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GLUCOSE BIOSENSER

By saurabh mandal

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Glucose biosensor

Diabetes is a world-wide ublic health roblem !"#$ million eole

worldwide% &'O reort% ()*)+,

&'O roects that diabetes will be the $th leadin. cause o/ death

in ()")•  0his metabolic disorder results /rom

Insulin de1ciency

'yer.lycemia and is re2ected by blood .lucose

concentrations .oes hi.her than the normal ran.e o/ 3)-

*() m.4dL

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•  0he dia.nosis andmana.ement o/ diabetesmellitus re5uires a ti.htmonitorin. o/ blood

.lucose le6els,

• 7ccordin.ly% millions o/diabetics test their blood.lucose le6els daily%

ma8in. .lucose the mostcommonly tested analyte

Clar8 and Lyons 1rstroosed the initialconcet o/ .lucoseen9yme electrodes in *:;(

Clar8 is considered the

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N7NO0EC'NOLOG?- N7NODE@ICE

• Nanotechnolo.y has aAected almost allasects o/ biomedicine

• Nanomaterials selecti6e% 6ersatile%stable% sensiti6e

• Glucose biosensors are o/ secial clinicaland industrial si.ni1cance because o/ theirrole in monitorin. blood-.lucose le6els

• Indeed% .lucose biosensors are amon. the

/ew commercially success/ul sensin.roducts to date

• Glucose biosensors account /or about 3o/ the entire biosensor mar8et, Such hu.emar8et si9e ma8es diabetes a modeldisease /or de6eloin. new biosensin.

concets

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• Biosensor - “compact analytical device or unit incorporating a

 biological or biologically derived sensitive recognition

element integrated or associated with a physio-chemicaltransducer”

•three main parts of a biosensor:

(i) biological recognition elements

(ii) transducer

(iii) signal processing system

 

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Glucose Biosensors

• 1rst .lucose en9yme electrode relied on a thin layer o/ GOentraed o6er an oy.en electrode 6ia a semiermeabledialysis membrane

• monitorin. the oy.en consumed by the en9yme-cataly9ed

reaction

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• En9ymatic amerometric .lucose biosensors are the mostcommon de6ices commercially a6ailable

• .lucose measurements are based onF

heo8inase.lucose oidase !GO+

  .lucose-*-dehydro.enase !GD'+

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/eatures

• accuracy

• Small si9e

•

testin. seed• etended memory caacity

• comuter downloadin. caabilities

•

cost o/ the meter% cost o/ the teststris used

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 0han8 you