Nuclear fragmentation in ion beam...
Transcript of Nuclear fragmentation in ion beam...
![Page 1: Nuclear fragmentation in ion beam therapyslcj.uw.edu.pl/wp-content/uploads/SlidesNusprasen/Wen_s2/Schuy.pdf · Nuclear fragmentation in ion beam therapy c.schuy@gsi.de. GSI Helmholtzzentrum](https://reader033.fdokument.com/reader033/viewer/2022060406/5f0f56d47e708231d443ab6d/html5/thumbnails/1.jpg)
GSI Helmholtzzentrum für Schwerionenforschung GmbH
GSI Helmholtzzentrum für Schwerionenforschung GmbH
Nuclear fragmentation in ion beam therapy
![Page 2: Nuclear fragmentation in ion beam therapyslcj.uw.edu.pl/wp-content/uploads/SlidesNusprasen/Wen_s2/Schuy.pdf · Nuclear fragmentation in ion beam therapy c.schuy@gsi.de. GSI Helmholtzzentrum](https://reader033.fdokument.com/reader033/viewer/2022060406/5f0f56d47e708231d443ab6d/html5/thumbnails/2.jpg)
GSI Helmholtzzentrum für Schwerionenforschung GmbH NuSPRASEN - C.Schuy - Biophysics
Content
▪ Motivation
▪ “New” ions - 4He@HIT ▪ Activation measurements
▪ Online monitoring of the Bragg peak ▪ Dose Delivery System
▪ Summary
![Page 3: Nuclear fragmentation in ion beam therapyslcj.uw.edu.pl/wp-content/uploads/SlidesNusprasen/Wen_s2/Schuy.pdf · Nuclear fragmentation in ion beam therapy c.schuy@gsi.de. GSI Helmholtzzentrum](https://reader033.fdokument.com/reader033/viewer/2022060406/5f0f56d47e708231d443ab6d/html5/thumbnails/3.jpg)
GSI Helmholtzzentrum für Schwerionenforschung GmbH NuSPRASEN - C.Schuy - Biophysics
Motivation
Patients treated
![Page 4: Nuclear fragmentation in ion beam therapyslcj.uw.edu.pl/wp-content/uploads/SlidesNusprasen/Wen_s2/Schuy.pdf · Nuclear fragmentation in ion beam therapy c.schuy@gsi.de. GSI Helmholtzzentrum](https://reader033.fdokument.com/reader033/viewer/2022060406/5f0f56d47e708231d443ab6d/html5/thumbnails/4.jpg)
GSI Helmholtzzentrum für Schwerionenforschung GmbH NuSPRASEN - C.Schuy - Biophysics
Motivation
M.Dosanjh 2017 based on PTCOG data
Patients treated
![Page 5: Nuclear fragmentation in ion beam therapyslcj.uw.edu.pl/wp-content/uploads/SlidesNusprasen/Wen_s2/Schuy.pdf · Nuclear fragmentation in ion beam therapy c.schuy@gsi.de. GSI Helmholtzzentrum](https://reader033.fdokument.com/reader033/viewer/2022060406/5f0f56d47e708231d443ab6d/html5/thumbnails/5.jpg)
GSI Helmholtzzentrum für Schwerionenforschung GmbH NuSPRASEN - C.Schuy - Biophysics
Increase of patient numbers
![Page 6: Nuclear fragmentation in ion beam therapyslcj.uw.edu.pl/wp-content/uploads/SlidesNusprasen/Wen_s2/Schuy.pdf · Nuclear fragmentation in ion beam therapy c.schuy@gsi.de. GSI Helmholtzzentrum](https://reader033.fdokument.com/reader033/viewer/2022060406/5f0f56d47e708231d443ab6d/html5/thumbnails/6.jpg)
GSI Helmholtzzentrum für Schwerionenforschung GmbH NuSPRASEN - C.Schuy - Biophysics
Motivation
range in water [cm]
rel.
dose
target
inverse depth dose profile
![Page 7: Nuclear fragmentation in ion beam therapyslcj.uw.edu.pl/wp-content/uploads/SlidesNusprasen/Wen_s2/Schuy.pdf · Nuclear fragmentation in ion beam therapy c.schuy@gsi.de. GSI Helmholtzzentrum](https://reader033.fdokument.com/reader033/viewer/2022060406/5f0f56d47e708231d443ab6d/html5/thumbnails/7.jpg)
GSI Helmholtzzentrum für Schwerionenforschung GmbH NuSPRASEN - C.Schuy - Biophysics
Motivation
range in water [cm]
rel.
dose
target
inverse depth dose profile increased biological effect
![Page 8: Nuclear fragmentation in ion beam therapyslcj.uw.edu.pl/wp-content/uploads/SlidesNusprasen/Wen_s2/Schuy.pdf · Nuclear fragmentation in ion beam therapy c.schuy@gsi.de. GSI Helmholtzzentrum](https://reader033.fdokument.com/reader033/viewer/2022060406/5f0f56d47e708231d443ab6d/html5/thumbnails/8.jpg)
GSI Helmholtzzentrum für Schwerionenforschung GmbH NuSPRASEN - C.Schuy - Biophysics
Motiviation
Cucinotta and Durante, Lancet Oncol. 2006
![Page 9: Nuclear fragmentation in ion beam therapyslcj.uw.edu.pl/wp-content/uploads/SlidesNusprasen/Wen_s2/Schuy.pdf · Nuclear fragmentation in ion beam therapy c.schuy@gsi.de. GSI Helmholtzzentrum](https://reader033.fdokument.com/reader033/viewer/2022060406/5f0f56d47e708231d443ab6d/html5/thumbnails/9.jpg)
GSI Helmholtzzentrum für Schwerionenforschung GmbH NuSPRASEN - C.Schuy - Biophysics
Motiviation
Cucinotta and Durante, Lancet Oncol. 2006
Higher ionization density
![Page 10: Nuclear fragmentation in ion beam therapyslcj.uw.edu.pl/wp-content/uploads/SlidesNusprasen/Wen_s2/Schuy.pdf · Nuclear fragmentation in ion beam therapy c.schuy@gsi.de. GSI Helmholtzzentrum](https://reader033.fdokument.com/reader033/viewer/2022060406/5f0f56d47e708231d443ab6d/html5/thumbnails/10.jpg)
GSI Helmholtzzentrum für Schwerionenforschung GmbH NuSPRASEN - C.Schuy - Biophysics
Motiviation
Cucinotta and Durante, Lancet Oncol. 2006
Higher ionization density
More complex damage
![Page 11: Nuclear fragmentation in ion beam therapyslcj.uw.edu.pl/wp-content/uploads/SlidesNusprasen/Wen_s2/Schuy.pdf · Nuclear fragmentation in ion beam therapy c.schuy@gsi.de. GSI Helmholtzzentrum](https://reader033.fdokument.com/reader033/viewer/2022060406/5f0f56d47e708231d443ab6d/html5/thumbnails/11.jpg)
GSI Helmholtzzentrum für Schwerionenforschung GmbH NuSPRASEN - C.Schuy - Biophysics
Motiviation
Cucinotta and Durante, Lancet Oncol. 2006
Higher ionization density
More complex damage
More difficult to repair
![Page 12: Nuclear fragmentation in ion beam therapyslcj.uw.edu.pl/wp-content/uploads/SlidesNusprasen/Wen_s2/Schuy.pdf · Nuclear fragmentation in ion beam therapy c.schuy@gsi.de. GSI Helmholtzzentrum](https://reader033.fdokument.com/reader033/viewer/2022060406/5f0f56d47e708231d443ab6d/html5/thumbnails/12.jpg)
GSI Helmholtzzentrum für Schwerionenforschung GmbH NuSPRASEN - C.Schuy - Biophysics
Motiviation
Cucinotta and Durante, Lancet Oncol. 2006
Higher ionization density
More complex damage
More difficult to repair
Higher biological efficiency
![Page 13: Nuclear fragmentation in ion beam therapyslcj.uw.edu.pl/wp-content/uploads/SlidesNusprasen/Wen_s2/Schuy.pdf · Nuclear fragmentation in ion beam therapy c.schuy@gsi.de. GSI Helmholtzzentrum](https://reader033.fdokument.com/reader033/viewer/2022060406/5f0f56d47e708231d443ab6d/html5/thumbnails/13.jpg)
GSI Helmholtzzentrum für Schwerionenforschung GmbH NuSPRASEN - C.Schuy - Biophysics
Motivation
Relative fluence 220 MeV/u 4He ions stopping in water
calculation courtesy of F. Horst
![Page 14: Nuclear fragmentation in ion beam therapyslcj.uw.edu.pl/wp-content/uploads/SlidesNusprasen/Wen_s2/Schuy.pdf · Nuclear fragmentation in ion beam therapy c.schuy@gsi.de. GSI Helmholtzzentrum](https://reader033.fdokument.com/reader033/viewer/2022060406/5f0f56d47e708231d443ab6d/html5/thumbnails/14.jpg)
GSI Helmholtzzentrum für Schwerionenforschung GmbH NuSPRASEN - C.Schuy - Biophysics
Motivation
▪ ~ 50 % of the primary 4He ions reach the Bragg peak
Relative fluence 220 MeV/u 4He ions stopping in water
calculation courtesy of F. Horst
![Page 15: Nuclear fragmentation in ion beam therapyslcj.uw.edu.pl/wp-content/uploads/SlidesNusprasen/Wen_s2/Schuy.pdf · Nuclear fragmentation in ion beam therapy c.schuy@gsi.de. GSI Helmholtzzentrum](https://reader033.fdokument.com/reader033/viewer/2022060406/5f0f56d47e708231d443ab6d/html5/thumbnails/15.jpg)
GSI Helmholtzzentrum für Schwerionenforschung GmbH NuSPRASEN - C.Schuy - Biophysics
Motivation
▪ ~ 50 % of the primary 4He ions reach the Bragg peak
▪ lighter fragments have increased penetration depth
Relative fluence 220 MeV/u 4He ions stopping in water
calculation courtesy of F. Horst
![Page 16: Nuclear fragmentation in ion beam therapyslcj.uw.edu.pl/wp-content/uploads/SlidesNusprasen/Wen_s2/Schuy.pdf · Nuclear fragmentation in ion beam therapy c.schuy@gsi.de. GSI Helmholtzzentrum](https://reader033.fdokument.com/reader033/viewer/2022060406/5f0f56d47e708231d443ab6d/html5/thumbnails/16.jpg)
GSI Helmholtzzentrum für Schwerionenforschung GmbH NuSPRASEN - C.Schuy - Biophysics
Motivation
▪ ~ 50 % of the primary 4He ions reach the Bragg peak
▪ lighter fragments have increased penetration depth
Relative fluence 220 MeV/u 4He ions stopping in water
calculation courtesy of F. Horst
Interaction with matter ↓
Change in radiation field ↓
Difference in radiation quality ↓
Prediction mandatory in therapy!
![Page 17: Nuclear fragmentation in ion beam therapyslcj.uw.edu.pl/wp-content/uploads/SlidesNusprasen/Wen_s2/Schuy.pdf · Nuclear fragmentation in ion beam therapy c.schuy@gsi.de. GSI Helmholtzzentrum](https://reader033.fdokument.com/reader033/viewer/2022060406/5f0f56d47e708231d443ab6d/html5/thumbnails/17.jpg)
GSI Helmholtzzentrum für Schwerionenforschung GmbH NuSPRASEN - C.Schuy - Biophysics
Insertion - Treatment planning
![Page 18: Nuclear fragmentation in ion beam therapyslcj.uw.edu.pl/wp-content/uploads/SlidesNusprasen/Wen_s2/Schuy.pdf · Nuclear fragmentation in ion beam therapy c.schuy@gsi.de. GSI Helmholtzzentrum](https://reader033.fdokument.com/reader033/viewer/2022060406/5f0f56d47e708231d443ab6d/html5/thumbnails/18.jpg)
GSI Helmholtzzentrum für Schwerionenforschung GmbH NuSPRASEN - C.Schuy - Biophysics
Insertion - Treatment planning
• TPS is trying to find optimal treatment within constraints• Biological effectiveness included!
![Page 19: Nuclear fragmentation in ion beam therapyslcj.uw.edu.pl/wp-content/uploads/SlidesNusprasen/Wen_s2/Schuy.pdf · Nuclear fragmentation in ion beam therapy c.schuy@gsi.de. GSI Helmholtzzentrum](https://reader033.fdokument.com/reader033/viewer/2022060406/5f0f56d47e708231d443ab6d/html5/thumbnails/19.jpg)
GSI Helmholtzzentrum für Schwerionenforschung GmbH NuSPRASEN - C.Schuy - Biophysics
Insertion - Treatment planning
• TPS is trying to find optimal treatment within constraints• Biological effectiveness included!
• Hybrid approach
![Page 20: Nuclear fragmentation in ion beam therapyslcj.uw.edu.pl/wp-content/uploads/SlidesNusprasen/Wen_s2/Schuy.pdf · Nuclear fragmentation in ion beam therapy c.schuy@gsi.de. GSI Helmholtzzentrum](https://reader033.fdokument.com/reader033/viewer/2022060406/5f0f56d47e708231d443ab6d/html5/thumbnails/20.jpg)
GSI Helmholtzzentrum für Schwerionenforschung GmbH NuSPRASEN - C.Schuy - Biophysics
Insertion - Treatment planning
• TPS is trying to find optimal treatment within constraints• Biological effectiveness included!
• Hybrid approach• Benchmark experiments (QA) using water -> Base data PTW website
![Page 21: Nuclear fragmentation in ion beam therapyslcj.uw.edu.pl/wp-content/uploads/SlidesNusprasen/Wen_s2/Schuy.pdf · Nuclear fragmentation in ion beam therapy c.schuy@gsi.de. GSI Helmholtzzentrum](https://reader033.fdokument.com/reader033/viewer/2022060406/5f0f56d47e708231d443ab6d/html5/thumbnails/21.jpg)
GSI Helmholtzzentrum für Schwerionenforschung GmbH NuSPRASEN - C.Schuy - Biophysics
Insertion - Treatment planning
• TPS is trying to find optimal treatment within constraints• Biological effectiveness included!
• Hybrid approach• Benchmark experiments (QA) using water -> Base data • MC (Fluka) for full base data calculation
PTW website
![Page 22: Nuclear fragmentation in ion beam therapyslcj.uw.edu.pl/wp-content/uploads/SlidesNusprasen/Wen_s2/Schuy.pdf · Nuclear fragmentation in ion beam therapy c.schuy@gsi.de. GSI Helmholtzzentrum](https://reader033.fdokument.com/reader033/viewer/2022060406/5f0f56d47e708231d443ab6d/html5/thumbnails/22.jpg)
GSI Helmholtzzentrum für Schwerionenforschung GmbH NuSPRASEN - C.Schuy - Biophysics
Insertion - Treatment planning
• TPS is trying to find optimal treatment within constraints• Biological effectiveness included!
• Hybrid approach• Benchmark experiments (QA) using water -> Base data • MC (Fluka) for full base data calculation• Deterministic Code (e.g. TRiP98) for planning
PTW website
![Page 23: Nuclear fragmentation in ion beam therapyslcj.uw.edu.pl/wp-content/uploads/SlidesNusprasen/Wen_s2/Schuy.pdf · Nuclear fragmentation in ion beam therapy c.schuy@gsi.de. GSI Helmholtzzentrum](https://reader033.fdokument.com/reader033/viewer/2022060406/5f0f56d47e708231d443ab6d/html5/thumbnails/23.jpg)
GSI Helmholtzzentrum für Schwerionenforschung GmbH NuSPRASEN - C.Schuy - Biophysics
Insertion - Treatment planning
• TPS is trying to find optimal treatment within constraints• Biological effectiveness included!
• Hybrid approach• Benchmark experiments (QA) using water -> Base data • MC (Fluka) for full base data calculation• Deterministic Code (e.g. TRiP98) for planning
• Plan QA
PTW website
![Page 24: Nuclear fragmentation in ion beam therapyslcj.uw.edu.pl/wp-content/uploads/SlidesNusprasen/Wen_s2/Schuy.pdf · Nuclear fragmentation in ion beam therapy c.schuy@gsi.de. GSI Helmholtzzentrum](https://reader033.fdokument.com/reader033/viewer/2022060406/5f0f56d47e708231d443ab6d/html5/thumbnails/24.jpg)
GSI Helmholtzzentrum für Schwerionenforschung GmbH NuSPRASEN - C.Schuy - Biophysics
“New” ions - 4He@HIT
![Page 25: Nuclear fragmentation in ion beam therapyslcj.uw.edu.pl/wp-content/uploads/SlidesNusprasen/Wen_s2/Schuy.pdf · Nuclear fragmentation in ion beam therapy c.schuy@gsi.de. GSI Helmholtzzentrum](https://reader033.fdokument.com/reader033/viewer/2022060406/5f0f56d47e708231d443ab6d/html5/thumbnails/25.jpg)
GSI Helmholtzzentrum für Schwerionenforschung GmbH NuSPRASEN - C.Schuy - Biophysics
“New” ions - 4He@HITBevalac USA
![Page 26: Nuclear fragmentation in ion beam therapyslcj.uw.edu.pl/wp-content/uploads/SlidesNusprasen/Wen_s2/Schuy.pdf · Nuclear fragmentation in ion beam therapy c.schuy@gsi.de. GSI Helmholtzzentrum](https://reader033.fdokument.com/reader033/viewer/2022060406/5f0f56d47e708231d443ab6d/html5/thumbnails/26.jpg)
GSI Helmholtzzentrum für Schwerionenforschung GmbH NuSPRASEN - C.Schuy - Biophysics
“New” ions - 4He@HIT
▪ physical and biological “compromise” between protons and 12C
Bevalac USA
![Page 27: Nuclear fragmentation in ion beam therapyslcj.uw.edu.pl/wp-content/uploads/SlidesNusprasen/Wen_s2/Schuy.pdf · Nuclear fragmentation in ion beam therapy c.schuy@gsi.de. GSI Helmholtzzentrum](https://reader033.fdokument.com/reader033/viewer/2022060406/5f0f56d47e708231d443ab6d/html5/thumbnails/27.jpg)
GSI Helmholtzzentrum für Schwerionenforschung GmbH NuSPRASEN - C.Schuy - Biophysics
“New” ions - 4He@HIT
▪ physical and biological “compromise” between protons and 12C▪ RBE in Bragg peak region > protons
Bevalac USA
![Page 28: Nuclear fragmentation in ion beam therapyslcj.uw.edu.pl/wp-content/uploads/SlidesNusprasen/Wen_s2/Schuy.pdf · Nuclear fragmentation in ion beam therapy c.schuy@gsi.de. GSI Helmholtzzentrum](https://reader033.fdokument.com/reader033/viewer/2022060406/5f0f56d47e708231d443ab6d/html5/thumbnails/28.jpg)
GSI Helmholtzzentrum für Schwerionenforschung GmbH NuSPRASEN - C.Schuy - Biophysics
“New” ions - 4He@HIT
▪ physical and biological “compromise” between protons and 12C▪ RBE in Bragg peak region > protons▪ Less energy straggling -> protons
Bevalac USA
![Page 29: Nuclear fragmentation in ion beam therapyslcj.uw.edu.pl/wp-content/uploads/SlidesNusprasen/Wen_s2/Schuy.pdf · Nuclear fragmentation in ion beam therapy c.schuy@gsi.de. GSI Helmholtzzentrum](https://reader033.fdokument.com/reader033/viewer/2022060406/5f0f56d47e708231d443ab6d/html5/thumbnails/29.jpg)
GSI Helmholtzzentrum für Schwerionenforschung GmbH NuSPRASEN - C.Schuy - Biophysics
“New” ions - 4He@HIT
▪ physical and biological “compromise” between protons and 12C▪ RBE in Bragg peak region > protons▪ Less energy straggling -> protons▪ Less lateral scattering -> protons
courtesy of M.Rovituso (Thesis)
Bevalac USA
![Page 30: Nuclear fragmentation in ion beam therapyslcj.uw.edu.pl/wp-content/uploads/SlidesNusprasen/Wen_s2/Schuy.pdf · Nuclear fragmentation in ion beam therapy c.schuy@gsi.de. GSI Helmholtzzentrum](https://reader033.fdokument.com/reader033/viewer/2022060406/5f0f56d47e708231d443ab6d/html5/thumbnails/30.jpg)
GSI Helmholtzzentrum für Schwerionenforschung GmbH NuSPRASEN - C.Schuy - Biophysics
“New” ions - 4He@HIT
▪ physical and biological “compromise” between protons and 12C▪ RBE in Bragg peak region > protons▪ Less energy straggling -> protons▪ Less lateral scattering -> protons▪ Less projectile fragmentation -> 12C
courtesy of M.Rovituso (Thesis) courtesy of M.Rovituso (Thesis)
Bevalac USA
![Page 31: Nuclear fragmentation in ion beam therapyslcj.uw.edu.pl/wp-content/uploads/SlidesNusprasen/Wen_s2/Schuy.pdf · Nuclear fragmentation in ion beam therapy c.schuy@gsi.de. GSI Helmholtzzentrum](https://reader033.fdokument.com/reader033/viewer/2022060406/5f0f56d47e708231d443ab6d/html5/thumbnails/31.jpg)
GSI Helmholtzzentrum für Schwerionenforschung GmbH NuSPRASEN - C.Schuy - Biophysics
“New” ions - 4He@HIT
▪ Planned start for 4He@HIT 2019
![Page 32: Nuclear fragmentation in ion beam therapyslcj.uw.edu.pl/wp-content/uploads/SlidesNusprasen/Wen_s2/Schuy.pdf · Nuclear fragmentation in ion beam therapy c.schuy@gsi.de. GSI Helmholtzzentrum](https://reader033.fdokument.com/reader033/viewer/2022060406/5f0f56d47e708231d443ab6d/html5/thumbnails/32.jpg)
GSI Helmholtzzentrum für Schwerionenforschung GmbH NuSPRASEN - C.Schuy - Biophysics
“New” ions - 4He@HIT
▪ Planned start for 4He@HIT 2019▪ Inaccurate/missing cross section data
![Page 33: Nuclear fragmentation in ion beam therapyslcj.uw.edu.pl/wp-content/uploads/SlidesNusprasen/Wen_s2/Schuy.pdf · Nuclear fragmentation in ion beam therapy c.schuy@gsi.de. GSI Helmholtzzentrum](https://reader033.fdokument.com/reader033/viewer/2022060406/5f0f56d47e708231d443ab6d/html5/thumbnails/33.jpg)
GSI Helmholtzzentrum für Schwerionenforschung GmbH NuSPRASEN - C.Schuy - Biophysics
“New” ions - 4He@HIT
▪ Planned start for 4He@HIT 2019▪ Inaccurate/missing cross section data▪ Measurement campaign to benchmark TRiP98
![Page 34: Nuclear fragmentation in ion beam therapyslcj.uw.edu.pl/wp-content/uploads/SlidesNusprasen/Wen_s2/Schuy.pdf · Nuclear fragmentation in ion beam therapy c.schuy@gsi.de. GSI Helmholtzzentrum](https://reader033.fdokument.com/reader033/viewer/2022060406/5f0f56d47e708231d443ab6d/html5/thumbnails/34.jpg)
GSI Helmholtzzentrum für Schwerionenforschung GmbH NuSPRASEN - C.Schuy - Biophysics
“New” ions - 4He@HIT
▪ Planned start for 4He@HIT 2019▪ Inaccurate/missing cross section data▪ Measurement campaign to benchmark TRiP98
▪ Attenuation of the primary beam
M.Kraemer et al, Med. Phys. 2016
4He@200MeV/u on water
![Page 35: Nuclear fragmentation in ion beam therapyslcj.uw.edu.pl/wp-content/uploads/SlidesNusprasen/Wen_s2/Schuy.pdf · Nuclear fragmentation in ion beam therapy c.schuy@gsi.de. GSI Helmholtzzentrum](https://reader033.fdokument.com/reader033/viewer/2022060406/5f0f56d47e708231d443ab6d/html5/thumbnails/35.jpg)
GSI Helmholtzzentrum für Schwerionenforschung GmbH NuSPRASEN - C.Schuy - Biophysics
“New” ions - 4He@HIT
▪ Planned start for 4He@HIT 2019▪ Inaccurate/missing cross section data▪ Measurement campaign to benchmark TRiP98
▪ Attenuation of the primary beam▪ Double differential yields
M.Kraemer et al, Med. Phys. 2016
4He@120MeV/u on 4.28cm water
M.Rovituso et al, PMB 2017
4He@200MeV/u on water
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GSI Helmholtzzentrum für Schwerionenforschung GmbH NuSPRASEN - C.Schuy - Biophysics
“New” ions - 4He@HIT
SOPB calculated in H20
calculation courtesy of F. Horst
![Page 37: Nuclear fragmentation in ion beam therapyslcj.uw.edu.pl/wp-content/uploads/SlidesNusprasen/Wen_s2/Schuy.pdf · Nuclear fragmentation in ion beam therapy c.schuy@gsi.de. GSI Helmholtzzentrum](https://reader033.fdokument.com/reader033/viewer/2022060406/5f0f56d47e708231d443ab6d/html5/thumbnails/37.jpg)
GSI Helmholtzzentrum für Schwerionenforschung GmbH NuSPRASEN - C.Schuy - Biophysics
“New” ions - 4He@HIT
SOPB calculated in H20
calculation courtesy of F. Horst
![Page 38: Nuclear fragmentation in ion beam therapyslcj.uw.edu.pl/wp-content/uploads/SlidesNusprasen/Wen_s2/Schuy.pdf · Nuclear fragmentation in ion beam therapy c.schuy@gsi.de. GSI Helmholtzzentrum](https://reader033.fdokument.com/reader033/viewer/2022060406/5f0f56d47e708231d443ab6d/html5/thumbnails/38.jpg)
GSI Helmholtzzentrum für Schwerionenforschung GmbH NuSPRASEN - C.Schuy - Biophysics
“New” ions - 4He@HIT
SOPB calculated in H20
calculation courtesy of F. Horst F. Horst et al. Phys. Rev. C 2017
![Page 39: Nuclear fragmentation in ion beam therapyslcj.uw.edu.pl/wp-content/uploads/SlidesNusprasen/Wen_s2/Schuy.pdf · Nuclear fragmentation in ion beam therapy c.schuy@gsi.de. GSI Helmholtzzentrum](https://reader033.fdokument.com/reader033/viewer/2022060406/5f0f56d47e708231d443ab6d/html5/thumbnails/39.jpg)
GSI Helmholtzzentrum für Schwerionenforschung GmbH NuSPRASEN - C.Schuy - Biophysics
“New” ions - 4He@HIT
SOPB calculated in H20
calculation courtesy of F. Horst F. Horst et al. Phys. Rev. C 2017
Tripathi cross section parametrization (implemented in TRiP) under-estimates the
4He+12C reaction cross section by up to 30%.
![Page 40: Nuclear fragmentation in ion beam therapyslcj.uw.edu.pl/wp-content/uploads/SlidesNusprasen/Wen_s2/Schuy.pdf · Nuclear fragmentation in ion beam therapy c.schuy@gsi.de. GSI Helmholtzzentrum](https://reader033.fdokument.com/reader033/viewer/2022060406/5f0f56d47e708231d443ab6d/html5/thumbnails/40.jpg)
GSI Helmholtzzentrum für Schwerionenforschung GmbH NuSPRASEN - C.Schuy - Biophysics
“New” ions - 4He@HIT
Courtesy of F. Horst and G. Arico*
Collaboration with Fluka core developers
Preliminary Preliminary
* as shown at MCMA 2017
![Page 41: Nuclear fragmentation in ion beam therapyslcj.uw.edu.pl/wp-content/uploads/SlidesNusprasen/Wen_s2/Schuy.pdf · Nuclear fragmentation in ion beam therapy c.schuy@gsi.de. GSI Helmholtzzentrum](https://reader033.fdokument.com/reader033/viewer/2022060406/5f0f56d47e708231d443ab6d/html5/thumbnails/41.jpg)
GSI Helmholtzzentrum für Schwerionenforschung GmbH NuSPRASEN - C.Schuy - Biophysics
▪ So far ...
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GSI Helmholtzzentrum für Schwerionenforschung GmbH NuSPRASEN - C.Schuy - Biophysics
▪ So far ...▪ Fragmentation -> Dose degradation
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GSI Helmholtzzentrum für Schwerionenforschung GmbH NuSPRASEN - C.Schuy - Biophysics
▪ So far ...▪ Fragmentation -> Dose degradation▪ But can be also useful -> PET
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GSI Helmholtzzentrum für Schwerionenforschung GmbH NuSPRASEN - C.Schuy - Biophysics
▪ So far ...▪ Fragmentation -> Dose degradation▪ But can be also useful -> PET
W. Enghardt et al, Nucl. Instr. Meth. Phys. Res. A 2004
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GSI Helmholtzzentrum für Schwerionenforschung GmbH NuSPRASEN - C.Schuy - Biophysics
Activation measurements
▪ PET measurement approach -> Target fragmentation
![Page 46: Nuclear fragmentation in ion beam therapyslcj.uw.edu.pl/wp-content/uploads/SlidesNusprasen/Wen_s2/Schuy.pdf · Nuclear fragmentation in ion beam therapy c.schuy@gsi.de. GSI Helmholtzzentrum](https://reader033.fdokument.com/reader033/viewer/2022060406/5f0f56d47e708231d443ab6d/html5/thumbnails/46.jpg)
GSI Helmholtzzentrum für Schwerionenforschung GmbH NuSPRASEN - C.Schuy - Biophysics
Activation measurements
▪ PET measurement approach -> Target fragmentation
Test experiment at Trento proton therapy center, Italy in June 2017
Protons on carbon
![Page 47: Nuclear fragmentation in ion beam therapyslcj.uw.edu.pl/wp-content/uploads/SlidesNusprasen/Wen_s2/Schuy.pdf · Nuclear fragmentation in ion beam therapy c.schuy@gsi.de. GSI Helmholtzzentrum](https://reader033.fdokument.com/reader033/viewer/2022060406/5f0f56d47e708231d443ab6d/html5/thumbnails/47.jpg)
GSI Helmholtzzentrum für Schwerionenforschung GmbH NuSPRASEN - C.Schuy - Biophysics
Activation measurements
▪ PET measurement approach -> Target fragmentation
Test experiment at Trento proton therapy center, Italy in June 2017
Protons on carbon
PRELIMINARY
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GSI Helmholtzzentrum für Schwerionenforschung GmbH NuSPRASEN - C.Schuy - Biophysics
Activation measurements
▪ PET measurement approach -> Target fragmentation
Test experiment at Trento proton therapy center, Italy in June 2017
Protons on carbon
PRELIMINARYFOOT collaboration (FragmentatiOn Of Target) • funded by INFN • 50+ researchers • Inverse kinematic strategy • Measurement ready 2019/20
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GSI Helmholtzzentrum für Schwerionenforschung GmbH NuSPRASEN - C.Schuy - Biophysics
Online monitoring of the Bragg peak
▪ PET is typically used after the treatment
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GSI Helmholtzzentrum für Schwerionenforschung GmbH NuSPRASEN - C.Schuy - Biophysics
Online monitoring of the Bragg peak
▪ PET is typically used after the treatment▪ Use prompt radiation to monitor treatment in real time
Beamline
Nozzle
Window Rifitarget volume
light fragments
prompt γ
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GSI Helmholtzzentrum für Schwerionenforschung GmbH NuSPRASEN - C.Schuy - Biophysics
Online monitoring of the Bragg peak
▪ PET is typically used after the treatment▪ Use prompt radiation to monitor treatment in real time▪ Problem -> Perform measurement within constraints of
treatment
Beamline
Nozzle
Window Rifitarget volume
light fragments
prompt γ
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GSI Helmholtzzentrum für Schwerionenforschung GmbH NuSPRASEN - C.Schuy - Biophysics
Dose Delivery System
▪ collaboration of CNAO and GSI for a next generation scanning system
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GSI Helmholtzzentrum für Schwerionenforschung GmbH NuSPRASEN - C.Schuy - Biophysics
Dose Delivery System
▪ collaboration of CNAO and GSI for a next generation scanning system
▪ => core of the irradiation controls
lateral:dipol magnets
longitudinal:beam energy
Beamline
Nozzle
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GSI Helmholtzzentrum für Schwerionenforschung GmbH NuSPRASEN - C.Schuy - Biophysics
Dose Delivery System
▪ collaboration of CNAO and GSI for a next generation scanning system
▪ => core of the irradiation controls▪ FPGA-based▪ 4D (tumor motion) capabilities
lateral:dipol magnets
longitudinal:beam energy
Beamline
Nozzle
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GSI Helmholtzzentrum für Schwerionenforschung GmbH NuSPRASEN - C.Schuy - Biophysics
Dose Delivery System
▪ collaboration of CNAO and GSI for a next generation scanning system
▪ => core of the irradiation controls▪ FPGA-based▪ 4D (tumor motion) capabilities
▪ Main problem -> Fast Beam monitoring detectors!
lateral:dipol magnets
longitudinal:beam energy
Beamline
Nozzle
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GSI Helmholtzzentrum für Schwerionenforschung GmbH NuSPRASEN - C.Schuy - Biophysics
Summary
▪ High quality cross section measurements are always needed!
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GSI Helmholtzzentrum für Schwerionenforschung GmbH NuSPRASEN - C.Schuy - Biophysics
Summary
▪ High quality cross section measurements are always needed!
▪ But there is more for the nuclear physics community to do:
▪ Online monitoring of the Bragg peak -> Experimental expertise
▪ Dose Delivery System -> Detector R&D
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GSI Helmholtzzentrum für Schwerionenforschung GmbH NuSPRASEN - C.Schuy - Biophysics
Thanks for your attention