphoton Microscopy Hayo Castrop

10:30 Coffee BreakSession VI Computational Challenges in Molecular Imaging Session Chairs: Martina Marchetti-Deschmann, Rainer Spang11:00 Metabolite Mass Spectrometry Imaging: Method Development,

Image Registration and Analysis, Bioinformatics and Statistical Analysis Liam McDonnell

11:30 Dimensionality Reduction and Image Segmentation in Mass Spectrometry Imaging Iain Styles

12:00 Visualization of Molecular Interaction Networks in Tissues by Mass Spectrometric Imaging Zoltan Takats

12:30 Computational Tissue Analysis Rainer Spang

13:00 LunchSession VII From Omics to Biomolecular Imaging Session Chairs: Zoltan Takats, Mary King14:00 Bridging MS Imaging with Spatially - Resolved Omics to Better

Characterize Tumor Microenvironment Isabelle Fournier

14:30 Multi-Omics Analysis to Reveal Immune Evasion and Metabolic Strategies of Tumor Cells Astrid Slany

15:00 Shotgun Lipidomics of Microdissected Tissues: a Complement for Molecular Imaging? Andrej Shevchenko

15:30 Morphology Driven High-Plex Spatial Analysis of Tissue Microenvironments Mathias Holpert

16:00 Coffee BreakSession VIII The Great Finale Session Chairs: Katja Dettmer, Astrid Slany16:30 Mass Spectrometric Imaging and Profiling Methods Meet Liquid

Chromatography for Pharmacological Applications Rémi Longuespée, Jürgen Burhenne

17:00 Quantification and Metabolic Profiling of Lipid Species Gerhard Liebisch

17:30 The Known and the Unknown Metabolism - The need for Metab-olite Identification Michael Witting

18:00 Accurate Quantification of Cholesterol and Cholesteryl Ester Species by FIA-FTMS Marcus Höring

18:15 Prediction of IDH Mutations in Gliomas Based on Full MRS Data Wolfram Gronwald

18:30 Concluding Remarks Peter Oefner