Wellness Traits Report Sample · If you have year round allergy-like symptoms, dust mites are...

Susan Smith� Allergies and Sensitivities� Fitness� Nutrition and Metabolism� Personality� Skin Care

09.30.2019

Table of Contents

Allergies and Sensitivities 1

� Predisposition Summary 2

� Indoor Allergies 3

Allergy to Cockroaches 3

Allergy to Dust Mites 4

Allergy to Mold 5

Allergy to Pets 6

Allergy to Eggs 7

Allergy to Milk 8

Allergy to Peanuts 9

General Food Sensitivities 11

Gluten Sensitivity 13

Lactose Intolerance 15

Birch Pollen Allergy Resistance 16

Grass Allergy Resistance 17

Hay Fever 18

Histamine Intolerance 19

Mugwort Allergy Resistance 20

Misophonia 21

Motion Sickness 22

Noise-induced Hearing Loss 23

Resistance to Stomach Flu 24

Table of Contents

Seasonality 25

Sensitivity to Benzene 26

Sensitivity to Mercury 27

Sensitivity to PCB 28

Fitness 29


� Injury Potential 31

Achilles Tendinopathy 31

Anterior Cruciate Ligament Rupture 33

Joint Injury Risk 35

Overall Tendon and Ligament Injury Risk 36

Stress Fracture 37

Aerobic Performance 38

Endurance 39

Exercise Aversion 40

Joint Flexibility 41

Lean Body Mass Potential 42

Power 43

Exercise Benefits for Blood Pressure 44

Exercise Benefits for Lowering Cholesterol 45

Exercise Benefits for Maximal Oxygen Uptake Response 46

Heartbeat Reduction Difficulty 47

Table of Contents

Lower Exercise Benefits for Heart Pump Function 48

Overall Fitness Benefits 49

Muscle Cramping 50

Muscle Damage Risk 51

Muscle Response to Resistance Training 52

Muscle Soreness 53

Muscle Strength Loss 55

Muscular Strength 56

Skeletal Muscle Performance 57

Slow Muscle Repair 58

Nutrition and Metabolism 59


� Diet And Metabolism 61

Bitter Taste Sensitivity 61

Caffeine Metabolism Impairment 62

Carb Overconsumption 63

Difficulty in Losing Weight 64

Fat Overconsumption 65

Fat Taste Perception 66

Low Protein Intake Risk 67

Low Vegetable Intake 68

Low-carb Diet Effectiveness 69

Table of Contents

Low-fat Diet Effectiveness 70

Mediterranean Diet Effectiveness 71

Monounsaturated Fats Increased Benefits 72

Overweight Potential 73

Polyunsaturated Fats Increased Benefits 74

Risk from Saturated Fats 75

Satiety Impairment 76

Snacking 77

Starch Metabolism 78

Sweet Snack Preference 79

Sweet Tooth 80

Trans Fats Sensitivity 81

Calcium Deficiency 82

Choline Deficiency 83

Coenzyme Q10 Deficiency 85

Copper Deficiency 86

Glutathione Deficiency 87

Iron Deficiency 88

Iron Overload 89

Magnesium Deficiency 90

Phosphorus Deficiency 91

Selenium Deficiency 92

Table of Contents

Sensitivity to Salt 93

Lutein and Zeaxanthin Deficiency 94

Lycopene Deficiency 95

Vitamin A (Carotene) Deficiency 96

Vitamin A (Retinol) Deficiency 97

Vitamin B1 Deficiency 98







Vitamin C Deficiency 105

Vitamin D Deficiency 106

Vitamin E Deficiency 107

Vitamin K Deficiency 108

Zinc Deficiency 109

Personality 110


� Personality Profile 112

Addictive Personality 112

Anger Response 113

Table of Contents

Exploratory Behavior 114

Impulsivity 115

Morning Person 116

Optimism 117

Warrior Personality 118

Worrier Personality 119

Agreeableness 120

Empathy 121

Extraversion 122

Leadership Potential 123

Sociability 124

Creativity 125

Experiential Learning Impairment 126

Mathematical Aptitude 127

Memory Performance 128

Music Performance Aptitude 129

Musical Creativity 130

Reading Aptitude 131

Skin Care 132


� Skin Profile 134

Acne 134

Table of Contents

Protection from Skin Cellulite 135

Skin Antioxidant Deficiency 136

Skin Inflammation 137

Skin Rosacea 138

Skin Stretch Marks 139

Collagen Breakdown 140

Sagging Eyelids Risk 141

Skin Glycation 142

Youthfulness 143

Contact Skin Sensitivity 144

Dermal Sensitivity 145

Pollution Defense Impairment 146

Skin Barrier Sensitivity 147

Skin Detoxification Impairment 148

Facial Pigmented Spots 149

Photoaging 150

Poor Tanning Ability 151

Sensitivity to Sun 152

Terms of Use 153

Allergies andSensitivities

� Indoor Allergies

� Food Allergies

� Outdoor Allergies

� Other Sensitivities

� Sensitivities To Chemicals

We live in a world that constantly challenges us with

allergens, toxins, bacteria and viruses. Hundreds of new

chemicals enter our food supply every year. Many more

are released into our environment. Ever-increasing noise

levels put our bodies under constant stress. But why do

some of us get sick constantly, suffer from allergies and

just barely make it through life, while others seem to

easily adapt to anything the environment throws at

them? Genetics has a lot to do with it. This report will

reveal your risks of various sensitivities based on your

unique genetic makeup.

1

Predisposition Summary

My Good Genes

AdvantagedBirch Pollen Allergy

Resistance

SlightlyAdvantagedGrass Allergy

Resistance

AdvantagedMugwort Allergy

Resistance

SlightlyAdvantagedResistance toStomach Flu

My Risky Genes

ElevatedAllergy to

Cockroaches

Slightly ElevatedAllergy to Dust Mites

ElevatedAllergy to Eggs

Slightly ElevatedAllergy to Milk

ElevatedGluten Sensitivity

ElevatedLactose Intolerance

Slightly ElevatedHay Fever

Slightly ElevatedHistamine

Intolerance

ElevatedMotion Sickness

ElevatedSensitivity to Mercury

2

Indoor Allergies

Allergy to Cockroaches

Elevated

Cockroaches live in many locations around the world, in all types of buildings and all kinds of neighborhoods. TheNational Pest Management Association reports that over 60 percent of homes in the United States contain cockroachallergens. This number rises to 80-90 percent in urban areas. The saliva, feces and shedding body parts of cockroachescontain a protein that can trigger allergies and even asthma in some people. A cockroach allergy is a trigger ofyear-round allergy and asthma. Common cockroach allergy symptoms include runny stuffy or itchy nose, itchy or redeyes, skin rash, cough, mucus. People with some genetic variations have higher risk of developing allergies tocockroaches.

Our Recommendations

� You may have a higher genetic risk of allergy to cockroaches, but genetics is only part of the equation.

� A cockroach allergy is a trigger of year-round allergy and asthma. Common cockroach allergy symptoms includerunny stuffy or itchy nose, itchy or red eyes, skin rash, cough, mucus. If you suspect that you have a cockroach allergy,you may try over-the-counter medicines such as nasal corticosteroids, antihistamines, decongestants

� Talk to your doctor about allergy test and what medications may be right for you

� In any case it is a good idea to minimize your exposure to cockroaches: fix leaky pipes under the sinks and in thebasement, seal cracks in the walls

� Store food in airtight containers, keep tables and floors free from crumbs, cover trash cans

� Do not use sprays as they can irritate allergies and trigger asthma

� Use cockroach baits and traps. Consult a pest control company.

2 Genetic Variations

rs12136904, rs2243123

3

Indoor Allergies

Allergy to Dust Mites

Slightly Elevated

Dust mites are microscopic creatures, related to ticks and spiders that live in house dust. The proteins in dust mite bodyparts and feces cause allergic reactions in some people. Dust allergy symptoms are similar to those of pollen allergiesand include red, itchy, watery eyes, runny, itchy, stuffy nose, sneezing. These symptoms persist all year round and feellike endless cold or even asthma. It is estimated that up to 20 million Americans have dust mite allergy. When inhaled,dust mite allergen triggers asthma attacks and is one of the most common causes of asthma attacks worldwide. This isprimarily because dust mites are found nearly everywhere, especially indoors. All homes contain some amount of dustmites. Because dust mites feed on dead human skin, the allergen tends to be concentrated in mattresses, bedding,upholstered furniture, carpets. Pets contribute dander to the dust and increase the food source for mites. Severalgenetic variations have been found to be associated with increased risk of allergy to dust-mites.

Our Recommendations

� While your genetics-based score is still within typical range, other factors may contribute to the risk of allergy

� If you have year round allergy-like symptoms, dust mites are likely to blame

� Even if you do not have these symptoms, reducing your exposure to dust is a good idea

� Use natural fiber rugs that can be cleaned easily

� Keep air in your house cool and clean


rs10174949, rs12924667, rs1800872

4

Indoor Allergies

Allergy to Mold

Normal

Mold are fungi that thrive both outside (in logs, fallen leaves, compost piles, grasses) and inside (in moist places likebathroom, kitchen, basement). There are many different types of mold, some are visible by eye, others are not. Moldsmake spores that float in the air like pollen. But unlike plants that produce pollen, mold do not die with the first frost.They simply slow down or stop growing during this time and they start growing in the spring. Some people are allergicto molds: when they inhale the spores they develop typical allergy symptoms. Genetic variations associated withallergies to two types of mold fungus (Cladosporium and Alternaria) have been identified.

Our Recommendations

� Take basic steps to reduce the mold in your house

� It is important to keep your house dry: molds thrive in moist conditions

� Do not use carpets in bathrooms and basement

� Fix water leaks

� Clean the garbage often and de-clutter (mold can grow in piles of old newspapers and clothing)


rs10189629, rs17388568

5

http://www.stuffed-pepper.com/am-i-gluten-sensitive-take-the-gluten-sensitivity-self-test/

http://allrecipes.com/recipes/741/healthy-recipes/gluten-free/

Fitness

� Injury Potential

� Fitness Profile

� Fitness Benefits

� Muscle Characteristics

Are you a sprinter or a marathon runner? Do you hit a

plateau easily and never reach your fitness goals? Get

injured often and for no apparent reason? Need extra

time between workouts because of sore muscles?

Haveto cut your workouts short or even skip them

altogether because of muscle cramps? Your DNA

makeup may hold the answers. Knowing your genetic

predispositions can help choose the right sport and

physical activity, adjust your exercise routine and avoid

pain. Working with your genes rather than against them

will help you stay ahead of the game.

29


My Good Genes

SlightlyAdvantaged

Aerobic Performance

AdvantagedExercise Benefits for

Blood Pressure

AdvantagedExercise Benefits forLowering Cholesterol

AdvantagedExercise Benefits for

Maximal OxygenUptake Response

AdvantagedOverall Fitness

Benefits

My Risky Genes

ElevatedAchilles

Tendinopathy

ElevatedAnterior Cruciate

Ligament Rupture

Slightly ElevatedJoint Injury Risk

ElevatedOverall Tendon andLigament Injury Risk

Slightly ElevatedStress Fracture

Slightly ElevatedExercise Aversion

Slightly ElevatedMuscle Soreness

ElevatedMuscle Strength Loss

30

Injury Potential

Achilles Tendinopathy

Elevated

Achilles tendon injury includes degenerative and painful conditions that affect athletes in a wide range of sports,including up to 20% of runners. This is a multifactorial condition for which various genetic risk factors have beenidentified. Genetic variants in the FBGN2, TNC and ADAMTS14 (metallopeptidase with thrombospondin) gene contributeto the reisk of achilles tendinopathy, while genetic variant in the MMP3 has been found to be protective.

Our Recommendations

� Your genetic risk for Achilles tendon injury seems to be slightly higher than average so you may need to extrameasures to protect your tendons.

� Try the following exercise to strengthen your calf muscles: � Use a resistance loop band or tie a long band into aloop 12" to 15" or 30 to 40 cm in diameter. Then, loop the resistance band around your foot with your toes pointed uptoward the ceiling. Holding the band tight, push your foot and ankle down against the band as far as comfortable.

� Hold the position for a second, then return back to your starting position slowly. Do 10 repetitions, then switch to yourother foot.

� Avoid an abrupt change of exercise intensity.

� Try to minimize high-impact sports, such as running which pose a higher risk for Achilles tendon injury.

� Switch to low-impact sports, such as walking, biking or swimming, which can both strengthen your muscles and poseless of an injury risk.


rs143383, rs4789932

31

Fitness Profile

Aerobic Performance

Slightly Advantaged

VO2 max (maximal aerobic capacity) is the maximum rate of oxygen uptake as measured during incremental exercise,most typically on a motorized treadmill. Maximal oxygen uptake reflects the aerobic physical fitness of the individual,and is an important determinant of their endurance capacity during prolonged, submaximal exercise. . Just a few of thebenefits of aerobic fitness are lower blood pressure, lower cholesterol and less risk of obesity, Type II diabetes andheart disease. Aerobic performance measured as the maximal rate of oxygen consumption (VO2max) is an importantdeterminant of the endurance capacity during prolonged exercise. VO2 max (V - volume, O2 - oxygen, max - maximum)is measured during incremental exercise. Overall, maximal oxygen consumption reflects the aerobic physical fitness ofthe individual, and it is widely accepted as the single best measure of cardiovascular fitness and maximal aerobicpower. Absolute values of VO2 max are typically 40-60% higher in men than in women. Starting at about the age of 30,our lung capacity begins to decrease. By the time we are 50 our lung capacity may be half of what it was in our youth.Decreased lung capacity means respiratory function is impaired and less oxygen is getting into our cells. This explainswhy shortness of breath, decreased endurance, and susceptibility to respiratory illness commonly increases with age.We check for several genetic variants that are associated with aerobic performance.

Our Recommendations

� You have a slightly elevated advantage likelihood for this trait. This means your lung capacity may be higher than anaverage adult. As such you may be able to do more strenuous exercises than the average population. However beforechanging any part of your fitness routine, always consult with a certified personal trainer.

� To improve your aerobic fitness even further, exercise intensity needs to be between 70 and 85 percent of yourtarget heart rate. In order to calculate your target heart rate, you must first determine your maximum heart rate, whichis 220 minus your age in years.

� If you are new to exercise you should aim for 10 to 20 minutes of aerobic exercise per session. Over time, graduallyincrease your exercise time until you can exercise continuously for 60 minutes.

� This will allow you to do more strenuous exercises with the same amount of oxygen uptake capacity.


rs7191721, rs9922134

38

Nutrition and Metabolism

� Diet And Metabolism

� Minerals

� Vitamins

Even a quick look around a restaurant on a busy night

makes it obvious we all have different tastes as well as

appetites. Are we born that way? Scientific evidence

shows that our preferences are swayed by our DNA. And

genetic influences don't stop there. They run much

deeper: our nutritional requirements, metabolic rate, the

ability to digest and absorb different types of food and

maintain proper levels of vitamins and minerals all have a

strong hereditary component. Even our propensity to

indulge in unhealthy food habits or benefit from healthy

diets are encoded in our genes.

59


My Good Genes

AdvantagedLow-fat DietEffectiveness

AdvantagedPolyunsaturated Fats

Increased Benefits

My Risky Genes

Slightly ElevatedFat Taste Perception

ElevatedOverweight Potential

ElevatedSatiety Impairment

Slightly ElevatedSnacking

Slightly ElevatedStarch Metabolism

ElevatedSweet SnackPreference

ElevatedSweet Tooth

Slightly ElevatedTrans Fats Sensitivity

ElevatedCholine Deficiency

+20

more

60

Diet And Metabolism

Bitter Taste Sensitivity

Normal

Taste perception plays a fundamental role in our dietary preferences and behaviors, by shaping aversions (or cravings)to foods and drinks. Adverse responses to bitterness are instinctive and drive rejection and avoidance behaviors. Theperception of bitterness is due to genetic variations in several bitter taste receptors: when food enters the mouth, themolecules, like phenylthiocarbamide (PTC) compound, interact with saliva, and then bind to taste receptors in themouth, giving the sensation of bitter taste. People with these genetic variations are sensitive to bitter vegetables thatare beneficial (like broccoli, Brussel sprouts, cabbage) or drinks (like coffee and dark beers). There is a growingevidence that taste genes play a much broader role in human health. A new study found that people who are naturallymore sensitive to bitterness are more likely to add sodium to their food, often exceeding recommended daily dietaryguidelines. At the same time, these people are more likely to avoid ingredients that are beneficial for health, includingdark leafy greens and broccoli.

Our Recommendations

� You are less likely to experience bitter taste sensitivity when consuming vegetables.

� Continue to eat a variety of vegetables to meet your daily needs.


rs978739

61

Minerals

Glutathione Deficiency

Slightly Elevated

Glutathione is a powerful antioxidant that is produced naturally by the liver. It is involved in tissue building, immuneresponse, nutrient metabolism, and regulation of cellular events, including cell proliferation and apoptosis. Glutathioneis often called the master antioxidant as it scavenges free radicals, peroxides, lipid peroxides and heavy metals.Glutathione is required for proper utilization and functioning of other antioxidants such as vitamins C, E, selenium andcarotenoids. Glutathione deficiency contributes to oxidative stress, which plays a key role in aging and the age-relateddiseases. Genetic variations (and deletions) in genes (GPX1 GSTP1 GSTT1 GSTM1) lead to lower production and activityof glutathione compromising its detoxification capacity. There is a growing scientific evidence that glutathione helpscontrol inflammation, fight infections, and boost immune system. It has been used to treat acne and as a skin lighteningagent. Glutathione occurs naturally in many foods but its absorption from fruits and vegetables may be low. Adequateamounts of protein increases the production of glutathione in our bodies.

Our Recommendations

� You may need to boost your body's production of glutathione by consuming the following food sources: beef, pork,poultry, fish, cheese, tofu, legumes. These foods are high in essential amino acids that provide building blocks forproducing glutathione.

� Studies showed that the expression and activity of GSTT1and GSTM1 genes coding for glutathione can be induced bythe consumption of cruciferous vegetables (cauliflower, cabbage, garden cress, bok choy, broccoli, Brussels sprouts).

� Regular exercise boosts glutathione production, however athletic over-training may result in lower glutathione.

� The use of intravenous glutathione injections is becoming popular, albeit controversial.

� Glutathione supplements are readily available but as always discuss it with your healthcare provider.


rs1050450, rs713041, rs7483

87

Minerals

Iron Deficiency

Elevated

Iron is an essential mineral that our bodies need for many functions. Iron is a key element in the metabolism of almostall living organisms. It is a part many proteins, including oxygen-carrying proteins, hemoglobin (found in red blood cells)and myglobin (found in muscle cells). Iron is also an essential component of antioxidant enzymes and metabolizingenzymes (cytochromes). Absorption, transport and storage of iron are tightly regulated, as iron is both an essential andpotentially toxic. Iron deficiency is the most common nutrient deficiency in the world. Symptoms of iron deficiency mayinclude fatigue, rapid heart rate and palpitations. Iron deficiency may interfere with physical and athletic performance.Young children, women of childbearing age, as well as vegetarians and vegans, are at higher risk of iron deficiency.

Our Recommendations

� You may want to consider increasing your iron intake through iron-rich foods. Hpowever be careful since too muchiron is also bad for the body.

� Typically, iron deficiency is diagnosed through blood tests, so discuss with your doctor about the need for screening.Depending on the screening results, your doctor might recommend an oral iron supplement.

� There are two types of iron: heme iron from animal sources and non-heme iron from plant sources. Heme iron isabsorbed more readily. Foods rich in heme iron include beef, poultry, liver, oysters, salmon, tuna. Good sources ofnon-heme iron include beans, fortified cereals, and dark leafy greens like spinach.

� If you are into strenuous physical activity, make sure your iron levels are within the norm.

� Do not take iron supplements without supervision of a healthcare professional as too much iron is harmful to thebody. Excessive intake of iron supplements can impair zinc absorption, increase risk for vascular disease, liver problemsand systemic iron overload.


rs13194491, rs228916, rs411988

88

Vitamins

Vitamin B12 Deficiency

Elevated

Vitamin B12 (cobalamin) is required for normal functioning of brain, nervous and digestive systems, red blood cellformation. It is involved in DNA synthesis, fatty acid and amino acid metabolism. Vitamin B12 can be only manufacturedby bacteria, and generally it can be found in animal food sources. Slight imbalances in vitamin B-12 can lead to anemia,fatigue, stomach inflammation, and affect nervous system. No toxic or adverse effects have been associated with largeintakes of vitamin B12 from food or supplements in healthy people. Genetic variants in several genes, including FUT2,MTHFR, MTRR, TCN2, have been linked to levels of vitamin B12.

Our Recommendations

� You are likely to benefit from increased intake of vitamin B12. Recommended dietary amounts (RDAs) are 2.4micrograms daily for ages 14 years and older, 2.6 micrograms daily for pregnant females, and 2.8 micrograms daily forbreastfeeding females.

� Top foods that contain vitamin B12 are liver, red meat, fish and shellfish, milk and dairy products, fortified soy, almondor rice beverages and products, fortified cereals, nutritional yeast and eggs.

� Since Vitamin B12 is found primarily in animal products, strict vegetarians and vegans in particular are at risk for adeficiency.

� Consult a registered dietitian or physician to make sure you are meeting your daily requirements for vitamin B12intake, in particular if you are a vegetarian or vegan.


rs1801131, rs1801198, rs1801222

99

Personality

� Personality Profile

� InterpersonalCharacteristics

� Learning Personality

Why are we all different? Leaders and followers, team

players and lone wolves, math geniuses and visual

artists, happy-go-lucky people and those always with a

chip on their shoulder... The list can go on. A lot of the

differences have to do with our surroundings and the

way we were raised. And yet, an ever-growing body of

scientific evidence shows that genetics plays a major role

in our personality traits and mental abilities. We are all

makers of our own destiny, but knowing your natural

predispositions may make life choices easier and the

path to success a bit shorter.

110


My Good Genes

AdvantagedWarrior Personality

AdvantagedAgreeableness

AdvantagedEmpathy

SlightlyAdvantaged

Leadership Potential

+2

more

My Risky Genes

111

Personality Profile

Addictive Personality

Normal

This trait measures whether you have genetic predispositions that would increase your likelihood of having an addictivepersonality. Addictions can come in a wide range of forms, including food, drugs, alcohol, gambling, pornography, oreven fitness/exercise. Addictive personality refers to a particular set of personality traits that make an individualpredisposed to developing addictions. Addictions can come in a wide range of forms, including food, drugs, alcohol,gambling, pornography, or even fitness/exercise. In addition to gene DRD2 that is implicated in reduced pleasureresponse, several other genetic variants have been found to be associated with addictive behaviors such as excessivealcohol consumption and smoking.

Our Recommendations

You do not seem to have known genetic predispositions for addictive personality.


rs10891549, rs1344694, rs1451240

112

Personality Profile

Anger Response

Normal

Individuals with higher anger response are more irritable and likely to get angry as a result of unsettling external stimuli.This is partially a result of the sensitivity of the central nervous system and the amygdala to external shocks and can beinfluenced by your genetics.

Our Recommendations

� You seem to have a typical predisposition likelihood for anger response.

� This doesn't mean you don't ever get angry, but it may mean that your anger outbursts may not be caused by knowngenetic variations.

� While anger is a natural and legitimate emotion, it is important to manage it to avoid hurting others or one's ownsense of peace.


rs2844775, rs555017, rs6012564

113

InterpersonalCharacteristics

Agreeableness

Advantaged

Agreeableness is a personality trait manifesting itself in individual behavioral characteristics that are perceived as kind,sympathetic, cooperative, warm and considerate. It is one of the Big Five personality traits. A person with a high level ofagreeableness in a personality test is usually warm, friendly, and tactful. They generally have an optimistic view ofhuman nature and get along well with others. We learn agreeableness within our family structures and the socialenvironments we grow up with. However research shows that agreeableness is partially influenced by our genetics.Interestingly, the agreeableness has been shown to be correlated with morningness. Indeed, the morningness allele ofthe circadian gene CLOCK is significantly associated with agreeableness.

Our Recommendations

� You score has advantaged for predisposition likelihood for agreeableness.

� If you are in a leadership position at work, this may help you build strong teams that have high cohesion.

� On the potentially negative side, you may dread making tough decisions and provide negative feedback even if it isnecessary.


rs1055356, rs1801260, rs2540226

120

Skin Care

� Skin Profile

� Skin And Aging

� Skin And The Environment

� Skin And The Sun

The skin is the largest organ in our body. Its importance is

hard to understate. Our skin is the first protective barrier

stopping pathogens, toxins and harmful UV rays from

entering our system and doing major damage. The

appearance of the skin is also an indicator of our health

and age. Our genes play a major role in our skin's ability

to fend off irritants and recover from damage. Wrinkles,

rashes, sunburn, acne, stretch marks - these areall

encoded in our DNA. Knowing your genetic

predispositions may help you keep your skin healthy and

looking great for many years.

132


My Good Genes

AdvantagedProtection from Skin

Cellulite

AdvantagedYouthfulness

My Risky Genes

ElevatedSkin Antioxidant

Deficiency

Slightly ElevatedSkin Inflammation

ElevatedSkin Rosacea

Slightly ElevatedSkin Stretch Marks

ElevatedCollagen Breakdown

ElevatedSkin Glycation

ElevatedDermal Sensitivity

Slightly ElevatedSkin BarrierSensitivity

ElevatedFacial Pigmented

Spots

+2

more

133

Skin Profile

Protection from Skin Cellulite

Advantaged

Cellulite is a condition when skin on thighs, hips, buttocks, and abdomen appears lumpy because of excess of fatbeneath the skin. It is most common in women than men and even thin people are prone to it.There are many causes ofcellulite including excessive weight, total body fat, poor diet, fad dieting, lack of physical activity, dehydration, hormonechanges, and genetic predisposition. A small study of 200 lean women with cellulite and 200 BMI-matched controlsidentified two variations in ACE and HIF1A genes that were significantly associated with appearance of cellulite. Manytreatments for cellulite, include massages, cellulite creams, lasers, and injections.Most of these treatments can workonly in combination with a healthy, active lifestyle.

Our Recommendations

� Follow general rules to minimize cellulite by maintaining a healthy weight: stay active and eat a healthy diet.

� Stay hydrated.

� For improved circulation, try daily dry skin brushing in circular motions.

� Use anti-cellulite creams. Recent clinical studies have suggested that caffeine-containing creams are effective inreducing the orange skin appearance caused by cellulite.


135

Skin Profile

Skin Antioxidant Deficiency

Elevated

A balance between free radicals and intrinsic antioxidants is necessary for proper physiological functioning as well as tomaintain youthful and healthy skin. Increased amounts of free radicals contribute to a dangerous chain of reactions thattarget tissues and organs in the body, including skin. This can trigger many chronic and late-onset diseases while alsoleading to premature aging by damaging the skinâ€™s proteins and lipids. To prevent such an occurrence, a masterregulator gene, NRF2 (NF-E2-Related Factor 2), prompts the activation of SOD2/CAT(enzyme/protein) when it istriggered by oxidative stress and electrophiles. These enzymes convert free radicals into less harmful products. Geneticvariations in NRF2, SOD2, and CAT can result in reduced antioxidant activities which then increases risk of damage tothe skinâ€™s lipids and proteins.

Our Recommendations

� Follow skin care recommendations that are infused with natural antioxidants (vitamin C, carotene, vitamin E, glutathione,green tea extract) which boost your skinâ€™s intrinsic antioxidant capacity.

� During the day, practice wearing antioxidant-rich day creams and sunscreen to help create a strong defense againstaging. For the night, use antioxidant-infused night creams which promote cellular repair and healing.

� Consume more antioxidant-rich foods in your diet such as blueberries, red berries, dark green leafy vegetables, sweetpotatoes, oranges, nuts, whole grains, and green tea.

� Consider intake of supplements that boost antioxidant NRF2 after consulting your physician.


rs35652124, rs6721961, rs769214

136

Wellness Traits Report Sample · If you have year round allergy-like symptoms, dust mites are...

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