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BIOSTRUCT@INNSBRUCK 2013 Bringing together structural biology methods, technology and topics of the

Innsbruck Campus

February 28 – March 1, 2013 CCB (Center for Chemistry & Biomedicine) Room: L.01.220 (1st

floor)

organized by Klaus Scheffzek, Klaus Liedl and Theresia Dunzendorfer-Matt

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P R O G R A M

Thursday, February 28, 2013 11:30-12:15 Registration / Lunch Snack (L.01.220 – Foyer)

12:15-12:30 Welcome and Opening

Session 1: Medicine (Chair: Klaus Scheffzek) 12:30-12:50 Mutation-specific structural changes: impact on clinical management in

inborn errors of metabolism (Johannes Zschocke, Innsbruck) 12:50-13:10 ABC transporter-mediated siderophore excretion in the opportunistic

fungal pathogen Aspergillus fumigatus (Hubertus Haas, Innsbruck) 13:10-13:30 Structure-function analysis of the vitamin E-binding protein afamin by X-ray

crystallography-enabled structure solution (Hans Dieplinger, Innsbruck) 13:30-13:50 Membrane enzymes in alkylglycerol degradation (Ernst Werner, Innsbruck) 13:50-14:40 Keynote (Chair: Klaus Scheffzek)

X-ray Free Electron Lasers - Emerging Opportunities for Structural Biology

(Ilme Schlichting, Heidelberg)

14:40-14:50 Break Session 2: Equipment (Chair: Marianna Biadene) 14:50-15:00 Insect cell culture (Stefan Lechner, Innsbruck) 15:00-15:10 Mass spectrometry (Herbert Lindner, Innsbruck)

15:10-15:20 NMR (Martin Tollinger, Innsbruck) 15:20-15:30 Crystallization and X-ray systems (Marianna Biadene, Innsbruck) 15:30-15:35 Molecules of life & mutations, a practical course (Siegfried Schwarz, Innsbruck) 15:35-16:05 Keynote (Chair: Marianna Biadene)

Trust but verify: The Good, the Bad and the Ugly (Bernhard Rupp, Innsbruck)

16:05-16:30 Coffee break 16:30-17:20 Keynote (Chair: Martin Tollinger)

NMR Spectroscopy for the Determination of Biomolecular Structures and Functions (Horst Kessler, München)

Session 3: Dynamics (Chair: Martin Tollinger) 17:20-17:40 Dynamics and structure of nucleic acids probed via solution NMR

spectroscopy (Christoph Kreutz, Innsbruck) 17:40-18:00 Protein dynamics and function (Martin Tollinger, Innsbruck) 18:00-18:20 Protein and RNA characterization by Mass spectrometry

(Kathrin Breuker, Innsbruck) 18:20-18:40 Computational Biomolecular Dynamics (Roland Huber, Innsbruck) 19:00 Dinner (canteen area) / informal get together

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Friday, March 1, 2013 08:15-08:30 Opening & wake up coffee

08:30-09:20 Keynote (Chair: Klaus Liedl)

Structure prediction of conformational changes within Nav channel voltage-sensing domain (Vladimir Yarov-Yarovoy, UC Davis/USA)

Session 4: Dynamics & Modeling (Chair: Klaus Liedl) 09:20-09:40 Dynamics Direct Specificity of Effector Caspases (Julian E. Fuchs, Innsbruck) 09:40-10:00 Can structure modeling explain differences in the voltage-sensitivity of

calcium channels? (Petronel Tuluc, Innsbruck) 10:00-10:50 Keynote (Chair: Theresia Dunzendorfer-Matt) Complexomics: New tools and strategies for multiprotein complex

research (Imre Berger, Grenoble)

10:50-11:10 Coffee break Session 5: Signaling (Chair: Eduard Stefan) 11:10-11:30 Oncogenic transcription factors and their cellular targets

(Klaus Bister, Innsbruck) 11:30-11:50 Structural insights into the LAMTOR complex - a multimeric LEGO® brick-

like platform on late endosomes that coordinates signaling and late endosomal biogenesis (Mariana Eca Guimaraes Araujo, Innsbruck)

11:50-12:10 Molecular link between the RASopathy disorders Neurofibromatosis and Legius Syndrome (Theresia Dunzendorfer-Matt, Innsbruck)

12:10-12:30 Functional analysis of CCNY-activated kinases (Stephan Geley, Innsbruck) 12:30-12:50 Analysis and perturbation of dynamic cellular protein complexes

(Eduard Stefan, Innsbruck) 12:50-13:00 Break 13:00-14:00 Keynote (Chair: Kristina Djinovic-Carugo, Vienna)

Structural Studies using Hybrid Methods/INSTRUCT (Wolfgang Baumeister, Munich)

14:00 Closing remarks / Lunch snack

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